Abl interactor 1 - Rattus norvegicus (Rat)

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Q9QZM5 (ABI1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 85. History...

Clusters with 100%, 90%, 50% identity |

Documents (1) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Abl interactor 1

Alternative name(s):
Abelson interactor 1
Short name=Abi-1
Eps8 SH3 domain-binding protein
Short name=Eps8-binding protein
e3B1

Gene names

Name:

Abi1

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	476 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level By similarity.
Subunit structure	Interacts with ABL1, ENAH, STX1A, SNAP25, VAMP2, EPS8, SOS1, SOS2, GRB2, SPTA1, NCKAP1/NAP1, the first SH3 domain of NCK1 and through its N-terminus with WASF1. Part of a complex consisting of ABI1, STX1A and SNAP25. Part of a complex consisting of ABI1, EPS8 and SOS1. Component of the WAVE2 complex composed of ABI1, CYFIP1/SRA1, NCKAP1/NAP1 and WASF2/WAVE2 By similarity.
Subcellular location	Cytoplasm By similarity. Nucleus By similarity. Cell projection › lamellipodium. Cell projection › filopodium. Cell projection › growth cone. Cell junction › synapse › synaptosome. Cytoplasm › cytoskeleton. Note: Localized to protruding lamellipodia and filopodia tips. Also localized to neuronal growth cones and synaptosomes. Ref.2
Domain	The t-SNARE coiled-coil homology domain is necessary and sufficient for interaction with STX1A By similarity.
Post-translational modification	Phosphorylated By similarity. In vitro substrate for v-Abl.
Sequence similarities	Belongs to the ABI family. Contains 1 SH3 domain. Contains 1 t-SNARE coiled-coil homology domain.

Ontologies

Keywords
Cellular component	Cell junction Cell projection Cytoplasm Cytoskeleton Nucleus Synapse Synaptosome
Domain	Coiled coil SH3 domain
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular component movement Inferred from electronic annotation. Source: Compara peptidyl-tyrosine phosphorylation Inferred from electronic annotation. Source: Compara somitogenesis Inferred from electronic annotation. Source: Compara
Cellular_component	cell junction Inferred from electronic annotation. Source: UniProtKB-KW cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell cytoskeleton Inferred from electronic annotation. Source: UniProtKB-SubCell filopodium Inferred from electronic annotation. Source: UniProtKB-SubCell growth cone Inferred from electronic annotation. Source: UniProtKB-SubCell lamellipodium Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell synapse Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	protein tyrosine kinase activator activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

Removed By similarity

Chain

2 – 476

475

Abl interactor 1

PRO_0000191789

Regions

Domain

45 – 107

t-SNARE coiled-coil homology

Domain

414 – 473

SH3

Compositional bias

332 – 386

Pro-rich

Amino acid modifications

Modified residue

N-acetylalanine By similarity

Modified residue

178

Phosphoserine By similarity

Modified residue

208

Phosphotyrosine By similarity

Modified residue

211

Phosphoserine By similarity

Modified residue

217

Phosphoserine By similarity

Modified residue

220

Phosphoserine By similarity

Modified residue

291

Phosphoserine By similarity

Modified residue

423

Phosphotyrosine By similarity

Modified residue

475

Phosphothreonine By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

Q9QZM5 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: A2B8CC377090BEA6
Show »

FASTA

476

51,705

        10         20         30         40         50         60 
MAELQMLLEE EIPSGKRALI ESYQNLTRVA DYCENNYIQA TDKRKALEET KAYTTQSLAS 

        70         80         90        100        110        120 
VAYQINALAN NVLQLLDIQA SQLRRMESSI NHISQTVDIH KEKVARREIG ILTTNKNTSR 

       130        140        150        160        170        180 
THKIIAPANM ERPVRYIRKP IDYTVLDDVG HGVKHGNNQP ARTGTLSRTN PPTQKPPSPP 

       190        200        210        220        230        240 
VSGRGTLGRN TPYKTLEPVK PPTVPNDYMT SPARLGSQHS PGRTASLNQR PRTHSGSSGG 

       250        260        270        280        290        300 
SGSRENSGSS SIGIPIAVPT PSPPTAGPAA PGAAPGSQYG TMTRQISRHN STTSSTSSGG 

       310        320        330        340        350        360 
YRRTPSVTAQ FSAQPHVNGG PLYSQNSISI APPPPPMPQL TPQIPLTGFV ARVQENIADS 

       370        380        390        400        410        420 
PTPPPPPPPD DIPMFDDSPP PPPPPPVDYE DEEAAVVQYS DPYADGDPAW APKNYIEKVV 

       430        440        450        460        470 
AIYDYTKDKD DELSFKEGAI IYVIKKNDDG WFEGVCNRVT GLFPGNYVES IMHYTD

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References

[1]	"cDNA sequence of the rat eps8 binding protein (e3B1)." Nicolas G., Galand C., Lecomte M.C. Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Sprague-Dawley.
[2]	"Localization and phosphorylation of Abl-interactor proteins, Abi-1 and Abi-2, in the developing nervous system." Courtney K.D., Grove M., Vandongen H., Vandongen A., LaMantia A.-S., Pendergast A.M. Mol. Cell. Neurosci. 16:244-257(2000) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF176784 mRNA. Translation: AAD55263.1.
IPI	IPI00215158.
UniGene	Rn.43675.
3D structure databases
ProteinModelPortal	Q9QZM5.
SMR	Q9QZM5. Positions 404-471.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9QZM5. 2 interactions.
MINT	MINT-4508312.
PTM databases
PhosphoSite	Q9QZM5.
Proteomic databases
PaxDb	Q9QZM5.
PRIDE	Q9QZM5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000057572; ENSRNOP00000054381; ENSRNOG00000031325.
UCSC	RGD:621008. rat.
Organism-specific databases
RGD	621008. Abi1.
Phylogenomic databases
eggNOG	NOG262939.
GeneTree	ENSGT00390000003756.
HOGENOM	HOG000293213.
HOVERGEN	HBG050446.
Gene expression databases
Genevestigator	Q9QZM5.
GermOnline	ENSRNOG00000031325. Rattus norvegicus.
Family and domain databases
InterPro	IPR012849. Abl-interactor_HHR_dom. IPR000108. p67phox. IPR001452. SH3_domain. IPR000727. T_SNARE_dom. [Graphical view]
Pfam	PF07815. Abi_HHR. 1 hit. PF00018. SH3_1. 1 hit. [Graphical view]
PRINTS	PR00499. P67PHOX. PR00452. SH3DOMAIN.
SMART	SM00326. SH3. 1 hit. [Graphical view]
SUPFAM	SSF50044. SH3. 1 hit.
PROSITE	PS50002. SH3. 1 hit. PS50192. T_SNARE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ABI1_RAT

Accession

Primary (citable) accession number: Q9QZM5

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
Last sequence update:	January 23, 2007
Last modified:	April 3, 2013
This is version 85 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Entry information

Relevant documents