ID   CLCF1_MOUSE             Reviewed;         225 AA.
AC   Q9QZM3; Q3SXK2;
DT   07-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   27-MAR-2024, entry version 146.
DE   RecName: Full=Cardiotrophin-like cytokine factor 1;
DE   AltName: Full=B-cell-stimulating factor 3;
DE            Short=BSF-3;
DE   AltName: Full=Novel neurotrophin-1;
DE            Short=NNT-1;
DE   Flags: Precursor;
GN   Name=Clcf1; Synonyms=Bsf3, Nnt1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RX   PubMed=10500198; DOI=10.1073/pnas.96.20.11458;
RA   Senaldi G., Varnum B.C., Sarmiento U., Starnes C., Lile J., Scully S.,
RA   Guo J., Elliott G., McNinch J., Shaklee C.L., Freeman D., Manu F.,
RA   Simonet W.S., Boone T., Chang M.-S.;
RT   "Novel neurotrophin-1/B cell-stimulating factor-3: a cytokine of the IL-6
RT   family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 96:11458-11463(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: In complex with CRLF1, forms a heterodimeric neurotropic
CC       cytokine that plays a crucial role during neuronal development (By
CC       similarity). Also stimulates B-cells. Binds to and activates the
CC       ILST/gp130 receptor (PubMed:10500198). {ECO:0000250|UniProtKB:Q9UBD9,
CC       ECO:0000269|PubMed:10500198}.
CC   -!- SUBUNIT: Forms a heteromeric complex with cardiotrophin-like cytokine
CC       CRLF1/CLF-1; the CRLF1-CLCF1 complex is a ligand for the ciliary
CC       neurotrophic factor receptor/CNTFR. The CRLF1-CLCF1 heterodimer binds
CC       SORL1 (via N-terminal ectodomain); within this complex, the interaction
CC       is mediated predominantly by the CRLF1 moiety. The tripartite signaling
CC       complex formed by CRLF1, CLCF1 and CNTFR also binds SORL1.
CC       {ECO:0000250|UniProtKB:Q9UBD9}.
CC   -!- INTERACTION:
CC       Q9QZM3; P08226: Apoe; NbExp=2; IntAct=EBI-3454258, EBI-1634131;
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IL-6 superfamily. {ECO:0000305}.
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DR   EMBL; AF176913; AAF00993.1; -; mRNA.
DR   EMBL; BC104258; AAI04259.1; -; mRNA.
DR   EMBL; BC104259; AAI04260.1; -; mRNA.
DR   EMBL; CH466612; EDL33037.1; -; Genomic_DNA.
DR   CCDS; CCDS29423.1; -.
DR   RefSeq; NP_001296967.1; NM_001310038.2.
DR   RefSeq; NP_001296968.1; NM_001310039.1.
DR   RefSeq; NP_064336.1; NM_019952.5.
DR   AlphaFoldDB; Q9QZM3; -.
DR   SMR; Q9QZM3; -.
DR   BioGRID; 208136; 2.
DR   IntAct; Q9QZM3; 2.
DR   STRING; 10090.ENSMUSP00000045562; -.
DR   ChEMBL; CHEMBL2176788; -.
DR   GlyCosmos; Q9QZM3; 1 site, No reported glycans.
DR   GlyGen; Q9QZM3; 1 site.
DR   PhosphoSitePlus; Q9QZM3; -.
DR   PaxDb; 10090-ENSMUSP00000045562; -.
DR   Antibodypedia; 44555; 280 antibodies from 26 providers.
DR   DNASU; 56708; -.
DR   Ensembl; ENSMUST00000046506.7; ENSMUSP00000045562.7; ENSMUSG00000040663.10.
DR   GeneID; 56708; -.
DR   KEGG; mmu:56708; -.
DR   UCSC; uc008fzj.1; mouse.
DR   AGR; MGI:1930088; -.
DR   CTD; 23529; -.
DR   MGI; MGI:1930088; Clcf1.
DR   VEuPathDB; HostDB:ENSMUSG00000040663; -.
DR   eggNOG; ENOG502QUIA; Eukaryota.
DR   GeneTree; ENSGT00510000048856; -.
DR   HOGENOM; CLU_079382_0_0_1; -.
DR   InParanoid; Q9QZM3; -.
DR   OMA; QEWHSLN; -.
DR   OrthoDB; 4253899at2759; -.
DR   PhylomeDB; Q9QZM3; -.
DR   TreeFam; TF333266; -.
DR   Reactome; R-MMU-6788467; IL-6-type cytokine receptor ligand interactions.
DR   BioGRID-ORCS; 56708; 2 hits in 115 CRISPR screens.
DR   PRO; PR:Q9QZM3; -.
DR   Proteomes; UP000000589; Chromosome 19.
DR   RNAct; Q9QZM3; Protein.
DR   Bgee; ENSMUSG00000040663; Expressed in spleen and 71 other cell types or tissues.
DR   ExpressionAtlas; Q9QZM3; baseline and differential.
DR   GO; GO:0097059; C:CNTFR-CLCF1 complex; ISO:MGI.
DR   GO; GO:0097058; C:CRLF-CLCF1 complex; ISS:BHF-UCL.
DR   GO; GO:0005576; C:extracellular region; ISS:BHF-UCL.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005127; F:ciliary neurotrophic factor receptor binding; ISO:MGI.
DR   GO; GO:0005125; F:cytokine activity; IDA:MGI.
DR   GO; GO:0005102; F:signaling receptor binding; ISS:UniProtKB.
DR   GO; GO:0030183; P:B cell differentiation; IDA:MGI.
DR   GO; GO:0007166; P:cell surface receptor signaling pathway; IDA:MGI.
DR   GO; GO:2000672; P:negative regulation of motor neuron apoptotic process; NAS:BHF-UCL.
DR   GO; GO:0043524; P:negative regulation of neuron apoptotic process; ISS:BHF-UCL.
DR   GO; GO:0048711; P:positive regulation of astrocyte differentiation; IDA:BHF-UCL.
DR   GO; GO:0030890; P:positive regulation of B cell proliferation; IDA:BHF-UCL.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; ISS:BHF-UCL.
DR   GO; GO:0051466; P:positive regulation of corticotropin-releasing hormone secretion; TAS:BHF-UCL.
DR   GO; GO:0002639; P:positive regulation of immunoglobulin production; IDA:BHF-UCL.
DR   GO; GO:0048295; P:positive regulation of isotype switching to IgE isotypes; IDA:BHF-UCL.
DR   GO; GO:0002830; P:positive regulation of type 2 immune response; NAS:BHF-UCL.
DR   GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IDA:BHF-UCL.
DR   GO; GO:0007259; P:receptor signaling pathway via JAK-STAT; IDA:MGI.
DR   GO; GO:0070372; P:regulation of ERK1 and ERK2 cascade; TAS:BHF-UCL.
DR   GO; GO:0050727; P:regulation of inflammatory response; NAS:BHF-UCL.
DR   GO; GO:0051896; P:regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; TAS:BHF-UCL.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR010681; PRF/CT.
DR   PANTHER; PTHR21353; -; 1.
DR   PANTHER; PTHR21353:SF7; CARDIOTROPHIN-LIKE CYTOKINE FACTOR 1; 1.
DR   Pfam; PF06875; PRF; 1.
DR   SUPFAM; SSF47266; 4-helical cytokines; 1.
DR   Genevisible; Q9QZM3; MM.
PE   1: Evidence at protein level;
KW   Cytokine; Glycoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000255"
FT   CHAIN           28..225
FT                   /note="Cardiotrophin-like cytokine factor 1"
FT                   /id="PRO_0000015617"
FT   CARBOHYD        29
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   225 AA;  25261 MW;  68B1FEAAB7F1A950 CRC64;
     MDLRAGDSWG MLACLCTVLW HLPAVPALNR TGDPGPGPSI QKTYDLTRYL EHQLRSLAGT
     YLNYLGPPFN EPDFNPPRLG AETLPRATVN LEVWRSLNDR LRLTQNYEAY SHLLCYLRGL
     NRQAATAELR RSLAHFCTSL QGLLGSIAGV MATLGYPLPQ PLPGTEPAWA PGPAHSDFLQ
     KMDDFWLLKE LQTWLWRSAK DFNRLKKKMQ PPAASVTLHL EAHGF
//