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Q9QZM3 (CLCF1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cardiotrophin-like cytokine factor 1
Alternative name(s):
B-cell-stimulating factor 3
Short name=BSF-3
Novel neurotrophin-1
Short name=NNT-1
Gene names
Name:Clcf1
Synonyms:Bsf3, Nnt1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length225 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cytokine with B-cell stimulating capability. Binds to and activates the ILST/gp130 receptor. Ref.1

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the IL-6 superfamily.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionCytokine
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processB cell differentiation

Inferred from direct assay Ref.1. Source: MGI

JAK-STAT cascade

Inferred from direct assay Ref.1. Source: MGI

cell surface receptor signaling pathway

Inferred from direct assay Ref.1. Source: MGI

negative regulation of motor neuron apoptotic process

Non-traceable author statement PubMed 14523086. Source: BHF-UCL

negative regulation of neuron apoptotic process

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of B cell proliferation

Inferred from direct assay PubMed 12023368. Source: BHF-UCL

positive regulation of astrocyte differentiation

Inferred from direct assay PubMed 12090754. Source: BHF-UCL

positive regulation of cell proliferation

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of corticotropin-releasing hormone secretion

Traceable author statement PubMed 15450249. Source: BHF-UCL

positive regulation of immunoglobulin production

Inferred from direct assay PubMed 12023368. Source: BHF-UCL

positive regulation of isotype switching to IgE isotypes

Inferred from direct assay PubMed 12023368. Source: BHF-UCL

positive regulation of type 2 immune response

Non-traceable author statement PubMed 12023368. Source: BHF-UCL

positive regulation of tyrosine phosphorylation of Stat3 protein

Inferred from direct assay PubMed 12090754. Source: BHF-UCL

regulation of ERK1 and ERK2 cascade

Traceable author statement PubMed 15450249. Source: BHF-UCL

regulation of inflammatory response

Non-traceable author statement Ref.1. Source: BHF-UCL

regulation of protein kinase B signaling

Traceable author statement PubMed 15450249. Source: BHF-UCL

   Cellular_componentCNTFR-CLCF1 complex

Inferred from electronic annotation. Source: Ensembl

CRLF-CLCF1 complex

Inferred from electronic annotation. Source: Ensembl

extracellular region

Inferred from sequence or structural similarity. Source: BHF-UCL

intracellular

Traceable author statement PubMed 15450249. Source: BHF-UCL

   Molecular_functionciliary neurotrophic factor receptor binding

Inferred from sequence or structural similarity. Source: BHF-UCL

cytokine activity

Inferred from direct assay Ref.1. Source: MGI

protein heterodimerization activity

Inferred from sequence or structural similarity. Source: BHF-UCL

receptor binding

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2727 Potential
Chain28 – 225198Cardiotrophin-like cytokine factor 1
PRO_0000015617

Amino acid modifications

Glycosylation291N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q9QZM3 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 68B1FEAAB7F1A950

FASTA22525,261
        10         20         30         40         50         60 
MDLRAGDSWG MLACLCTVLW HLPAVPALNR TGDPGPGPSI QKTYDLTRYL EHQLRSLAGT 

        70         80         90        100        110        120 
YLNYLGPPFN EPDFNPPRLG AETLPRATVN LEVWRSLNDR LRLTQNYEAY SHLLCYLRGL 

       130        140        150        160        170        180 
NRQAATAELR RSLAHFCTSL QGLLGSIAGV MATLGYPLPQ PLPGTEPAWA PGPAHSDFLQ 

       190        200        210        220 
KMDDFWLLKE LQTWLWRSAK DFNRLKKKMQ PPAASVTLHL EAHGF 

« Hide

References

« Hide 'large scale' references
[1]"Novel neurotrophin-1/B cell-stimulating factor-3: a cytokine of the IL-6 family."
Senaldi G., Varnum B.C., Sarmiento U., Starnes C., Lile J., Scully S., Guo J., Elliott G., McNinch J., Shaklee C.L., Freeman D., Manu F., Simonet W.S., Boone T., Chang M.-S.
Proc. Natl. Acad. Sci. U.S.A. 96:11458-11463(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
[2]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF176913 mRNA. Translation: AAF00993.1.
BC104258 mRNA. Translation: AAI04259.1.
BC104259 mRNA. Translation: AAI04260.1.
CH466612 Genomic DNA. Translation: EDL33037.1.
CCDSCCDS29423.1.
RefSeqNP_064336.1. NM_019952.3.
UniGeneMm.347919.

3D structure databases

ProteinModelPortalQ9QZM3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ9QZM3. 1 interaction.
STRING10090.ENSMUSP00000045562.

Chemistry

ChEMBLCHEMBL2176788.

Proteomic databases

PaxDbQ9QZM3.
PRIDEQ9QZM3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000046506; ENSMUSP00000045562; ENSMUSG00000040663.
ENSMUST00000180925; ENSMUSP00000138037; ENSMUSG00000097629.
GeneID56708.
KEGGmmu:56708.
UCSCuc008fzj.1. mouse.

Organism-specific databases

CTD23529.
MGIMGI:1930088. Clcf1.

Phylogenomic databases

eggNOGNOG43976.
GeneTreeENSGT00510000048856.
HOGENOMHOG000111785.
HOVERGENHBG050737.
InParanoidQ3SXK2.
KOK05421.
OMAAGDSWGM.
OrthoDBEOG7B05DT.
PhylomeDBQ9QZM3.
TreeFamTF333266.

Gene expression databases

ArrayExpressQ9QZM3.
BgeeQ9QZM3.
CleanExMM_CLCF1.
GenevestigatorQ9QZM3.

Family and domain databases

Gene3D1.20.1250.10. 1 hit.
InterProIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR010681. PRF.
[Graphical view]
PANTHERPTHR21353. PTHR21353. 1 hit.
PfamPF06875. PRF. 1 hit.
[Graphical view]
SUPFAMSSF47266. SSF47266. 1 hit.
ProtoNetSearch...

Other

NextBio313167.
PROQ9QZM3.
SOURCESearch...

Entry information

Entry nameCLCF1_MOUSE
AccessionPrimary (citable) accession number: Q9QZM3
Secondary accession number(s): Q3SXK2
Entry history
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot