Q9QZM3 (CLCF1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cardiotrophin-like cytokine factor 1

Alternative name(s):
B-cell-stimulating factor 3
Short name=BSF-3
Novel neurotrophin-1
Short name=NNT-1

Gene names

Name:	Clcf1
Synonyms:	Bsf3, Nnt1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	225 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Cytokine with B-cell stimulating capability. Binds to and activates the ILST/gp130 receptor. Ref.1
Subcellular location	Secreted By similarity.
Sequence similarities	Belongs to the IL-6 superfamily.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Cytokine
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	B cell differentiation Inferred from direct assay Ref.1. Source: MGI JAK-STAT cascade Inferred from direct assay Ref.1. Source: MGI cell surface receptor signaling pathway Inferred from direct assay Ref.1. Source: MGI negative regulation of motor neuron apoptotic process Non-traceable author statement PubMed 14523086. Source: BHF-UCL positive regulation of B cell proliferation Inferred from direct assay PubMed 12023368. Source: BHF-UCL positive regulation of astrocyte differentiation Inferred from direct assay PubMed 12090754. Source: BHF-UCL positive regulation of corticotropin-releasing hormone secretion Traceable author statement PubMed 15450249. Source: BHF-UCL positive regulation of immunoglobulin production Inferred from direct assay PubMed 12023368. Source: BHF-UCL positive regulation of isotype switching to IgE isotypes Inferred from direct assay PubMed 12023368. Source: BHF-UCL positive regulation of type 2 immune response Non-traceable author statement PubMed 12023368. Source: BHF-UCL positive regulation of tyrosine phosphorylation of Stat3 protein Inferred from direct assay PubMed 12090754. Source: BHF-UCL regulation of ERK1 and ERK2 cascade Traceable author statement PubMed 15450249. Source: BHF-UCL regulation of inflammatory response Non-traceable author statement Ref.1. Source: BHF-UCL regulation of protein kinase B signaling cascade Traceable author statement PubMed 15450249. Source: BHF-UCL
Cellular_component	CNTFR-CLCF1 complex Inferred from electronic annotation. Source: Compara CRLF-CLCF1 complex Inferred from electronic annotation. Source: Compara extracellular region Inferred from sequence or structural similarity. Source: BHF-UCL intracellular Traceable author statement PubMed 15450249. Source: BHF-UCL
Molecular_function	ciliary neurotrophic factor receptor binding Inferred from sequence or structural similarity. Source: BHF-UCL cytokine activity Inferred from direct assay Ref.1. Source: MGI protein heterodimerization activity Inferred from sequence or structural similarity. Source: BHF-UCL
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 27	27	Potential
	Chain	28 – 225	198	Cardiotrophin-like cytokine factor 1		PRO_0000015617
Amino acid modifications
	Glycosylation	29	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9QZM3 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 68B1FEAAB7F1A950	FASTA	225	25,261
	10 20 30 40 50 60 MDLRAGDSWG MLACLCTVLW HLPAVPALNR TGDPGPGPSI QKTYDLTRYL EHQLRSLAGT 70 80 90 100 110 120 YLNYLGPPFN EPDFNPPRLG AETLPRATVN LEVWRSLNDR LRLTQNYEAY SHLLCYLRGL 130 140 150 160 170 180 NRQAATAELR RSLAHFCTSL QGLLGSIAGV MATLGYPLPQ PLPGTEPAWA PGPAHSDFLQ 190 200 210 220 KMDDFWLLKE LQTWLWRSAK DFNRLKKKMQ PPAASVTLHL EAHGF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Novel neurotrophin-1/B cell-stimulating factor-3: a cytokine of the IL-6 family." Senaldi G., Varnum B.C., Sarmiento U., Starnes C., Lile J., Scully S., Guo J., Elliott G., McNinch J., Shaklee C.L., Freeman D., Manu F., Simonet W.S., Boone T., Chang M.-S. Proc. Natl. Acad. Sci. U.S.A. 96:11458-11463(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
[2]	Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF176913 mRNA. Translation: AAF00993.1. BC104258 mRNA. Translation: AAI04259.1. BC104259 mRNA. Translation: AAI04260.1. CH466612 Genomic DNA. Translation: EDL33037.1.
IPI	IPI00317193.
RefSeq	NP_064336.1. NM_019952.3.
UniGene	Mm.347919.
3D structure databases
ProteinModelPortal	Q9QZM3.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9QZM3. 1 interaction.
STRING	10090.ENSMUSP00000045562.
Proteomic databases
PaxDb	Q9QZM3.
PRIDE	Q9QZM3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000046506; ENSMUSP00000045562; ENSMUSG00000040663. ENSMUST00000180925; ENSMUSP00000138037; ENSMUSG00000097629.
GeneID	56708.
KEGG	mmu:56708.
UCSC	uc008fzj.1. mouse.
Organism-specific databases
CTD	23529.
MGI	MGI:1930088. Clcf1.
Phylogenomic databases
eggNOG	NOG43976.
GeneTree	ENSGT00510000048856.
HOGENOM	HOG000111785.
HOVERGEN	HBG050737.
InParanoid	Q3SXK2.
KO	K05421.
OMA	AGDSWGM.
OrthoDB	EOG4HT8TG.
Gene expression databases
ArrayExpress	Q9QZM3.
Bgee	Q9QZM3.
CleanEx	MM_CLCF1.
Genevestigator	Q9QZM3.
GermOnline	ENSMUSG00000040663. Mus musculus.
Family and domain databases
Gene3D	1.20.1250.10. 1 hit.
InterPro	IPR009079. 4_helix_cytokine-like_core. IPR012351. 4_helix_cytokine_core. IPR010681. PRF. [Graphical view]
PANTHER	PTHR21353. PTHR21353. 1 hit.
Pfam	PF06875. PRF. 1 hit. [Graphical view]
SUPFAM	SSF47266. 4_helix_cytokine. 1 hit.
ProtoNet	Search...
Other
NextBio	313167.
SOURCE	Search...

Entry information

Entry name

CLCF1_MOUSE

Accession

Primary (citable) accession number: Q9QZM3
Secondary accession number(s): Q3SXK2

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 7, 2004
Last sequence update:	May 1, 2000
Last modified:	April 3, 2013
This is version 84 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program