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Protein

Cardiotrophin-like cytokine factor 1

Gene

Clcf1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Cytokine with B-cell stimulating capability. Binds to and activates the ILST/gp130 receptor.1 Publication

GO - Molecular functioni

GO - Biological processi

  • B cell differentiation Source: MGI
  • cell surface receptor signaling pathway Source: MGI
  • JAK-STAT cascade Source: MGI
  • negative regulation of motor neuron apoptotic process Source: BHF-UCL
  • negative regulation of neuron apoptotic process Source: BHF-UCL
  • positive regulation of astrocyte differentiation Source: BHF-UCL
  • positive regulation of B cell proliferation Source: BHF-UCL
  • positive regulation of cell proliferation Source: BHF-UCL
  • positive regulation of corticotropin-releasing hormone secretion Source: BHF-UCL
  • positive regulation of immunoglobulin production Source: BHF-UCL
  • positive regulation of isotype switching to IgE isotypes Source: BHF-UCL
  • positive regulation of type 2 immune response Source: BHF-UCL
  • positive regulation of tyrosine phosphorylation of Stat3 protein Source: BHF-UCL
  • regulation of ERK1 and ERK2 cascade Source: BHF-UCL
  • regulation of inflammatory response Source: BHF-UCL
  • regulation of protein kinase B signaling Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Cardiotrophin-like cytokine factor 1
Alternative name(s):
B-cell-stimulating factor 3
Short name:
BSF-3
Novel neurotrophin-1
Short name:
NNT-1
Gene namesi
Name:Clcf1
Synonyms:Bsf3, Nnt1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componentsi: Chromosome 19, Unplaced

Organism-specific databases

MGIiMGI:1930088. Clcf1.

Subcellular locationi

GO - Cellular componenti

  • CNTFR-CLCF1 complex Source: MGI
  • CRLF-CLCF1 complex Source: BHF-UCL
  • extracellular exosome Source: MGI
  • extracellular region Source: BHF-UCL
  • intracellular Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence AnalysisAdd
BLAST
Chaini28 – 225198Cardiotrophin-like cytokine factor 1PRO_0000015617Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi29 – 291N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9QZM3.
PRIDEiQ9QZM3.

Expressioni

Gene expression databases

BgeeiQ9QZM3.
CleanExiMM_CLCF1.
ExpressionAtlasiQ9QZM3. baseline and differential.
GenevisibleiQ9QZM3. MM.

Interactioni

Protein-protein interaction databases

IntActiQ9QZM3. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ9QZM3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-6 superfamily.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG43976.
GeneTreeiENSGT00510000048856.
HOGENOMiHOG000111785.
HOVERGENiHBG050737.
InParanoidiQ9QZM3.
KOiK05421.
OMAiAGDSWGM.
OrthoDBiEOG7B05DT.
PhylomeDBiQ9QZM3.
TreeFamiTF333266.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR010681. PRF.
[Graphical view]
PANTHERiPTHR21353. PTHR21353. 1 hit.
PfamiPF06875. PRF. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QZM3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLRAGDSWG MLACLCTVLW HLPAVPALNR TGDPGPGPSI QKTYDLTRYL
60 70 80 90 100
EHQLRSLAGT YLNYLGPPFN EPDFNPPRLG AETLPRATVN LEVWRSLNDR
110 120 130 140 150
LRLTQNYEAY SHLLCYLRGL NRQAATAELR RSLAHFCTSL QGLLGSIAGV
160 170 180 190 200
MATLGYPLPQ PLPGTEPAWA PGPAHSDFLQ KMDDFWLLKE LQTWLWRSAK
210 220
DFNRLKKKMQ PPAASVTLHL EAHGF
Length:225
Mass (Da):25,261
Last modified:May 1, 2000 - v1
Checksum:i68B1FEAAB7F1A950
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF176913 mRNA. Translation: AAF00993.1.
BC104258 mRNA. Translation: AAI04259.1.
BC104259 mRNA. Translation: AAI04260.1.
CH466612 Genomic DNA. Translation: EDL33037.1.
CCDSiCCDS29423.1.
RefSeqiNP_064336.1. NM_019952.3.
UniGeneiMm.347919.

Genome annotation databases

EnsembliENSMUST00000046506; ENSMUSP00000045562; ENSMUSG00000040663.
ENSMUST00000180925; ENSMUSP00000138037; ENSMUSG00000097629.
GeneIDi56708.
KEGGimmu:56708.
UCSCiuc008fzj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF176913 mRNA. Translation: AAF00993.1.
BC104258 mRNA. Translation: AAI04259.1.
BC104259 mRNA. Translation: AAI04260.1.
CH466612 Genomic DNA. Translation: EDL33037.1.
CCDSiCCDS29423.1.
RefSeqiNP_064336.1. NM_019952.3.
UniGeneiMm.347919.

3D structure databases

ProteinModelPortaliQ9QZM3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9QZM3. 1 interaction.

Chemistry

ChEMBLiCHEMBL2176788.

Proteomic databases

PaxDbiQ9QZM3.
PRIDEiQ9QZM3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000046506; ENSMUSP00000045562; ENSMUSG00000040663.
ENSMUST00000180925; ENSMUSP00000138037; ENSMUSG00000097629.
GeneIDi56708.
KEGGimmu:56708.
UCSCiuc008fzj.1. mouse.

Organism-specific databases

CTDi23529.
MGIiMGI:1930088. Clcf1.

Phylogenomic databases

eggNOGiNOG43976.
GeneTreeiENSGT00510000048856.
HOGENOMiHOG000111785.
HOVERGENiHBG050737.
InParanoidiQ9QZM3.
KOiK05421.
OMAiAGDSWGM.
OrthoDBiEOG7B05DT.
PhylomeDBiQ9QZM3.
TreeFamiTF333266.

Miscellaneous databases

NextBioi313167.
PROiQ9QZM3.
SOURCEiSearch...

Gene expression databases

BgeeiQ9QZM3.
CleanExiMM_CLCF1.
ExpressionAtlasiQ9QZM3. baseline and differential.
GenevisibleiQ9QZM3. MM.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR010681. PRF.
[Graphical view]
PANTHERiPTHR21353. PTHR21353. 1 hit.
PfamiPF06875. PRF. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiCLCF1_MOUSE
AccessioniPrimary (citable) accession number: Q9QZM3
Secondary accession number(s): Q3SXK2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: May 1, 2000
Last modified: June 24, 2015
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.