Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9QZM3

- CLCF1_MOUSE

UniProt

Q9QZM3 - CLCF1_MOUSE

Protein

Cardiotrophin-like cytokine factor 1

Gene

Clcf1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Cytokine with B-cell stimulating capability. Binds to and activates the ILST/gp130 receptor.1 Publication

    GO - Molecular functioni

    1. ciliary neurotrophic factor receptor binding Source: BHF-UCL
    2. cytokine activity Source: MGI
    3. protein binding Source: ParkinsonsUK-UCL
    4. protein heterodimerization activity Source: BHF-UCL
    5. receptor binding Source: UniProtKB

    GO - Biological processi

    1. B cell differentiation Source: MGI
    2. cell surface receptor signaling pathway Source: MGI
    3. JAK-STAT cascade Source: MGI
    4. negative regulation of motor neuron apoptotic process Source: BHF-UCL
    5. negative regulation of neuron apoptotic process Source: BHF-UCL
    6. positive regulation of astrocyte differentiation Source: BHF-UCL
    7. positive regulation of B cell proliferation Source: BHF-UCL
    8. positive regulation of cell proliferation Source: BHF-UCL
    9. positive regulation of corticotropin-releasing hormone secretion Source: BHF-UCL
    10. positive regulation of immunoglobulin production Source: BHF-UCL
    11. positive regulation of isotype switching to IgE isotypes Source: BHF-UCL
    12. positive regulation of type 2 immune response Source: BHF-UCL
    13. positive regulation of tyrosine phosphorylation of Stat3 protein Source: BHF-UCL
    14. regulation of ERK1 and ERK2 cascade Source: BHF-UCL
    15. regulation of inflammatory response Source: BHF-UCL
    16. regulation of protein kinase B signaling Source: BHF-UCL

    Keywords - Molecular functioni

    Cytokine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cardiotrophin-like cytokine factor 1
    Alternative name(s):
    B-cell-stimulating factor 3
    Short name:
    BSF-3
    Novel neurotrophin-1
    Short name:
    NNT-1
    Gene namesi
    Name:Clcf1
    Synonyms:Bsf3, Nnt1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 19

    Organism-specific databases

    MGIiMGI:1930088. Clcf1.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. CNTFR-CLCF1 complex Source: Ensembl
    2. CRLF-CLCF1 complex Source: Ensembl
    3. extracellular region Source: BHF-UCL
    4. intracellular Source: BHF-UCL

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2727Sequence AnalysisAdd
    BLAST
    Chaini28 – 225198Cardiotrophin-like cytokine factor 1PRO_0000015617Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi29 – 291N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9QZM3.
    PRIDEiQ9QZM3.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9QZM3.
    BgeeiQ9QZM3.
    CleanExiMM_CLCF1.
    GenevestigatoriQ9QZM3.

    Interactioni

    Protein-protein interaction databases

    IntActiQ9QZM3. 1 interaction.
    STRINGi10090.ENSMUSP00000045562.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9QZM3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the IL-6 superfamily.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG43976.
    GeneTreeiENSGT00510000048856.
    HOGENOMiHOG000111785.
    HOVERGENiHBG050737.
    InParanoidiQ3SXK2.
    KOiK05421.
    OMAiAGDSWGM.
    OrthoDBiEOG7B05DT.
    PhylomeDBiQ9QZM3.
    TreeFamiTF333266.

    Family and domain databases

    Gene3Di1.20.1250.10. 1 hit.
    InterProiIPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR010681. PRF.
    [Graphical view]
    PANTHERiPTHR21353. PTHR21353. 1 hit.
    PfamiPF06875. PRF. 1 hit.
    [Graphical view]
    SUPFAMiSSF47266. SSF47266. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9QZM3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDLRAGDSWG MLACLCTVLW HLPAVPALNR TGDPGPGPSI QKTYDLTRYL    50
    EHQLRSLAGT YLNYLGPPFN EPDFNPPRLG AETLPRATVN LEVWRSLNDR 100
    LRLTQNYEAY SHLLCYLRGL NRQAATAELR RSLAHFCTSL QGLLGSIAGV 150
    MATLGYPLPQ PLPGTEPAWA PGPAHSDFLQ KMDDFWLLKE LQTWLWRSAK 200
    DFNRLKKKMQ PPAASVTLHL EAHGF 225
    Length:225
    Mass (Da):25,261
    Last modified:May 1, 2000 - v1
    Checksum:i68B1FEAAB7F1A950
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF176913 mRNA. Translation: AAF00993.1.
    BC104258 mRNA. Translation: AAI04259.1.
    BC104259 mRNA. Translation: AAI04260.1.
    CH466612 Genomic DNA. Translation: EDL33037.1.
    CCDSiCCDS29423.1.
    RefSeqiNP_064336.1. NM_019952.3.
    UniGeneiMm.347919.

    Genome annotation databases

    EnsembliENSMUST00000046506; ENSMUSP00000045562; ENSMUSG00000040663.
    ENSMUST00000180925; ENSMUSP00000138037; ENSMUSG00000097629.
    GeneIDi56708.
    KEGGimmu:56708.
    UCSCiuc008fzj.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF176913 mRNA. Translation: AAF00993.1 .
    BC104258 mRNA. Translation: AAI04259.1 .
    BC104259 mRNA. Translation: AAI04260.1 .
    CH466612 Genomic DNA. Translation: EDL33037.1 .
    CCDSi CCDS29423.1.
    RefSeqi NP_064336.1. NM_019952.3.
    UniGenei Mm.347919.

    3D structure databases

    ProteinModelPortali Q9QZM3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9QZM3. 1 interaction.
    STRINGi 10090.ENSMUSP00000045562.

    Chemistry

    ChEMBLi CHEMBL2176788.

    Proteomic databases

    PaxDbi Q9QZM3.
    PRIDEi Q9QZM3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000046506 ; ENSMUSP00000045562 ; ENSMUSG00000040663 .
    ENSMUST00000180925 ; ENSMUSP00000138037 ; ENSMUSG00000097629 .
    GeneIDi 56708.
    KEGGi mmu:56708.
    UCSCi uc008fzj.1. mouse.

    Organism-specific databases

    CTDi 23529.
    MGIi MGI:1930088. Clcf1.

    Phylogenomic databases

    eggNOGi NOG43976.
    GeneTreei ENSGT00510000048856.
    HOGENOMi HOG000111785.
    HOVERGENi HBG050737.
    InParanoidi Q3SXK2.
    KOi K05421.
    OMAi AGDSWGM.
    OrthoDBi EOG7B05DT.
    PhylomeDBi Q9QZM3.
    TreeFami TF333266.

    Miscellaneous databases

    NextBioi 313167.
    PROi Q9QZM3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9QZM3.
    Bgeei Q9QZM3.
    CleanExi MM_CLCF1.
    Genevestigatori Q9QZM3.

    Family and domain databases

    Gene3Di 1.20.1250.10. 1 hit.
    InterProi IPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR010681. PRF.
    [Graphical view ]
    PANTHERi PTHR21353. PTHR21353. 1 hit.
    Pfami PF06875. PRF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47266. SSF47266. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiCLCF1_MOUSE
    AccessioniPrimary (citable) accession number: Q9QZM3
    Secondary accession number(s): Q3SXK2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 7, 2004
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3