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Q9QZM2

- DPOG2_MOUSE

UniProt

Q9QZM2 - DPOG2_MOUSE

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Protein
DNA polymerase subunit gamma-2, mitochondrial
Gene
Polg2, Mtpolb
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Mitochondrial polymerase processivity subunit. Stimulates the polymerase and exonuclease activities, and increases the processivity of the enzyme. Binds to ss-DNA.

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. DNA-directed DNA polymerase activity Source: MGI
  3. identical protein binding Source: IntAct

GO - Biological processi

  1. DNA repair Source: MGI
  2. DNA replication Source: MGI
  3. DNA-dependent DNA replication Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase subunit gamma-2, mitochondrial (EC:2.7.7.7)
Alternative name(s):
DNA polymerase gamma accessory 55 kDa subunit
Short name:
p55
Mitochondrial DNA polymerase accessory subunit
MtPolB
PolG-beta
Gene namesi
Name:Polg2
Synonyms:Mtpolb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1354947. Polg2.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial nucleoid Source: Ensembl
  2. mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 459DNA polymerase subunit gamma-2, mitochondrialPRO_0000007315
Transit peptidei1 – ?Mitochondrion Reviewed prediction

Proteomic databases

PaxDbiQ9QZM2.
PRIDEiQ9QZM2.

PTM databases

PhosphoSiteiQ9QZM2.

Expressioni

Gene expression databases

ArrayExpressiQ9QZM2.
BgeeiQ9QZM2.
GenevestigatoriQ9QZM2.

Interactioni

Subunit structurei

Heterotrimer composed of a catalytic subunit and a homodimer of accessory subunits.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-853043,EBI-853043

Protein-protein interaction databases

IntActiQ9QZM2. 1 interaction.
MINTiMINT-4093495.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi42 – 498
Helixi57 – 604
Helixi62 – 676
Helixi75 – 9218
Turni93 – 953
Beta strandi99 – 1013
Beta strandi106 – 1083
Beta strandi120 – 1223
Helixi124 – 1318
Helixi138 – 15114
Beta strandi152 – 1554
Helixi160 – 1656
Helixi167 – 1737
Turni174 – 1763
Beta strandi180 – 19213
Beta strandi204 – 21714
Helixi219 – 23820
Helixi244 – 2463
Beta strandi247 – 2537
Beta strandi259 – 2679
Beta strandi270 – 28213
Helixi283 – 2886
Helixi293 – 2953
Beta strandi298 – 3003
Beta strandi303 – 3053
Beta strandi308 – 3158
Helixi316 – 32712
Turni350 – 3523
Beta strandi357 – 3615
Helixi366 – 38217
Beta strandi387 – 3893
Helixi390 – 3923
Helixi399 – 40810
Beta strandi412 – 4176
Helixi419 – 4246
Beta strandi426 – 4316
Turni432 – 4343
Beta strandi437 – 4415
Turni442 – 4443
Helixi445 – 45915

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1G5HX-ray1.95A/B/C/D17-459[»]
1G5IX-ray2.30A/B/C/D17-459[»]
ProteinModelPortaliQ9QZM2.
SMRiQ9QZM2. Positions 40-459.

Miscellaneous databases

EvolutionaryTraceiQ9QZM2.

Family & Domainsi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0423.
GeneTreeiENSGT00390000000244.
HOGENOMiHOG000049133.
HOVERGENiHBG051401.
InParanoidiB1ARB5.
KOiK02333.
OMAiDHELLHM.
OrthoDBiEOG7S7SFV.
TreeFamiTF103005.

Family and domain databases

Gene3Di3.40.50.800. 1 hit.
InterProiIPR004154. Anticodon-bd.
IPR027031. Gly-tRNA_synthase/POLG2.
IPR027030. POLG2.
[Graphical view]
PANTHERiPTHR10745. PTHR10745. 1 hit.
PTHR10745:SF3. PTHR10745:SF3. 1 hit.
PfamiPF03129. HGTP_anticodon. 1 hit.
[Graphical view]
SUPFAMiSSF52954. SSF52954. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QZM2-1 [UniParc]FASTAAdd to Basket

« Hide

MRCGGGARAC RRACRCWLSG YAGPADGTQQ PDAPEHAVAR EALVDLCRRR    50
HFFSGTPQQL STAALLSGCH ARFGPLGVEL RKNLASQWWS SMVVFREQVF 100
AVDSLHQEPG SSQPRDSAFR LVSPESIREI LQDREPSKEQ LVAFLENLLK 150
TSGKLRATLL HGALEHYVNC LDLVNRKLPF GLAQIGVCFH PVSNSNQTPS 200
SVTRVGEKTE ASLVWFTPTR TSSQWLDFWL RHRLLWWRKF AMSPSNFSSA 250
DCQDELGRKG SKLYYSFPWG KEPIETLWNL GDQELLHTYP GNVSTIQGRD 300
GRKNVVPCVL SVSGDVDLGT LAYLYDSFQL AENSFARKKS LQRKVLKLHP 350
CLAPIKVALD VGKGPTVELR QVCQGLLNEL LENGISVWPG YSETVHSSLE 400
QLHSKYDEMS VLFSVLVTET TLENGLIQLR SRDTTMKEMM HISKLRDFLV 450
KYLASASNV 459
Length:459
Mass (Da):51,467
Last modified:July 27, 2011 - v2
Checksum:i052C790C2AF9A249
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti53 – 531F → L in AAD56641. 1 Publication
Sequence conflicti226 – 2261L → S in AAB62894. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF177202 mRNA. Translation: AAD56641.1.
AL603664 Genomic DNA. Translation: CAM18563.1.
AF006072 mRNA. Translation: AAB62894.1.
CCDSiCCDS25561.1.
RefSeqiNP_056625.2. NM_015810.2.
UniGeneiMm.859.

Genome annotation databases

EnsembliENSMUST00000021060; ENSMUSP00000021060; ENSMUSG00000020718.
GeneIDi50776.
KEGGimmu:50776.
UCSCiuc007lzm.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF177202 mRNA. Translation: AAD56641.1 .
AL603664 Genomic DNA. Translation: CAM18563.1 .
AF006072 mRNA. Translation: AAB62894.1 .
CCDSi CCDS25561.1.
RefSeqi NP_056625.2. NM_015810.2.
UniGenei Mm.859.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1G5H X-ray 1.95 A/B/C/D 17-459 [» ]
1G5I X-ray 2.30 A/B/C/D 17-459 [» ]
ProteinModelPortali Q9QZM2.
SMRi Q9QZM2. Positions 40-459.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9QZM2. 1 interaction.
MINTi MINT-4093495.

PTM databases

PhosphoSitei Q9QZM2.

Proteomic databases

PaxDbi Q9QZM2.
PRIDEi Q9QZM2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000021060 ; ENSMUSP00000021060 ; ENSMUSG00000020718 .
GeneIDi 50776.
KEGGi mmu:50776.
UCSCi uc007lzm.2. mouse.

Organism-specific databases

CTDi 11232.
MGIi MGI:1354947. Polg2.

Phylogenomic databases

eggNOGi COG0423.
GeneTreei ENSGT00390000000244.
HOGENOMi HOG000049133.
HOVERGENi HBG051401.
InParanoidi B1ARB5.
KOi K02333.
OMAi DHELLHM.
OrthoDBi EOG7S7SFV.
TreeFami TF103005.

Miscellaneous databases

EvolutionaryTracei Q9QZM2.
NextBioi 307713.
PROi Q9QZM2.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9QZM2.
Bgeei Q9QZM2.
Genevestigatori Q9QZM2.

Family and domain databases

Gene3Di 3.40.50.800. 1 hit.
InterProi IPR004154. Anticodon-bd.
IPR027031. Gly-tRNA_synthase/POLG2.
IPR027030. POLG2.
[Graphical view ]
PANTHERi PTHR10745. PTHR10745. 1 hit.
PTHR10745:SF3. PTHR10745:SF3. 1 hit.
Pfami PF03129. HGTP_anticodon. 1 hit.
[Graphical view ]
SUPFAMi SSF52954. SSF52954. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Protein sequences conserved in prokaryotic aminoacyl-tRNA synthetases are important for the activity of the processivity factor of human mitochondrial DNA polymerase."
    Carrodeguas J.A., Bogenhagen D.F.
    Nucleic Acids Res. 28:1237-1244(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Swiss Webster / NIH.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Kaguni L.S.
    Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 164-459.
  4. "Crystal structure and deletion analysis show that the accessory subunit of mammalian DNA polymerase gamma, Pol gamma B, functions as a homodimer."
    Carrodeguas J.A., Theis K., Bogenhagen D.F., Kisker C.
    Mol. Cell 7:43-54(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 1-459, SUBUNIT.

Entry informationi

Entry nameiDPOG2_MOUSE
AccessioniPrimary (citable) accession number: Q9QZM2
Secondary accession number(s): B1ARB5, O35614
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

External Data

Dasty 3

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