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Protein

DNA polymerase subunit gamma-2, mitochondrial

Gene

Polg2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mitochondrial polymerase processivity subunit. Stimulates the polymerase and exonuclease activities, and increases the processivity of the enzyme. Binds to ss-DNA.

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • DNA-directed DNA polymerase activity Source: MGI
  • glycine-tRNA ligase activity Source: GO_Central

GO - Biological processi

  • DNA repair Source: MGI
  • DNA replication Source: MGI
  • glycyl-tRNA aminoacylation Source: GO_Central
  • in utero embryonic development Source: MGI
  • mitochondrial DNA metabolic process Source: MGI
  • mitochondrion morphogenesis Source: MGI
  • respiratory electron transport chain Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase subunit gamma-2, mitochondrial (EC:2.7.7.7)
Alternative name(s):
DNA polymerase gamma accessory 55 kDa subunit
Short name:
p55
Mitochondrial DNA polymerase accessory subunit
MtPolB
PolG-beta
Gene namesi
Name:Polg2
Synonyms:Mtpolb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1354947. Polg2.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: MGI
  • mitochondrial nucleoid Source: MGI
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000007315? – 459DNA polymerase subunit gamma-2, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

MaxQBiQ9QZM2.
PaxDbiQ9QZM2.
PRIDEiQ9QZM2.

PTM databases

iPTMnetiQ9QZM2.
PhosphoSitePlusiQ9QZM2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000020718.
ExpressionAtlasiQ9QZM2. baseline and differential.
GenevisibleiQ9QZM2. MM.

Interactioni

Subunit structurei

Heterotrimer composed of a catalytic subunit and a homodimer of accessory subunits.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-853043,EBI-853043

Protein-protein interaction databases

IntActiQ9QZM2. 1 interactor.
MINTiMINT-4093495.
STRINGi10090.ENSMUSP00000021060.

Structurei

Secondary structure

1459
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi42 – 49Combined sources8
Helixi57 – 60Combined sources4
Helixi62 – 67Combined sources6
Helixi75 – 92Combined sources18
Turni93 – 95Combined sources3
Beta strandi99 – 101Combined sources3
Beta strandi106 – 108Combined sources3
Beta strandi120 – 122Combined sources3
Helixi124 – 131Combined sources8
Helixi138 – 151Combined sources14
Beta strandi152 – 155Combined sources4
Helixi160 – 165Combined sources6
Helixi167 – 173Combined sources7
Turni174 – 176Combined sources3
Beta strandi180 – 192Combined sources13
Beta strandi204 – 217Combined sources14
Helixi219 – 238Combined sources20
Helixi244 – 246Combined sources3
Beta strandi247 – 253Combined sources7
Beta strandi259 – 267Combined sources9
Beta strandi270 – 282Combined sources13
Helixi283 – 288Combined sources6
Helixi293 – 295Combined sources3
Beta strandi298 – 300Combined sources3
Beta strandi303 – 305Combined sources3
Beta strandi308 – 315Combined sources8
Helixi316 – 327Combined sources12
Beta strandi337 – 339Combined sources3
Turni350 – 352Combined sources3
Beta strandi357 – 361Combined sources5
Helixi366 – 382Combined sources17
Beta strandi387 – 389Combined sources3
Helixi390 – 392Combined sources3
Helixi399 – 408Combined sources10
Beta strandi412 – 417Combined sources6
Helixi419 – 424Combined sources6
Beta strandi426 – 431Combined sources6
Turni432 – 434Combined sources3
Beta strandi437 – 441Combined sources5
Turni442 – 444Combined sources3
Helixi445 – 459Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1G5HX-ray1.95A/B/C/D17-459[»]
1G5IX-ray2.30A/B/C/D17-459[»]
ProteinModelPortaliQ9QZM2.
SMRiQ9QZM2.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9QZM2.

Family & Domainsi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2298. Eukaryota.
COG0423. LUCA.
GeneTreeiENSGT00390000000244.
HOGENOMiHOG000049133.
HOVERGENiHBG051401.
InParanoidiQ9QZM2.
KOiK02333.
OMAiLYYNFPW.
OrthoDBiEOG091G0B28.
TreeFamiTF103005.

Family and domain databases

CDDicd00774. GlyRS-like_core. 1 hit.
Gene3Di3.40.50.800. 1 hit.
InterProiIPR004154. Anticodon-bd.
IPR027031. Gly-tRNA_synthase/POLG2.
IPR033731. GlyRS-like_core.
IPR027030. POLG2.
[Graphical view]
PANTHERiPTHR10745. PTHR10745. 1 hit.
PTHR10745:SF8. PTHR10745:SF8. 1 hit.
PfamiPF03129. HGTP_anticodon. 1 hit.
[Graphical view]
SUPFAMiSSF52954. SSF52954. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QZM2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRCGGGARAC RRACRCWLSG YAGPADGTQQ PDAPEHAVAR EALVDLCRRR
60 70 80 90 100
HFFSGTPQQL STAALLSGCH ARFGPLGVEL RKNLASQWWS SMVVFREQVF
110 120 130 140 150
AVDSLHQEPG SSQPRDSAFR LVSPESIREI LQDREPSKEQ LVAFLENLLK
160 170 180 190 200
TSGKLRATLL HGALEHYVNC LDLVNRKLPF GLAQIGVCFH PVSNSNQTPS
210 220 230 240 250
SVTRVGEKTE ASLVWFTPTR TSSQWLDFWL RHRLLWWRKF AMSPSNFSSA
260 270 280 290 300
DCQDELGRKG SKLYYSFPWG KEPIETLWNL GDQELLHTYP GNVSTIQGRD
310 320 330 340 350
GRKNVVPCVL SVSGDVDLGT LAYLYDSFQL AENSFARKKS LQRKVLKLHP
360 370 380 390 400
CLAPIKVALD VGKGPTVELR QVCQGLLNEL LENGISVWPG YSETVHSSLE
410 420 430 440 450
QLHSKYDEMS VLFSVLVTET TLENGLIQLR SRDTTMKEMM HISKLRDFLV

KYLASASNV
Length:459
Mass (Da):51,467
Last modified:July 27, 2011 - v2
Checksum:i052C790C2AF9A249
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti53F → L in AAD56641 (PubMed:10666468).Curated1
Sequence conflicti226L → S in AAB62894 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF177202 mRNA. Translation: AAD56641.1.
AL603664 Genomic DNA. Translation: CAM18563.1.
AF006072 mRNA. Translation: AAB62894.1.
CCDSiCCDS25561.1.
RefSeqiNP_056625.2. NM_015810.2.
UniGeneiMm.859.

Genome annotation databases

EnsembliENSMUST00000021060; ENSMUSP00000021060; ENSMUSG00000020718.
GeneIDi50776.
KEGGimmu:50776.
UCSCiuc007lzm.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF177202 mRNA. Translation: AAD56641.1.
AL603664 Genomic DNA. Translation: CAM18563.1.
AF006072 mRNA. Translation: AAB62894.1.
CCDSiCCDS25561.1.
RefSeqiNP_056625.2. NM_015810.2.
UniGeneiMm.859.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1G5HX-ray1.95A/B/C/D17-459[»]
1G5IX-ray2.30A/B/C/D17-459[»]
ProteinModelPortaliQ9QZM2.
SMRiQ9QZM2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9QZM2. 1 interactor.
MINTiMINT-4093495.
STRINGi10090.ENSMUSP00000021060.

PTM databases

iPTMnetiQ9QZM2.
PhosphoSitePlusiQ9QZM2.

Proteomic databases

MaxQBiQ9QZM2.
PaxDbiQ9QZM2.
PRIDEiQ9QZM2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021060; ENSMUSP00000021060; ENSMUSG00000020718.
GeneIDi50776.
KEGGimmu:50776.
UCSCiuc007lzm.2. mouse.

Organism-specific databases

CTDi11232.
MGIiMGI:1354947. Polg2.

Phylogenomic databases

eggNOGiKOG2298. Eukaryota.
COG0423. LUCA.
GeneTreeiENSGT00390000000244.
HOGENOMiHOG000049133.
HOVERGENiHBG051401.
InParanoidiQ9QZM2.
KOiK02333.
OMAiLYYNFPW.
OrthoDBiEOG091G0B28.
TreeFamiTF103005.

Miscellaneous databases

ChiTaRSiPolg2. mouse.
EvolutionaryTraceiQ9QZM2.
PROiQ9QZM2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020718.
ExpressionAtlasiQ9QZM2. baseline and differential.
GenevisibleiQ9QZM2. MM.

Family and domain databases

CDDicd00774. GlyRS-like_core. 1 hit.
Gene3Di3.40.50.800. 1 hit.
InterProiIPR004154. Anticodon-bd.
IPR027031. Gly-tRNA_synthase/POLG2.
IPR033731. GlyRS-like_core.
IPR027030. POLG2.
[Graphical view]
PANTHERiPTHR10745. PTHR10745. 1 hit.
PTHR10745:SF8. PTHR10745:SF8. 1 hit.
PfamiPF03129. HGTP_anticodon. 1 hit.
[Graphical view]
SUPFAMiSSF52954. SSF52954. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDPOG2_MOUSE
AccessioniPrimary (citable) accession number: Q9QZM2
Secondary accession number(s): B1ARB5, O35614
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 137 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.