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Q9QZM2

- DPOG2_MOUSE

UniProt

Q9QZM2 - DPOG2_MOUSE

Protein

DNA polymerase subunit gamma-2, mitochondrial

Gene

Polg2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Mitochondrial polymerase processivity subunit. Stimulates the polymerase and exonuclease activities, and increases the processivity of the enzyme. Binds to ss-DNA.

    Catalytic activityi

    Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. DNA-directed DNA polymerase activity Source: MGI
    3. identical protein binding Source: IntAct

    GO - Biological processi

    1. DNA-dependent DNA replication Source: GOC
    2. DNA repair Source: MGI
    3. DNA replication Source: MGI

    Keywords - Molecular functioni

    DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase

    Keywords - Biological processi

    DNA replication

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA polymerase subunit gamma-2, mitochondrial (EC:2.7.7.7)
    Alternative name(s):
    DNA polymerase gamma accessory 55 kDa subunit
    Short name:
    p55
    Mitochondrial DNA polymerase accessory subunit
    MtPolB
    PolG-beta
    Gene namesi
    Name:Polg2
    Synonyms:Mtpolb
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:1354947. Polg2.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial nucleoid Source: Ensembl
    2. mitochondrion Source: MGI

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 459DNA polymerase subunit gamma-2, mitochondrialPRO_0000007315
    Transit peptidei1 – ?MitochondrionSequence Analysis

    Proteomic databases

    PaxDbiQ9QZM2.
    PRIDEiQ9QZM2.

    PTM databases

    PhosphoSiteiQ9QZM2.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9QZM2.
    BgeeiQ9QZM2.
    GenevestigatoriQ9QZM2.

    Interactioni

    Subunit structurei

    Heterotrimer composed of a catalytic subunit and a homodimer of accessory subunits.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    itself2EBI-853043,EBI-853043

    Protein-protein interaction databases

    IntActiQ9QZM2. 1 interaction.
    MINTiMINT-4093495.

    Structurei

    Secondary structure

    1
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi42 – 498
    Helixi57 – 604
    Helixi62 – 676
    Helixi75 – 9218
    Turni93 – 953
    Beta strandi99 – 1013
    Beta strandi106 – 1083
    Beta strandi120 – 1223
    Helixi124 – 1318
    Helixi138 – 15114
    Beta strandi152 – 1554
    Helixi160 – 1656
    Helixi167 – 1737
    Turni174 – 1763
    Beta strandi180 – 19213
    Beta strandi204 – 21714
    Helixi219 – 23820
    Helixi244 – 2463
    Beta strandi247 – 2537
    Beta strandi259 – 2679
    Beta strandi270 – 28213
    Helixi283 – 2886
    Helixi293 – 2953
    Beta strandi298 – 3003
    Beta strandi303 – 3053
    Beta strandi308 – 3158
    Helixi316 – 32712
    Turni350 – 3523
    Beta strandi357 – 3615
    Helixi366 – 38217
    Beta strandi387 – 3893
    Helixi390 – 3923
    Helixi399 – 40810
    Beta strandi412 – 4176
    Helixi419 – 4246
    Beta strandi426 – 4316
    Turni432 – 4343
    Beta strandi437 – 4415
    Turni442 – 4443
    Helixi445 – 45915

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1G5HX-ray1.95A/B/C/D17-459[»]
    1G5IX-ray2.30A/B/C/D17-459[»]
    ProteinModelPortaliQ9QZM2.
    SMRiQ9QZM2. Positions 40-459.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9QZM2.

    Family & Domainsi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0423.
    GeneTreeiENSGT00390000000244.
    HOGENOMiHOG000049133.
    HOVERGENiHBG051401.
    InParanoidiB1ARB5.
    KOiK02333.
    OMAiDHELLHM.
    OrthoDBiEOG7S7SFV.
    TreeFamiTF103005.

    Family and domain databases

    Gene3Di3.40.50.800. 1 hit.
    InterProiIPR004154. Anticodon-bd.
    IPR027031. Gly-tRNA_synthase/POLG2.
    IPR027030. POLG2.
    [Graphical view]
    PANTHERiPTHR10745. PTHR10745. 1 hit.
    PTHR10745:SF3. PTHR10745:SF3. 1 hit.
    PfamiPF03129. HGTP_anticodon. 1 hit.
    [Graphical view]
    SUPFAMiSSF52954. SSF52954. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9QZM2-1 [UniParc]FASTAAdd to Basket

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    MRCGGGARAC RRACRCWLSG YAGPADGTQQ PDAPEHAVAR EALVDLCRRR    50
    HFFSGTPQQL STAALLSGCH ARFGPLGVEL RKNLASQWWS SMVVFREQVF 100
    AVDSLHQEPG SSQPRDSAFR LVSPESIREI LQDREPSKEQ LVAFLENLLK 150
    TSGKLRATLL HGALEHYVNC LDLVNRKLPF GLAQIGVCFH PVSNSNQTPS 200
    SVTRVGEKTE ASLVWFTPTR TSSQWLDFWL RHRLLWWRKF AMSPSNFSSA 250
    DCQDELGRKG SKLYYSFPWG KEPIETLWNL GDQELLHTYP GNVSTIQGRD 300
    GRKNVVPCVL SVSGDVDLGT LAYLYDSFQL AENSFARKKS LQRKVLKLHP 350
    CLAPIKVALD VGKGPTVELR QVCQGLLNEL LENGISVWPG YSETVHSSLE 400
    QLHSKYDEMS VLFSVLVTET TLENGLIQLR SRDTTMKEMM HISKLRDFLV 450
    KYLASASNV 459
    Length:459
    Mass (Da):51,467
    Last modified:July 27, 2011 - v2
    Checksum:i052C790C2AF9A249
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti53 – 531F → L in AAD56641. (PubMed:10666468)Curated
    Sequence conflicti226 – 2261L → S in AAB62894. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF177202 mRNA. Translation: AAD56641.1.
    AL603664 Genomic DNA. Translation: CAM18563.1.
    AF006072 mRNA. Translation: AAB62894.1.
    CCDSiCCDS25561.1.
    RefSeqiNP_056625.2. NM_015810.2.
    UniGeneiMm.859.

    Genome annotation databases

    EnsembliENSMUST00000021060; ENSMUSP00000021060; ENSMUSG00000020718.
    GeneIDi50776.
    KEGGimmu:50776.
    UCSCiuc007lzm.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF177202 mRNA. Translation: AAD56641.1 .
    AL603664 Genomic DNA. Translation: CAM18563.1 .
    AF006072 mRNA. Translation: AAB62894.1 .
    CCDSi CCDS25561.1.
    RefSeqi NP_056625.2. NM_015810.2.
    UniGenei Mm.859.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1G5H X-ray 1.95 A/B/C/D 17-459 [» ]
    1G5I X-ray 2.30 A/B/C/D 17-459 [» ]
    ProteinModelPortali Q9QZM2.
    SMRi Q9QZM2. Positions 40-459.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9QZM2. 1 interaction.
    MINTi MINT-4093495.

    PTM databases

    PhosphoSitei Q9QZM2.

    Proteomic databases

    PaxDbi Q9QZM2.
    PRIDEi Q9QZM2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000021060 ; ENSMUSP00000021060 ; ENSMUSG00000020718 .
    GeneIDi 50776.
    KEGGi mmu:50776.
    UCSCi uc007lzm.2. mouse.

    Organism-specific databases

    CTDi 11232.
    MGIi MGI:1354947. Polg2.

    Phylogenomic databases

    eggNOGi COG0423.
    GeneTreei ENSGT00390000000244.
    HOGENOMi HOG000049133.
    HOVERGENi HBG051401.
    InParanoidi B1ARB5.
    KOi K02333.
    OMAi DHELLHM.
    OrthoDBi EOG7S7SFV.
    TreeFami TF103005.

    Miscellaneous databases

    EvolutionaryTracei Q9QZM2.
    NextBioi 307713.
    PROi Q9QZM2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9QZM2.
    Bgeei Q9QZM2.
    Genevestigatori Q9QZM2.

    Family and domain databases

    Gene3Di 3.40.50.800. 1 hit.
    InterProi IPR004154. Anticodon-bd.
    IPR027031. Gly-tRNA_synthase/POLG2.
    IPR027030. POLG2.
    [Graphical view ]
    PANTHERi PTHR10745. PTHR10745. 1 hit.
    PTHR10745:SF3. PTHR10745:SF3. 1 hit.
    Pfami PF03129. HGTP_anticodon. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52954. SSF52954. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Protein sequences conserved in prokaryotic aminoacyl-tRNA synthetases are important for the activity of the processivity factor of human mitochondrial DNA polymerase."
      Carrodeguas J.A., Bogenhagen D.F.
      Nucleic Acids Res. 28:1237-1244(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Swiss Webster / NIH.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. Kaguni L.S.
      Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 164-459.
    4. "Crystal structure and deletion analysis show that the accessory subunit of mammalian DNA polymerase gamma, Pol gamma B, functions as a homodimer."
      Carrodeguas J.A., Theis K., Bogenhagen D.F., Kisker C.
      Mol. Cell 7:43-54(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 1-459, SUBUNIT.

    Entry informationi

    Entry nameiDPOG2_MOUSE
    AccessioniPrimary (citable) accession number: Q9QZM2
    Secondary accession number(s): B1ARB5, O35614
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 16, 2001
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 119 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references

    External Data

    Dasty 3