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Q9QZM0

- UBQL2_MOUSE

UniProt

Q9QZM0 - UBQL2_MOUSE

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Protein
Ubiquilin-2
Gene
Ubqln2, Plic2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Increases the half-life of proteins destined to be degraded by the proteasome; may modulate proteasome-mediated protein degradation By similarity. Links CD47 to vimentin-containing intermediate filaments of the cytoskeleton.1 Publication

GO - Molecular functioni

  1. protein binding Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquilin-2
Alternative name(s):
Chap1
DSK2 homolog
Protein linking IAP with cytoskeleton 2
Short name:
PLIC-2
Ubiquitin-like product Chap1/Dsk2
Gene namesi
Name:Ubqln2
Synonyms:Plic2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:1860283. Ubqln2.

Subcellular locationi

Cytoplasm. Nucleus. Membrane
Note: Associated with fibers and membrane-associated.1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
  3. plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 638637Ubiquilin-2
PRO_0000211012Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine By similarity
Modified residuei25 – 251Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9QZM0.
PaxDbiQ9QZM0.
PRIDEiQ9QZM0.

PTM databases

PhosphoSiteiQ9QZM0.

Expressioni

Tissue specificityi

Highly expressed in smooth muscle. Expression in other tissues is very low.1 Publication

Gene expression databases

BgeeiQ9QZM0.
CleanExiMM_UBQLN2.
GenevestigatoriQ9QZM0.

Interactioni

Subunit structurei

Binds UBE3A and BTRC. Interacts with the 19S proteasome subunit By similarity. Interacts with C9orf72. Binds CD47.1 Publication

Protein-protein interaction databases

BioGridi207684. 3 interactions.
IntActiQ9QZM0. 1 interaction.
MINTiMINT-4139365.

Structurei

3D structure databases

ProteinModelPortaliQ9QZM0.
SMRiQ9QZM0. Positions 1-103, 587-635.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 10775Ubiquitin-like
Add
BLAST
Repeati505 – 50731
Repeati508 – 51032
Repeati511 – 51333
Repeati514 – 51634
Repeati517 – 51935
Repeati520 – 52236
Repeati523 – 52537
Repeati526 – 52838
Repeati529 – 53139
Repeati532 – 533210
Repeati535 – 537311
Domaini589 – 63547UBA
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni505 – 5373311 X 3 AA tandem repeats P-X-X
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi10 – 3021Pro-rich
Add
BLAST
Compositional biasi113 – 15240Thr-rich
Add
BLAST
Compositional biasi336 – 36126Ser/Thr-rich
Add
BLAST

Sequence similaritiesi

Contains 1 UBA domain.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5272.
GeneTreeiENSGT00390000005720.
HOGENOMiHOG000234878.
HOVERGENiHBG064537.
InParanoidiB1AY62.
KOiK04523.
OMAiAVVINIR.
OrthoDBiEOG7HF1J8.
TreeFamiTF314412.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR006636. STI1_HS-bd.
IPR009060. UBA-like.
IPR015940. UBA/transl_elong_EF1B_N_euk.
IPR000449. UBA/Ts_N.
IPR015496. Ubiquilin.
IPR028430. Ubiquilin-2.
IPR000626. Ubiquitin-like.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PANTHERiPTHR10677. PTHR10677. 1 hit.
PTHR10677:SF5. PTHR10677:SF5. 1 hit.
PfamiPF00627. UBA. 1 hit.
PF00240. ubiquitin. 1 hit.
[Graphical view]
SMARTiSM00727. STI1. 4 hits.
SM00165. UBA. 1 hit.
SM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 1 hit.
SSF48371. SSF48371. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50030. UBA. 1 hit.
PS50053. UBIQUITIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QZM0-1 [UniParc]FASTAAdd to Basket

« Hide

MAENGESSGP PRPSRGPAAA PGAASPPAEP KIIKVTVKTP KEKEEFAVPE    50
NSTVQQFKEA ISKRFKSQTD QLVLIFAGKI LKDQDTLMQH GIHDGLTVHL 100
VIKSQNRPQG QATTQPSTTA GTSTTTTTTT TAAAPAATTS SAPRSSSTPT 150
TTNSSSFGLG SLSSLSNLGL NSPNFTELQN QMQQQLLASP EMMIQIMENP 200
FVQSMLSNPD LMRQLIMANP QMQQLIQRNP EISHLLNNPD IMRQTLEIAR 250
NPAMMQEMMR NQDLALSNLE SIPGGYNALR RMYTDIQEPM LNAAQEQFGG 300
NPFATVGSSS TSGEGTQPSR TENRDPLPNP WAPPPTTQTA ATTTTTTTTS 350
SGSGSGSSSS STTAGNTMAA ANYVASIFST PGMQSLLQQI TENPQLIQNM 400
LSAPYMRSMM QSLSQNPDMA AQMMLSSPLF TSNPQLQEQM RPQLPNFLQQ 450
MQNPETIAAM SNPRAMQALM QIQQGLQTLA TEAPGLIPSF APGVGMGVLG 500
TAITPVGPVT PIGPIGPIVP FTPIGPIGPI GPTGPASSPG STGTGIPPAT 550
TVSSSAPTET ISPTSESGPN QQFIQQMVQA LTGGSPPQPP NPEVRFQQQL 600
EQLNAMGFLN REANLQALIA TGGDINAAIE RLLGSQPS 638
Length:638
Mass (Da):67,351
Last modified:July 27, 2011 - v2
Checksum:iA9E7350F978B8E2A
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti179 – 1791Q → R in AAF01366. 1 Publication
Sequence conflicti362 – 3621Missing in AAH21824. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF177346 mRNA. Translation: AAF01366.1.
AL844583 Genomic DNA. Translation: CAM18356.1.
CH466653 Genomic DNA. Translation: EDL31351.1.
BC021824 mRNA. Translation: AAH21824.1.
BC053022 mRNA. Translation: AAH53022.1.
CCDSiCCDS30482.1.
RefSeqiNP_061268.2. NM_018798.2.
UniGeneiMm.430772.

Genome annotation databases

EnsembliENSMUST00000060714; ENSMUSP00000056888; ENSMUSG00000050148.
GeneIDi54609.
KEGGimmu:54609.
UCSCiuc009uqw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF177346 mRNA. Translation: AAF01366.1 .
AL844583 Genomic DNA. Translation: CAM18356.1 .
CH466653 Genomic DNA. Translation: EDL31351.1 .
BC021824 mRNA. Translation: AAH21824.1 .
BC053022 mRNA. Translation: AAH53022.1 .
CCDSi CCDS30482.1.
RefSeqi NP_061268.2. NM_018798.2.
UniGenei Mm.430772.

3D structure databases

ProteinModelPortali Q9QZM0.
SMRi Q9QZM0. Positions 1-103, 587-635.
ModBasei Search...

Protein-protein interaction databases

BioGridi 207684. 3 interactions.
IntActi Q9QZM0. 1 interaction.
MINTi MINT-4139365.

PTM databases

PhosphoSitei Q9QZM0.

Proteomic databases

MaxQBi Q9QZM0.
PaxDbi Q9QZM0.
PRIDEi Q9QZM0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000060714 ; ENSMUSP00000056888 ; ENSMUSG00000050148 .
GeneIDi 54609.
KEGGi mmu:54609.
UCSCi uc009uqw.1. mouse.

Organism-specific databases

CTDi 29978.
MGIi MGI:1860283. Ubqln2.

Phylogenomic databases

eggNOGi COG5272.
GeneTreei ENSGT00390000005720.
HOGENOMi HOG000234878.
HOVERGENi HBG064537.
InParanoidi B1AY62.
KOi K04523.
OMAi AVVINIR.
OrthoDBi EOG7HF1J8.
TreeFami TF314412.

Miscellaneous databases

NextBioi 311408.
PROi Q9QZM0.
SOURCEi Search...

Gene expression databases

Bgeei Q9QZM0.
CleanExi MM_UBQLN2.
Genevestigatori Q9QZM0.

Family and domain databases

InterProi IPR016024. ARM-type_fold.
IPR006636. STI1_HS-bd.
IPR009060. UBA-like.
IPR015940. UBA/transl_elong_EF1B_N_euk.
IPR000449. UBA/Ts_N.
IPR015496. Ubiquilin.
IPR028430. Ubiquilin-2.
IPR000626. Ubiquitin-like.
IPR029071. Ubiquitin-rel_dom.
[Graphical view ]
PANTHERi PTHR10677. PTHR10677. 1 hit.
PTHR10677:SF5. PTHR10677:SF5. 1 hit.
Pfami PF00627. UBA. 1 hit.
PF00240. ubiquitin. 1 hit.
[Graphical view ]
SMARTi SM00727. STI1. 4 hits.
SM00165. UBA. 1 hit.
SM00213. UBQ. 1 hit.
[Graphical view ]
SUPFAMi SSF46934. SSF46934. 1 hit.
SSF48371. SSF48371. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEi PS50030. UBA. 1 hit.
PS50053. UBIQUITIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Ubiquitin-related proteins regulate interaction of vimentin intermediate filaments with the plasma membrane."
    Wu A.-L., Wang J., Zheleznyak A., Brown E.J.
    Mol. Cell 4:619-625(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH CD47.
    Strain: Swiss Webster / NIH.
    Tissue: Embryo.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-25, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic brain.

Entry informationi

Entry nameiUBQL2_MOUSE
AccessioniPrimary (citable) accession number: Q9QZM0
Secondary accession number(s): B1AY62, Q7TSJ8, Q8VDH9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi