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Q9QZM0 (UBQL2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquilin-2
Alternative name(s):
Chap1
DSK2 homolog
Protein linking IAP with cytoskeleton 2
Short name=PLIC-2
Ubiquitin-like product Chap1/Dsk2
Gene names
Name:Ubqln2
Synonyms:Plic2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length638 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Increases the half-life of proteins destined to be degraded by the proteasome; may modulate proteasome-mediated protein degradation By similarity. Links CD47 to vimentin-containing intermediate filaments of the cytoskeleton. Ref.1

Subunit structure

Binds UBE3A and BTRC. Interacts with the 19S proteasome subunit By similarity. Binds CD47. Ref.1

Subcellular location

Cytoplasm. Nucleus. Membrane. Note: Associated with fibers and membrane-associated. Ref.1

Tissue specificity

Highly expressed in smooth muscle. Expression in other tissues is very low. Ref.1

Sequence similarities

Contains 1 UBA domain.

Contains 1 ubiquitin-like domain.

Ontologies

Keywords
   Cellular componentCytoplasm
Membrane
Nucleus
   DomainRepeat
   PTMAcetylation
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

plasma membrane

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 638637Ubiquilin-2
PRO_0000211012

Regions

Domain33 – 10775Ubiquitin-like
Repeat505 – 50731
Repeat508 – 51032
Repeat511 – 51333
Repeat514 – 51634
Repeat517 – 51935
Repeat520 – 52236
Repeat523 – 52537
Repeat526 – 52838
Repeat529 – 53139
Repeat532 – 533210
Repeat535 – 537311
Domain589 – 63547UBA
Region505 – 5373311 X 3 AA tandem repeats P-X-X
Compositional bias10 – 3021Pro-rich
Compositional bias113 – 15240Thr-rich
Compositional bias336 – 36126Ser/Thr-rich

Amino acid modifications

Modified residue21N-acetylalanine By similarity
Modified residue251Phosphoserine Ref.5

Experimental info

Sequence conflict1791Q → R in AAF01366. Ref.1
Sequence conflict3621Missing in AAH21824. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Q9QZM0 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: A9E7350F978B8E2A

FASTA63867,351
        10         20         30         40         50         60 
MAENGESSGP PRPSRGPAAA PGAASPPAEP KIIKVTVKTP KEKEEFAVPE NSTVQQFKEA 

        70         80         90        100        110        120 
ISKRFKSQTD QLVLIFAGKI LKDQDTLMQH GIHDGLTVHL VIKSQNRPQG QATTQPSTTA 

       130        140        150        160        170        180 
GTSTTTTTTT TAAAPAATTS SAPRSSSTPT TTNSSSFGLG SLSSLSNLGL NSPNFTELQN 

       190        200        210        220        230        240 
QMQQQLLASP EMMIQIMENP FVQSMLSNPD LMRQLIMANP QMQQLIQRNP EISHLLNNPD 

       250        260        270        280        290        300 
IMRQTLEIAR NPAMMQEMMR NQDLALSNLE SIPGGYNALR RMYTDIQEPM LNAAQEQFGG 

       310        320        330        340        350        360 
NPFATVGSSS TSGEGTQPSR TENRDPLPNP WAPPPTTQTA ATTTTTTTTS SGSGSGSSSS 

       370        380        390        400        410        420 
STTAGNTMAA ANYVASIFST PGMQSLLQQI TENPQLIQNM LSAPYMRSMM QSLSQNPDMA 

       430        440        450        460        470        480 
AQMMLSSPLF TSNPQLQEQM RPQLPNFLQQ MQNPETIAAM SNPRAMQALM QIQQGLQTLA 

       490        500        510        520        530        540 
TEAPGLIPSF APGVGMGVLG TAITPVGPVT PIGPIGPIVP FTPIGPIGPI GPTGPASSPG 

       550        560        570        580        590        600 
STGTGIPPAT TVSSSAPTET ISPTSESGPN QQFIQQMVQA LTGGSPPQPP NPEVRFQQQL 

       610        620        630 
EQLNAMGFLN REANLQALIA TGGDINAAIE RLLGSQPS 

« Hide

References

« Hide 'large scale' references
[1]"Ubiquitin-related proteins regulate interaction of vimentin intermediate filaments with the plasma membrane."
Wu A.-L., Wang J., Zheleznyak A., Brown E.J.
Mol. Cell 4:619-625(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH CD47.
Strain: Swiss Webster / NIH.
Tissue: Embryo.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain.
[5]"Phosphoproteomic analysis of the developing mouse brain."
Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.
Mol. Cell. Proteomics 3:1093-1101(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-25, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Embryonic brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF177346 mRNA. Translation: AAF01366.1.
AL844583 Genomic DNA. Translation: CAM18356.1.
CH466653 Genomic DNA. Translation: EDL31351.1.
BC021824 mRNA. Translation: AAH21824.1.
BC053022 mRNA. Translation: AAH53022.1.
RefSeqNP_061268.2. NM_018798.2.
UniGeneMm.430772.

3D structure databases

ProteinModelPortalQ9QZM0.
SMRQ9QZM0. Positions 1-103, 587-635.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid207684. 3 interactions.
IntActQ9QZM0. 1 interaction.
MINTMINT-4139365.

PTM databases

PhosphoSiteQ9QZM0.

Proteomic databases

PaxDbQ9QZM0.
PRIDEQ9QZM0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000060714; ENSMUSP00000056888; ENSMUSG00000050148.
GeneID54609.
KEGGmmu:54609.
UCSCuc009uqw.1. mouse.

Organism-specific databases

CTD29978.
MGIMGI:1860283. Ubqln2.

Phylogenomic databases

eggNOGCOG5272.
GeneTreeENSGT00390000005720.
HOGENOMHOG000234878.
HOVERGENHBG064537.
InParanoidB1AY62.
KOK04523.
OMAMANRMIS.
OrthoDBEOG7HF1J8.
TreeFamTF314412.

Gene expression databases

BgeeQ9QZM0.
CleanExMM_UBQLN2.
GenevestigatorQ9QZM0.

Family and domain databases

InterProIPR016024. ARM-type_fold.
IPR006636. STI1_HS-bd.
IPR009060. UBA-like.
IPR015940. UBA/transl_elong_EF1B_N_euk.
IPR000449. UBA/Ts_N.
IPR015496. Ubiquilin.
IPR028430. Ubiquilin-2.
IPR000626. Ubiquitin-like.
[Graphical view]
PANTHERPTHR10677. PTHR10677. 1 hit.
PTHR10677:SF5. PTHR10677:SF5. 1 hit.
PfamPF00627. UBA. 1 hit.
PF00240. ubiquitin. 1 hit.
[Graphical view]
SMARTSM00727. STI1. 4 hits.
SM00165. UBA. 1 hit.
SM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMSSF46934. SSF46934. 1 hit.
SSF48371. SSF48371. 1 hit.
PROSITEPS50030. UBA. 1 hit.
PS50053. UBIQUITIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio311408.
PROQ9QZM0.
SOURCESearch...

Entry information

Entry nameUBQL2_MOUSE
AccessionPrimary (citable) accession number: Q9QZM0
Secondary accession number(s): B1AY62, Q7TSJ8, Q8VDH9
Entry history
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: July 27, 2011
Last modified: April 16, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot