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Q9QZM0

- UBQL2_MOUSE

UniProt

Q9QZM0 - UBQL2_MOUSE

Protein

Ubiquilin-2

Gene

Ubqln2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Increases the half-life of proteins destined to be degraded by the proteasome; may modulate proteasome-mediated protein degradation By similarity. Links CD47 to vimentin-containing intermediate filaments of the cytoskeleton.By similarity1 Publication

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquilin-2
    Alternative name(s):
    Chap1
    DSK2 homolog
    Protein linking IAP with cytoskeleton 2
    Short name:
    PLIC-2
    Ubiquitin-like product Chap1/Dsk2
    Gene namesi
    Name:Ubqln2
    Synonyms:Plic2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome X

    Organism-specific databases

    MGIiMGI:1860283. Ubqln2.

    Subcellular locationi

    Cytoplasm 1 Publication. Nucleus 1 Publication. Membrane 1 Publication
    Note: Associated with fibers and membrane-associated.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell
    3. plasma membrane Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm, Membrane, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 638637Ubiquilin-2PRO_0000211012Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei25 – 251Phosphoserine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ9QZM0.
    PaxDbiQ9QZM0.
    PRIDEiQ9QZM0.

    PTM databases

    PhosphoSiteiQ9QZM0.

    Expressioni

    Tissue specificityi

    Highly expressed in smooth muscle. Expression in other tissues is very low.1 Publication

    Gene expression databases

    BgeeiQ9QZM0.
    CleanExiMM_UBQLN2.
    GenevestigatoriQ9QZM0.

    Interactioni

    Subunit structurei

    Binds UBE3A and BTRC. Interacts with the 19S proteasome subunit By similarity. Interacts with C9orf72. Binds CD47.By similarity1 Publication

    Protein-protein interaction databases

    BioGridi207684. 3 interactions.
    IntActiQ9QZM0. 1 interaction.
    MINTiMINT-4139365.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9QZM0.
    SMRiQ9QZM0. Positions 1-103, 587-635.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini33 – 10775Ubiquitin-likePROSITE-ProRule annotationAdd
    BLAST
    Repeati505 – 50731
    Repeati508 – 51032
    Repeati511 – 51333
    Repeati514 – 51634
    Repeati517 – 51935
    Repeati520 – 52236
    Repeati523 – 52537
    Repeati526 – 52838
    Repeati529 – 53139
    Repeati532 – 533210
    Repeati535 – 537311
    Domaini589 – 63547UBAPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni505 – 5373311 X 3 AA tandem repeats P-X-XAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi10 – 3021Pro-richAdd
    BLAST
    Compositional biasi113 – 15240Thr-richAdd
    BLAST
    Compositional biasi336 – 36126Ser/Thr-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 UBA domain.PROSITE-ProRule annotation
    Contains 1 ubiquitin-like domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG5272.
    GeneTreeiENSGT00390000005720.
    HOGENOMiHOG000234878.
    HOVERGENiHBG064537.
    InParanoidiB1AY62.
    KOiK04523.
    OMAiAVVINIR.
    OrthoDBiEOG7HF1J8.
    TreeFamiTF314412.

    Family and domain databases

    InterProiIPR016024. ARM-type_fold.
    IPR006636. STI1_HS-bd.
    IPR009060. UBA-like.
    IPR015940. UBA/transl_elong_EF1B_N_euk.
    IPR000449. UBA/Ts_N.
    IPR015496. Ubiquilin.
    IPR028430. Ubiquilin-2.
    IPR000626. Ubiquitin-like.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view]
    PANTHERiPTHR10677. PTHR10677. 1 hit.
    PTHR10677:SF5. PTHR10677:SF5. 1 hit.
    PfamiPF00627. UBA. 1 hit.
    PF00240. ubiquitin. 1 hit.
    [Graphical view]
    SMARTiSM00727. STI1. 4 hits.
    SM00165. UBA. 1 hit.
    SM00213. UBQ. 1 hit.
    [Graphical view]
    SUPFAMiSSF46934. SSF46934. 1 hit.
    SSF48371. SSF48371. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEiPS50030. UBA. 1 hit.
    PS50053. UBIQUITIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9QZM0-1 [UniParc]FASTAAdd to Basket

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    MAENGESSGP PRPSRGPAAA PGAASPPAEP KIIKVTVKTP KEKEEFAVPE    50
    NSTVQQFKEA ISKRFKSQTD QLVLIFAGKI LKDQDTLMQH GIHDGLTVHL 100
    VIKSQNRPQG QATTQPSTTA GTSTTTTTTT TAAAPAATTS SAPRSSSTPT 150
    TTNSSSFGLG SLSSLSNLGL NSPNFTELQN QMQQQLLASP EMMIQIMENP 200
    FVQSMLSNPD LMRQLIMANP QMQQLIQRNP EISHLLNNPD IMRQTLEIAR 250
    NPAMMQEMMR NQDLALSNLE SIPGGYNALR RMYTDIQEPM LNAAQEQFGG 300
    NPFATVGSSS TSGEGTQPSR TENRDPLPNP WAPPPTTQTA ATTTTTTTTS 350
    SGSGSGSSSS STTAGNTMAA ANYVASIFST PGMQSLLQQI TENPQLIQNM 400
    LSAPYMRSMM QSLSQNPDMA AQMMLSSPLF TSNPQLQEQM RPQLPNFLQQ 450
    MQNPETIAAM SNPRAMQALM QIQQGLQTLA TEAPGLIPSF APGVGMGVLG 500
    TAITPVGPVT PIGPIGPIVP FTPIGPIGPI GPTGPASSPG STGTGIPPAT 550
    TVSSSAPTET ISPTSESGPN QQFIQQMVQA LTGGSPPQPP NPEVRFQQQL 600
    EQLNAMGFLN REANLQALIA TGGDINAAIE RLLGSQPS 638
    Length:638
    Mass (Da):67,351
    Last modified:July 27, 2011 - v2
    Checksum:iA9E7350F978B8E2A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti179 – 1791Q → R in AAF01366. (PubMed:10549293)Curated
    Sequence conflicti362 – 3621Missing in AAH21824. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF177346 mRNA. Translation: AAF01366.1.
    AL844583 Genomic DNA. Translation: CAM18356.1.
    CH466653 Genomic DNA. Translation: EDL31351.1.
    BC021824 mRNA. Translation: AAH21824.1.
    BC053022 mRNA. Translation: AAH53022.1.
    CCDSiCCDS30482.1.
    RefSeqiNP_061268.2. NM_018798.2.
    UniGeneiMm.430772.

    Genome annotation databases

    EnsembliENSMUST00000060714; ENSMUSP00000056888; ENSMUSG00000050148.
    GeneIDi54609.
    KEGGimmu:54609.
    UCSCiuc009uqw.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF177346 mRNA. Translation: AAF01366.1 .
    AL844583 Genomic DNA. Translation: CAM18356.1 .
    CH466653 Genomic DNA. Translation: EDL31351.1 .
    BC021824 mRNA. Translation: AAH21824.1 .
    BC053022 mRNA. Translation: AAH53022.1 .
    CCDSi CCDS30482.1.
    RefSeqi NP_061268.2. NM_018798.2.
    UniGenei Mm.430772.

    3D structure databases

    ProteinModelPortali Q9QZM0.
    SMRi Q9QZM0. Positions 1-103, 587-635.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 207684. 3 interactions.
    IntActi Q9QZM0. 1 interaction.
    MINTi MINT-4139365.

    PTM databases

    PhosphoSitei Q9QZM0.

    Proteomic databases

    MaxQBi Q9QZM0.
    PaxDbi Q9QZM0.
    PRIDEi Q9QZM0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000060714 ; ENSMUSP00000056888 ; ENSMUSG00000050148 .
    GeneIDi 54609.
    KEGGi mmu:54609.
    UCSCi uc009uqw.1. mouse.

    Organism-specific databases

    CTDi 29978.
    MGIi MGI:1860283. Ubqln2.

    Phylogenomic databases

    eggNOGi COG5272.
    GeneTreei ENSGT00390000005720.
    HOGENOMi HOG000234878.
    HOVERGENi HBG064537.
    InParanoidi B1AY62.
    KOi K04523.
    OMAi AVVINIR.
    OrthoDBi EOG7HF1J8.
    TreeFami TF314412.

    Miscellaneous databases

    NextBioi 311408.
    PROi Q9QZM0.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9QZM0.
    CleanExi MM_UBQLN2.
    Genevestigatori Q9QZM0.

    Family and domain databases

    InterProi IPR016024. ARM-type_fold.
    IPR006636. STI1_HS-bd.
    IPR009060. UBA-like.
    IPR015940. UBA/transl_elong_EF1B_N_euk.
    IPR000449. UBA/Ts_N.
    IPR015496. Ubiquilin.
    IPR028430. Ubiquilin-2.
    IPR000626. Ubiquitin-like.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view ]
    PANTHERi PTHR10677. PTHR10677. 1 hit.
    PTHR10677:SF5. PTHR10677:SF5. 1 hit.
    Pfami PF00627. UBA. 1 hit.
    PF00240. ubiquitin. 1 hit.
    [Graphical view ]
    SMARTi SM00727. STI1. 4 hits.
    SM00165. UBA. 1 hit.
    SM00213. UBQ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46934. SSF46934. 1 hit.
    SSF48371. SSF48371. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEi PS50030. UBA. 1 hit.
    PS50053. UBIQUITIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Ubiquitin-related proteins regulate interaction of vimentin intermediate filaments with the plasma membrane."
      Wu A.-L., Wang J., Zheleznyak A., Brown E.J.
      Mol. Cell 4:619-625(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH CD47.
      Strain: Swiss Webster / NIH.
      Tissue: Embryo.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.
    5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-25, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic brain.

    Entry informationi

    Entry nameiUBQL2_MOUSE
    AccessioniPrimary (citable) accession number: Q9QZM0
    Secondary accession number(s): B1AY62, Q7TSJ8, Q8VDH9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 29, 2004
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 107 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3