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Q9QZL2

- CHST3_RAT

UniProt

Q9QZL2 - CHST3_RAT

Protein

Carbohydrate sulfotransferase 3

Gene

Chst3

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 2 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Can also sulfate Gal residues of keratan sulfate, another glycosaminoglycan, and the Gal residues in sialyl N-acetyllactosamine (sialyl LacNAc) oligosaccharides. May play a role in the maintenance of naive T-lymphocytes in the spleen By similarity.By similarity

    Catalytic activityi

    3'-phosphoadenylyl sulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi137 – 1437PAPSBy similarity
    Nucleotide bindingi297 – 3059PAPSBy similarity

    GO - Molecular functioni

    1. chondroitin 6-sulfotransferase activity Source: UniProtKB-EC
    2. proteoglycan sulfotransferase activity Source: RGD

    GO - Biological processi

    1. carbohydrate metabolic process Source: UniProtKB-KW
    2. peripheral nervous system axon regeneration Source: RGD
    3. positive regulation of cellular component movement Source: RGD
    4. sulfur compound metabolic process Source: RGD

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Carbohydrate metabolism

    Enzyme and pathway databases

    BRENDAi2.8.2.17. 5301.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Carbohydrate sulfotransferase 3 (EC:2.8.2.17)
    Alternative name(s):
    Chondroitin 6-O-sulfotransferase 1
    Short name:
    C6ST-1
    Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 0
    Short name:
    GST-0
    Gene namesi
    Name:Chst3
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi620355. Chst3.

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 474474Carbohydrate sulfotransferase 3PRO_0000085190Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi63 – 631N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi74 – 741N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi96 – 961N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi252 – 2521N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi415 – 4151N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi459 – 4591N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ9QZL2.

    PTM databases

    PhosphoSiteiQ9QZL2.

    Expressioni

    Gene expression databases

    GenevestigatoriQ9QZL2.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-4998399.
    STRINGi10116.ENSRNOP00000000697.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9QZL2.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1919CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini39 – 474436LumenalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei20 – 3819Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG80862.
    HOGENOMiHOG000261614.
    HOVERGENiHBG106811.
    InParanoidiQ9QZL2.
    KOiK01020.
    PhylomeDBiQ9QZL2.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR016469. Carbohydrate_sulfotransferase.
    IPR027417. P-loop_NTPase.
    IPR000863. Sulfotransferase_dom.
    [Graphical view]
    PfamiPF00685. Sulfotransfer_1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005883. Carbohydrate_sulfotransferase. 1 hit.
    SUPFAMiSSF52540. SSF52540. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    Q9QZL2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEKGLALPQD CRDLVHNLKI RGRYVLFLAF VVIVFIFIEK ENKIISRVSD    50
    KLKQIPQFVA DANSTDPALL LSENASLLSL SELDSTFSHL RSRLHNLSLQ 100
    LGIAPAMEAQ GQEAVAEKPS QQAGAGTRRH VLLMATTRTG SSFVGEFFNQ 150
    QGNIFYLFEP LWHIERTVFF QQGGASAAGS ALVYRDVLKQ LLLCDLYVLE 200
    PFISPPPEDH LTQFLFRRGS SRSLCEDPVC TPFVKKVFEK YHCRNRHCGP 250
    LNVTLAAEAC RRKDHMALKV VRIRQLEFLQ PLAEDPRLDL RVIQLVRDPR 300
    AVLASRMVAF AGKYESWKKW LSEGQDQLSE NEVQRLRGNC ENIRLSAELG 350
    LRQPAWLRGR YMLVRYEDVA RRPLQKAREM YRSAGIPLTP QVEDWIQKNT 400
    QAARDSSDVY STQKNSSEQF EKWRFSIPFK LAQVVQAVCG PAMHLFGHKL 450
    AKDTASLTNR SISLLEERGT FWVT 474
    Length:474
    Mass (Da):54,018
    Last modified:March 1, 2001 - v2
    Checksum:i83EC94C3894CE77E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF178689 mRNA. Translation: AAD54386.2.
    RefSeqiNP_445860.1. NM_053408.1.
    UniGeneiRn.64646.

    Genome annotation databases

    GeneIDi84468.
    KEGGirno:84468.
    UCSCiRGD:620355. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF178689 mRNA. Translation: AAD54386.2 .
    RefSeqi NP_445860.1. NM_053408.1.
    UniGenei Rn.64646.

    3D structure databases

    ProteinModelPortali Q9QZL2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-4998399.
    STRINGi 10116.ENSRNOP00000000697.

    PTM databases

    PhosphoSitei Q9QZL2.

    Proteomic databases

    PRIDEi Q9QZL2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 84468.
    KEGGi rno:84468.
    UCSCi RGD:620355. rat.

    Organism-specific databases

    CTDi 9469.
    RGDi 620355. Chst3.

    Phylogenomic databases

    eggNOGi NOG80862.
    HOGENOMi HOG000261614.
    HOVERGENi HBG106811.
    InParanoidi Q9QZL2.
    KOi K01020.
    PhylomeDBi Q9QZL2.

    Enzyme and pathway databases

    BRENDAi 2.8.2.17. 5301.

    Miscellaneous databases

    NextBioi 616944.
    PROi Q9QZL2.

    Gene expression databases

    Genevestigatori Q9QZL2.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR016469. Carbohydrate_sulfotransferase.
    IPR027417. P-loop_NTPase.
    IPR000863. Sulfotransferase_dom.
    [Graphical view ]
    Pfami PF00685. Sulfotransfer_1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005883. Carbohydrate_sulfotransferase. 1 hit.
    SUPFAMi SSF52540. SSF52540. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Chondroitin 6-sulfotransferase of rat sciatic nerve."
      Li X., Kwok C.-F., Shum K.-Y.
      Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.

    Entry informationi

    Entry nameiCHST3_RAT
    AccessioniPrimary (citable) accession number: Q9QZL2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2005
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 83 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3