Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9QZL2

- CHST3_RAT

UniProt

Q9QZL2 - CHST3_RAT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Carbohydrate sulfotransferase 3

Gene

Chst3

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Can also sulfate Gal residues of keratan sulfate, another glycosaminoglycan, and the Gal residues in sialyl N-acetyllactosamine (sialyl LacNAc) oligosaccharides. May play a role in the maintenance of naive T-lymphocytes in the spleen By similarity.By similarity

Catalytic activityi

3'-phosphoadenylyl sulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi137 – 1437PAPSBy similarity
Nucleotide bindingi297 – 3059PAPSBy similarity

GO - Molecular functioni

  1. chondroitin 6-sulfotransferase activity Source: UniProtKB-EC
  2. proteoglycan sulfotransferase activity Source: RGD

GO - Biological processi

  1. carbohydrate metabolic process Source: UniProtKB-KW
  2. peripheral nervous system axon regeneration Source: RGD
  3. positive regulation of cellular component movement Source: RGD
  4. sulfur compound metabolic process Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Carbohydrate metabolism

Enzyme and pathway databases

BRENDAi2.8.2.17. 5301.

Names & Taxonomyi

Protein namesi
Recommended name:
Carbohydrate sulfotransferase 3 (EC:2.8.2.17)
Alternative name(s):
Chondroitin 6-O-sulfotransferase 1
Short name:
C6ST-1
Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 0
Short name:
GST-0
Gene namesi
Name:Chst3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi620355. Chst3.

Subcellular locationi

GO - Cellular componenti

  1. Golgi membrane Source: InterPro
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 474474Carbohydrate sulfotransferase 3PRO_0000085190Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi63 – 631N-linked (GlcNAc...)Sequence Analysis
Glycosylationi74 – 741N-linked (GlcNAc...)Sequence Analysis
Glycosylationi96 – 961N-linked (GlcNAc...)Sequence Analysis
Glycosylationi252 – 2521N-linked (GlcNAc...)Sequence Analysis
Glycosylationi415 – 4151N-linked (GlcNAc...)Sequence Analysis
Glycosylationi459 – 4591N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ9QZL2.

PTM databases

PhosphoSiteiQ9QZL2.

Expressioni

Gene expression databases

GenevestigatoriQ9QZL2.

Interactioni

Protein-protein interaction databases

MINTiMINT-4998399.
STRINGi10116.ENSRNOP00000000697.

Structurei

3D structure databases

ProteinModelPortaliQ9QZL2.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1919CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini39 – 474436LumenalSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei20 – 3819Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG80862.
HOGENOMiHOG000261614.
HOVERGENiHBG106811.
InParanoidiQ9QZL2.
KOiK01020.
PhylomeDBiQ9QZL2.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR016469. Carbohydrate_sulfotransferase.
IPR027417. P-loop_NTPase.
IPR000863. Sulfotransferase_dom.
[Graphical view]
PfamiPF00685. Sulfotransfer_1. 1 hit.
[Graphical view]
PIRSFiPIRSF005883. Carbohydrate_sulfotransferase. 1 hit.
SUPFAMiSSF52540. SSF52540. 2 hits.

Sequencei

Sequence statusi: Complete.

Q9QZL2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEKGLALPQD CRDLVHNLKI RGRYVLFLAF VVIVFIFIEK ENKIISRVSD
60 70 80 90 100
KLKQIPQFVA DANSTDPALL LSENASLLSL SELDSTFSHL RSRLHNLSLQ
110 120 130 140 150
LGIAPAMEAQ GQEAVAEKPS QQAGAGTRRH VLLMATTRTG SSFVGEFFNQ
160 170 180 190 200
QGNIFYLFEP LWHIERTVFF QQGGASAAGS ALVYRDVLKQ LLLCDLYVLE
210 220 230 240 250
PFISPPPEDH LTQFLFRRGS SRSLCEDPVC TPFVKKVFEK YHCRNRHCGP
260 270 280 290 300
LNVTLAAEAC RRKDHMALKV VRIRQLEFLQ PLAEDPRLDL RVIQLVRDPR
310 320 330 340 350
AVLASRMVAF AGKYESWKKW LSEGQDQLSE NEVQRLRGNC ENIRLSAELG
360 370 380 390 400
LRQPAWLRGR YMLVRYEDVA RRPLQKAREM YRSAGIPLTP QVEDWIQKNT
410 420 430 440 450
QAARDSSDVY STQKNSSEQF EKWRFSIPFK LAQVVQAVCG PAMHLFGHKL
460 470
AKDTASLTNR SISLLEERGT FWVT
Length:474
Mass (Da):54,018
Last modified:March 1, 2001 - v2
Checksum:i83EC94C3894CE77E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF178689 mRNA. Translation: AAD54386.2.
RefSeqiNP_445860.1. NM_053408.1.
UniGeneiRn.64646.

Genome annotation databases

GeneIDi84468.
KEGGirno:84468.
UCSCiRGD:620355. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF178689 mRNA. Translation: AAD54386.2 .
RefSeqi NP_445860.1. NM_053408.1.
UniGenei Rn.64646.

3D structure databases

ProteinModelPortali Q9QZL2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-4998399.
STRINGi 10116.ENSRNOP00000000697.

PTM databases

PhosphoSitei Q9QZL2.

Proteomic databases

PRIDEi Q9QZL2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 84468.
KEGGi rno:84468.
UCSCi RGD:620355. rat.

Organism-specific databases

CTDi 9469.
RGDi 620355. Chst3.

Phylogenomic databases

eggNOGi NOG80862.
HOGENOMi HOG000261614.
HOVERGENi HBG106811.
InParanoidi Q9QZL2.
KOi K01020.
PhylomeDBi Q9QZL2.

Enzyme and pathway databases

BRENDAi 2.8.2.17. 5301.

Miscellaneous databases

NextBioi 616944.
PROi Q9QZL2.

Gene expression databases

Genevestigatori Q9QZL2.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR016469. Carbohydrate_sulfotransferase.
IPR027417. P-loop_NTPase.
IPR000863. Sulfotransferase_dom.
[Graphical view ]
Pfami PF00685. Sulfotransfer_1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005883. Carbohydrate_sulfotransferase. 1 hit.
SUPFAMi SSF52540. SSF52540. 2 hits.
ProtoNeti Search...

Publicationsi

  1. "Chondroitin 6-sulfotransferase of rat sciatic nerve."
    Li X., Kwok C.-F., Shum K.-Y.
    Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.

Entry informationi

Entry nameiCHST3_RAT
AccessioniPrimary (citable) accession number: Q9QZL2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 1, 2001
Last modified: October 29, 2014
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3