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Q9QZL2

- CHST3_RAT

UniProt

Q9QZL2 - CHST3_RAT

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Protein
Carbohydrate sulfotransferase 3
Gene
Chst3
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Can also sulfate Gal residues of keratan sulfate, another glycosaminoglycan, and the Gal residues in sialyl N-acetyllactosamine (sialyl LacNAc) oligosaccharides. May play a role in the maintenance of naive T-lymphocytes in the spleen By similarity.

Catalytic activityi

3'-phosphoadenylyl sulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi137 – 1437PAPS By similarity
Nucleotide bindingi297 – 3059PAPS By similarity

GO - Molecular functioni

  1. chondroitin 6-sulfotransferase activity Source: UniProtKB-EC
  2. proteoglycan sulfotransferase activity Source: RGD

GO - Biological processi

  1. carbohydrate metabolic process Source: UniProtKB-KW
  2. peripheral nervous system axon regeneration Source: RGD
  3. positive regulation of cellular component movement Source: RGD
  4. sulfur compound metabolic process Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Carbohydrate metabolism

Enzyme and pathway databases

BRENDAi2.8.2.17. 5301.

Names & Taxonomyi

Protein namesi
Recommended name:
Carbohydrate sulfotransferase 3 (EC:2.8.2.17)
Alternative name(s):
Chondroitin 6-O-sulfotransferase 1
Short name:
C6ST-1
Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 0
Short name:
GST-0
Gene namesi
Name:Chst3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi620355. Chst3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1919Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei20 – 3819Helical; Signal-anchor for type II membrane protein; Reviewed prediction
Add
BLAST
Topological domaini39 – 474436Lumenal Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Golgi membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 474474Carbohydrate sulfotransferase 3
PRO_0000085190Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi63 – 631N-linked (GlcNAc...) Reviewed prediction
Glycosylationi74 – 741N-linked (GlcNAc...) Reviewed prediction
Glycosylationi96 – 961N-linked (GlcNAc...) Reviewed prediction
Glycosylationi252 – 2521N-linked (GlcNAc...) Reviewed prediction
Glycosylationi415 – 4151N-linked (GlcNAc...) Reviewed prediction
Glycosylationi459 – 4591N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ9QZL2.

PTM databases

PhosphoSiteiQ9QZL2.

Expressioni

Gene expression databases

GenevestigatoriQ9QZL2.

Interactioni

Protein-protein interaction databases

MINTiMINT-4998399.
STRINGi10116.ENSRNOP00000000697.

Structurei

3D structure databases

ProteinModelPortaliQ9QZL2.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG80862.
HOGENOMiHOG000261614.
HOVERGENiHBG106811.
InParanoidiQ9QZL2.
KOiK01020.
PhylomeDBiQ9QZL2.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR016469. Carbohydrate_sulfotransferase.
IPR027417. P-loop_NTPase.
IPR000863. Sulfotransferase_dom.
[Graphical view]
PfamiPF00685. Sulfotransfer_1. 1 hit.
[Graphical view]
PIRSFiPIRSF005883. Carbohydrate_sulfotransferase. 1 hit.
SUPFAMiSSF52540. SSF52540. 2 hits.

Sequencei

Sequence statusi: Complete.

Q9QZL2-1 [UniParc]FASTAAdd to Basket

« Hide

MEKGLALPQD CRDLVHNLKI RGRYVLFLAF VVIVFIFIEK ENKIISRVSD    50
KLKQIPQFVA DANSTDPALL LSENASLLSL SELDSTFSHL RSRLHNLSLQ 100
LGIAPAMEAQ GQEAVAEKPS QQAGAGTRRH VLLMATTRTG SSFVGEFFNQ 150
QGNIFYLFEP LWHIERTVFF QQGGASAAGS ALVYRDVLKQ LLLCDLYVLE 200
PFISPPPEDH LTQFLFRRGS SRSLCEDPVC TPFVKKVFEK YHCRNRHCGP 250
LNVTLAAEAC RRKDHMALKV VRIRQLEFLQ PLAEDPRLDL RVIQLVRDPR 300
AVLASRMVAF AGKYESWKKW LSEGQDQLSE NEVQRLRGNC ENIRLSAELG 350
LRQPAWLRGR YMLVRYEDVA RRPLQKAREM YRSAGIPLTP QVEDWIQKNT 400
QAARDSSDVY STQKNSSEQF EKWRFSIPFK LAQVVQAVCG PAMHLFGHKL 450
AKDTASLTNR SISLLEERGT FWVT 474
Length:474
Mass (Da):54,018
Last modified:March 1, 2001 - v2
Checksum:i83EC94C3894CE77E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF178689 mRNA. Translation: AAD54386.2.
RefSeqiNP_445860.1. NM_053408.1.
UniGeneiRn.64646.

Genome annotation databases

GeneIDi84468.
KEGGirno:84468.
UCSCiRGD:620355. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF178689 mRNA. Translation: AAD54386.2 .
RefSeqi NP_445860.1. NM_053408.1.
UniGenei Rn.64646.

3D structure databases

ProteinModelPortali Q9QZL2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-4998399.
STRINGi 10116.ENSRNOP00000000697.

PTM databases

PhosphoSitei Q9QZL2.

Proteomic databases

PRIDEi Q9QZL2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 84468.
KEGGi rno:84468.
UCSCi RGD:620355. rat.

Organism-specific databases

CTDi 9469.
RGDi 620355. Chst3.

Phylogenomic databases

eggNOGi NOG80862.
HOGENOMi HOG000261614.
HOVERGENi HBG106811.
InParanoidi Q9QZL2.
KOi K01020.
PhylomeDBi Q9QZL2.

Enzyme and pathway databases

BRENDAi 2.8.2.17. 5301.

Miscellaneous databases

NextBioi 616944.
PROi Q9QZL2.

Gene expression databases

Genevestigatori Q9QZL2.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR016469. Carbohydrate_sulfotransferase.
IPR027417. P-loop_NTPase.
IPR000863. Sulfotransferase_dom.
[Graphical view ]
Pfami PF00685. Sulfotransfer_1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005883. Carbohydrate_sulfotransferase. 1 hit.
SUPFAMi SSF52540. SSF52540. 2 hits.
ProtoNeti Search...

Publicationsi

  1. "Chondroitin 6-sulfotransferase of rat sciatic nerve."
    Li X., Kwok C.-F., Shum K.-Y.
    Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.

Entry informationi

Entry nameiCHST3_RAT
AccessioniPrimary (citable) accession number: Q9QZL2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 1, 2001
Last modified: April 16, 2014
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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