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Protein

Breast cancer anti-estrogen resistance protein 3

Gene

Bcar3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May act as an adapter protein and couple activated growth factor receptors to signaling molecules that regulate src kinase activity and promote cell migration.2 Publications

GO - Molecular functioni

GO - Biological processi

  • lens morphogenesis in camera-type eye Source: MGI
  • positive regulation of peptidyl-serine phosphorylation Source: MGI
  • signal transduction Source: GO_Central
  • small GTPase mediated signal transduction Source: InterPro

Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Names & Taxonomyi

Protein namesi
Recommended name:
Breast cancer anti-estrogen resistance protein 3
Alternative name(s):
p130Cas-binding protein AND-34
Gene namesi
Name:Bcar3
Synonyms:And34
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1352501 Bcar3

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002302862 – 820Breast cancer anti-estrogen resistance protein 3Add BLAST819

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei32PhosphoserineBy similarity1
Modified residuei72PhosphoserineBy similarity1
Modified residuei77PhosphoserineBy similarity1
Modified residuei176PhosphoserineBy similarity1
Modified residuei284PhosphoserineBy similarity1
Modified residuei329N6-methyllysineBy similarity1
Modified residuei353PhosphoserineBy similarity1
Modified residuei358PhosphoserineBy similarity1
Modified residuei370PhosphoserineCombined sources1
Modified residuei437Omega-N-methylarginineBy similarity1
Modified residuei466PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated on tyrosine.1 Publication

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

PaxDbiQ9QZK2
PeptideAtlasiQ9QZK2
PRIDEiQ9QZK2

PTM databases

iPTMnetiQ9QZK2
PhosphoSitePlusiQ9QZK2

Expressioni

Tissue specificityi

Expressed in B-cells.2 Publications

Inductioni

Up-regulated by IL1A and LTA, in thymus cortical reticular cell lines.1 Publication

Gene expression databases

BgeeiENSMUSG00000028121
CleanExiMM_BCAR3
ExpressionAtlasiQ9QZK2 baseline and differential
GenevisibleiQ9QZK2 MM

Interactioni

Subunit structurei

Interacts with BCAR1, NEDD9, PTK2/FAK1 and PTPN1.3 Publications

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029766

Structurei

3D structure databases

ProteinModelPortaliQ9QZK2
SMRiQ9QZK2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini148 – 247SH2PROSITE-ProRule annotationAdd BLAST100
Domaini543 – 813Ras-GEFPROSITE-ProRule annotationAdd BLAST271

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiENOG410IFQG Eukaryota
ENOG410XTJR LUCA
GeneTreeiENSGT00390000008976
HOGENOMiHOG000231595
HOVERGENiHBG053174
InParanoidiQ9QZK2
OMAiNYCELNP
OrthoDBiEOG091G01KG
PhylomeDBiQ9QZK2
TreeFamiTF323756

Family and domain databases

Gene3Di1.10.840.10, 1 hit
3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR028849 BCAR3
IPR023578 Ras_GEF_dom_sf
IPR001895 RASGEF_cat_dom
IPR036964 RASGEF_cat_dom_sf
IPR000980 SH2
IPR036860 SH2_dom_sf
PANTHERiPTHR14247:SF10 PTHR14247:SF10, 1 hit
PfamiView protein in Pfam
PF00617 RasGEF, 1 hit
PF00017 SH2, 1 hit
SMARTiView protein in SMART
SM00147 RasGEF, 1 hit
SM00252 SH2, 1 hit
SUPFAMiSSF48366 SSF48366, 1 hit
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50009 RASGEF_CAT, 1 hit
PS50001 SH2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9QZK2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAGKFASLP RNMPVNHQFP LASSMDLLSS KSPLAERRTD AYQDVSIHGT
60 70 80 90 100
LPRKKKGPPS IRSCDNAGHS KSPRQSSPLT QDIIQENPLQ DRKGENFIFR
110 120 130 140 150
DPYLLDPTLE YVKFSKERHI MDRTPERLKK ELEEELLLSS EDLRSHAWYH
160 170 180 190 200
GRIPRQVSEN LVQRDGDFLV RDSLSSPGNF VLTCQWKNLA QHFKINRTVL
210 220 230 240 250
RLSEAYSRVQ YQFEMESFDS IPGLVRCYVG NRRPISQQSG AIIFQPINRT
260 270 280 290 300
VPLWCLEERY GTSPGRGREG SLAEGRPDVV KRLSLTTGSS IQAREHSLPR
310 320 330 340 350
GNLLRNKEKS GSQPACLDHV QDRKALTLKA HQSESHLPIG CKLPPQSPSM
360 370 380 390 400
DTSPCPSSPV FRTGSEPTLS PALVRRFSSD ARTGEALRGS DSQLCPKPPP
410 420 430 440 450
KPCKVPFLKT PPSPSPWLTS EANYCELNPA FAVGCDRGAK LPMQAHDSHE
460 470 480 490 500
MLLTAKQNGP SGPRNSGINY MILDGDDQAR HWDPLAVQTD EGQEDKTKFV
510 520 530 540 550
PPLMETVSSF RPNDFESKLL PPENKPLETA MLKHAKELFT NHDARVIAQH
560 570 580 590 600
MLSVDCKVAR ILEVSEDRKR SMGVSSGLEL ITLPHGRQLR LDIIERHNTM
610 620 630 640 650
AIGIAVDILG CTGTLENRAG TLNKIIQVAV ELKDAMGDLY AFSAIMKALE
660 670 680 690 700
MPQITRLEKT WTALRHHYTQ TAILYEKQLK PFSKILHEGR ESTYVPASNV
710 720 730 740 750
SVPLLMPLVT LMERQAVTFE GTDMWENNDE SCEILLNHLA TARFMAEASE
760 770 780 790 800
SYRMNAERIL ADFQPDEEMT EILRTEFQMR LLWGSKGAEV NQNERYDKFN
810 820
QILTALSRKL EPPSGKQAEL
Length:820
Mass (Da):92,263
Last modified:May 1, 2000 - v1
Checksum:i69DDACECDE869F01
GO
Isoform 2 (identifier: Q9QZK2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-120: Missing.

Note: No experimental confirmation available.
Show »
Length:700
Mass (Da):78,735
Checksum:i569413486AA3F464
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti36E → G in BAE25587 (PubMed:16141072).Curated1
Sequence conflicti525K → E in BAE25587 (PubMed:16141072).Curated1
Sequence conflicti795R → G in BAE38160 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0178151 – 120Missing in isoform 2. 1 PublicationAdd BLAST120

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF179566 mRNA Translation: AAD53182.1
AK143894 mRNA Translation: BAE25587.1
AK165396 mRNA Translation: BAE38160.1
BC023930 mRNA Translation: AAH23930.1
CCDSiCCDS17810.1 [Q9QZK2-1]
RefSeqiNP_038895.1, NM_013867.2 [Q9QZK2-1]
UniGeneiMm.398478
Mm.45815

Genome annotation databases

EnsembliENSMUST00000029766; ENSMUSP00000029766; ENSMUSG00000028121 [Q9QZK2-1]
GeneIDi29815
KEGGimmu:29815
UCSCiuc008req.2 mouse [Q9QZK2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiBCAR3_MOUSE
AccessioniPrimary (citable) accession number: Q9QZK2
Secondary accession number(s): Q3TNC9, Q3UP10
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: May 1, 2000
Last modified: March 28, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health