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Protein

Microfibrillar-associated protein 5

Gene

Mfap5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in hematopoiesis. In the cardiovascular system, could regulate growth factors or participate in cell signaling in maintaining large vessel integrity (PubMed:23963447). Component of the elastin-associated microfibrils (By similarity).By similarity1 Publication

GO - Molecular functioni

  • extracellular matrix constituent conferring elasticity Source: MGI

GO - Biological processi

  • definitive hemopoiesis Source: UniProtKB
  • extracellular fibril organization Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-1566948. Elastic fibre formation.
R-MMU-2129379. Molecules associated with elastic fibres.

Names & Taxonomyi

Protein namesi
Recommended name:
Microfibrillar-associated protein 5
Short name:
MFAP-5
Alternative name(s):
Microfibril-associated glycoprotein 2
Short name:
MAGP-2
Gene namesi
Name:Mfap5
Synonyms:Magp2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1354387. Mfap5.

Subcellular locationi

GO - Cellular componenti

  • microfibril Source: MGI
  • proteinaceous extracellular matrix Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Disruption phenotypei

Mice appear normal by several measures, are fertile, and have a normal life span, but are neutropenic.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Sequence analysisAdd
BLAST
Chaini29 – 164136Microfibrillar-associated protein 5PRO_0000018686Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi70 – 701N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

Forms intermolecular disulfide bonds either with other MAGP-2 molecules or with other components of the microfibrils.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9QZJ6.
PaxDbiQ9QZJ6.
PRIDEiQ9QZJ6.

PTM databases

PhosphoSiteiQ9QZJ6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000030116.
CleanExiMM_MFAP5.
ExpressionAtlasiQ9QZJ6. baseline and differential.
GenevisibleiQ9QZJ6. MM.

Interactioni

Subunit structurei

Interacts with TGFB2. Interacts with BMP2.1 Publication

Protein-protein interaction databases

IntActiQ9QZJ6. 1 interaction.
STRINGi10090.ENSMUSP00000122863.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi30 – 323Cell attachment siteSequence analysis

Sequence similaritiesi

Belongs to the MFAP family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J1DR. Eukaryota.
ENOG410YT9K. LUCA.
GeneTreeiENSGT00390000017736.
HOGENOMiHOG000034641.
HOVERGENiHBG052464.
InParanoidiQ9QZJ6.
OMAiVNKEICS.
OrthoDBiEOG091G0QMI.
TreeFamiTF333418.

Family and domain databases

InterProiIPR008673. MAGP.
[Graphical view]
PANTHERiPTHR16485. PTHR16485. 1 hit.
PfamiPF05507. MAGP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QZJ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFLGQKALL LVLAISIPSD WLPLGVSGQR GDDVPETFTD DPNLVNDPST
60 70 80 90 100
DDTALADITP STDDLAGDKN ATAECRDEKF ACTRLYSVHR PVRQCVHQSC
110 120 130 140 150
FTSLRRMYII NNEICSRLVC KEHEAMKDEL CRQMAGLPPR RLRRSNYFRL
160
PPCENMNLQR PDGL
Length:164
Mass (Da):18,538
Last modified:May 1, 2000 - v1
Checksum:i8DDB1EECADE52E13
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti15 – 151I → V in AAH25131 (PubMed:15489334).Curated
Sequence conflicti67 – 671G → D in AAH25131 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF180805 mRNA. Translation: AAD53950.1.
AK011458 mRNA. Translation: BAB27631.1.
AK003479 mRNA. Translation: BAB22810.1.
BC025131 mRNA. Translation: AAH25131.1.
CCDSiCCDS20496.1.
RefSeqiNP_056591.1. NM_015776.2.
UniGeneiMm.41931.

Genome annotation databases

EnsembliENSMUST00000148517; ENSMUSP00000122863; ENSMUSG00000030116.
GeneIDi50530.
KEGGimmu:50530.
UCSCiuc009dpi.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF180805 mRNA. Translation: AAD53950.1.
AK011458 mRNA. Translation: BAB27631.1.
AK003479 mRNA. Translation: BAB22810.1.
BC025131 mRNA. Translation: AAH25131.1.
CCDSiCCDS20496.1.
RefSeqiNP_056591.1. NM_015776.2.
UniGeneiMm.41931.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9QZJ6. 1 interaction.
STRINGi10090.ENSMUSP00000122863.

PTM databases

PhosphoSiteiQ9QZJ6.

Proteomic databases

MaxQBiQ9QZJ6.
PaxDbiQ9QZJ6.
PRIDEiQ9QZJ6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000148517; ENSMUSP00000122863; ENSMUSG00000030116.
GeneIDi50530.
KEGGimmu:50530.
UCSCiuc009dpi.1. mouse.

Organism-specific databases

CTDi8076.
MGIiMGI:1354387. Mfap5.

Phylogenomic databases

eggNOGiENOG410J1DR. Eukaryota.
ENOG410YT9K. LUCA.
GeneTreeiENSGT00390000017736.
HOGENOMiHOG000034641.
HOVERGENiHBG052464.
InParanoidiQ9QZJ6.
OMAiVNKEICS.
OrthoDBiEOG091G0QMI.
TreeFamiTF333418.

Enzyme and pathway databases

ReactomeiR-MMU-1566948. Elastic fibre formation.
R-MMU-2129379. Molecules associated with elastic fibres.

Miscellaneous databases

PROiQ9QZJ6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030116.
CleanExiMM_MFAP5.
ExpressionAtlasiQ9QZJ6. baseline and differential.
GenevisibleiQ9QZJ6. MM.

Family and domain databases

InterProiIPR008673. MAGP.
[Graphical view]
PANTHERiPTHR16485. PTHR16485. 1 hit.
PfamiPF05507. MAGP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMFAP5_MOUSE
AccessioniPrimary (citable) accession number: Q9QZJ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: May 1, 2000
Last modified: September 7, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.