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Protein

Microfibrillar-associated protein 5

Gene

Mfap5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in hematopoiesis. In the cardiovascular system, could regulate growth factors or participate in cell signaling in maintaining large vessel integrity (PubMed:23963447). Component of the elastin-associated microfibrils (By similarity).By similarity1 Publication

GO - Molecular functioni

  • extracellular matrix constituent conferring elasticity Source: MGI

GO - Biological processi

  • definitive hemopoiesis Source: UniProtKB
  • supramolecular fiber organization Source: MGI

Enzyme and pathway databases

ReactomeiR-MMU-1566948 Elastic fibre formation
R-MMU-2129379 Molecules associated with elastic fibres

Names & Taxonomyi

Protein namesi
Recommended name:
Microfibrillar-associated protein 5
Short name:
MFAP-5
Alternative name(s):
Microfibril-associated glycoprotein 2
Short name:
MAGP-2
Gene namesi
Name:Mfap5
Synonyms:Magp2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1354387 Mfap5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Disruption phenotypei

Mice appear normal by several measures, are fertile, and have a normal life span, but are neutropenic.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000001868629 – 164Microfibrillar-associated protein 5Add BLAST136

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi70N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Forms intermolecular disulfide bonds either with other MAGP-2 molecules or with other components of the microfibrils.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9QZJ6
PaxDbiQ9QZJ6
PRIDEiQ9QZJ6

PTM databases

iPTMnetiQ9QZJ6
PhosphoSitePlusiQ9QZJ6

Expressioni

Gene expression databases

BgeeiENSMUSG00000030116
CleanExiMM_MFAP5
ExpressionAtlasiQ9QZJ6 baseline and differential
GenevisibleiQ9QZJ6 MM

Interactioni

Subunit structurei

Interacts with TGFB2 (PubMed:23963447). Interacts with BMP2. Interacts with FBN1 (via N-terminal domain) and FBN2 (By similarity).By similarity1 Publication

Protein-protein interaction databases

IntActiQ9QZJ6, 1 interactor
STRINGi10090.ENSMUSP00000122863

Structurei

3D structure databases

SMRiQ9QZJ6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi30 – 32Cell attachment siteSequence analysis3

Sequence similaritiesi

Belongs to the MFAP family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J1DR Eukaryota
ENOG410YT9K LUCA
GeneTreeiENSGT00390000017736
HOGENOMiHOG000034641
HOVERGENiHBG052464
InParanoidiQ9QZJ6
OMAiKNTTAEC
OrthoDBiEOG091G0QMI
TreeFamiTF333418

Family and domain databases

InterProiView protein in InterPro
IPR008673 MAGP
PANTHERiPTHR16485 PTHR16485, 1 hit
PfamiView protein in Pfam
PF05507 MAGP, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QZJ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFLGQKALL LVLAISIPSD WLPLGVSGQR GDDVPETFTD DPNLVNDPST
60 70 80 90 100
DDTALADITP STDDLAGDKN ATAECRDEKF ACTRLYSVHR PVRQCVHQSC
110 120 130 140 150
FTSLRRMYII NNEICSRLVC KEHEAMKDEL CRQMAGLPPR RLRRSNYFRL
160
PPCENMNLQR PDGL
Length:164
Mass (Da):18,538
Last modified:May 1, 2000 - v1
Checksum:i8DDB1EECADE52E13
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti15I → V in AAH25131 (PubMed:15489334).Curated1
Sequence conflicti67G → D in AAH25131 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF180805 mRNA Translation: AAD53950.1
AK011458 mRNA Translation: BAB27631.1
AK003479 mRNA Translation: BAB22810.1
BC025131 mRNA Translation: AAH25131.1
CCDSiCCDS20496.1
RefSeqiNP_056591.1, NM_015776.2
UniGeneiMm.41931

Genome annotation databases

EnsembliENSMUST00000148517; ENSMUSP00000122863; ENSMUSG00000030116
GeneIDi50530
UCSCiuc009dpi.1 mouse

Similar proteinsi

Entry informationi

Entry nameiMFAP5_MOUSE
AccessioniPrimary (citable) accession number: Q9QZJ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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