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Protein

Serine incorporator 3

Gene

Serinc3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Restriction factor required to restrict infectivity of gammaretroviruses: acts by inhibiting early step of viral infection and impairing the ability of the viral particle to translocate its content to the cytoplasm.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Antiviral defense, Immunity, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Serine incorporator 3
Alternative name(s):
Axotomy-induced glyco/Golgi protein 11 Publication
Short name:
AIGP-11 Publication
Axotomy-induced glycoprotein 11 Publication
Membrane protein TMS-1
Tumor differentially expressed protein 1
Gene namesi
Name:Serinc3
Synonyms:Aigp11 Publication, Diff33, Tde1, Tms1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1349457. Serinc3.

Subcellular locationi

  • Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication
  • Golgi apparatus membrane 1 Publication; Multi-pass membrane protein 1 Publication

  • Note: Localizes to the cell membrane, where it is efficiently incorporated into budding gammaretrovirus virions and impairs subsequent virion penetration of susceptible target cells (By similarity).By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 9696ExtracellularSequence analysisAdd
BLAST
Transmembranei97 – 11721HelicalSequence analysisAdd
BLAST
Topological domaini118 – 13215CytoplasmicSequence analysisAdd
BLAST
Transmembranei133 – 15321HelicalSequence analysisAdd
BLAST
Topological domaini154 – 1585ExtracellularSequence analysis
Transmembranei159 – 17921HelicalSequence analysisAdd
BLAST
Topological domaini180 – 20627CytoplasmicSequence analysisAdd
BLAST
Transmembranei207 – 22721HelicalSequence analysisAdd
BLAST
Topological domaini228 – 23811ExtracellularSequence analysisAdd
BLAST
Transmembranei239 – 25921HelicalSequence analysisAdd
BLAST
Topological domaini260 – 32970CytoplasmicSequence analysisAdd
BLAST
Transmembranei330 – 35021HelicalSequence analysisAdd
BLAST
Topological domaini351 – 40555ExtracellularSequence analysisAdd
BLAST
Transmembranei406 – 42621HelicalSequence analysisAdd
BLAST
Topological domaini427 – 44519CytoplasmicSequence analysisAdd
BLAST
Transmembranei446 – 46621HelicalSequence analysisAdd
BLAST
Topological domaini467 – 4726ExtracellularSequence analysis

GO - Cellular componenti

  • Golgi apparatus Source: MGI
  • Golgi membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 472472Serine incorporator 3PRO_0000218971Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi34 – 341N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9QZI9.
MaxQBiQ9QZI9.
PaxDbiQ9QZI9.
PRIDEiQ9QZI9.

PTM databases

iPTMnetiQ9QZI9.
PhosphoSiteiQ9QZI9.

Expressioni

Tissue specificityi

Highly expressed in the neuronal populations such as Purkinje cells in the cerebellum, brainstem and spinal motor neurons, locus coeruleus and raphe nuclei. Highly expressed also in thymus, kidney liver and testis.1 Publication

Gene expression databases

BgeeiQ9QZI9.
CleanExiMM_SERINC3.
GenevisibleiQ9QZI9. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000017851.

Structurei

3D structure databases

ProteinModelPortaliQ9QZI9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TDE1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2592. Eukaryota.
ENOG410XP7K. LUCA.
GeneTreeiENSGT00550000074522.
HOGENOMiHOG000165463.
HOVERGENiHBG025699.
InParanoidiQ9QZI9.
OMAiLMIGVKN.
OrthoDBiEOG7TXKGQ.
TreeFamiTF312881.

Family and domain databases

InterProiIPR029557. Serinc3.
IPR005016. TDE1/TMS.
[Graphical view]
PANTHERiPTHR10383. PTHR10383. 1 hit.
PTHR10383:SF27. PTHR10383:SF27. 1 hit.
PfamiPF03348. Serinc. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9QZI9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAVLGVFSL ASWVPCLCSG ASCLLCSCCP ISKNSTVTRL IYAFILFLGT
60 70 80 90 100
IVSCIMMTEG IQTQLKKIPG FCEGGFQIKM VDTKAEKDCD VLVGFKAVYR
110 120 130 140 150
INFAVAIFFF AFFLLMLKVK TSKDPRAAVH NGFWFFKIAA IIGIMIGSFY
160 170 180 190 200
IPGGSFTEVW FVAGMLGASF FIIIQLVLLV DMAHSWNELW VNRMEEGNPR
210 220 230 240 250
LWYAALLSFT SLFYILSIVF AALLYVFYTK PDDCTENKVF ISLNLIFCVA
260 270 280 290 300
VSIVSILPKV QEHQPRSGLL QSSIITLYTL YLTWSAMTNE PERSCNPSLM
310 320 330 340 350
SIITHLTSPT VSPANSTTLA PAYAPPSQSG HFMNLDDIWG LIIFVFCLIY
360 370 380 390 400
SSFRTSSNSQ VNKLTLSGSD SVILGDTTNG ANDEEDGQPR RAVDNEKEGV
410 420 430 440 450
QYSYSFFHLM LCCASLYIMM TITSWYSPDA KFQKVSSKWL AVWFKMGSSW
460 470
LCLLLYLWTL VAPLVLTGRD FS
Length:472
Mass (Da):52,623
Last modified:October 31, 2003 - v2
Checksum:iF0EE1DA4BECE8CF0
GO

Sequence cautioni

The sequence AAA74236.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti6 – 61G → A in AAD54420 (PubMed:10637174).Curated
Sequence conflicti108 – 1081F → I in BAC27253 (PubMed:16141072).Curated
Sequence conflicti162 – 1621V → F in AAH11295 (PubMed:15489334).Curated
Sequence conflicti162 – 1621V → F in AAH22901 (PubMed:15489334).Curated
Sequence conflicti162 – 1621V → F in AAH29026 (PubMed:15489334).Curated
Sequence conflicti324 – 3241A → R (PubMed:10637174).Curated
Sequence conflicti324 – 3241A → R (PubMed:7894057).Curated
Sequence conflicti403 – 4031S → N in AAH11295 (PubMed:15489334).Curated
Sequence conflicti403 – 4031S → N in AAH22901 (PubMed:15489334).Curated
Sequence conflicti403 – 4031S → N in AAH29026 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF181684 mRNA. Translation: AAD54420.1.
AB029499 mRNA. Translation: BAC44828.1.
AB078029 Genomic DNA. Translation: BAC05511.1.
AK031101 mRNA. Translation: BAC27253.1.
AK150106 mRNA. Translation: BAE29313.1.
AK152720 mRNA. Translation: BAE31443.1.
AK155921 mRNA. Translation: BAE33504.1.
AK159347 mRNA. Translation: BAE35009.1.
AK159819 mRNA. Translation: BAE35399.1.
AK160005 mRNA. Translation: BAE35553.1.
AK160055 mRNA. Translation: BAE35593.1.
AK161981 mRNA. Translation: BAE36664.1.
AK164807 mRNA. Translation: BAE37929.1.
AK166924 mRNA. Translation: BAE39119.1.
AK170350 mRNA. Translation: BAE41738.1.
BC011295 mRNA. Translation: AAH11295.1.
BC022901 mRNA. Translation: AAH22901.1.
BC029026 mRNA. Translation: AAH29026.1.
L29441 mRNA. Translation: AAA74236.1. Different initiation.
CCDSiCCDS17013.1.
PIRiI53063.
RefSeqiNP_036162.3. NM_012032.4.
UniGeneiMm.218473.
Mm.281691.

Genome annotation databases

EnsembliENSMUST00000017851; ENSMUSP00000017851; ENSMUSG00000017707.
GeneIDi26943.
KEGGimmu:26943.
UCSCiuc008ntg.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF181684 mRNA. Translation: AAD54420.1.
AB029499 mRNA. Translation: BAC44828.1.
AB078029 Genomic DNA. Translation: BAC05511.1.
AK031101 mRNA. Translation: BAC27253.1.
AK150106 mRNA. Translation: BAE29313.1.
AK152720 mRNA. Translation: BAE31443.1.
AK155921 mRNA. Translation: BAE33504.1.
AK159347 mRNA. Translation: BAE35009.1.
AK159819 mRNA. Translation: BAE35399.1.
AK160005 mRNA. Translation: BAE35553.1.
AK160055 mRNA. Translation: BAE35593.1.
AK161981 mRNA. Translation: BAE36664.1.
AK164807 mRNA. Translation: BAE37929.1.
AK166924 mRNA. Translation: BAE39119.1.
AK170350 mRNA. Translation: BAE41738.1.
BC011295 mRNA. Translation: AAH11295.1.
BC022901 mRNA. Translation: AAH22901.1.
BC029026 mRNA. Translation: AAH29026.1.
L29441 mRNA. Translation: AAA74236.1. Different initiation.
CCDSiCCDS17013.1.
PIRiI53063.
RefSeqiNP_036162.3. NM_012032.4.
UniGeneiMm.218473.
Mm.281691.

3D structure databases

ProteinModelPortaliQ9QZI9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000017851.

PTM databases

iPTMnetiQ9QZI9.
PhosphoSiteiQ9QZI9.

Proteomic databases

EPDiQ9QZI9.
MaxQBiQ9QZI9.
PaxDbiQ9QZI9.
PRIDEiQ9QZI9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000017851; ENSMUSP00000017851; ENSMUSG00000017707.
GeneIDi26943.
KEGGimmu:26943.
UCSCiuc008ntg.2. mouse.

Organism-specific databases

CTDi10955.
MGIiMGI:1349457. Serinc3.

Phylogenomic databases

eggNOGiKOG2592. Eukaryota.
ENOG410XP7K. LUCA.
GeneTreeiENSGT00550000074522.
HOGENOMiHOG000165463.
HOVERGENiHBG025699.
InParanoidiQ9QZI9.
OMAiLMIGVKN.
OrthoDBiEOG7TXKGQ.
TreeFamiTF312881.

Miscellaneous databases

ChiTaRSiSerinc3. mouse.
NextBioi304869.
PROiQ9QZI9.
SOURCEiSearch...

Gene expression databases

BgeeiQ9QZI9.
CleanExiMM_SERINC3.
GenevisibleiQ9QZI9. MM.

Family and domain databases

InterProiIPR029557. Serinc3.
IPR005016. TDE1/TMS.
[Graphical view]
PANTHERiPTHR10383. PTHR10383. 1 hit.
PTHR10383:SF27. PTHR10383:SF27. 1 hit.
PfamiPF03348. Serinc. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a ubiquitous family of membrane proteins and their expression in mouse brain."
    Grossman T.R., Luque J.M., Nelson N.
    J. Exp. Biol. 203:447-457(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "Identification of an axotomy-induced glycosylated protein, AIGP1, possibly involved in cell death triggered by endoplasmic reticulum-Golgi stress."
    Aoki S., Su Q., Li H., Nishikawa K., Ayukawa K., Hara Y., Namikawa K., Kiryu-Seo S., Kiyama H., Wada K.
    J. Neurosci. 22:10751-10760(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], GLYCOSYLATION, SUBCELLULAR LOCATION.
    Tissue: Hypoglossal nucleus.
  3. "An axotomy activated gene, mouse AIGP1: genomic organization, transcriptional regulation and genetic mapping on chromosome 2."
    Li H., Aoki S., Hara Y., Wada K.
    Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Brain.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Bone marrow, Cerebellum, Forelimb and Heart.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary tumor.
  6. "Sequence analysis of a novel cDNA which is overexpressed in testicular tumors from polyomavirus large T-antigen transgenic mice."
    Lebel M., Mes-Masson A.-M.
    DNA Seq. 5:31-39(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 67-472.
    Tissue: Testis.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  8. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Heart, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiSERC3_MOUSE
AccessioniPrimary (citable) accession number: Q9QZI9
Secondary accession number(s): Q3U7C6
, Q62310, Q8BSP9, Q8CFD3, Q91VN9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: October 31, 2003
Last modified: May 11, 2016
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.