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Protein

Serine incorporator 1

Gene

Serinc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Enhances the incorporation of serine into phosphatidylserine and sphingolipids.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Serine incorporator 1
Alternative name(s):
Axotomy-induced glyco/Golgi protein 2
Membrane protein TMS-2
Tumor differentially expressed protein 1-like
Tumor differentially expressed protein 2
Gene namesi
Name:Serinc1
Synonyms:Aigp2, Tde1l, Tde2, Tms2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1926228. Serinc1.

Subcellular locationi

  • Endoplasmic reticulum membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 39CytoplasmicSequence analysisAdd BLAST38
Transmembranei40 – 60HelicalSequence analysisAdd BLAST21
Topological domaini61 – 88LumenalSequence analysisAdd BLAST28
Transmembranei89 – 109HelicalSequence analysisAdd BLAST21
Topological domaini110 – 123CytoplasmicSequence analysisAdd BLAST14
Transmembranei124 – 144HelicalSequence analysisAdd BLAST21
Topological domaini145 – 151LumenalSequence analysis7
Transmembranei152 – 172HelicalSequence analysisAdd BLAST21
Topological domaini173 – 197CytoplasmicSequence analysisAdd BLAST25
Transmembranei198 – 218HelicalSequence analysisAdd BLAST21
Topological domaini219 – 231LumenalSequence analysisAdd BLAST13
Transmembranei232 – 252HelicalSequence analysisAdd BLAST21
Topological domaini253 – 259CytoplasmicSequence analysis7
Transmembranei260 – 280HelicalSequence analysisAdd BLAST21
Topological domaini281 – 309LumenalSequence analysisAdd BLAST29
Transmembranei310 – 330HelicalSequence analysisAdd BLAST21
Topological domaini331 – 387CytoplasmicSequence analysisAdd BLAST57
Transmembranei388 – 408HelicalSequence analysisAdd BLAST21
Topological domaini409 – 426LumenalSequence analysisAdd BLAST18
Transmembranei427 – 447HelicalSequence analysisAdd BLAST21
Topological domaini448 – 453CytoplasmicSequence analysis6

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002189672 – 453Serine incorporator 1Add BLAST452

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineBy similarity1
Modified residuei351PhosphoserineBy similarity1
Modified residuei352PhosphothreonineBy similarity1
Modified residuei361PhosphoserineBy similarity1
Modified residuei364PhosphoserineCombined sources1

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

EPDiQ9QZI8.
MaxQBiQ9QZI8.
PaxDbiQ9QZI8.
PRIDEiQ9QZI8.

PTM databases

iPTMnetiQ9QZI8.
PhosphoSitePlusiQ9QZI8.
SwissPalmiQ9QZI8.

Expressioni

Tissue specificityi

Highly expressed in the neuronal populations such as Purkinje cells in the cerebellum, brainstem and spinal motor neurons, locus coeruleus and raphe nuclei.

Gene expression databases

BgeeiENSMUSG00000019877.
CleanExiMM_SERINC1.
ExpressionAtlasiQ9QZI8. baseline and differential.
GenevisibleiQ9QZI8. MM.

Interactioni

Subunit structurei

Interacts with SPTLC1.By similarity

Protein-protein interaction databases

BioGridi207983. 1 interactor.
STRINGi10090.ENSMUSP00000020027.

Structurei

3D structure databases

ProteinModelPortaliQ9QZI8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TDE1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2592. Eukaryota.
ENOG410XP7K. LUCA.
GeneTreeiENSGT00550000074522.
HOGENOMiHOG000165463.
HOVERGENiHBG025699.
InParanoidiQ9QZI8.
OMAiSSSWICI.
OrthoDBiEOG091G07WS.
PhylomeDBiQ9QZI8.
TreeFamiTF312881.

Family and domain databases

InterProiIPR029552. SERINC1.
IPR005016. TDE1/TMS.
[Graphical view]
PANTHERiPTHR10383. PTHR10383. 1 hit.
PTHR10383:SF15. PTHR10383:SF15. 1 hit.
PfamiPF03348. Serinc. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QZI8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSVLGLCSV ASWIPCLCGS APCLLCRCCP SGNNSTVTRL IYALFLLVGV
60 70 80 90 100
CVACVMLIPG MEEQLNKIPG FCENEKGVVP CNILVGYKAV YRLCFGLAMF
110 120 130 140 150
YLLLSLLMIK VKSSSDPRAA VHNGFWFFKF ATAVAIIIGA FFIPEGTFTT
160 170 180 190 200
VWFYVGMAGA FCFILIQLVL LIDFAHSWNE SWVEKMEEGN SRCWYAALLS
210 220 230 240 250
ATALNYLLSL VAVVLFFVYY THPASCAENK AFISVNMLLC IGASVMSILP
260 270 280 290 300
KIQESQPRSG LLQSSVITVY TMYLTWSAMT NEPETNCNPS LLSIIGFNTT
310 320 330 340 350
RPIPKDGQSV QWWHPQGIIG LVLFLLCVFY SSIRTSNNSQ VNKLTLTSDE
360 370 380 390 400
STLIEDGNGR SDGSLDDGDG IHRAVDNERD GVTYSYSFFH FMLFLASLYI
410 420 430 440 450
MMTLTNWYRY EPSREMKSQW TAVWVKISSS WIGLVLYVWT LVAPLVLTNR

DFD
Length:453
Mass (Da):50,509
Last modified:May 1, 2000 - v1
Checksum:i0FE8718FA3EA62B7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF181685 mRNA. Translation: AAD54421.1.
AB078030 Genomic DNA. Translation: BAC05512.1.
AK002847 mRNA. Translation: BAB22403.1.
AK005203 mRNA. Translation: BAB23881.1.
AK088340 mRNA. Translation: BAC40293.1.
AK133668 mRNA. Translation: BAE21775.1.
AK133975 mRNA. Translation: BAE21964.1.
AK135359 mRNA. Translation: BAE22504.1.
AK141574 mRNA. Translation: BAE24743.1.
AK148745 mRNA. Translation: BAE28654.1.
AK159280 mRNA. Translation: BAE34958.1.
AK159436 mRNA. Translation: BAE35082.1.
BC017148 mRNA. Translation: AAH17148.1.
CCDSiCCDS23853.1.
RefSeqiNP_062734.1. NM_019760.3.
UniGeneiMm.29344.

Genome annotation databases

EnsembliENSMUST00000020027; ENSMUSP00000020027; ENSMUSG00000019877.
GeneIDi56442.
KEGGimmu:56442.
UCSCiuc007fcm.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF181685 mRNA. Translation: AAD54421.1.
AB078030 Genomic DNA. Translation: BAC05512.1.
AK002847 mRNA. Translation: BAB22403.1.
AK005203 mRNA. Translation: BAB23881.1.
AK088340 mRNA. Translation: BAC40293.1.
AK133668 mRNA. Translation: BAE21775.1.
AK133975 mRNA. Translation: BAE21964.1.
AK135359 mRNA. Translation: BAE22504.1.
AK141574 mRNA. Translation: BAE24743.1.
AK148745 mRNA. Translation: BAE28654.1.
AK159280 mRNA. Translation: BAE34958.1.
AK159436 mRNA. Translation: BAE35082.1.
BC017148 mRNA. Translation: AAH17148.1.
CCDSiCCDS23853.1.
RefSeqiNP_062734.1. NM_019760.3.
UniGeneiMm.29344.

3D structure databases

ProteinModelPortaliQ9QZI8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207983. 1 interactor.
STRINGi10090.ENSMUSP00000020027.

PTM databases

iPTMnetiQ9QZI8.
PhosphoSitePlusiQ9QZI8.
SwissPalmiQ9QZI8.

Proteomic databases

EPDiQ9QZI8.
MaxQBiQ9QZI8.
PaxDbiQ9QZI8.
PRIDEiQ9QZI8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020027; ENSMUSP00000020027; ENSMUSG00000019877.
GeneIDi56442.
KEGGimmu:56442.
UCSCiuc007fcm.3. mouse.

Organism-specific databases

CTDi57515.
MGIiMGI:1926228. Serinc1.

Phylogenomic databases

eggNOGiKOG2592. Eukaryota.
ENOG410XP7K. LUCA.
GeneTreeiENSGT00550000074522.
HOGENOMiHOG000165463.
HOVERGENiHBG025699.
InParanoidiQ9QZI8.
OMAiSSSWICI.
OrthoDBiEOG091G07WS.
PhylomeDBiQ9QZI8.
TreeFamiTF312881.

Miscellaneous databases

ChiTaRSiSerinc1. mouse.
PROiQ9QZI8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000019877.
CleanExiMM_SERINC1.
ExpressionAtlasiQ9QZI8. baseline and differential.
GenevisibleiQ9QZI8. MM.

Family and domain databases

InterProiIPR029552. SERINC1.
IPR005016. TDE1/TMS.
[Graphical view]
PANTHERiPTHR10383. PTHR10383. 1 hit.
PTHR10383:SF15. PTHR10383:SF15. 1 hit.
PfamiPF03348. Serinc. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSERC1_MOUSE
AccessioniPrimary (citable) accession number: Q9QZI8
Secondary accession number(s): Q3UZ93
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: May 1, 2000
Last modified: November 2, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.