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Q9QZI8

- SERC1_MOUSE

UniProt

Q9QZI8 - SERC1_MOUSE

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Protein

Serine incorporator 1

Gene

Serinc1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Enhances the incorporation of serine into phosphatidylserine and sphingolipids.By similarity

GO - Molecular functioni

  1. L-serine transmembrane transporter activity Source: HGNC

GO - Biological processi

  1. L-serine transport Source: HGNC
  2. phosphatidylserine metabolic process Source: HGNC
  3. phospholipid biosynthetic process Source: UniProtKB-KW
  4. positive regulation of transferase activity Source: HGNC
  5. sphingolipid metabolic process Source: HGNC
Complete GO annotation...

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Serine incorporator 1
Alternative name(s):
Axotomy-induced glyco/Golgi protein 2
Membrane protein TMS-2
Tumor differentially expressed protein 1-like
Tumor differentially expressed protein 2
Gene namesi
Name:Serinc1
Synonyms:Aigp2, Tde1l, Tde2, Tms2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:1926228. Serinc1.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: HGNC
  2. extracellular vesicular exosome Source: Ensembl
  3. integral component of membrane Source: UniProtKB-KW
  4. plasma membrane Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 453452Serine incorporator 1PRO_0000218967Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycineBy similarity
Modified residuei351 – 3511PhosphoserineBy similarity
Modified residuei352 – 3521PhosphothreonineBy similarity
Modified residuei361 – 3611PhosphoserineBy similarity
Modified residuei364 – 3641Phosphoserine1 Publication

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

MaxQBiQ9QZI8.
PRIDEiQ9QZI8.

PTM databases

PhosphoSiteiQ9QZI8.

Expressioni

Tissue specificityi

Highly expressed in the neuronal populations such as Purkinje cells in the cerebellum, brainstem and spinal motor neurons, locus coeruleus and raphe nuclei.

Gene expression databases

BgeeiQ9QZI8.
CleanExiMM_SERINC1.
ExpressionAtlasiQ9QZI8. baseline and differential.
GenevestigatoriQ9QZI8.

Interactioni

Subunit structurei

Interacts with SPTLC1.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9QZI8.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 3938CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini61 – 8828LumenalSequence AnalysisAdd
BLAST
Topological domaini110 – 12314CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini145 – 1517LumenalSequence Analysis
Topological domaini173 – 19725CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini219 – 23113LumenalSequence AnalysisAdd
BLAST
Topological domaini253 – 2597CytoplasmicSequence Analysis
Topological domaini281 – 30929LumenalSequence AnalysisAdd
BLAST
Topological domaini331 – 38757CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini409 – 42618LumenalSequence AnalysisAdd
BLAST
Topological domaini448 – 4536CytoplasmicSequence Analysis

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei40 – 6021HelicalSequence AnalysisAdd
BLAST
Transmembranei89 – 10921HelicalSequence AnalysisAdd
BLAST
Transmembranei124 – 14421HelicalSequence AnalysisAdd
BLAST
Transmembranei152 – 17221HelicalSequence AnalysisAdd
BLAST
Transmembranei198 – 21821HelicalSequence AnalysisAdd
BLAST
Transmembranei232 – 25221HelicalSequence AnalysisAdd
BLAST
Transmembranei260 – 28021HelicalSequence AnalysisAdd
BLAST
Transmembranei310 – 33021HelicalSequence AnalysisAdd
BLAST
Transmembranei388 – 40821HelicalSequence AnalysisAdd
BLAST
Transmembranei427 – 44721HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the TDE1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG308011.
GeneTreeiENSGT00550000074522.
HOGENOMiHOG000165463.
HOVERGENiHBG025699.
InParanoidiQ9QZI8.
OMAiSSSWICI.
OrthoDBiEOG7TXKGQ.
PhylomeDBiQ9QZI8.
TreeFamiTF312881.

Family and domain databases

InterProiIPR029552. SERINC1.
IPR005016. TDE1/TMS.
[Graphical view]
PANTHERiPTHR10383. PTHR10383. 1 hit.
PTHR10383:SF15. PTHR10383:SF15. 1 hit.
PfamiPF03348. Serinc. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QZI8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGSVLGLCSV ASWIPCLCGS APCLLCRCCP SGNNSTVTRL IYALFLLVGV
60 70 80 90 100
CVACVMLIPG MEEQLNKIPG FCENEKGVVP CNILVGYKAV YRLCFGLAMF
110 120 130 140 150
YLLLSLLMIK VKSSSDPRAA VHNGFWFFKF ATAVAIIIGA FFIPEGTFTT
160 170 180 190 200
VWFYVGMAGA FCFILIQLVL LIDFAHSWNE SWVEKMEEGN SRCWYAALLS
210 220 230 240 250
ATALNYLLSL VAVVLFFVYY THPASCAENK AFISVNMLLC IGASVMSILP
260 270 280 290 300
KIQESQPRSG LLQSSVITVY TMYLTWSAMT NEPETNCNPS LLSIIGFNTT
310 320 330 340 350
RPIPKDGQSV QWWHPQGIIG LVLFLLCVFY SSIRTSNNSQ VNKLTLTSDE
360 370 380 390 400
STLIEDGNGR SDGSLDDGDG IHRAVDNERD GVTYSYSFFH FMLFLASLYI
410 420 430 440 450
MMTLTNWYRY EPSREMKSQW TAVWVKISSS WIGLVLYVWT LVAPLVLTNR

DFD
Length:453
Mass (Da):50,509
Last modified:May 1, 2000 - v1
Checksum:i0FE8718FA3EA62B7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF181685 mRNA. Translation: AAD54421.1.
AB078030 Genomic DNA. Translation: BAC05512.1.
AK002847 mRNA. Translation: BAB22403.1.
AK005203 mRNA. Translation: BAB23881.1.
AK088340 mRNA. Translation: BAC40293.1.
AK133668 mRNA. Translation: BAE21775.1.
AK133975 mRNA. Translation: BAE21964.1.
AK135359 mRNA. Translation: BAE22504.1.
AK141574 mRNA. Translation: BAE24743.1.
AK148745 mRNA. Translation: BAE28654.1.
AK159280 mRNA. Translation: BAE34958.1.
AK159436 mRNA. Translation: BAE35082.1.
BC017148 mRNA. Translation: AAH17148.1.
CCDSiCCDS23853.1.
RefSeqiNP_062734.1. NM_019760.3.
UniGeneiMm.29344.

Genome annotation databases

EnsembliENSMUST00000020027; ENSMUSP00000020027; ENSMUSG00000019877.
GeneIDi56442.
KEGGimmu:56442.
UCSCiuc007fcm.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF181685 mRNA. Translation: AAD54421.1 .
AB078030 Genomic DNA. Translation: BAC05512.1 .
AK002847 mRNA. Translation: BAB22403.1 .
AK005203 mRNA. Translation: BAB23881.1 .
AK088340 mRNA. Translation: BAC40293.1 .
AK133668 mRNA. Translation: BAE21775.1 .
AK133975 mRNA. Translation: BAE21964.1 .
AK135359 mRNA. Translation: BAE22504.1 .
AK141574 mRNA. Translation: BAE24743.1 .
AK148745 mRNA. Translation: BAE28654.1 .
AK159280 mRNA. Translation: BAE34958.1 .
AK159436 mRNA. Translation: BAE35082.1 .
BC017148 mRNA. Translation: AAH17148.1 .
CCDSi CCDS23853.1.
RefSeqi NP_062734.1. NM_019760.3.
UniGenei Mm.29344.

3D structure databases

ProteinModelPortali Q9QZI8.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9QZI8.

Proteomic databases

MaxQBi Q9QZI8.
PRIDEi Q9QZI8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000020027 ; ENSMUSP00000020027 ; ENSMUSG00000019877 .
GeneIDi 56442.
KEGGi mmu:56442.
UCSCi uc007fcm.3. mouse.

Organism-specific databases

CTDi 57515.
MGIi MGI:1926228. Serinc1.

Phylogenomic databases

eggNOGi NOG308011.
GeneTreei ENSGT00550000074522.
HOGENOMi HOG000165463.
HOVERGENi HBG025699.
InParanoidi Q9QZI8.
OMAi SSSWICI.
OrthoDBi EOG7TXKGQ.
PhylomeDBi Q9QZI8.
TreeFami TF312881.

Miscellaneous databases

ChiTaRSi SERINC1. mouse.
NextBioi 312638.
PROi Q9QZI8.
SOURCEi Search...

Gene expression databases

Bgeei Q9QZI8.
CleanExi MM_SERINC1.
ExpressionAtlasi Q9QZI8. baseline and differential.
Genevestigatori Q9QZI8.

Family and domain databases

InterProi IPR029552. SERINC1.
IPR005016. TDE1/TMS.
[Graphical view ]
PANTHERi PTHR10383. PTHR10383. 1 hit.
PTHR10383:SF15. PTHR10383:SF15. 1 hit.
Pfami PF03348. Serinc. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a ubiquitous family of membrane proteins and their expression in mouse brain."
    Grossman T.R., Luque J.M., Nelson N.
    J. Exp. Biol. 203:447-457(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "An axotomy activated gene, mouse AIGP1: genomic organization, transcriptional regulation and genetic mapping on chromosome 2."
    Li H., Aoki S., Hara Y., Wada K.
    Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Cerebellum, Hippocampus, Kidney, Pituitary, Sympathetic ganglion and Thymus.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Eye.
  5. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-364, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSERC1_MOUSE
AccessioniPrimary (citable) accession number: Q9QZI8
Secondary accession number(s): Q3UZ93
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3