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Q9QZI8

- SERC1_MOUSE

UniProt

Q9QZI8 - SERC1_MOUSE

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Protein
Serine incorporator 1
Gene
Serinc1, Aigp2, Tde1l, Tde2, Tms2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Enhances the incorporation of serine into phosphatidylserine and sphingolipids By similarity.

GO - Molecular functioni

  1. L-serine transmembrane transporter activity Source: HGNC

GO - Biological processi

  1. L-serine transport Source: HGNC
  2. phosphatidylserine metabolic process Source: HGNC
  3. phospholipid biosynthetic process Source: UniProtKB-KW
  4. positive regulation of transferase activity Source: HGNC
  5. sphingolipid metabolic process Source: HGNC
Complete GO annotation...

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Serine incorporator 1
Alternative name(s):
Axotomy-induced glyco/Golgi protein 2
Membrane protein TMS-2
Tumor differentially expressed protein 1-like
Tumor differentially expressed protein 2
Gene namesi
Name:Serinc1
Synonyms:Aigp2, Tde1l, Tde2, Tms2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:1926228. Serinc1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 3938Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei40 – 6021Helical; Reviewed prediction
Add
BLAST
Topological domaini61 – 8828Lumenal Reviewed prediction
Add
BLAST
Transmembranei89 – 10921Helical; Reviewed prediction
Add
BLAST
Topological domaini110 – 12314Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei124 – 14421Helical; Reviewed prediction
Add
BLAST
Topological domaini145 – 1517Lumenal Reviewed prediction
Transmembranei152 – 17221Helical; Reviewed prediction
Add
BLAST
Topological domaini173 – 19725Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei198 – 21821Helical; Reviewed prediction
Add
BLAST
Topological domaini219 – 23113Lumenal Reviewed prediction
Add
BLAST
Transmembranei232 – 25221Helical; Reviewed prediction
Add
BLAST
Topological domaini253 – 2597Cytoplasmic Reviewed prediction
Transmembranei260 – 28021Helical; Reviewed prediction
Add
BLAST
Topological domaini281 – 30929Lumenal Reviewed prediction
Add
BLAST
Transmembranei310 – 33021Helical; Reviewed prediction
Add
BLAST
Topological domaini331 – 38757Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei388 – 40821Helical; Reviewed prediction
Add
BLAST
Topological domaini409 – 42618Lumenal Reviewed prediction
Add
BLAST
Transmembranei427 – 44721Helical; Reviewed prediction
Add
BLAST
Topological domaini448 – 4536Cytoplasmic Reviewed prediction

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: HGNC
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 453452Serine incorporator 1
PRO_0000218967Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycine By similarity
Modified residuei351 – 3511Phosphoserine By similarity
Modified residuei352 – 3521Phosphothreonine By similarity
Modified residuei361 – 3611Phosphoserine By similarity
Modified residuei364 – 3641Phosphoserine1 Publication

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

PRIDEiQ9QZI8.

PTM databases

PhosphoSiteiQ9QZI8.

Expressioni

Tissue specificityi

Highly expressed in the neuronal populations such as Purkinje cells in the cerebellum, brainstem and spinal motor neurons, locus coeruleus and raphe nuclei.

Gene expression databases

ArrayExpressiQ9QZI8.
BgeeiQ9QZI8.
CleanExiMM_SERINC1.
GenevestigatoriQ9QZI8.

Interactioni

Subunit structurei

Interacts with SPTLC1 By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ9QZI8.

Family & Domainsi

Sequence similaritiesi

Belongs to the TDE1 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG308011.
GeneTreeiENSGT00550000074522.
HOGENOMiHOG000165463.
HOVERGENiHBG025699.
InParanoidiQ9QZI8.
OMAiSSSWICI.
OrthoDBiEOG7TXKGQ.
PhylomeDBiQ9QZI8.
TreeFamiTF312881.

Family and domain databases

InterProiIPR029552. SERINC1.
IPR005016. TDE1/TMS.
[Graphical view]
PANTHERiPTHR10383. PTHR10383. 1 hit.
PTHR10383:SF15. PTHR10383:SF15. 1 hit.
PfamiPF03348. Serinc. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QZI8-1 [UniParc]FASTAAdd to Basket

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MGSVLGLCSV ASWIPCLCGS APCLLCRCCP SGNNSTVTRL IYALFLLVGV    50
CVACVMLIPG MEEQLNKIPG FCENEKGVVP CNILVGYKAV YRLCFGLAMF 100
YLLLSLLMIK VKSSSDPRAA VHNGFWFFKF ATAVAIIIGA FFIPEGTFTT 150
VWFYVGMAGA FCFILIQLVL LIDFAHSWNE SWVEKMEEGN SRCWYAALLS 200
ATALNYLLSL VAVVLFFVYY THPASCAENK AFISVNMLLC IGASVMSILP 250
KIQESQPRSG LLQSSVITVY TMYLTWSAMT NEPETNCNPS LLSIIGFNTT 300
RPIPKDGQSV QWWHPQGIIG LVLFLLCVFY SSIRTSNNSQ VNKLTLTSDE 350
STLIEDGNGR SDGSLDDGDG IHRAVDNERD GVTYSYSFFH FMLFLASLYI 400
MMTLTNWYRY EPSREMKSQW TAVWVKISSS WIGLVLYVWT LVAPLVLTNR 450
DFD 453
Length:453
Mass (Da):50,509
Last modified:May 1, 2000 - v1
Checksum:i0FE8718FA3EA62B7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF181685 mRNA. Translation: AAD54421.1.
AB078030 Genomic DNA. Translation: BAC05512.1.
AK002847 mRNA. Translation: BAB22403.1.
AK005203 mRNA. Translation: BAB23881.1.
AK088340 mRNA. Translation: BAC40293.1.
AK133668 mRNA. Translation: BAE21775.1.
AK133975 mRNA. Translation: BAE21964.1.
AK135359 mRNA. Translation: BAE22504.1.
AK141574 mRNA. Translation: BAE24743.1.
AK148745 mRNA. Translation: BAE28654.1.
AK159280 mRNA. Translation: BAE34958.1.
AK159436 mRNA. Translation: BAE35082.1.
BC017148 mRNA. Translation: AAH17148.1.
CCDSiCCDS23853.1.
RefSeqiNP_062734.1. NM_019760.3.
UniGeneiMm.29344.

Genome annotation databases

EnsembliENSMUST00000020027; ENSMUSP00000020027; ENSMUSG00000019877.
GeneIDi56442.
KEGGimmu:56442.
UCSCiuc007fcm.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF181685 mRNA. Translation: AAD54421.1 .
AB078030 Genomic DNA. Translation: BAC05512.1 .
AK002847 mRNA. Translation: BAB22403.1 .
AK005203 mRNA. Translation: BAB23881.1 .
AK088340 mRNA. Translation: BAC40293.1 .
AK133668 mRNA. Translation: BAE21775.1 .
AK133975 mRNA. Translation: BAE21964.1 .
AK135359 mRNA. Translation: BAE22504.1 .
AK141574 mRNA. Translation: BAE24743.1 .
AK148745 mRNA. Translation: BAE28654.1 .
AK159280 mRNA. Translation: BAE34958.1 .
AK159436 mRNA. Translation: BAE35082.1 .
BC017148 mRNA. Translation: AAH17148.1 .
CCDSi CCDS23853.1.
RefSeqi NP_062734.1. NM_019760.3.
UniGenei Mm.29344.

3D structure databases

ProteinModelPortali Q9QZI8.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9QZI8.

Proteomic databases

PRIDEi Q9QZI8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000020027 ; ENSMUSP00000020027 ; ENSMUSG00000019877 .
GeneIDi 56442.
KEGGi mmu:56442.
UCSCi uc007fcm.3. mouse.

Organism-specific databases

CTDi 57515.
MGIi MGI:1926228. Serinc1.

Phylogenomic databases

eggNOGi NOG308011.
GeneTreei ENSGT00550000074522.
HOGENOMi HOG000165463.
HOVERGENi HBG025699.
InParanoidi Q9QZI8.
OMAi SSSWICI.
OrthoDBi EOG7TXKGQ.
PhylomeDBi Q9QZI8.
TreeFami TF312881.

Miscellaneous databases

ChiTaRSi SERINC1. mouse.
NextBioi 312638.
PROi Q9QZI8.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9QZI8.
Bgeei Q9QZI8.
CleanExi MM_SERINC1.
Genevestigatori Q9QZI8.

Family and domain databases

InterProi IPR029552. SERINC1.
IPR005016. TDE1/TMS.
[Graphical view ]
PANTHERi PTHR10383. PTHR10383. 1 hit.
PTHR10383:SF15. PTHR10383:SF15. 1 hit.
Pfami PF03348. Serinc. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a ubiquitous family of membrane proteins and their expression in mouse brain."
    Grossman T.R., Luque J.M., Nelson N.
    J. Exp. Biol. 203:447-457(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "An axotomy activated gene, mouse AIGP1: genomic organization, transcriptional regulation and genetic mapping on chromosome 2."
    Li H., Aoki S., Hara Y., Wada K.
    Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Cerebellum, Hippocampus, Kidney, Pituitary, Sympathetic ganglion and Thymus.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Eye.
  5. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-364, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSERC1_MOUSE
AccessioniPrimary (citable) accession number: Q9QZI8
Secondary accession number(s): Q3UZ93
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: May 1, 2000
Last modified: September 3, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi