Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9QZI8

- SERC1_MOUSE

UniProt

Q9QZI8 - SERC1_MOUSE

Protein

Serine incorporator 1

Gene

Serinc1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Enhances the incorporation of serine into phosphatidylserine and sphingolipids.By similarity

    GO - Molecular functioni

    1. L-serine transmembrane transporter activity Source: HGNC

    GO - Biological processi

    1. L-serine transport Source: HGNC
    2. phosphatidylserine metabolic process Source: HGNC
    3. phospholipid biosynthetic process Source: UniProtKB-KW
    4. positive regulation of transferase activity Source: HGNC
    5. sphingolipid metabolic process Source: HGNC

    Keywords - Biological processi

    Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine incorporator 1
    Alternative name(s):
    Axotomy-induced glyco/Golgi protein 2
    Membrane protein TMS-2
    Tumor differentially expressed protein 1-like
    Tumor differentially expressed protein 2
    Gene namesi
    Name:Serinc1
    Synonyms:Aigp2, Tde1l, Tde2, Tms2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:1926228. Serinc1.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: HGNC
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: HGNC

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 453452Serine incorporator 1PRO_0000218967Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi2 – 21N-myristoyl glycineBy similarity
    Modified residuei351 – 3511PhosphoserineBy similarity
    Modified residuei352 – 3521PhosphothreonineBy similarity
    Modified residuei361 – 3611PhosphoserineBy similarity
    Modified residuei364 – 3641Phosphoserine1 Publication

    Keywords - PTMi

    Lipoprotein, Myristate, Phosphoprotein

    Proteomic databases

    PRIDEiQ9QZI8.

    PTM databases

    PhosphoSiteiQ9QZI8.

    Expressioni

    Tissue specificityi

    Highly expressed in the neuronal populations such as Purkinje cells in the cerebellum, brainstem and spinal motor neurons, locus coeruleus and raphe nuclei.

    Gene expression databases

    ArrayExpressiQ9QZI8.
    BgeeiQ9QZI8.
    CleanExiMM_SERINC1.
    GenevestigatoriQ9QZI8.

    Interactioni

    Subunit structurei

    Interacts with SPTLC1.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9QZI8.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini2 – 3938CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini61 – 8828LumenalSequence AnalysisAdd
    BLAST
    Topological domaini110 – 12314CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini145 – 1517LumenalSequence Analysis
    Topological domaini173 – 19725CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini219 – 23113LumenalSequence AnalysisAdd
    BLAST
    Topological domaini253 – 2597CytoplasmicSequence Analysis
    Topological domaini281 – 30929LumenalSequence AnalysisAdd
    BLAST
    Topological domaini331 – 38757CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini409 – 42618LumenalSequence AnalysisAdd
    BLAST
    Topological domaini448 – 4536CytoplasmicSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei40 – 6021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei89 – 10921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei124 – 14421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei152 – 17221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei198 – 21821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei232 – 25221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei260 – 28021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei310 – 33021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei388 – 40821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei427 – 44721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TDE1 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG308011.
    GeneTreeiENSGT00550000074522.
    HOGENOMiHOG000165463.
    HOVERGENiHBG025699.
    InParanoidiQ9QZI8.
    OMAiSSSWICI.
    OrthoDBiEOG7TXKGQ.
    PhylomeDBiQ9QZI8.
    TreeFamiTF312881.

    Family and domain databases

    InterProiIPR029552. SERINC1.
    IPR005016. TDE1/TMS.
    [Graphical view]
    PANTHERiPTHR10383. PTHR10383. 1 hit.
    PTHR10383:SF15. PTHR10383:SF15. 1 hit.
    PfamiPF03348. Serinc. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9QZI8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGSVLGLCSV ASWIPCLCGS APCLLCRCCP SGNNSTVTRL IYALFLLVGV    50
    CVACVMLIPG MEEQLNKIPG FCENEKGVVP CNILVGYKAV YRLCFGLAMF 100
    YLLLSLLMIK VKSSSDPRAA VHNGFWFFKF ATAVAIIIGA FFIPEGTFTT 150
    VWFYVGMAGA FCFILIQLVL LIDFAHSWNE SWVEKMEEGN SRCWYAALLS 200
    ATALNYLLSL VAVVLFFVYY THPASCAENK AFISVNMLLC IGASVMSILP 250
    KIQESQPRSG LLQSSVITVY TMYLTWSAMT NEPETNCNPS LLSIIGFNTT 300
    RPIPKDGQSV QWWHPQGIIG LVLFLLCVFY SSIRTSNNSQ VNKLTLTSDE 350
    STLIEDGNGR SDGSLDDGDG IHRAVDNERD GVTYSYSFFH FMLFLASLYI 400
    MMTLTNWYRY EPSREMKSQW TAVWVKISSS WIGLVLYVWT LVAPLVLTNR 450
    DFD 453
    Length:453
    Mass (Da):50,509
    Last modified:May 1, 2000 - v1
    Checksum:i0FE8718FA3EA62B7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF181685 mRNA. Translation: AAD54421.1.
    AB078030 Genomic DNA. Translation: BAC05512.1.
    AK002847 mRNA. Translation: BAB22403.1.
    AK005203 mRNA. Translation: BAB23881.1.
    AK088340 mRNA. Translation: BAC40293.1.
    AK133668 mRNA. Translation: BAE21775.1.
    AK133975 mRNA. Translation: BAE21964.1.
    AK135359 mRNA. Translation: BAE22504.1.
    AK141574 mRNA. Translation: BAE24743.1.
    AK148745 mRNA. Translation: BAE28654.1.
    AK159280 mRNA. Translation: BAE34958.1.
    AK159436 mRNA. Translation: BAE35082.1.
    BC017148 mRNA. Translation: AAH17148.1.
    CCDSiCCDS23853.1.
    RefSeqiNP_062734.1. NM_019760.3.
    UniGeneiMm.29344.

    Genome annotation databases

    EnsembliENSMUST00000020027; ENSMUSP00000020027; ENSMUSG00000019877.
    GeneIDi56442.
    KEGGimmu:56442.
    UCSCiuc007fcm.3. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF181685 mRNA. Translation: AAD54421.1 .
    AB078030 Genomic DNA. Translation: BAC05512.1 .
    AK002847 mRNA. Translation: BAB22403.1 .
    AK005203 mRNA. Translation: BAB23881.1 .
    AK088340 mRNA. Translation: BAC40293.1 .
    AK133668 mRNA. Translation: BAE21775.1 .
    AK133975 mRNA. Translation: BAE21964.1 .
    AK135359 mRNA. Translation: BAE22504.1 .
    AK141574 mRNA. Translation: BAE24743.1 .
    AK148745 mRNA. Translation: BAE28654.1 .
    AK159280 mRNA. Translation: BAE34958.1 .
    AK159436 mRNA. Translation: BAE35082.1 .
    BC017148 mRNA. Translation: AAH17148.1 .
    CCDSi CCDS23853.1.
    RefSeqi NP_062734.1. NM_019760.3.
    UniGenei Mm.29344.

    3D structure databases

    ProteinModelPortali Q9QZI8.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9QZI8.

    Proteomic databases

    PRIDEi Q9QZI8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000020027 ; ENSMUSP00000020027 ; ENSMUSG00000019877 .
    GeneIDi 56442.
    KEGGi mmu:56442.
    UCSCi uc007fcm.3. mouse.

    Organism-specific databases

    CTDi 57515.
    MGIi MGI:1926228. Serinc1.

    Phylogenomic databases

    eggNOGi NOG308011.
    GeneTreei ENSGT00550000074522.
    HOGENOMi HOG000165463.
    HOVERGENi HBG025699.
    InParanoidi Q9QZI8.
    OMAi SSSWICI.
    OrthoDBi EOG7TXKGQ.
    PhylomeDBi Q9QZI8.
    TreeFami TF312881.

    Miscellaneous databases

    ChiTaRSi SERINC1. mouse.
    NextBioi 312638.
    PROi Q9QZI8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9QZI8.
    Bgeei Q9QZI8.
    CleanExi MM_SERINC1.
    Genevestigatori Q9QZI8.

    Family and domain databases

    InterProi IPR029552. SERINC1.
    IPR005016. TDE1/TMS.
    [Graphical view ]
    PANTHERi PTHR10383. PTHR10383. 1 hit.
    PTHR10383:SF15. PTHR10383:SF15. 1 hit.
    Pfami PF03348. Serinc. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a ubiquitous family of membrane proteins and their expression in mouse brain."
      Grossman T.R., Luque J.M., Nelson N.
      J. Exp. Biol. 203:447-457(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "An axotomy activated gene, mouse AIGP1: genomic organization, transcriptional regulation and genetic mapping on chromosome 2."
      Li H., Aoki S., Hara Y., Wada K.
      Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and NOD.
      Tissue: Cerebellum, Hippocampus, Kidney, Pituitary, Sympathetic ganglion and Thymus.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Eye.
    5. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-364, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSERC1_MOUSE
    AccessioniPrimary (citable) accession number: Q9QZI8
    Secondary accession number(s): Q3UZ93
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 25, 2002
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3