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Q9QZI8 (SERC1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine incorporator 1
Alternative name(s):
Axotomy-induced glyco/Golgi protein 2
Membrane protein TMS-2
Tumor differentially expressed protein 1-like
Tumor differentially expressed protein 2
Gene names
Name:Serinc1
Synonyms:Aigp2, Tde1l, Tde2, Tms2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length453 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Enhances the incorporation of serine into phosphatidylserine and sphingolipids By similarity.

Subunit structure

Interacts with SPTLC1 By similarity.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.

Tissue specificity

Highly expressed in the neuronal populations such as Purkinje cells in the cerebellum, brainstem and spinal motor neurons, locus coeruleus and raphe nuclei.

Sequence similarities

Belongs to the TDE1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 453453Serine incorporator 1
PRO_0000218967

Regions

Topological domain1 – 3939Cytoplasmic Potential
Transmembrane40 – 6021Helical; Potential
Topological domain61 – 8828Lumenal Potential
Transmembrane89 – 10921Helical; Potential
Topological domain110 – 12314Cytoplasmic Potential
Transmembrane124 – 14421Helical; Potential
Topological domain145 – 1517Lumenal Potential
Transmembrane152 – 17221Helical; Potential
Topological domain173 – 19725Cytoplasmic Potential
Transmembrane198 – 21821Helical; Potential
Topological domain219 – 23113Lumenal Potential
Transmembrane232 – 25221Helical; Potential
Topological domain253 – 2597Cytoplasmic Potential
Transmembrane260 – 28021Helical; Potential
Topological domain281 – 30929Lumenal Potential
Transmembrane310 – 33021Helical; Potential
Topological domain331 – 38757Cytoplasmic Potential
Transmembrane388 – 40821Helical; Potential
Topological domain409 – 42618Lumenal Potential
Transmembrane427 – 44721Helical; Potential
Topological domain448 – 4536Cytoplasmic Potential

Amino acid modifications

Modified residue3511Phosphoserine By similarity
Modified residue3521Phosphothreonine By similarity
Modified residue3611Phosphoserine By similarity
Modified residue3641Phosphoserine Ref.5 Ref.6
Lipidation21N-myristoyl glycine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9QZI8 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 0FE8718FA3EA62B7

FASTA45350,509
        10         20         30         40         50         60 
MGSVLGLCSV ASWIPCLCGS APCLLCRCCP SGNNSTVTRL IYALFLLVGV CVACVMLIPG 

        70         80         90        100        110        120 
MEEQLNKIPG FCENEKGVVP CNILVGYKAV YRLCFGLAMF YLLLSLLMIK VKSSSDPRAA 

       130        140        150        160        170        180 
VHNGFWFFKF ATAVAIIIGA FFIPEGTFTT VWFYVGMAGA FCFILIQLVL LIDFAHSWNE 

       190        200        210        220        230        240 
SWVEKMEEGN SRCWYAALLS ATALNYLLSL VAVVLFFVYY THPASCAENK AFISVNMLLC 

       250        260        270        280        290        300 
IGASVMSILP KIQESQPRSG LLQSSVITVY TMYLTWSAMT NEPETNCNPS LLSIIGFNTT 

       310        320        330        340        350        360 
RPIPKDGQSV QWWHPQGIIG LVLFLLCVFY SSIRTSNNSQ VNKLTLTSDE STLIEDGNGR 

       370        380        390        400        410        420 
SDGSLDDGDG IHRAVDNERD GVTYSYSFFH FMLFLASLYI MMTLTNWYRY EPSREMKSQW 

       430        440        450 
TAVWVKISSS WIGLVLYVWT LVAPLVLTNR DFD

« Hide

References

« Hide 'large scale' references
[1]"Identification of a ubiquitous family of membrane proteins and their expression in mouse brain."
Grossman T.R., Luque J.M., Nelson N.
J. Exp. Biol. 203:447-457(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"An axotomy activated gene, mouse AIGP1: genomic organization, transcriptional regulation and genetic mapping on chromosome 2."
Li H., Aoki S., Hara Y., Wada K.
Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J and NOD.
Tissue: Cerebellum, Hippocampus, Kidney, Pituitary, Sympathetic ganglion and Thymus.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Eye.
[5]"Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry."
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J., Faessler R., Mann M.
J. Proteome Res. 7:5314-5326(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-364, MASS SPECTROMETRY.
Tissue: Melanoma.
[6]"The phagosomal proteome in interferon-gamma-activated macrophages."
Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-364, MASS SPECTROMETRY.
Tissue: Macrophage.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF181685 mRNA. Translation: AAD54421.1.
AB078030 Genomic DNA. Translation: BAC05512.1.
AK002847 mRNA. Translation: BAB22403.1.
AK005203 mRNA. Translation: BAB23881.1.
AK088340 mRNA. Translation: BAC40293.1.
AK133668 mRNA. Translation: BAE21775.1.
AK133975 mRNA. Translation: BAE21964.1.
AK135359 mRNA. Translation: BAE22504.1.
AK141574 mRNA. Translation: BAE24743.1.
AK148745 mRNA. Translation: BAE28654.1.
AK159280 mRNA. Translation: BAE34958.1.
AK159436 mRNA. Translation: BAE35082.1.
BC017148 mRNA. Translation: AAH17148.1.
IPIIPI00137465.
RefSeqNP_062734.1. NM_019760.3.
UniGeneMm.29344.

3D structure databases

ProteinModelPortalQ9QZI8.
ModBaseSearch...

PTM databases

PhosphoSiteQ9QZI8.

Proteomic databases

PRIDEQ9QZI8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000020027; ENSMUSP00000020027; ENSMUSG00000019877.
GeneID56442.
KEGGmmu:56442.

Organism-specific databases

CTD57515.
MGIMGI:1926228. Serinc1.

Phylogenomic databases

eggNOGNOG308011.
GeneTreeENSGT00550000074522.
HOGENOMHOG000165463.
HOVERGENHBG025699.
InParanoidQ9QZI8.
OMAHVNCDVL.
OrthoDBEOG4S4PGF.

Gene expression databases

ArrayExpressQ9QZI8.
BgeeQ9QZI8.
CleanExMM_SERINC1.
GenevestigatorQ9QZI8.
GermOnlineENSMUSG00000019877. Mus musculus.

Family and domain databases

InterProIPR005016. TMS_TDE.
[Graphical view]
PANTHERPTHR10383. PTHR10383. 1 hit.
PfamPF03348. Serinc. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSERINC1. mouse.
NextBio312638.
SOURCESearch...

Entry information

Entry nameSERC1_MOUSE
AccessionPrimary (citable) accession number: Q9QZI8
Secondary accession number(s): Q3UZ93
Entry history
Integrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: May 1, 2000
Last modified: April 3, 2013
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents