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Protein

tRNA selenocysteine 1-associated protein 1

Gene

Trnau1ap

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the early steps of selenocysteine biosynthesis and tRNA(Sec) charging to the later steps resulting in the cotranslational incorporation of selenocysteine into selenoproteins. Stabilizes the SECISBP2, EEFSEC and tRNA(Sec) complex. May be involved in the methylation of tRNA(Sec). Enhances efficiency of selenoproteins synthesis (By similarity).By similarity

GO - Molecular functioni

  • nucleotide binding Source: InterPro
  • tRNA binding Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA selenocysteine 1-associated protein 1
Alternative name(s):
SECp43
tRNA selenocysteine-associated protein 1
Gene namesi
Name:Trnau1ap
Synonyms:Secp43, Trspap1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi619995. Trnau1ap.

Subcellular locationi

  • Nucleus 1 Publication
  • Cytoplasm 1 Publication

  • Note: Abundant in the nucleus.

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 287287tRNA selenocysteine 1-associated protein 1PRO_0000304920Add
BLAST

Proteomic databases

PaxDbiQ9QZI7.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Interactioni

Subunit structurei

Component of the tRNA(Sec) complex composed at least of EEFSEC, SECISBP2, SEPHS1, SEPSECS, TRNAU1AP and tRNA(Sec). Associates with mRNP and/or polysomes (By similarity). Found in a complex with tRNA(Sec). Interacts with SEPSECS.By similarity1 Publication

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000065702.

Structurei

3D structure databases

ProteinModelPortaliQ9QZI7.
SMRiQ9QZI7. Positions 1-184.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 8684RRM 1PROSITE-ProRule annotationAdd
BLAST
Domaini96 – 17580RRM 2PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi185 – 22541Tyr-richAdd
BLAST

Sequence similaritiesi

Belongs to the RRM TRSPAP family.Curated
Contains 2 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0118. Eukaryota.
COG0724. LUCA.
HOVERGENiHBG056959.
InParanoidiQ9QZI7.
PhylomeDBiQ9QZI7.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 2 hits.
[Graphical view]
SMARTiSM00360. RRM. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9QZI7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASLWMGDL EPYMDENFIS RAFATMGETV MSVKIIRNRL TGIPAGYCFV
60 70 80 90 100
EFADLATAEK CLHKINGKPL PGATPAKRFK LNYATYGKQP DNSPEYSLFV
110 120 130 140 150
GDLTPDVDDG MLYEFFVKVY PSCRGGKVVL DQTGVSKGYG FVKFTDELEQ
160 170 180 190 200
KRALTECQGA VGLGCKPVRL SVAIPKASRV KPVEYSQMYS YSYNQYYQQY
210 220 230 240 250
QNYYAQWGYD QNTGSYSYSY PQYGYTQSTM QTYEEVGDDA LEDPAPQLDV
260 270 280
TEANKEFMEQ SEELYDALMD CHWQPLDTVS SEIPAMM
Length:287
Mass (Da):32,454
Last modified:May 1, 2000 - v1
Checksum:i5485AE4CB30E56F5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF181856 mRNA. Translation: AAD54419.1.
RefSeqiNP_075416.1. NM_023027.1.
UniGeneiRn.170540.

Genome annotation databases

GeneIDi65241.
KEGGirno:65241.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF181856 mRNA. Translation: AAD54419.1.
RefSeqiNP_075416.1. NM_023027.1.
UniGeneiRn.170540.

3D structure databases

ProteinModelPortaliQ9QZI7.
SMRiQ9QZI7. Positions 1-184.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000065702.

Proteomic databases

PaxDbiQ9QZI7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi65241.
KEGGirno:65241.

Organism-specific databases

CTDi54952.
RGDi619995. Trnau1ap.

Phylogenomic databases

eggNOGiKOG0118. Eukaryota.
COG0724. LUCA.
HOVERGENiHBG056959.
InParanoidiQ9QZI7.
PhylomeDBiQ9QZI7.

Miscellaneous databases

NextBioi614199.
PROiQ9QZI7.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 2 hits.
[Graphical view]
SMARTiSM00360. RRM. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Identification of a protein component of a mammalian tRNA(Sec) complex implicated in the decoding of UGA as selenocysteine."
    Ding F., Grabowski P.J.
    RNA 5:1561-1569(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], IDENTIFICATION IN A COMPLEX WITH TRNA(SEC), INTERACTION WITH SEPSECS, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Cerebellum.

Entry informationi

Entry nameiTSAP1_RAT
AccessioniPrimary (citable) accession number: Q9QZI7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: May 1, 2000
Last modified: January 20, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.