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Protein

F-box/LRR-repeat protein 20

Gene

Fbxl20

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Role in neural transmission (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
F-box/LRR-repeat protein 20
Alternative name(s):
F-box and leucine-rich repeat protein 20
F-box/LRR-repeat protein 2-like
Gene namesi
Name:Fbxl20
Synonyms:Fbl2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621722. Fbxl20.

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001198721 – 276F-box/LRR-repeat protein 20Add BLAST276

Proteomic databases

PaxDbiQ9QZH7.
PRIDEiQ9QZH7.

Expressioni

Tissue specificityi

Widely expressed, with highest expression in skeletal muscle, heart and brain.1 Publication

Gene expression databases

GenevisibleiQ9QZH7. RN.

Interactioni

Subunit structurei

Interacts with SKP1 and CUL1.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000060552.

Structurei

3D structure databases

ProteinModelPortaliQ9QZH7.
SMRiQ9QZH7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 68F-boxPROSITE-ProRule annotationAdd BLAST47
Repeati74 – 100LRR 1Add BLAST27
Repeati101 – 126LRR 2Add BLAST26
Repeati127 – 152LRR 3Add BLAST26
Repeati153 – 178LRR 4Add BLAST26
Repeati179 – 204LRR 5Add BLAST26
Repeati205 – 230LRR 6Add BLAST26
Repeati231 – 256LRR 7Add BLAST26
Repeati257 – 276LRR 8Add BLAST20

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG4341. Eukaryota.
ENOG410XQ54. LUCA.
HOGENOMiHOG000230659.
HOVERGENiHBG051586.
InParanoidiQ9QZH7.
KOiK10268.
OrthoDBiEOG091G060Y.
PhylomeDBiQ9QZH7.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiView protein in InterPro
IPR001810. F-box_dom.
IPR001611. Leu-rich_rpt.
IPR006553. Leu-rich_rpt_Cys-con_subtyp.
IPR032675. LRR_dom_sf.
PfamiView protein in Pfam
PF12937. F-box-like. 1 hit.
PF13516. LRR_6. 3 hits.
SMARTiView protein in SMART
SM00256. FBOX. 1 hit.
SM00367. LRR_CC. 7 hits.
PROSITEiView protein in PROSITE
PS50181. FBOX. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9QZH7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRDVNGVTK SRFEMFSNSD EAVINKKLPK ELLLRIFSFL DVVTLCRCAQ
60 70 80 90 100
VSRAWNVLAL DGSNWQRIDL FDFQRDIEGR VVENISKRCG GFLRKLSLRG
110 120 130 140 150
CLGVGDNALR TFAQNCRNIE VLSLNGCTKT TDATCTSLSK FCSKLRHLDL
160 170 180 190 200
ASCTSITNMS LKALSEGCPL LEQLNISWCD QVTKDGIQAL VRGCGGLKAL
210 220 230 240 250
FLKGCTQLED EALKYIGAHC PELVTLNLQT CLQITDEGLI TICRGCHKLQ
260 270
SLCASGCSNI TDAILNALGQ NCPRLR
Length:276
Mass (Da):30,460
Last modified:May 1, 2000 - v1
Checksum:i982994F91A265E1E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF182443 mRNA. Translation: AAF01221.1.
PIRiT52349.
RefSeqiNP_071608.1. NM_022272.1.
UniGeneiRn.11637.
Rn.18281.

Genome annotation databases

GeneIDi64039.
KEGGirno:64039.
UCSCiRGD:621722. rat.

Similar proteinsi

Entry informationi

Entry nameiFXL20_RAT
AccessioniPrimary (citable) accession number: Q9QZH7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: May 1, 2000
Last modified: November 22, 2017
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome