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Protein

F-box/LRR-repeat protein 20

Gene

Fbxl20

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Role in neural transmission (By similarity).By similarity

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
F-box/LRR-repeat protein 20
Alternative name(s):
F-box and leucine-rich repeat protein 20
F-box/LRR-repeat protein 2-like
Gene namesi
Name:Fbxl20
Synonyms:Fbl2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621722. Fbxl20.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 276276F-box/LRR-repeat protein 20PRO_0000119872Add
BLAST

Proteomic databases

PaxDbiQ9QZH7.
PRIDEiQ9QZH7.

Expressioni

Tissue specificityi

Widely expressed, with highest expression in skeletal muscle, heart and brain.1 Publication

Gene expression databases

GenevisibleiQ9QZH7. RN.

Interactioni

Subunit structurei

Interacts with SKP1 and CUL1.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000060552.

Structurei

3D structure databases

ProteinModelPortaliQ9QZH7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 6847F-boxPROSITE-ProRule annotationAdd
BLAST
Repeati74 – 10027LRR 1Add
BLAST
Repeati101 – 12626LRR 2Add
BLAST
Repeati127 – 15226LRR 3Add
BLAST
Repeati153 – 17826LRR 4Add
BLAST
Repeati179 – 20426LRR 5Add
BLAST
Repeati205 – 23026LRR 6Add
BLAST
Repeati231 – 25626LRR 7Add
BLAST
Repeati257 – 27620LRR 8Add
BLAST

Sequence similaritiesi

Contains 1 F-box domain.PROSITE-ProRule annotation
Contains 8 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG4341. Eukaryota.
ENOG410XQ54. LUCA.
HOGENOMiHOG000230659.
HOVERGENiHBG051586.
InParanoidiQ9QZH7.
KOiK10268.
OMAiKSRFEXA.
OrthoDBiEOG7CVPXM.
PhylomeDBiQ9QZH7.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR001810. F-box_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR006553. Leu-rich_rpt_Cys-con_subtyp.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
PF13516. LRR_6. 3 hits.
[Graphical view]
SMARTiSM00256. FBOX. 1 hit.
SM00367. LRR_CC. 7 hits.
[Graphical view]
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9QZH7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRDVNGVTK SRFEMFSNSD EAVINKKLPK ELLLRIFSFL DVVTLCRCAQ
60 70 80 90 100
VSRAWNVLAL DGSNWQRIDL FDFQRDIEGR VVENISKRCG GFLRKLSLRG
110 120 130 140 150
CLGVGDNALR TFAQNCRNIE VLSLNGCTKT TDATCTSLSK FCSKLRHLDL
160 170 180 190 200
ASCTSITNMS LKALSEGCPL LEQLNISWCD QVTKDGIQAL VRGCGGLKAL
210 220 230 240 250
FLKGCTQLED EALKYIGAHC PELVTLNLQT CLQITDEGLI TICRGCHKLQ
260 270
SLCASGCSNI TDAILNALGQ NCPRLR
Length:276
Mass (Da):30,460
Last modified:May 1, 2000 - v1
Checksum:i982994F91A265E1E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF182443 mRNA. Translation: AAF01221.1.
PIRiT52349.
RefSeqiNP_071608.1. NM_022272.1.
UniGeneiRn.11637.
Rn.18281.

Genome annotation databases

GeneIDi64039.
KEGGirno:64039.
UCSCiRGD:621722. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF182443 mRNA. Translation: AAF01221.1.
PIRiT52349.
RefSeqiNP_071608.1. NM_022272.1.
UniGeneiRn.11637.
Rn.18281.

3D structure databases

ProteinModelPortaliQ9QZH7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000060552.

Proteomic databases

PaxDbiQ9QZH7.
PRIDEiQ9QZH7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi64039.
KEGGirno:64039.
UCSCiRGD:621722. rat.

Organism-specific databases

CTDi84961.
RGDi621722. Fbxl20.

Phylogenomic databases

eggNOGiKOG4341. Eukaryota.
ENOG410XQ54. LUCA.
HOGENOMiHOG000230659.
HOVERGENiHBG051586.
InParanoidiQ9QZH7.
KOiK10268.
OMAiKSRFEXA.
OrthoDBiEOG7CVPXM.
PhylomeDBiQ9QZH7.

Miscellaneous databases

PROiQ9QZH7.

Gene expression databases

GenevisibleiQ9QZH7. RN.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR001810. F-box_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR006553. Leu-rich_rpt_Cys-con_subtyp.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
PF13516. LRR_6. 3 hits.
[Graphical view]
SMARTiSM00256. FBOX. 1 hit.
SM00367. LRR_CC. 7 hits.
[Graphical view]
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Identification of a novel Skp2-like mammalian protein containing F-box and leucine-rich repeats."
    Ilyin G.P., Rialland M., Glaise D., Guguen-Guillouzo C.
    FEBS Lett. 459:75-79(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH SKP1, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Strain: Buffalo.
    Tissue: Liver.

Entry informationi

Entry nameiFXL20_RAT
AccessioniPrimary (citable) accession number: Q9QZH7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: May 1, 2000
Last modified: June 8, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.