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Q9QZH6

- ECSIT_MOUSE

UniProt

Q9QZH6 - ECSIT_MOUSE

Protein

Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

Gene

Ecsit

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 2 (26 Jun 2007)
      Previous versions | rss
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    Functioni

    Adapter protein of the Toll-like and IL-1 receptor signaling pathway that is involved in the activation of NF-kappa-B via MAP3K1. Promotes proteolytic activation of MAP3K1. Involved in the BMP signaling pathway. Required for normal embryonic development.2 Publications
    Required for efficient assembly of mitochondrial NADH:ubiquinone oxidoreductase.By similarity

    GO - Molecular functioni

    1. oxidoreductase activity, acting on NAD(P)H Source: UniProtKB
    2. protein binding Source: IntAct
    3. sequence-specific DNA binding transcription factor activity Source: MGI
    4. signal transducer activity Source: MGI

    GO - Biological processi

    1. BMP signaling pathway Source: MGI
    2. innate immune response Source: UniProtKB-KW
    3. mesoderm formation Source: MGI
    4. oxidation-reduction process Source: GOC
    5. regulation of oxidoreductase activity Source: UniProtKB
    6. regulation of transcription from RNA polymerase II promoter Source: MGI
    7. transmembrane receptor protein serine/threonine kinase signaling pathway Source: MGI

    Keywords - Biological processi

    Immunity, Innate immunity

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial
    Alternative name(s):
    Protein SITPEC
    Gene namesi
    Name:Ecsit
    Synonyms:Sitpec
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:1349469. Ecsit.

    Subcellular locationi

    Cytoplasm 1 Publication. Nucleus 1 Publication. Mitochondrion By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. mitochondrion Source: UniProtKB
    3. nucleus Source: UniProtKB
    4. transcription factor complex Source: MGI

    Keywords - Cellular componenti

    Cytoplasm, Mitochondrion, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 4848MitochondrionSequence AnalysisAdd
    BLAST
    Chaini49 – 435387Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrialPRO_0000291987Add
    BLAST

    Proteomic databases

    MaxQBiQ9QZH6.
    PaxDbiQ9QZH6.
    PRIDEiQ9QZH6.

    PTM databases

    PhosphoSiteiQ9QZH6.

    Expressioni

    Tissue specificityi

    Detected in heart, brain, lung, liver, skeletal muscle, kidney and testis. Detected in embryonic mesoderm and epiblast, and in extraembryonic ectoderm.2 Publications

    Gene expression databases

    ArrayExpressiQ9QZH6.
    BgeeiQ9QZH6.
    CleanExiMM_ECSIT.
    GenevestigatoriQ9QZH6.

    Interactioni

    Subunit structurei

    Interacts with NDUFAF1 By similarity. Part of the mitochondrial complex I assembly (MCIA) complex. The complex comprises at least TMEM126B, NDUFAF1, ECSIT, and ACAD9 By similarity. Interacts with MAP3K1, SMAD4 and TRAF6. Interacts with SMAD1 only after BMP4-treatment.By similarity2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    TRAF6Q9Y4K32EBI-527020,EBI-359276From a different organism.
    Traf6P701964EBI-527020,EBI-448028

    Protein-protein interaction databases

    BioGridi205076. 5 interactions.
    DIPiDIP-33901N.
    IntActiQ9QZH6. 3 interactions.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ECSIT family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiNOG260596.
    GeneTreeiENSGT00390000005147.
    HOGENOMiHOG000112324.
    HOVERGENiHBG059532.
    InParanoidiQ9QZH6.
    KOiK04405.
    OrthoDBiEOG76T9RM.
    PhylomeDBiQ9QZH6.
    TreeFamiTF314943.

    Family and domain databases

    InterProiIPR029342. ECIST_C.
    IPR010418. ECSIT.
    [Graphical view]
    PANTHERiPTHR13113. PTHR13113. 1 hit.
    PfamiPF14784. ECIST_Cterm. 1 hit.
    PF06239. ECSIT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9QZH6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSWVQVNLLV RSLSRGWGGL CRPALSGTPF AQVSLQALRG LHCSAATHKD    50
    EPWLVPRPPE PQRKPIKVPA MHEDLFKPSG NRERDKASFL NAVRSFGAHN 100
    VRKRGHVDFI YLALRKMPEF GVERDLSVYN LLLDVFPKEV FRPRNVIQRI 150
    FVHYPRQQEC GVAVLEQMER HGVMPSAETE FLLIQIFGRK SYPMLKFLRM 200
    KLWFTRFKNI NPYPVPRDLP QDPLDLAKLG LRHMEPDLSA KVTVYQMSLP 250
    SDSTGMEDPT QPHIVGIQSP DQQAALARHN PSRPVFVEGP FPLWLRNKCV 300
    YYHILRADLP PPEEEKVEEI PEEWELYYPQ KLDLEYSRSG WDDYEFDVDE 350
    VTEGPVFAMC MAGAHDQATL IKWIQGLQET NPTLAQIPVV FRLARSTGEL 400
    LTTSRLEGQS PPHSPPKGPE EDDETIQAEQ QQGQS 435
    Length:435
    Mass (Da):49,799
    Last modified:June 26, 2007 - v2
    Checksum:iA2ABA68F1E2C6BF3
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti75 – 751L → S in AAF01219. (PubMed:10465784)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF182510 mRNA. Translation: AAF01219.1.
    BC004583 mRNA. Translation: AAH04583.1.
    BC016424 mRNA. Translation: AAH16424.1.
    CCDSiCCDS22920.1.
    RefSeqiNP_001240826.1. NM_001253897.1.
    NP_001240827.1. NM_001253898.1.
    NP_036159.1. NM_012029.2.
    XP_006510432.1. XM_006510369.1.
    XP_006510433.1. XM_006510370.1.
    UniGeneiMm.425568.

    Genome annotation databases

    EnsembliENSMUST00000098937; ENSMUSP00000096537; ENSMUSG00000066839.
    ENSMUST00000179422; ENSMUSP00000137424; ENSMUSG00000066839.
    ENSMUST00000180180; ENSMUSP00000136247; ENSMUSG00000066839.
    GeneIDi26940.
    KEGGimmu:26940.
    UCSCiuc009ons.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF182510 mRNA. Translation: AAF01219.1 .
    BC004583 mRNA. Translation: AAH04583.1 .
    BC016424 mRNA. Translation: AAH16424.1 .
    CCDSi CCDS22920.1.
    RefSeqi NP_001240826.1. NM_001253897.1.
    NP_001240827.1. NM_001253898.1.
    NP_036159.1. NM_012029.2.
    XP_006510432.1. XM_006510369.1.
    XP_006510433.1. XM_006510370.1.
    UniGenei Mm.425568.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 205076. 5 interactions.
    DIPi DIP-33901N.
    IntActi Q9QZH6. 3 interactions.

    PTM databases

    PhosphoSitei Q9QZH6.

    Proteomic databases

    MaxQBi Q9QZH6.
    PaxDbi Q9QZH6.
    PRIDEi Q9QZH6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000098937 ; ENSMUSP00000096537 ; ENSMUSG00000066839 .
    ENSMUST00000179422 ; ENSMUSP00000137424 ; ENSMUSG00000066839 .
    ENSMUST00000180180 ; ENSMUSP00000136247 ; ENSMUSG00000066839 .
    GeneIDi 26940.
    KEGGi mmu:26940.
    UCSCi uc009ons.2. mouse.

    Organism-specific databases

    CTDi 51295.
    MGIi MGI:1349469. Ecsit.

    Phylogenomic databases

    eggNOGi NOG260596.
    GeneTreei ENSGT00390000005147.
    HOGENOMi HOG000112324.
    HOVERGENi HBG059532.
    InParanoidi Q9QZH6.
    KOi K04405.
    OrthoDBi EOG76T9RM.
    PhylomeDBi Q9QZH6.
    TreeFami TF314943.

    Miscellaneous databases

    NextBioi 304857.
    PROi Q9QZH6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9QZH6.
    Bgeei Q9QZH6.
    CleanExi MM_ECSIT.
    Genevestigatori Q9QZH6.

    Family and domain databases

    InterProi IPR029342. ECIST_C.
    IPR010418. ECSIT.
    [Graphical view ]
    PANTHERi PTHR13113. PTHR13113. 1 hit.
    Pfami PF14784. ECIST_Cterm. 1 hit.
    PF06239. ECSIT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway."
      Kopp E., Medzhitov R., Carothers J., Xiao C., Douglas I., Janeway C.A., Ghosh S.
      Genes Dev. 13:2059-2071(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH TRAF6 AND MAP3K1, FUNCTION, ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
      Tissue: Liver.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Czech II and FVB/N.
      Tissue: Mammary tumor.
    3. "Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis."
      Xiao C., Shim J.-H., Klueppel M., Zhang S.S.-M., Dong C., Flavell R.A., Fu X.-Y., Wrana J.L., Hogan B.L.M., Ghosh S.
      Genes Dev. 17:2933-2949(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH SMAD1 AND SMAD4, ALTERNATIVE SPLICING, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiECSIT_MOUSE
    AccessioniPrimary (citable) accession number: Q9QZH6
    Secondary accession number(s): Q91V53
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 26, 2007
    Last sequence update: June 26, 2007
    Last modified: October 1, 2014
    This is version 77 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3