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Protein

Solute carrier family 22 member 23

Gene

Slc22a23

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 22 member 23
Alternative name(s):
Ion transporter protein
Gene namesi
Name:Slc22a23
Synonyms:Nritp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 17

Organism-specific databases

RGDi620302. Slc22a23.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei229 – 249HelicalSequence analysisAdd BLAST21
Transmembranei253 – 273HelicalSequence analysisAdd BLAST21
Transmembranei283 – 303HelicalSequence analysisAdd BLAST21
Transmembranei310 – 330HelicalSequence analysisAdd BLAST21
Transmembranei339 – 359HelicalSequence analysisAdd BLAST21
Transmembranei462 – 482HelicalSequence analysisAdd BLAST21
Transmembranei489 – 509HelicalSequence analysisAdd BLAST21
Transmembranei541 – 561HelicalSequence analysisAdd BLAST21
Transmembranei572 – 592HelicalSequence analysisAdd BLAST21
Transmembranei601 – 621HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003083171 – 689Solute carrier family 22 member 23Add BLAST689

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi24N-linked (GlcNAc...)Sequence analysis1
Glycosylationi274N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9QZG1.
PRIDEiQ9QZG1.

Expressioni

Tissue specificityi

Expressed in many tissues, including brain, spinal cord, kidney, liver, eye, adipose tissue, lung, epididymis, adrenal gland, pineal gland, skeletal muscle, heart, spleen, thymus, ovary, uterus, testis and epididymis.1 Publication

Gene expression databases

BgeeiENSRNOG00000017210.
GenevisibleiQ9QZG1. RN.

Interactioni

Protein-protein interaction databases

BioGridi249140. 1 interactor.
STRINGi10116.ENSRNOP00000023149.

Structurei

3D structure databases

ProteinModelPortaliQ9QZG1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0255. Eukaryota.
ENOG410ZZ6M. LUCA.
GeneTreeiENSGT00390000014377.
HOGENOMiHOG000124569.
HOVERGENiHBG108437.
InParanoidiQ9QZG1.
KOiK08215.
OMAiDQPNFWC.
OrthoDBiEOG091G03U2.
PhylomeDBiQ9QZG1.
TreeFamiTF335753.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS00216. SUGAR_TRANSPORT_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9QZG1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIDRRREAA GSGAGRQPAP AEENGSLPPG DAAASAPLGG RAGSGGSAEI
60 70 80 90 100
QPLPALHPSG GPHSSCCAAA AAPSLLLLDY DGSVLPFLGG LGGGYQKTLV
110 120 130 140 150
VLTWIPALFI GFSQFSDSFL LDQPNFWCHG AGKGTELAGA TVTGRWGDMG
160 170 180 190 200
NWTSPSATPF STASWGTTSN RSNSSDTPPL PSPPGKGNND SNCECHAWDY
210 220 230 240 250
GIRTGLVQNV VSKWDLVCDN AWKVHVAKFS LLVGLIFGYL ITGCIADWVG
260 270 280 290 300
RRPVLLFSVI FILIFGLTVA LSVNVTMFST LRFFEGFCLA GIILTLYALR
310 320 330 340 350
IELCPPGKRF IITMVASFVA MAGQFLMPGL AALCRDWQVL QALIICPFLL
360 370 380 390 400
MLLYWSIFPE SLRWLMATQQ FESAKKLILY LTQKNCVSPE SDIKGVMPEL
410 420 430 440 450
EKELSRRPKK VCIVKVVGTR NLWKNIVVLC VNSLTGYGIH HCFARSMMGH
460 470 480 490 500
EVKVPLLENF YADYYTMASI ALASCLAMCL VVRFLGRRGG LLLFMILTAL
510 520 530 540 550
ASLLQLGLLN LIGKYSQHPD SELQLKLAVG MSDSVKDKFS IAFSIVGMFA
560 570 580 590 600
SHAVGSLSVF FCAEITPTVI RCGGLGLVLA SAGFGMLTAP IIELHNQKGY
610 620 630 640 650
FLHHIIFACC TLICIICILL LPESRDQNLP ENIANGEHYT RQPLLSHKKG
660 670 680
EQPLLLTNAE LKDYSGLHDV AAVGDGLSEG ATANGMKTM
Length:689
Mass (Da):74,208
Last modified:October 23, 2007 - v2
Checksum:i870316640E94B856
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti327 – 328MP → AT in AAF01243 (PubMed:10719212).Curated2
Sequence conflicti388S → G in AAF01243 (PubMed:10719212).Curated1
Sequence conflicti522 – 529Missing in AAF01243 (PubMed:10719212).Curated8

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03104826 Genomic DNA. No translation available.
AABR03104847 Genomic DNA. No translation available.
AABR03105090 Genomic DNA. No translation available.
AABR03105777 Genomic DNA. No translation available.
AABR03106468 Genomic DNA. No translation available.
AF184921 mRNA. Translation: AAF01243.1.
RefSeqiNP_072146.1. NM_022624.1.
UniGeneiRn.45804.

Genome annotation databases

EnsembliENSRNOT00000023149; ENSRNOP00000023149; ENSRNOG00000017210.
GeneIDi64559.
KEGGirno:64559.
UCSCiRGD:620302. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03104826 Genomic DNA. No translation available.
AABR03104847 Genomic DNA. No translation available.
AABR03105090 Genomic DNA. No translation available.
AABR03105777 Genomic DNA. No translation available.
AABR03106468 Genomic DNA. No translation available.
AF184921 mRNA. Translation: AAF01243.1.
RefSeqiNP_072146.1. NM_022624.1.
UniGeneiRn.45804.

3D structure databases

ProteinModelPortaliQ9QZG1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi249140. 1 interactor.
STRINGi10116.ENSRNOP00000023149.

Proteomic databases

PaxDbiQ9QZG1.
PRIDEiQ9QZG1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000023149; ENSRNOP00000023149; ENSRNOG00000017210.
GeneIDi64559.
KEGGirno:64559.
UCSCiRGD:620302. rat.

Organism-specific databases

CTDi63027.
RGDi620302. Slc22a23.

Phylogenomic databases

eggNOGiKOG0255. Eukaryota.
ENOG410ZZ6M. LUCA.
GeneTreeiENSGT00390000014377.
HOGENOMiHOG000124569.
HOVERGENiHBG108437.
InParanoidiQ9QZG1.
KOiK08215.
OMAiDQPNFWC.
OrthoDBiEOG091G03U2.
PhylomeDBiQ9QZG1.
TreeFamiTF335753.

Miscellaneous databases

PROiQ9QZG1.

Gene expression databases

BgeeiENSRNOG00000017210.
GenevisibleiQ9QZG1. RN.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS00216. SUGAR_TRANSPORT_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS22AN_RAT
AccessioniPrimary (citable) accession number: Q9QZG1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: November 30, 2016
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.