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Protein

Translin-associated protein X

Gene

Tsnax

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing complex (RISC). Possible role in spermatogenesis (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi129 – 1291MagnesiumBy similarity
Metal bindingi197 – 1971MagnesiumBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Spermatogenesis

Keywords - Ligandi

DNA-binding, Magnesium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-426486. Small interfering RNA (siRNA) biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Translin-associated protein X
Alternative name(s):
Translin-associated factor X
Gene namesi
Name:Tsnax
Synonyms:Trax
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1855672. Tsnax.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • Golgi apparatus Source: UniProtKB-SubCell
  • nucleus Source: UniProtKB-SubCell
  • perinuclear region of cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 290290Translin-associated protein XPRO_0000191687Add
BLAST

Post-translational modificationi

Sumoylated with SUMO1.By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

EPDiQ9QZE7.
MaxQBiQ9QZE7.
PaxDbiQ9QZE7.
PRIDEiQ9QZE7.

PTM databases

iPTMnetiQ9QZE7.
PhosphoSiteiQ9QZE7.

Expressioni

Tissue specificityi

Detected in heart, brain, lung, liver, kidney and testis.1 Publication

Gene expression databases

BgeeiQ9QZE7.
CleanExiMM_TSNAX.
GenevisibleiQ9QZE7. MM.

Interactioni

Subunit structurei

Ring-shaped heterooctamer of six TSN and two TSNAX subunits. Interacts with GOLGA3, TSNAXIP1, SUN1 and AKAP9. Interacts with the homodimeric form of C1D following gamma-radiation. Interacts with TSN and C1D in a mutually exclusive manner (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Adora2aP305436EBI-2910751,EBI-2902822From a different organism.

Protein-protein interaction databases

BioGridi207317. 5 interactions.
IntActiQ9QZE7. 3 interactions.
MINTiMINT-4130678.
STRINGi10090.ENSMUSP00000075290.

Structurei

3D structure databases

ProteinModelPortaliQ9QZE7.
SMRiQ9QZE7. Positions 32-272.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni73 – 208136Interaction with C1DBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the translin family.Curated

Phylogenomic databases

eggNOGiKOG3066. Eukaryota.
COG2178. LUCA.
GeneTreeiENSGT00390000014716.
HOGENOMiHOG000008075.
HOVERGENiHBG059067.
InParanoidiQ9QZE7.
OMAiCISSVGN.
OrthoDBiEOG7XWPPR.
PhylomeDBiQ9QZE7.
TreeFamiTF323633.

Family and domain databases

Gene3Di1.20.58.190. 1 hit.
1.20.58.200. 1 hit.
InterProiIPR002848. Translin.
IPR016069. Translin_C.
IPR016068. Translin_N.
[Graphical view]
PANTHERiPTHR10741. PTHR10741. 1 hit.
PfamiPF01997. Translin. 1 hit.
[Graphical view]
SUPFAMiSSF74784. SSF74784. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9QZE7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNGKEGPGGF RKRKHDTFPH NQRREGKDAS LSSPVMLAFK SFQQELDARH
60 70 80 90 100
DKYERLVKLS RDITVESKRT IFLLHRITSA PDMEEILTES ESKLDGVRQK
110 120 130 140 150
ILQVAQELSG EDMHQFHRAV TTGLQEYVEA VSFQHFIKTR SLISMEEINK
160 170 180 190 200
QLTFTAEDSG KESKTPPAEG QEKQLVTWRL KLTPVDYLLG VADLTGELMR
210 220 230 240 250
MCINSVGNGD IDTPFEVSQF LRQVYDGFSF IGNTGPYEVS KKLYTLKQSL
260 270 280 290
AKVENACYAL KVRGSEIPKH MLADVFSVKT DMIDQEESIS
Length:290
Mass (Da):32,926
Last modified:May 1, 2000 - v1
Checksum:i62038133C46B7952
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF187040 mRNA. Translation: AAF05529.1.
AK030407 mRNA. Translation: BAC26948.1.
AK146339 mRNA. Translation: BAE27093.1.
BC004611 mRNA. Translation: AAH04611.1.
CCDSiCCDS22778.1.
RefSeqiNP_058605.1. NM_016909.2.
UniGeneiMm.458292.
Mm.472734.
Mm.5248.

Genome annotation databases

EnsembliENSMUST00000075896; ENSMUSP00000075290; ENSMUSG00000056820.
GeneIDi53424.
KEGGimmu:53424.
UCSCiuc009nxz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF187040 mRNA. Translation: AAF05529.1.
AK030407 mRNA. Translation: BAC26948.1.
AK146339 mRNA. Translation: BAE27093.1.
BC004611 mRNA. Translation: AAH04611.1.
CCDSiCCDS22778.1.
RefSeqiNP_058605.1. NM_016909.2.
UniGeneiMm.458292.
Mm.472734.
Mm.5248.

3D structure databases

ProteinModelPortaliQ9QZE7.
SMRiQ9QZE7. Positions 32-272.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207317. 5 interactions.
IntActiQ9QZE7. 3 interactions.
MINTiMINT-4130678.
STRINGi10090.ENSMUSP00000075290.

PTM databases

iPTMnetiQ9QZE7.
PhosphoSiteiQ9QZE7.

Proteomic databases

EPDiQ9QZE7.
MaxQBiQ9QZE7.
PaxDbiQ9QZE7.
PRIDEiQ9QZE7.

Protocols and materials databases

DNASUi53424.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000075896; ENSMUSP00000075290; ENSMUSG00000056820.
GeneIDi53424.
KEGGimmu:53424.
UCSCiuc009nxz.1. mouse.

Organism-specific databases

CTDi7257.
MGIiMGI:1855672. Tsnax.

Phylogenomic databases

eggNOGiKOG3066. Eukaryota.
COG2178. LUCA.
GeneTreeiENSGT00390000014716.
HOGENOMiHOG000008075.
HOVERGENiHBG059067.
InParanoidiQ9QZE7.
OMAiCISSVGN.
OrthoDBiEOG7XWPPR.
PhylomeDBiQ9QZE7.
TreeFamiTF323633.

Enzyme and pathway databases

ReactomeiR-MMU-426486. Small interfering RNA (siRNA) biogenesis.

Miscellaneous databases

PROiQ9QZE7.
SOURCEiSearch...

Gene expression databases

BgeeiQ9QZE7.
CleanExiMM_TSNAX.
GenevisibleiQ9QZE7. MM.

Family and domain databases

Gene3Di1.20.58.190. 1 hit.
1.20.58.200. 1 hit.
InterProiIPR002848. Translin.
IPR016069. Translin_C.
IPR016068. Translin_N.
[Graphical view]
PANTHERiPTHR10741. PTHR10741. 1 hit.
PfamiPF01997. Translin. 1 hit.
[Graphical view]
SUPFAMiSSF74784. SSF74784. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of the mouse translin-associated protein X (Trax) gene."
    Devon R.S., Taylor M.S., Millar J.K., Porteous D.J.
    Mamm. Genome 11:395-398(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and DBA/2.
    Tissue: Pituitary.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  4. "Co-localization of Trax and Mea2 in Golgi complex of pachytene spermatocytes in the mouse."
    Matsuda M., Kondo M., Kashiwabara S., Yoshihara M., Sutou S., Matsukuma S.
    J. Histochem. Cytochem. 52:1245-1248(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, INTERACTION WITH GOLGA3.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiTSNAX_MOUSE
AccessioniPrimary (citable) accession number: Q9QZE7
Secondary accession number(s): Q3UJR2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: May 1, 2000
Last modified: June 8, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.