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Protein

Translin-associated protein X

Gene

Tsnax

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing complex (RISC). Possible role in spermatogenesis (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi129MagnesiumBy similarity1
Metal bindingi197MagnesiumBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processDifferentiation, Spermatogenesis
LigandMagnesium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-426486 Small interfering RNA (siRNA) biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Translin-associated protein X
Alternative name(s):
Translin-associated factor X
Gene namesi
Name:Tsnax
Synonyms:Trax
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1855672 Tsnax

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001916871 – 290Translin-associated protein XAdd BLAST290

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki279Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Post-translational modificationi

Sumoylated with SUMO1.By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ9QZE7
MaxQBiQ9QZE7
PaxDbiQ9QZE7
PeptideAtlasiQ9QZE7
PRIDEiQ9QZE7

PTM databases

iPTMnetiQ9QZE7
PhosphoSitePlusiQ9QZE7

Expressioni

Tissue specificityi

Detected in heart, brain, lung, liver, kidney and testis.1 Publication

Gene expression databases

BgeeiENSMUSG00000056820
CleanExiMM_TSNAX
ExpressionAtlasiQ9QZE7 baseline and differential
GenevisibleiQ9QZE7 MM

Interactioni

Subunit structurei

Ring-shaped heterooctamer of six TSN and two TSNAX subunits. Interacts with GOLGA3, TSNAXIP1, SUN1 and AKAP9. Interacts with the homodimeric form of C1D following gamma-radiation. Interacts with TSN and C1D in a mutually exclusive manner (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Adora2aP305436EBI-2910751,EBI-2902822From Rattus norvegicus.

Protein-protein interaction databases

BioGridi207317, 5 interactors
IntActiQ9QZE7, 3 interactors
MINTiQ9QZE7
STRINGi10090.ENSMUSP00000075290

Structurei

3D structure databases

ProteinModelPortaliQ9QZE7
SMRiQ9QZE7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni73 – 208Interaction with C1DBy similarityAdd BLAST136

Sequence similaritiesi

Belongs to the translin family.Curated

Phylogenomic databases

eggNOGiKOG3066 Eukaryota
COG2178 LUCA
GeneTreeiENSGT00390000014716
HOGENOMiHOG000008075
HOVERGENiHBG059067
InParanoidiQ9QZE7
OMAiKAENVCY
OrthoDBiEOG091G0JHU
PhylomeDBiQ9QZE7
TreeFamiTF323633

Family and domain databases

Gene3Di1.20.58.190, 1 hit
1.20.58.200, 1 hit
InterProiView protein in InterPro
IPR016069 Translin_C
IPR002848 Translin_fam
IPR016068 Translin_N
IPR036081 Translin_sf
PANTHERiPTHR10741 PTHR10741, 1 hit
PfamiView protein in Pfam
PF01997 Translin, 1 hit
SUPFAMiSSF74784 SSF74784, 1 hit

Sequencei

Sequence statusi: Complete.

Q9QZE7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNGKEGPGGF RKRKHDTFPH NQRREGKDAS LSSPVMLAFK SFQQELDARH
60 70 80 90 100
DKYERLVKLS RDITVESKRT IFLLHRITSA PDMEEILTES ESKLDGVRQK
110 120 130 140 150
ILQVAQELSG EDMHQFHRAV TTGLQEYVEA VSFQHFIKTR SLISMEEINK
160 170 180 190 200
QLTFTAEDSG KESKTPPAEG QEKQLVTWRL KLTPVDYLLG VADLTGELMR
210 220 230 240 250
MCINSVGNGD IDTPFEVSQF LRQVYDGFSF IGNTGPYEVS KKLYTLKQSL
260 270 280 290
AKVENACYAL KVRGSEIPKH MLADVFSVKT DMIDQEESIS
Length:290
Mass (Da):32,926
Last modified:May 1, 2000 - v1
Checksum:i62038133C46B7952
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF187040 mRNA Translation: AAF05529.1
AK030407 mRNA Translation: BAC26948.1
AK146339 mRNA Translation: BAE27093.1
BC004611 mRNA Translation: AAH04611.1
CCDSiCCDS22778.1
RefSeqiNP_058605.1, NM_016909.2
UniGeneiMm.458292
Mm.472734
Mm.5248

Genome annotation databases

EnsembliENSMUST00000075896; ENSMUSP00000075290; ENSMUSG00000056820
GeneIDi53424
KEGGimmu:53424
UCSCiuc009nxz.1 mouse

Similar proteinsi

Entry informationi

Entry nameiTSNAX_MOUSE
AccessioniPrimary (citable) accession number: Q9QZE7
Secondary accession number(s): Q3UJR2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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