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Q9QZE5

- COPG1_MOUSE

UniProt

Q9QZE5 - COPG1_MOUSE

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Protein
Coatomer subunit gamma-1
Gene
Copg1, Copg
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors By similarity. Required for limiting lipid storage in lipid droplets. Involved in lipid homeostasis by regulating the presence of perilipin family members PLIN2 and PLIN3 at the lipid droplet surface and promoting the association of adipocyte triglyceride lipase (PNPLA2) with the lipid droplet surface to mediate lipolysis.1 Publication

GO - Molecular functioni

  1. structural molecule activity Source: InterPro

GO - Biological processi

  1. establishment of Golgi localization Source: Ensembl
  2. intracellular protein transport Source: InterPro
  3. organelle transport along microtubule Source: Ensembl
  4. vesicle-mediated transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiREACT_227904. COPI Mediated Transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Coatomer subunit gamma-1
Alternative name(s):
Gamma-1-coat protein
Short name:
Gamma-1-COP
Gene namesi
Name:Copg1
Synonyms:Copg
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:1858696. Copg1.

Subcellular locationi

Cytoplasmcytosol. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicleCOPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side By similarity
Note: The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it By similarity. Predominantly located in the cis-Golgi apparatus By similarity.1 Publication

GO - Cellular componenti

  1. COPI vesicle coat Source: InterPro
  2. cytosol Source: UniProtKB-SubCell
  3. nucleus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 874874Coatomer subunit gamma-1
PRO_0000304939Add
BLAST

Proteomic databases

MaxQBiQ9QZE5.
PaxDbiQ9QZE5.
PRIDEiQ9QZE5.

PTM databases

PhosphoSiteiQ9QZE5.

Expressioni

Gene expression databases

ArrayExpressiQ9QZE5.
BgeeiQ9QZE5.
CleanExiMM_COPG.
GenevestigatoriQ9QZE5.

Interactioni

Subunit structurei

Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits. Interacts with ZNF289/ARFGAP2 through its C-terminal appendage domain By similarity. Interacts with EGFR upon EGF treatment; interaction is essential for regulation of EGF-dependent nuclear transport of EGFR by retrograde trafficking from the Golgi to the ER By similarity. Interacts with COPB1 By similarity. Interacts with TMED10 (via C-terminus). Interacts with TMED2, TMED3, TMED7 and TMED9 By similarity.

Protein-protein interaction databases

BioGridi207587. 1 interaction.
IntActiQ9QZE5. 1 interaction.
MINTiMINT-1865908.

Structurei

3D structure databases

ProteinModelPortaliQ9QZE5.
SMRiQ9QZE5. Positions 20-311, 604-874.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati64 – 10138HEAT 1
Add
BLAST
Repeati283 – 32038HEAT 2
Add
BLAST
Repeati322 – 35534HEAT 3
Add
BLAST
Repeati356 – 39237HEAT 4
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni609 – 874266Interaction with ZNF289/ARFGAP2 By similarity
Add
BLAST

Sequence similaritiesi

Belongs to the COPG family.
Contains 4 HEAT repeats.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5240.
GeneTreeiENSGT00390000016313.
HOGENOMiHOG000184434.
HOVERGENiHBG004368.
InParanoidiQ922C6.
KOiK17267.
OMAiEFHGLGP.
OrthoDBiEOG75XGK5.
PhylomeDBiQ9QZE5.
TreeFamiTF300324.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
2.60.40.1480. 1 hit.
3.30.310.30. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR002553. Clathrin/coatomer_adapt-like_N.
IPR015873. Clathrin_a/coatomer_app_sub_C.
IPR009028. Coatomer/calthrin_app_sub_C.
IPR013041. Coatomer/clathrin_app_Ig-like.
IPR017106. Coatomer_gsu.
IPR013040. Coatomer_gsu_app_Ig-like-sub.
[Graphical view]
PANTHERiPTHR10261. PTHR10261. 1 hit.
PfamiPF01602. Adaptin_N. 1 hit.
PF08752. COP-gamma_platf. 1 hit.
[Graphical view]
PIRSFiPIRSF037093. Coatomer_gamma_subunit. 1 hit.
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF49348. SSF49348. 1 hit.
SSF55711. SSF55711. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9QZE5-1 [UniParc]FASTAAdd to Basket

« Hide

MLKKFDKKDE ESGGGSNPLQ HLEKSAVLQE ARVFNETPIN PRKCAHILTK    50
ILYLINQGEH LGTTEATEAF FAMTKLFQSN DPTLRRMCYL TIKEMSCIAE 100
DVIIVTSSLT KDMTGKEDNY RGPAVRALCQ ITDSTMLQAV ERYMKQAIVD 150
KVPSVSSSAL VSSLHLLKCS FDVVKRWVNE AQEAASSDNI MVQYHALGLL 200
YHVRKNDRLA VSKMISKFTR HGLKSPFAYC MMIRVASKQL EEEDGSRDSP 250
LFDFIESCLR NKHEMVVYEA ASAIVNLPGC SAKELAPAVS VLQLFCSSPK 300
AALRYAAVRT LNKVAMKHPS AVTACNLDLE NLVTDSNRSI ATLAITTLLK 350
TGSESSIDRL MKQISSFMSE ISDEFKVVVV QAISALCQKY PRKHAVLMNF 400
LFTMLREEGG FEYKRAIVDC IISIIEENSE SKETGLSHLC EFIEDCEFTV 450
LATRILHLLG QEGPKTNNPS KYIRFIYNRV VLEHEEVRAG AVSALAKFGA 500
QNEEMLPSIL VLLKRCVMDD DNEVRDRATF YLNVLEQKQK ALNAGYILNG 550
LTVSIPGLEK ALQQYTLEPS EKPFDLKSVP LATTPMAEQR PESTATAAVK 600
QPEKVAATRQ EIFQEQLAAV PEFQGLGPLF KSSPEPVALT ESETEYVIRC 650
TKHTFSDHLV FQFDCTNTLN DQTLENVTVQ MEPTEAYEVL SYVPARSLPY 700
NQPGTCYTLV ALPTEDPTAV ACTFSCVMKF TVKDCDPNTG EIDEEGYEDE 750
YVLEDLEVTV ADHIQKVMKV NFEAAWDEVG DEFEKEETFT LSTIKTLEEA 800
VGNIVKFLGM HPCERSDKVP ENKNTHTLLL AGVFRGGHDI LVRSRLLLLD 850
TVTMQVTARS SEELPVDIIL ASVG 874
Length:874
Mass (Da):97,513
Last modified:May 1, 2000 - v1
Checksum:iCAF3201AD1118728
GO

Sequence cautioni

The sequence BAC36811.1 differs from that shown. Reason: Frameshift at position 864.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti811 – 8111H → P in AAH24896. 1 Publication
Sequence conflicti841 – 8411L → F in BAE31753. 1 Publication
Sequence conflicti841 – 8411L → F in BAE30713. 1 Publication
Sequence conflicti841 – 8411L → F in BAE30269. 1 Publication
Sequence conflicti843 – 8431R → H in BAC36811. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF187079 mRNA. Translation: AAF01325.1.
AK049417 mRNA. Translation: BAC33743.1.
AK077461 mRNA. Translation: BAC36811.1. Frameshift.
AK147895 mRNA. Translation: BAE28212.1.
AK151284 mRNA. Translation: BAE30269.1.
AK151816 mRNA. Translation: BAE30713.1.
AK153142 mRNA. Translation: BAE31753.1.
AK164280 mRNA. Translation: BAE37716.1.
AK169256 mRNA. Translation: BAE41019.1.
AK171950 mRNA. Translation: BAE42743.1.
AK172519 mRNA. Translation: BAE43046.1.
BC008553 mRNA. Translation: AAH08553.1.
BC024686 mRNA. Translation: AAH24686.1.
BC024896 mRNA. Translation: AAH24896.1.
CCDSiCCDS39549.1.
RefSeqiNP_059505.1. NM_017477.2.
UniGeneiMm.258785.

Genome annotation databases

EnsembliENSMUST00000113607; ENSMUSP00000109237; ENSMUSG00000030058.
GeneIDi54161.
KEGGimmu:54161.
UCSCiuc009cug.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF187079 mRNA. Translation: AAF01325.1 .
AK049417 mRNA. Translation: BAC33743.1 .
AK077461 mRNA. Translation: BAC36811.1 . Frameshift.
AK147895 mRNA. Translation: BAE28212.1 .
AK151284 mRNA. Translation: BAE30269.1 .
AK151816 mRNA. Translation: BAE30713.1 .
AK153142 mRNA. Translation: BAE31753.1 .
AK164280 mRNA. Translation: BAE37716.1 .
AK169256 mRNA. Translation: BAE41019.1 .
AK171950 mRNA. Translation: BAE42743.1 .
AK172519 mRNA. Translation: BAE43046.1 .
BC008553 mRNA. Translation: AAH08553.1 .
BC024686 mRNA. Translation: AAH24686.1 .
BC024896 mRNA. Translation: AAH24896.1 .
CCDSi CCDS39549.1.
RefSeqi NP_059505.1. NM_017477.2.
UniGenei Mm.258785.

3D structure databases

ProteinModelPortali Q9QZE5.
SMRi Q9QZE5. Positions 20-311, 604-874.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 207587. 1 interaction.
IntActi Q9QZE5. 1 interaction.
MINTi MINT-1865908.

PTM databases

PhosphoSitei Q9QZE5.

Proteomic databases

MaxQBi Q9QZE5.
PaxDbi Q9QZE5.
PRIDEi Q9QZE5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000113607 ; ENSMUSP00000109237 ; ENSMUSG00000030058 .
GeneIDi 54161.
KEGGi mmu:54161.
UCSCi uc009cug.1. mouse.

Organism-specific databases

CTDi 22820.
MGIi MGI:1858696. Copg1.

Phylogenomic databases

eggNOGi COG5240.
GeneTreei ENSGT00390000016313.
HOGENOMi HOG000184434.
HOVERGENi HBG004368.
InParanoidi Q922C6.
KOi K17267.
OMAi EFHGLGP.
OrthoDBi EOG75XGK5.
PhylomeDBi Q9QZE5.
TreeFami TF300324.

Enzyme and pathway databases

Reactomei REACT_227904. COPI Mediated Transport.

Miscellaneous databases

ChiTaRSi COPG1. mouse.
NextBioi 311004.
PROi Q9QZE5.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9QZE5.
Bgeei Q9QZE5.
CleanExi MM_COPG.
Genevestigatori Q9QZE5.

Family and domain databases

Gene3Di 1.25.10.10. 1 hit.
2.60.40.1480. 1 hit.
3.30.310.30. 1 hit.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR002553. Clathrin/coatomer_adapt-like_N.
IPR015873. Clathrin_a/coatomer_app_sub_C.
IPR009028. Coatomer/calthrin_app_sub_C.
IPR013041. Coatomer/clathrin_app_Ig-like.
IPR017106. Coatomer_gsu.
IPR013040. Coatomer_gsu_app_Ig-like-sub.
[Graphical view ]
PANTHERi PTHR10261. PTHR10261. 1 hit.
Pfami PF01602. Adaptin_N. 1 hit.
PF08752. COP-gamma_platf. 1 hit.
[Graphical view ]
PIRSFi PIRSF037093. Coatomer_gamma_subunit. 1 hit.
SUPFAMi SSF48371. SSF48371. 1 hit.
SSF49348. SSF49348. 1 hit.
SSF55711. SSF55711. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Duplication of genes encoding non-clathrin coat protein gamma-COP in vertebrate, insect and plant evolution."
    Hahn Y., Lee Y.J., Yun J.H., Yang S.K., Park C.W., Mita K., Huh T.-L., Rhee M., Chung J.H.
    FEBS Lett. 482:31-36(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Bone marrow, Embryo, Kidney and Spleen.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II and FVB/N.
    Tissue: Mammary tumor and Salivary gland.
  4. Cited for: SUBCELLULAR LOCATION.
  5. Cited for: FUNCTION.

Entry informationi

Entry nameiCOPG1_MOUSE
AccessioniPrimary (citable) accession number: Q9QZE5
Secondary accession number(s): Q3U9F4
, Q8BP96, Q8R1A7, Q922C6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: May 1, 2000
Last modified: September 3, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi