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Q9QZE5

- COPG1_MOUSE

UniProt

Q9QZE5 - COPG1_MOUSE

Protein

Coatomer subunit gamma-1

Gene

Copg1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors By similarity. Required for limiting lipid storage in lipid droplets. Involved in lipid homeostasis by regulating the presence of perilipin family members PLIN2 and PLIN3 at the lipid droplet surface and promoting the association of adipocyte triglyceride lipase (PNPLA2) with the lipid droplet surface to mediate lipolysis.By similarity1 Publication

    GO - Molecular functioni

    1. structural molecule activity Source: InterPro

    GO - Biological processi

    1. establishment of Golgi localization Source: Ensembl
    2. intracellular protein transport Source: InterPro
    3. organelle transport along microtubule Source: Ensembl
    4. vesicle-mediated transport Source: UniProtKB-KW

    Keywords - Biological processi

    ER-Golgi transport, Protein transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_227904. COPI Mediated Transport.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Coatomer subunit gamma-1
    Alternative name(s):
    Gamma-1-coat protein
    Short name:
    Gamma-1-COP
    Gene namesi
    Name:Copg1
    Synonyms:Copg
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:1858696. Copg1.

    Subcellular locationi

    Cytoplasmcytosol 1 Publication. Golgi apparatus membrane 1 Publication; Peripheral membrane protein 1 Publication; Cytoplasmic side 1 Publication. Cytoplasmic vesicleCOPI-coated vesicle membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
    Note: The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. Predominantly located in the cis-Golgi apparatus.By similarity

    GO - Cellular componenti

    1. COPI vesicle coat Source: InterPro
    2. cytosol Source: UniProtKB-SubCell
    3. nucleus Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 874874Coatomer subunit gamma-1PRO_0000304939Add
    BLAST

    Proteomic databases

    MaxQBiQ9QZE5.
    PaxDbiQ9QZE5.
    PRIDEiQ9QZE5.

    PTM databases

    PhosphoSiteiQ9QZE5.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9QZE5.
    BgeeiQ9QZE5.
    CleanExiMM_COPG.
    GenevestigatoriQ9QZE5.

    Interactioni

    Subunit structurei

    Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits. Interacts with ZNF289/ARFGAP2 through its C-terminal appendage domain By similarity. Interacts with EGFR upon EGF treatment; interaction is essential for regulation of EGF-dependent nuclear transport of EGFR by retrograde trafficking from the Golgi to the ER By similarity. Interacts with COPB1 By similarity. Interacts with TMED10 (via C-terminus). Interacts with TMED2, TMED3, TMED7 and TMED9 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi207587. 1 interaction.
    IntActiQ9QZE5. 1 interaction.
    MINTiMINT-1865908.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9QZE5.
    SMRiQ9QZE5. Positions 20-311, 604-874.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati64 – 10138HEAT 1Add
    BLAST
    Repeati283 – 32038HEAT 2Add
    BLAST
    Repeati322 – 35534HEAT 3Add
    BLAST
    Repeati356 – 39237HEAT 4Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni609 – 874266Interaction with ZNF289/ARFGAP2By similarityAdd
    BLAST

    Sequence similaritiesi

    Belongs to the COPG family.Curated
    Contains 4 HEAT repeats.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG5240.
    GeneTreeiENSGT00390000016313.
    HOGENOMiHOG000184434.
    HOVERGENiHBG004368.
    InParanoidiQ922C6.
    KOiK17267.
    OMAiEFHGLGP.
    OrthoDBiEOG75XGK5.
    PhylomeDBiQ9QZE5.
    TreeFamiTF300324.

    Family and domain databases

    Gene3Di1.25.10.10. 1 hit.
    2.60.40.1480. 1 hit.
    3.30.310.30. 1 hit.
    InterProiIPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR002553. Clathrin/coatomer_adapt-like_N.
    IPR015873. Clathrin_a/coatomer_app_sub_C.
    IPR009028. Coatomer/calthrin_app_sub_C.
    IPR013041. Coatomer/clathrin_app_Ig-like.
    IPR017106. Coatomer_gsu.
    IPR013040. Coatomer_gsu_app_Ig-like-sub.
    [Graphical view]
    PANTHERiPTHR10261. PTHR10261. 1 hit.
    PfamiPF01602. Adaptin_N. 1 hit.
    PF08752. COP-gamma_platf. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037093. Coatomer_gamma_subunit. 1 hit.
    SUPFAMiSSF48371. SSF48371. 1 hit.
    SSF49348. SSF49348. 1 hit.
    SSF55711. SSF55711. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9QZE5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLKKFDKKDE ESGGGSNPLQ HLEKSAVLQE ARVFNETPIN PRKCAHILTK    50
    ILYLINQGEH LGTTEATEAF FAMTKLFQSN DPTLRRMCYL TIKEMSCIAE 100
    DVIIVTSSLT KDMTGKEDNY RGPAVRALCQ ITDSTMLQAV ERYMKQAIVD 150
    KVPSVSSSAL VSSLHLLKCS FDVVKRWVNE AQEAASSDNI MVQYHALGLL 200
    YHVRKNDRLA VSKMISKFTR HGLKSPFAYC MMIRVASKQL EEEDGSRDSP 250
    LFDFIESCLR NKHEMVVYEA ASAIVNLPGC SAKELAPAVS VLQLFCSSPK 300
    AALRYAAVRT LNKVAMKHPS AVTACNLDLE NLVTDSNRSI ATLAITTLLK 350
    TGSESSIDRL MKQISSFMSE ISDEFKVVVV QAISALCQKY PRKHAVLMNF 400
    LFTMLREEGG FEYKRAIVDC IISIIEENSE SKETGLSHLC EFIEDCEFTV 450
    LATRILHLLG QEGPKTNNPS KYIRFIYNRV VLEHEEVRAG AVSALAKFGA 500
    QNEEMLPSIL VLLKRCVMDD DNEVRDRATF YLNVLEQKQK ALNAGYILNG 550
    LTVSIPGLEK ALQQYTLEPS EKPFDLKSVP LATTPMAEQR PESTATAAVK 600
    QPEKVAATRQ EIFQEQLAAV PEFQGLGPLF KSSPEPVALT ESETEYVIRC 650
    TKHTFSDHLV FQFDCTNTLN DQTLENVTVQ MEPTEAYEVL SYVPARSLPY 700
    NQPGTCYTLV ALPTEDPTAV ACTFSCVMKF TVKDCDPNTG EIDEEGYEDE 750
    YVLEDLEVTV ADHIQKVMKV NFEAAWDEVG DEFEKEETFT LSTIKTLEEA 800
    VGNIVKFLGM HPCERSDKVP ENKNTHTLLL AGVFRGGHDI LVRSRLLLLD 850
    TVTMQVTARS SEELPVDIIL ASVG 874
    Length:874
    Mass (Da):97,513
    Last modified:May 1, 2000 - v1
    Checksum:iCAF3201AD1118728
    GO

    Sequence cautioni

    The sequence BAC36811.1 differs from that shown. Reason: Frameshift at position 864.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti811 – 8111H → P in AAH24896. (PubMed:15489334)Curated
    Sequence conflicti841 – 8411L → F in BAE31753. (PubMed:16141072)Curated
    Sequence conflicti841 – 8411L → F in BAE30713. (PubMed:16141072)Curated
    Sequence conflicti841 – 8411L → F in BAE30269. (PubMed:16141072)Curated
    Sequence conflicti843 – 8431R → H in BAC36811. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF187079 mRNA. Translation: AAF01325.1.
    AK049417 mRNA. Translation: BAC33743.1.
    AK077461 mRNA. Translation: BAC36811.1. Frameshift.
    AK147895 mRNA. Translation: BAE28212.1.
    AK151284 mRNA. Translation: BAE30269.1.
    AK151816 mRNA. Translation: BAE30713.1.
    AK153142 mRNA. Translation: BAE31753.1.
    AK164280 mRNA. Translation: BAE37716.1.
    AK169256 mRNA. Translation: BAE41019.1.
    AK171950 mRNA. Translation: BAE42743.1.
    AK172519 mRNA. Translation: BAE43046.1.
    BC008553 mRNA. Translation: AAH08553.1.
    BC024686 mRNA. Translation: AAH24686.1.
    BC024896 mRNA. Translation: AAH24896.1.
    CCDSiCCDS39549.1.
    RefSeqiNP_059505.1. NM_017477.2.
    UniGeneiMm.258785.

    Genome annotation databases

    EnsembliENSMUST00000113607; ENSMUSP00000109237; ENSMUSG00000030058.
    GeneIDi54161.
    KEGGimmu:54161.
    UCSCiuc009cug.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF187079 mRNA. Translation: AAF01325.1 .
    AK049417 mRNA. Translation: BAC33743.1 .
    AK077461 mRNA. Translation: BAC36811.1 . Frameshift.
    AK147895 mRNA. Translation: BAE28212.1 .
    AK151284 mRNA. Translation: BAE30269.1 .
    AK151816 mRNA. Translation: BAE30713.1 .
    AK153142 mRNA. Translation: BAE31753.1 .
    AK164280 mRNA. Translation: BAE37716.1 .
    AK169256 mRNA. Translation: BAE41019.1 .
    AK171950 mRNA. Translation: BAE42743.1 .
    AK172519 mRNA. Translation: BAE43046.1 .
    BC008553 mRNA. Translation: AAH08553.1 .
    BC024686 mRNA. Translation: AAH24686.1 .
    BC024896 mRNA. Translation: AAH24896.1 .
    CCDSi CCDS39549.1.
    RefSeqi NP_059505.1. NM_017477.2.
    UniGenei Mm.258785.

    3D structure databases

    ProteinModelPortali Q9QZE5.
    SMRi Q9QZE5. Positions 20-311, 604-874.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 207587. 1 interaction.
    IntActi Q9QZE5. 1 interaction.
    MINTi MINT-1865908.

    PTM databases

    PhosphoSitei Q9QZE5.

    Proteomic databases

    MaxQBi Q9QZE5.
    PaxDbi Q9QZE5.
    PRIDEi Q9QZE5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000113607 ; ENSMUSP00000109237 ; ENSMUSG00000030058 .
    GeneIDi 54161.
    KEGGi mmu:54161.
    UCSCi uc009cug.1. mouse.

    Organism-specific databases

    CTDi 22820.
    MGIi MGI:1858696. Copg1.

    Phylogenomic databases

    eggNOGi COG5240.
    GeneTreei ENSGT00390000016313.
    HOGENOMi HOG000184434.
    HOVERGENi HBG004368.
    InParanoidi Q922C6.
    KOi K17267.
    OMAi EFHGLGP.
    OrthoDBi EOG75XGK5.
    PhylomeDBi Q9QZE5.
    TreeFami TF300324.

    Enzyme and pathway databases

    Reactomei REACT_227904. COPI Mediated Transport.

    Miscellaneous databases

    ChiTaRSi COPG1. mouse.
    NextBioi 311004.
    PROi Q9QZE5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9QZE5.
    Bgeei Q9QZE5.
    CleanExi MM_COPG.
    Genevestigatori Q9QZE5.

    Family and domain databases

    Gene3Di 1.25.10.10. 1 hit.
    2.60.40.1480. 1 hit.
    3.30.310.30. 1 hit.
    InterProi IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR002553. Clathrin/coatomer_adapt-like_N.
    IPR015873. Clathrin_a/coatomer_app_sub_C.
    IPR009028. Coatomer/calthrin_app_sub_C.
    IPR013041. Coatomer/clathrin_app_Ig-like.
    IPR017106. Coatomer_gsu.
    IPR013040. Coatomer_gsu_app_Ig-like-sub.
    [Graphical view ]
    PANTHERi PTHR10261. PTHR10261. 1 hit.
    Pfami PF01602. Adaptin_N. 1 hit.
    PF08752. COP-gamma_platf. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037093. Coatomer_gamma_subunit. 1 hit.
    SUPFAMi SSF48371. SSF48371. 1 hit.
    SSF49348. SSF49348. 1 hit.
    SSF55711. SSF55711. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Duplication of genes encoding non-clathrin coat protein gamma-COP in vertebrate, insect and plant evolution."
      Hahn Y., Lee Y.J., Yun J.H., Yang S.K., Park C.W., Mita K., Huh T.-L., Rhee M., Chung J.H.
      FEBS Lett. 482:31-36(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and NOD.
      Tissue: Bone marrow, Embryo, Kidney and Spleen.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Czech II and FVB/N.
      Tissue: Mammary tumor and Salivary gland.
    4. Cited for: SUBCELLULAR LOCATION.
    5. Cited for: FUNCTION.

    Entry informationi

    Entry nameiCOPG1_MOUSE
    AccessioniPrimary (citable) accession number: Q9QZE5
    Secondary accession number(s): Q3U9F4
    , Q8BP96, Q8R1A7, Q922C6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 2, 2007
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3