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Q9QZD8 (DIC_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mitochondrial dicarboxylate carrier
Alternative name(s):
Solute carrier family 25 member 10
Gene names
Name:Slc25a10
Synonyms:Dic
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length287 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in translocation of malonate, malate and succinate in exchange for phosphate, sulfate, sulfite or thiosulfate across mitochondrial inner membrane.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Tissue specificity

Expressed at very high levels in white adipocytes.

Sequence similarities

Belongs to the mitochondrial carrier (TC 2.A.29) family. [View classification]

Contains 3 Solcar repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 287287Mitochondrial dicarboxylate carrier
PRO_0000090610

Regions

Transmembrane9 – 2921Helical; Name=1; Potential
Transmembrane62 – 8120Helical; Name=2; Potential
Transmembrane102 – 12221Helical; Name=3; Potential
Transmembrane162 – 18120Helical; Name=4; Potential
Transmembrane202 – 22221Helical; Name=5; Potential
Transmembrane254 – 27421Helical; Name=6; Potential
Repeat7 – 8781Solcar 1
Repeat100 – 18788Solcar 2
Repeat196 – 27984Solcar 3

Amino acid modifications

Modified residue1581N6-acetyllysine Ref.4

Experimental info

Sequence conflict61A → T in AAF03412. Ref.1
Sequence conflict461M → L in AAF03412. Ref.1
Sequence conflict781F → L in BAB25425. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9QZD8 [UniParc].

Last modified February 11, 2002. Version 2.
Checksum: E351D1CE18E5B568

FASTA28731,715
        10         20         30         40         50         60 
MAEARASRWY FGGLASCGAA CCTHPLDLLK VHLQTQQEVK LRMTGMALQV VRTDGFLALY 

        70         80         90        100        110        120 
NGLSASLCRQ MTYSLTRFAI YETMRDYMTK DSQGPLPFYN KVLLGGISGL TGGFVGTPAD 

       130        140        150        160        170        180 
LVNVRMQNDM KLPPSQRRNY SHALDGLYRV AREESLRKLF SGATMASSRG ALVTVGQLSC 

       190        200        210        220        230        240 
YDQAKQLVLS TGYLSDNIFT HFVSSFIAGG CATFLCQPLD VLKTRLMNSK GEYQGVFHCA 

       250        260        270        280 
METAKLGPQA FFKGLFPAGI RLIPHTVLTF MFLEQLRKHF GIKVPTT 

« Hide

References

« Hide 'large scale' references
[1]"Predominant expression of the mitochondrial dicarboxylate carrier in white adipose tissue."
Das K., Lewis R.Y., Combatsiaris T.P., Lin Y., Shapiro L., Charron M.J., Scherer P.E.
Biochem. J. 344:313-320(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Bone marrow, Liver and Small intestine.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways."
Rardin M.J., Newman J.C., Held J.M., Cusack M.P., Sorensen D.J., Li B., Schilling B., Mooney S.D., Kahn C.R., Verdin E., Gibson B.W.
Proc. Natl. Acad. Sci. U.S.A. 110:6601-6606(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-158, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF188712 mRNA. Translation: AAF03412.1.
AK008038 mRNA. Translation: BAB25425.1.
AK050282 mRNA. Translation: BAC34165.1.
AK151645 mRNA. Translation: BAE30575.1.
BC003222 mRNA. Translation: AAH03222.1.
RefSeqNP_038798.2. NM_013770.2.
UniGeneMm.3991.

3D structure databases

ProteinModelPortalQ9QZD8.
SMRQ9QZD8. Positions 12-278.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ9QZD8. 3 interactions.
MINTMINT-1845114.
STRING10090.ENSMUSP00000026899.

PTM databases

PhosphoSiteQ9QZD8.

Proteomic databases

PaxDbQ9QZD8.
PRIDEQ9QZD8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000026899; ENSMUSP00000026899; ENSMUSG00000025792.
GeneID27376.
KEGGmmu:27376.
UCSCuc007mtb.2. mouse.

Organism-specific databases

CTD1468.
MGIMGI:1353497. Slc25a10.

Phylogenomic databases

eggNOGNOG300113.
GeneTreeENSGT00750000117384.
HOGENOMHOG000165139.
HOVERGENHBG009528.
InParanoidQ9QZD8.
KOK13577.
OMAFIPAWAR.
OrthoDBEOG793B7Z.
PhylomeDBQ9QZD8.
TreeFamTF312920.

Gene expression databases

BgeeQ9QZD8.
GenevestigatorQ9QZD8.

Family and domain databases

Gene3D1.50.40.10. 1 hit.
InterProIPR002030. Mit_uncoupling.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSPR00784. MTUNCOUPLING.
SUPFAMSSF103506. SSF103506. 1 hit.
PROSITEPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSLC25A10. mouse.
NextBio305296.
PROQ9QZD8.
SOURCESearch...

Entry information

Entry nameDIC_MOUSE
AccessionPrimary (citable) accession number: Q9QZD8
Secondary accession number(s): Q543J6, Q99LJ9, Q9D8G8
Entry history
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: February 11, 2002
Last modified: April 16, 2014
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot