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Protein

Mitochondrial dicarboxylate carrier

Gene

Slc25a10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in translocation of malonate, malate and succinate in exchange for phosphate, sulfate, sulfite or thiosulfate across mitochondrial inner membrane.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiREACT_273024. Sulfide oxidation to sulfate.
REACT_280974. Organic anion transporters.
REACT_308431. Gluconeogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial dicarboxylate carrier
Alternative name(s):
Solute carrier family 25 member 10
Gene namesi
Name:Slc25a10
Synonyms:Dic
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1353497. Slc25a10.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei9 – 2921Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei62 – 8120Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei102 – 12221Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei162 – 18120Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei202 – 22221Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei254 – 27421Helical; Name=6Sequence AnalysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: MGI
  • mitochondrion Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 287287Mitochondrial dicarboxylate carrierPRO_0000090610Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei158 – 1581N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9QZD8.
PaxDbiQ9QZD8.
PRIDEiQ9QZD8.

PTM databases

PhosphoSiteiQ9QZD8.

Expressioni

Tissue specificityi

Expressed at very high levels in white adipocytes.

Gene expression databases

BgeeiQ9QZD8.
GenevisibleiQ9QZD8. MM.

Interactioni

Protein-protein interaction databases

BioGridi205183. 1 interaction.
IntActiQ9QZD8. 3 interactions.
MINTiMINT-1845114.
STRINGi10090.ENSMUSP00000026899.

Structurei

3D structure databases

ProteinModelPortaliQ9QZD8.
SMRiQ9QZD8. Positions 12-278.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati7 – 8781Solcar 1Add
BLAST
Repeati100 – 18788Solcar 2Add
BLAST
Repeati196 – 27984Solcar 3Add
BLAST

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG300113.
GeneTreeiENSGT00760000119170.
HOGENOMiHOG000165139.
HOVERGENiHBG009528.
InParanoidiQ9QZD8.
KOiK13577.
OMAiFIPAWAR.
OrthoDBiEOG793B7Z.
PhylomeDBiQ9QZD8.
TreeFamiTF312920.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002030. Mit_uncoupling.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00784. MTUNCOUPLING.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9QZD8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEARASRWY FGGLASCGAA CCTHPLDLLK VHLQTQQEVK LRMTGMALQV
60 70 80 90 100
VRTDGFLALY NGLSASLCRQ MTYSLTRFAI YETMRDYMTK DSQGPLPFYN
110 120 130 140 150
KVLLGGISGL TGGFVGTPAD LVNVRMQNDM KLPPSQRRNY SHALDGLYRV
160 170 180 190 200
AREESLRKLF SGATMASSRG ALVTVGQLSC YDQAKQLVLS TGYLSDNIFT
210 220 230 240 250
HFVSSFIAGG CATFLCQPLD VLKTRLMNSK GEYQGVFHCA METAKLGPQA
260 270 280
FFKGLFPAGI RLIPHTVLTF MFLEQLRKHF GIKVPTT
Length:287
Mass (Da):31,715
Last modified:February 11, 2002 - v2
Checksum:iE351D1CE18E5B568
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti6 – 61A → T in AAF03412 (PubMed:10567211).Curated
Sequence conflicti46 – 461M → L in AAF03412 (PubMed:10567211).Curated
Sequence conflicti78 – 781F → L in BAB25425 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF188712 mRNA. Translation: AAF03412.1.
AK008038 mRNA. Translation: BAB25425.1.
AK050282 mRNA. Translation: BAC34165.1.
AK151645 mRNA. Translation: BAE30575.1.
BC003222 mRNA. Translation: AAH03222.1.
CCDSiCCDS25738.1.
RefSeqiNP_038798.2. NM_013770.2.
UniGeneiMm.3991.

Genome annotation databases

EnsembliENSMUST00000026899; ENSMUSP00000026899; ENSMUSG00000025792.
GeneIDi27376.
KEGGimmu:27376.
UCSCiuc007mtb.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF188712 mRNA. Translation: AAF03412.1.
AK008038 mRNA. Translation: BAB25425.1.
AK050282 mRNA. Translation: BAC34165.1.
AK151645 mRNA. Translation: BAE30575.1.
BC003222 mRNA. Translation: AAH03222.1.
CCDSiCCDS25738.1.
RefSeqiNP_038798.2. NM_013770.2.
UniGeneiMm.3991.

3D structure databases

ProteinModelPortaliQ9QZD8.
SMRiQ9QZD8. Positions 12-278.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi205183. 1 interaction.
IntActiQ9QZD8. 3 interactions.
MINTiMINT-1845114.
STRINGi10090.ENSMUSP00000026899.

PTM databases

PhosphoSiteiQ9QZD8.

Proteomic databases

MaxQBiQ9QZD8.
PaxDbiQ9QZD8.
PRIDEiQ9QZD8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026899; ENSMUSP00000026899; ENSMUSG00000025792.
GeneIDi27376.
KEGGimmu:27376.
UCSCiuc007mtb.2. mouse.

Organism-specific databases

CTDi1468.
MGIiMGI:1353497. Slc25a10.

Phylogenomic databases

eggNOGiNOG300113.
GeneTreeiENSGT00760000119170.
HOGENOMiHOG000165139.
HOVERGENiHBG009528.
InParanoidiQ9QZD8.
KOiK13577.
OMAiFIPAWAR.
OrthoDBiEOG793B7Z.
PhylomeDBiQ9QZD8.
TreeFamiTF312920.

Enzyme and pathway databases

ReactomeiREACT_273024. Sulfide oxidation to sulfate.
REACT_280974. Organic anion transporters.
REACT_308431. Gluconeogenesis.

Miscellaneous databases

ChiTaRSiSlc25a10. mouse.
NextBioi305296.
PROiQ9QZD8.
SOURCEiSearch...

Gene expression databases

BgeeiQ9QZD8.
GenevisibleiQ9QZD8. MM.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002030. Mit_uncoupling.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00784. MTUNCOUPLING.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Predominant expression of the mitochondrial dicarboxylate carrier in white adipose tissue."
    Das K., Lewis R.Y., Combatsiaris T.P., Lin Y., Shapiro L., Charron M.J., Scherer P.E.
    Biochem. J. 344:313-320(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone marrow, Liver and Small intestine.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways."
    Rardin M.J., Newman J.C., Held J.M., Cusack M.P., Sorensen D.J., Li B., Schilling B., Mooney S.D., Kahn C.R., Verdin E., Gibson B.W.
    Proc. Natl. Acad. Sci. U.S.A. 110:6601-6606(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-158, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiDIC_MOUSE
AccessioniPrimary (citable) accession number: Q9QZD8
Secondary accession number(s): Q543J6, Q99LJ9, Q9D8G8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: February 11, 2002
Last modified: June 24, 2015
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.