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Q9QZD8

- DIC_MOUSE

UniProt

Q9QZD8 - DIC_MOUSE

Protein

Mitochondrial dicarboxylate carrier

Gene

Slc25a10

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 2 (11 Feb 2002)
      Previous versions | rss
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    Functioni

    Involved in translocation of malonate, malate and succinate in exchange for phosphate, sulfate, sulfite or thiosulfate across mitochondrial inner membrane.

    GO - Molecular functioni

    1. antiporter activity Source: Ensembl
    2. malate transmembrane transporter activity Source: Ensembl
    3. phosphate ion transmembrane transporter activity Source: Ensembl
    4. secondary active transmembrane transporter activity Source: MGI
    5. succinate transmembrane transporter activity Source: Ensembl
    6. sulfate transmembrane transporter activity Source: Ensembl
    7. thiosulfate transmembrane transporter activity Source: Ensembl

    GO - Biological processi

    1. mitochondrial transport Source: MGI
    2. thiosulfate transport Source: Ensembl

    Keywords - Biological processi

    Transport

    Enzyme and pathway databases

    ReactomeiREACT_198963. Sulfide oxidation to sulfate.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitochondrial dicarboxylate carrier
    Alternative name(s):
    Solute carrier family 25 member 10
    Gene namesi
    Name:Slc25a10
    Synonyms:Dic
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:1353497. Slc25a10.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: MGI
    3. mitochondrion Source: MGI

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 287287Mitochondrial dicarboxylate carrierPRO_0000090610Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei158 – 1581N6-acetyllysine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ9QZD8.
    PaxDbiQ9QZD8.
    PRIDEiQ9QZD8.

    PTM databases

    PhosphoSiteiQ9QZD8.

    Expressioni

    Tissue specificityi

    Expressed at very high levels in white adipocytes.

    Gene expression databases

    BgeeiQ9QZD8.
    GenevestigatoriQ9QZD8.

    Interactioni

    Protein-protein interaction databases

    BioGridi205183. 1 interaction.
    IntActiQ9QZD8. 3 interactions.
    MINTiMINT-1845114.
    STRINGi10090.ENSMUSP00000026899.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9QZD8.
    SMRiQ9QZD8. Positions 12-278.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei9 – 2921Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei62 – 8120Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei102 – 12221Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei162 – 18120Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei202 – 22221Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei254 – 27421Helical; Name=6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati7 – 8781Solcar 1Add
    BLAST
    Repeati100 – 18788Solcar 2Add
    BLAST
    Repeati196 – 27984Solcar 3Add
    BLAST

    Sequence similaritiesi

    Contains 3 Solcar repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG300113.
    GeneTreeiENSGT00750000117384.
    HOGENOMiHOG000165139.
    HOVERGENiHBG009528.
    InParanoidiQ9QZD8.
    KOiK13577.
    OMAiFIPAWAR.
    OrthoDBiEOG793B7Z.
    PhylomeDBiQ9QZD8.
    TreeFamiTF312920.

    Family and domain databases

    Gene3Di1.50.40.10. 1 hit.
    InterProiIPR002030. Mit_uncoupling.
    IPR018108. Mitochondrial_sb/sol_carrier.
    IPR023395. Mt_carrier_dom.
    [Graphical view]
    PfamiPF00153. Mito_carr. 3 hits.
    [Graphical view]
    PRINTSiPR00784. MTUNCOUPLING.
    SUPFAMiSSF103506. SSF103506. 1 hit.
    PROSITEiPS50920. SOLCAR. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9QZD8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAEARASRWY FGGLASCGAA CCTHPLDLLK VHLQTQQEVK LRMTGMALQV    50
    VRTDGFLALY NGLSASLCRQ MTYSLTRFAI YETMRDYMTK DSQGPLPFYN 100
    KVLLGGISGL TGGFVGTPAD LVNVRMQNDM KLPPSQRRNY SHALDGLYRV 150
    AREESLRKLF SGATMASSRG ALVTVGQLSC YDQAKQLVLS TGYLSDNIFT 200
    HFVSSFIAGG CATFLCQPLD VLKTRLMNSK GEYQGVFHCA METAKLGPQA 250
    FFKGLFPAGI RLIPHTVLTF MFLEQLRKHF GIKVPTT 287
    Length:287
    Mass (Da):31,715
    Last modified:February 11, 2002 - v2
    Checksum:iE351D1CE18E5B568
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti6 – 61A → T in AAF03412. (PubMed:10567211)Curated
    Sequence conflicti46 – 461M → L in AAF03412. (PubMed:10567211)Curated
    Sequence conflicti78 – 781F → L in BAB25425. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF188712 mRNA. Translation: AAF03412.1.
    AK008038 mRNA. Translation: BAB25425.1.
    AK050282 mRNA. Translation: BAC34165.1.
    AK151645 mRNA. Translation: BAE30575.1.
    BC003222 mRNA. Translation: AAH03222.1.
    CCDSiCCDS25738.1.
    RefSeqiNP_038798.2. NM_013770.2.
    UniGeneiMm.3991.

    Genome annotation databases

    EnsembliENSMUST00000026899; ENSMUSP00000026899; ENSMUSG00000025792.
    GeneIDi27376.
    KEGGimmu:27376.
    UCSCiuc007mtb.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF188712 mRNA. Translation: AAF03412.1 .
    AK008038 mRNA. Translation: BAB25425.1 .
    AK050282 mRNA. Translation: BAC34165.1 .
    AK151645 mRNA. Translation: BAE30575.1 .
    BC003222 mRNA. Translation: AAH03222.1 .
    CCDSi CCDS25738.1.
    RefSeqi NP_038798.2. NM_013770.2.
    UniGenei Mm.3991.

    3D structure databases

    ProteinModelPortali Q9QZD8.
    SMRi Q9QZD8. Positions 12-278.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 205183. 1 interaction.
    IntActi Q9QZD8. 3 interactions.
    MINTi MINT-1845114.
    STRINGi 10090.ENSMUSP00000026899.

    PTM databases

    PhosphoSitei Q9QZD8.

    Proteomic databases

    MaxQBi Q9QZD8.
    PaxDbi Q9QZD8.
    PRIDEi Q9QZD8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000026899 ; ENSMUSP00000026899 ; ENSMUSG00000025792 .
    GeneIDi 27376.
    KEGGi mmu:27376.
    UCSCi uc007mtb.2. mouse.

    Organism-specific databases

    CTDi 1468.
    MGIi MGI:1353497. Slc25a10.

    Phylogenomic databases

    eggNOGi NOG300113.
    GeneTreei ENSGT00750000117384.
    HOGENOMi HOG000165139.
    HOVERGENi HBG009528.
    InParanoidi Q9QZD8.
    KOi K13577.
    OMAi FIPAWAR.
    OrthoDBi EOG793B7Z.
    PhylomeDBi Q9QZD8.
    TreeFami TF312920.

    Enzyme and pathway databases

    Reactomei REACT_198963. Sulfide oxidation to sulfate.

    Miscellaneous databases

    ChiTaRSi SLC25A10. mouse.
    NextBioi 305296.
    PROi Q9QZD8.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9QZD8.
    Genevestigatori Q9QZD8.

    Family and domain databases

    Gene3Di 1.50.40.10. 1 hit.
    InterProi IPR002030. Mit_uncoupling.
    IPR018108. Mitochondrial_sb/sol_carrier.
    IPR023395. Mt_carrier_dom.
    [Graphical view ]
    Pfami PF00153. Mito_carr. 3 hits.
    [Graphical view ]
    PRINTSi PR00784. MTUNCOUPLING.
    SUPFAMi SSF103506. SSF103506. 1 hit.
    PROSITEi PS50920. SOLCAR. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Predominant expression of the mitochondrial dicarboxylate carrier in white adipose tissue."
      Das K., Lewis R.Y., Combatsiaris T.P., Lin Y., Shapiro L., Charron M.J., Scherer P.E.
      Biochem. J. 344:313-320(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Bone marrow, Liver and Small intestine.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways."
      Rardin M.J., Newman J.C., Held J.M., Cusack M.P., Sorensen D.J., Li B., Schilling B., Mooney S.D., Kahn C.R., Verdin E., Gibson B.W.
      Proc. Natl. Acad. Sci. U.S.A. 110:6601-6606(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-158, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiDIC_MOUSE
    AccessioniPrimary (citable) accession number: Q9QZD8
    Secondary accession number(s): Q543J6, Q99LJ9, Q9D8G8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 11, 2002
    Last sequence update: February 11, 2002
    Last modified: October 1, 2014
    This is version 119 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3