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Protein
Submitted name:

Chemokine (C-X-C motif) ligand 12 (Stromal cell-derived factor 1)

Gene

Cxcl12

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • chemokine activity Source: RGD

GO - Biological processi

  • adult locomotory behavior Source: RGD
  • brain development Source: RGD
  • cell chemotaxis Source: GOC
  • cell migration Source: RGD
  • immune response Source: InterPro
  • neuron migration Source: RGD
  • organ regeneration Source: RGD
  • positive regulation of axon extension involved in axon guidance Source: RGD
  • positive regulation of cell migration Source: RGD
  • positive regulation of cell proliferation Source: RGD
  • positive regulation of dopamine secretion Source: RGD
  • positive regulation of endothelial cell proliferation Source: RGD
  • positive regulation of neuron differentiation Source: RGD
  • regulation of calcium ion transport Source: RGD
  • response to heat Source: RGD
  • response to hypoxia Source: RGD
  • response to mechanical stimulus Source: RGD
  • response to peptide hormone Source: RGD
  • response to radiation Source: RGD
  • telencephalon cell migration Source: RGD
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Chemokine (C-X-C motif) ligand 12 (Stromal cell-derived factor 1)Imported
Submitted name:
Stromal cell-derived factor 1Imported
Submitted name:
Stromal cell-derived factor-1 alphaImported
Gene namesi
Name:Cxcl12Imported
Synonyms:SDF-1Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi3651. Cxcl12.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: RGD
  • plasma membrane Source: RGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 8968Sequence analysisPRO_5007324837Add
BLAST

Interactioni

GO - Molecular functioni

  • chemokine activity Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000059574.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 8660SCYInterPro annotationAdd
BLAST

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410J1S5. Eukaryota.
ENOG4112BS6. LUCA.
HOGENOMiHOG000220915.
HOVERGENiHBG107437.

Family and domain databases

InterProiIPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9QZD1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAKVVAVLA LVLAALCISD GKPVSLSYRC PCRFFESHVA RANVKHLKIL
60 70 80
NTPNCALQIV ARLKSNNRQV CIDPKLKWIQ EYLDKALNK
Length:89
Mass (Da):9,977
Last modified:May 1, 2000 - v1
Checksum:iD86977626A2E35FA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF189724 mRNA. Translation: AAF01066.1.
AF209976 mRNA. Translation: AAG43506.1.
BC078737 mRNA. Translation: AAH78737.1.
RefSeqiNP_071513.1. NM_022177.3.
UniGeneiRn.54439.

Genome annotation databases

GeneIDi24772.
UCSCiRGD:3651. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF189724 mRNA. Translation: AAF01066.1.
AF209976 mRNA. Translation: AAG43506.1.
BC078737 mRNA. Translation: AAH78737.1.
RefSeqiNP_071513.1. NM_022177.3.
UniGeneiRn.54439.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000059574.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi24772.
UCSCiRGD:3651. rat.

Organism-specific databases

CTDi6387.
RGDi3651. Cxcl12.

Phylogenomic databases

eggNOGiENOG410J1S5. Eukaryota.
ENOG4112BS6. LUCA.
HOGENOMiHOG000220915.
HOVERGENiHBG107437.

Family and domain databases

InterProiIPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA cloning of rat stromal cell-derived factor-1 alpha (SDF-1 alpha)."
    Ohtani Y., Okada M., Kawaguchi N., Minami M., Satoh M.
    Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Sprague-DawleyImported.
  2. "Identification and molecular cloning of a novel rat ortholog of the alpha chemokine, stromal cell derived factor-1 (SDF-1)."
    Pillarisetti K., Gupta S.K.
    Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: KidneyImported.

Entry informationi

Entry nameiQ9QZD1_RAT
AccessioniPrimary (citable) accession number: Q9QZD1
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: June 8, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.