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Protein
Submitted name:

Chemokine (C-X-C motif) ligand 12 (Stromal cell-derived factor 1)

Gene

Cxcl12

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • chemokine activity Source: RGD

GO - Biological processi

  • adult locomotory behavior Source: RGD
  • brain development Source: RGD
  • cell migration Source: RGD
  • immune response Source: InterPro
  • neuron migration Source: RGD
  • organ regeneration Source: RGD
  • positive regulation of axon extension involved in axon guidance Source: RGD
  • positive regulation of cell migration Source: RGD
  • positive regulation of cell proliferation Source: RGD
  • positive regulation of dopamine secretion Source: RGD
  • positive regulation of endothelial cell proliferation Source: RGD
  • positive regulation of neuron differentiation Source: RGD
  • regulation of calcium ion transport Source: RGD
  • response to heat Source: RGD
  • response to hypoxia Source: RGD
  • response to mechanical stimulus Source: RGD
  • response to peptide hormone Source: RGD
  • response to radiation Source: RGD
  • telencephalon cell migration Source: RGD
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Chemokine (C-X-C motif) ligand 12 (Stromal cell-derived factor 1)Imported
Submitted name:
Stromal cell-derived factor 1Imported
Submitted name:
Stromal cell-derived factor-1 alphaImported
Gene namesi
Name:Cxcl12Imported
Synonyms:SDF-1Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi3651. Cxcl12.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: RGD
  • plasma membrane Source: RGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 8968Sequence analysisPRO_5007717544Add
BLAST

Expressioni

Gene expression databases

BgeeiENSRNOG00000013589.

Interactioni

GO - Molecular functioni

  • chemokine activity Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000059574.

Structurei

3D structure databases

SMRiQ9QZD1. Positions 22-89.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 8660SCYInterPro annotationAdd
BLAST

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410J1S5. Eukaryota.
ENOG4112BS6. LUCA.
HOGENOMiHOG000220915.
HOVERGENiHBG107437.
PhylomeDBiQ9QZD1.

Family and domain databases

InterProiIPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9QZD1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAKVVAVLA LVLAALCISD GKPVSLSYRC PCRFFESHVA RANVKHLKIL
60 70 80
NTPNCALQIV ARLKSNNRQV CIDPKLKWIQ EYLDKALNK
Length:89
Mass (Da):9,977
Last modified:May 1, 2000 - v1
Checksum:iD86977626A2E35FA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF189724 mRNA. Translation: AAF01066.1.
AF209976 mRNA. Translation: AAG43506.1.
BC078737 mRNA. Translation: AAH78737.1.
RefSeqiNP_071513.1. NM_022177.3.
UniGeneiRn.54439.

Genome annotation databases

GeneIDi24772.
UCSCiRGD:3651. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF189724 mRNA. Translation: AAF01066.1.
AF209976 mRNA. Translation: AAG43506.1.
BC078737 mRNA. Translation: AAH78737.1.
RefSeqiNP_071513.1. NM_022177.3.
UniGeneiRn.54439.

3D structure databases

SMRiQ9QZD1. Positions 22-89.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000059574.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi24772.
UCSCiRGD:3651. rat.

Organism-specific databases

CTDi6387.
RGDi3651. Cxcl12.

Phylogenomic databases

eggNOGiENOG410J1S5. Eukaryota.
ENOG4112BS6. LUCA.
HOGENOMiHOG000220915.
HOVERGENiHBG107437.
PhylomeDBiQ9QZD1.

Gene expression databases

BgeeiENSRNOG00000013589.

Family and domain databases

InterProiIPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ9QZD1_RAT
AccessioniPrimary (citable) accession number: Q9QZD1
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: September 7, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.