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Protein

Protein ABHD1

Gene

Abhd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei211Charge relay systemBy similarity1
Active sitei337Charge relay systemBy similarity1
Active sitei366Charge relay systemBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Serine esterase

Protein family/group databases

ESTHERimouse-abhd1 abh_upf0017

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ABHD1Curated (EC:3.1.1.-)
Alternative name(s):
Alpha/beta hydrolase domain-containing protein 1Curated
Short name:
Abhydrolase domain-containing protein 1Imported
Lung alpha/beta hydrolase 1
Short name:
MmLABH1
Gene namesi
Name:Abhd1Imported
Synonyms:Labh1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1931013 Abhd1

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei25 – 45Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002802051 – 412Protein ABHD1Add BLAST412

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi18N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9QZC8
PeptideAtlasiQ9QZC8
PRIDEiQ9QZC8

PTM databases

PhosphoSitePlusiQ9QZC8
SwissPalmiQ9QZC8

Expressioni

Tissue specificityi

Widely expressed with higher expression in liver.1 Publication

Developmental stagei

Detected in embryos from E7 to E17.1 Publication

Gene expression databases

CleanExiMM_ABHD1

Interactioni

Protein-protein interaction databases

IntActiQ9QZC8, 1 interactor
MINTiQ9QZC8

Structurei

3D structure databases

ProteinModelPortaliQ9QZC8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini131 – 372AB hydrolase-1Sequence analysisAdd BLAST242

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG053994
InParanoidiQ9QZC8
KOiK13696
PhylomeDBiQ9QZC8

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR000073 AB_hydrolase_1
IPR012020 ABHD4
PfamiView protein in Pfam
PF00561 Abhydrolase_1, 1 hit
PIRSFiPIRSF005211 Ab_hydro_YheT, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit

Sequencei

Sequence statusi: Complete.

Q9QZC8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEYPYTTKML SSSLSPQNGT WSDTISLLLA LGVALYLGYY WACVPQRPRL
60 70 80 90 100
VAGPQFLAFL EQHCPVTVET FYPTLWCFEG RLQTIFRVLL QSQPVVPYRS
110 120 130 140 150
EVLQTPDGGQ FLLDWAEQPN STHYPDPTTQ PIVLLLPGIS GSSQEPYILH
160 170 180 190 200
LVNQALKDGY RAVVFNNRGC RGEELLTHRA YCASNTEDLE TVVKHIKRRY
210 220 230 240 250
SQAPLLAVGI SFGGILVLNY LAQTGKAGGL VAGLTMSACW DSFETVDSLE
260 270 280 290 300
TPLNSLLFNQ PLTAGLCRLV ARNRKPIEKV LDVDFAIKAR TIRQLDERYT
310 320 330 340 350
SVAFGYKDCA AYYQAASPRT KVDAIHTPVL CLNAADDPFS PVHAFPLQAA
360 370 380 390 400
QKSPYVALLI TARGGHIGFL EGLMPWQHCY MNRVLHQYAR AIFQHSVGLP
410
DLGVLTPEDG KS
Length:412
Mass (Da):45,725
Last modified:June 1, 2001 - v2
Checksum:i22C8C41ECCBB9213
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF189764 mRNA Translation: AAF01068.2
AK156413 mRNA Translation: BAE33704.1
BC013505 mRNA Translation: AAH13505.1
RefSeqiNP_067279.2, NM_021304.3
UniGeneiMm.389615

Genome annotation databases

GeneIDi57742
KEGGimmu:57742
UCSCiuc008wwp.1 mouse

Similar proteinsi

Entry informationi

Entry nameiABHD1_MOUSE
AccessioniPrimary (citable) accession number: Q9QZC8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 106 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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