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Protein

Protein ABHD1

Gene

Abhd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei211 – 2111Charge relay systemBy similarity
Active sitei337 – 3371Charge relay systemBy similarity
Active sitei366 – 3661Charge relay systemBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Serine esterase

Protein family/group databases

ESTHERimouse-abhd1. abh_upf0017.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ABHD1Curated (EC:3.1.1.-)
Alternative name(s):
Alpha/beta hydrolase domain-containing protein 1Curated
Short name:
Abhydrolase domain-containing protein 1Imported
Lung alpha/beta hydrolase 1
Short name:
MmLABH1
Gene namesi
Name:Abhd1Imported
Synonyms:Labh1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1931013. Abhd1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei25 – 4521Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 412412Protein ABHD1PRO_0000280205Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi18 – 181N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9QZC8.
PeptideAtlasiQ9QZC8.
PRIDEiQ9QZC8.

PTM databases

PhosphoSiteiQ9QZC8.

Expressioni

Tissue specificityi

Widely expressed with higher expression in liver.1 Publication

Developmental stagei

Detected in embryos from E7 to E17.1 Publication

Gene expression databases

CleanExiMM_ABHD1.

Interactioni

Protein-protein interaction databases

IntActiQ9QZC8. 1 interaction.
MINTiMINT-4130667.

Structurei

3D structure databases

ProteinModelPortaliQ9QZC8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG053994.
InParanoidiQ9QZC8.
KOiK13696.
PhylomeDBiQ9QZC8.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR012020. ABHD4.
[Graphical view]
PfamiPF00561. Abhydrolase_1. 1 hit.
[Graphical view]
PIRSFiPIRSF005211. Ab_hydro_YheT. 1 hit.
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9QZC8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEYPYTTKML SSSLSPQNGT WSDTISLLLA LGVALYLGYY WACVPQRPRL
60 70 80 90 100
VAGPQFLAFL EQHCPVTVET FYPTLWCFEG RLQTIFRVLL QSQPVVPYRS
110 120 130 140 150
EVLQTPDGGQ FLLDWAEQPN STHYPDPTTQ PIVLLLPGIS GSSQEPYILH
160 170 180 190 200
LVNQALKDGY RAVVFNNRGC RGEELLTHRA YCASNTEDLE TVVKHIKRRY
210 220 230 240 250
SQAPLLAVGI SFGGILVLNY LAQTGKAGGL VAGLTMSACW DSFETVDSLE
260 270 280 290 300
TPLNSLLFNQ PLTAGLCRLV ARNRKPIEKV LDVDFAIKAR TIRQLDERYT
310 320 330 340 350
SVAFGYKDCA AYYQAASPRT KVDAIHTPVL CLNAADDPFS PVHAFPLQAA
360 370 380 390 400
QKSPYVALLI TARGGHIGFL EGLMPWQHCY MNRVLHQYAR AIFQHSVGLP
410
DLGVLTPEDG KS
Length:412
Mass (Da):45,725
Last modified:June 1, 2001 - v2
Checksum:i22C8C41ECCBB9213
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF189764 mRNA. Translation: AAF01068.2.
AK156413 mRNA. Translation: BAE33704.1.
BC013505 mRNA. Translation: AAH13505.1.
RefSeqiNP_067279.2. NM_021304.3.
UniGeneiMm.389615.

Genome annotation databases

GeneIDi57742.
KEGGimmu:57742.
UCSCiuc008wwp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF189764 mRNA. Translation: AAF01068.2.
AK156413 mRNA. Translation: BAE33704.1.
BC013505 mRNA. Translation: AAH13505.1.
RefSeqiNP_067279.2. NM_021304.3.
UniGeneiMm.389615.

3D structure databases

ProteinModelPortaliQ9QZC8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9QZC8. 1 interaction.
MINTiMINT-4130667.

Protein family/group databases

ESTHERimouse-abhd1. abh_upf0017.

PTM databases

PhosphoSiteiQ9QZC8.

Proteomic databases

MaxQBiQ9QZC8.
PeptideAtlasiQ9QZC8.
PRIDEiQ9QZC8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi57742.
KEGGimmu:57742.
UCSCiuc008wwp.1. mouse.

Organism-specific databases

CTDi84696.
MGIiMGI:1931013. Abhd1.

Phylogenomic databases

HOVERGENiHBG053994.
InParanoidiQ9QZC8.
KOiK13696.
PhylomeDBiQ9QZC8.

Miscellaneous databases

PROiQ9QZC8.
SOURCEiSearch...

Gene expression databases

CleanExiMM_ABHD1.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR012020. ABHD4.
[Graphical view]
PfamiPF00561. Abhydrolase_1. 1 hit.
[Graphical view]
PIRSFiPIRSF005211. Ab_hydro_YheT. 1 hit.
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiABHD1_MOUSE
AccessioniPrimary (citable) accession number: Q9QZC8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: June 1, 2001
Last modified: July 6, 2016
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.