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Protein

Choline-phosphate cytidylyltransferase B

Gene

Pcyt1b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Controls phosphatidylcholine synthesis.

Catalytic activityi

CTP + phosphocholine = diphosphate + CDP-choline.By similarity

Pathwayi: phosphatidylcholine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes phosphatidylcholine from phosphocholine.By similarity
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Choline-phosphate cytidylyltransferase A (Pcyt1a), Choline-phosphate cytidylyltransferase B (Pcyt1b)
  2. Choline/ethanolaminephosphotransferase 1 (Cept1), Cholinephosphotransferase 1 (Chpt1)
This subpathway is part of the pathway phosphatidylcholine biosynthesis, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes phosphatidylcholine from phosphocholine, the pathway phosphatidylcholine biosynthesis and in Phospholipid metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei122 – 1221CTPBy similarity
Binding sitei122 – 1221SubstrateBy similarity
Binding sitei151 – 1511SubstrateBy similarity
Binding sitei173 – 1731CTPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi84 – 929CTPBy similarity
Nucleotide bindingi168 – 1692CTPBy similarity
Nucleotide bindingi196 – 2005CTPBy similarity

GO - Molecular functioni

GO - Biological processi

  • response to vasopressin Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00753; UER00739.

Names & Taxonomyi

Protein namesi
Recommended name:
Choline-phosphate cytidylyltransferase B (EC:2.7.7.15By similarity)
Alternative name(s):
CCT-beta
CTP:phosphocholine cytidylyltransferase B
Short name:
CCT B
Short name:
CT B
Phosphorylcholine transferase B
Gene namesi
Name:Pcyt1b
Synonyms:Cctb
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi708434. Pcyt1b.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 369369Choline-phosphate cytidylyltransferase BPRO_0000208457Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei315 – 3151PhosphoserineBy similarity
Modified residuei319 – 3191PhosphoserineBy similarity
Modified residuei323 – 3231PhosphoserineBy similarity
Modified residuei335 – 3351PhosphoserineCombined sources
Modified residuei360 – 3601PhosphoserineBy similarity
Modified residuei362 – 3621PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9QZC4.
PRIDEiQ9QZC4.

PTM databases

iPTMnetiQ9QZC4.
PhosphoSiteiQ9QZC4.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi251926. 1 interaction.
STRINGi10116.ENSRNOP00000016669.

Structurei

3D structure databases

ProteinModelPortaliQ9QZC4.
SMRiQ9QZC4. Positions 236-268.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytidylyltransferase family.Curated

Phylogenomic databases

eggNOGiKOG2804. Eukaryota.
COG0615. LUCA.
HOGENOMiHOG000230945.
HOVERGENiHBG053531.
InParanoidiQ9QZC4.
KOiK00968.
PhylomeDBiQ9QZC4.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
InterProiIPR004821. Cyt_trans-like.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF01467. CTP_transf_like. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00125. cyt_tran_rel. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9QZC4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVVTTDAES ETGIPKSLSN EPPSETMEEI EHTCPQPRLT LTAPAPFADE
60 70 80 90 100
SSCQCQAPHE KLTIAQARLG TPVDRPVRVY ADGIFDLFHS GHARALMQAK
110 120 130 140 150
TLFPNSYLLV GVCSDDLTHK FKGFTVMNEA ERYEALRHCR YVDEVIRDAP
160 170 180 190 200
WTLTPEFLEK HKIDFVAHDD IPYSSAGSDD VYKHIKEAGM FVPTQRTEGI
210 220 230 240 250
STSDIITRIV RDYDVYARRN LQRGYTAKEL NVSFINEKKY RFQNQVDKMK
260 270 280 290 300
EKVKNVEERS KEFVNRVEEK SHDLIQKWEE KSREFIGNFL ELFGPDGAWK
310 320 330 340 350
QMFQERSSRM LQALSPKQSP VSSPTRSRSP SRSPSPTFSW LPNKTSPPSS
360
PKAASASISS MSEGDEDEK
Length:369
Mass (Da):41,900
Last modified:May 1, 2000 - v1
Checksum:i4F5C5D7667110E10
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF190256 mRNA. Translation: AAF04586.1.
RefSeqiNP_775174.1. NM_173151.1.
UniGeneiRn.48742.

Genome annotation databases

GeneIDi286936.
KEGGirno:286936.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF190256 mRNA. Translation: AAF04586.1.
RefSeqiNP_775174.1. NM_173151.1.
UniGeneiRn.48742.

3D structure databases

ProteinModelPortaliQ9QZC4.
SMRiQ9QZC4. Positions 236-268.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi251926. 1 interaction.
STRINGi10116.ENSRNOP00000016669.

PTM databases

iPTMnetiQ9QZC4.
PhosphoSiteiQ9QZC4.

Proteomic databases

PaxDbiQ9QZC4.
PRIDEiQ9QZC4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi286936.
KEGGirno:286936.

Organism-specific databases

CTDi9468.
RGDi708434. Pcyt1b.

Phylogenomic databases

eggNOGiKOG2804. Eukaryota.
COG0615. LUCA.
HOGENOMiHOG000230945.
HOVERGENiHBG053531.
InParanoidiQ9QZC4.
KOiK00968.
PhylomeDBiQ9QZC4.

Enzyme and pathway databases

UniPathwayiUPA00753; UER00739.

Miscellaneous databases

PROiQ9QZC4.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
InterProiIPR004821. Cyt_trans-like.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF01467. CTP_transf_like. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00125. cyt_tran_rel. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a gene in rat brain induced to be expressed differently by AVP(4-8) with differential display PCR."
    Xiong Y., Wang Y., Liu X.L., Du Y.C.
    Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao 31:509-512(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Brain.
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-335 AND SER-362, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPCY1B_RAT
AccessioniPrimary (citable) accession number: Q9QZC4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: May 1, 2000
Last modified: June 8, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.