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Protein

Plexin-C1

Gene

Plxnc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for SEMA7A, for vaccinia virus semaphorin A39R and for herpesvirus Sema protein. Binding of semaphorins triggers cellular responses leading to the rearrangement of the cytoskeleton and to secretion of IL6 and IL8 (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiR-MMU-416700. Other semaphorin interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Plexin-C1
Alternative name(s):
Virus-encoded semaphorin protein receptor
CD_antigen: CD232
Gene namesi
Name:Plxnc1
Synonyms:Vespr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1890127. Plxnc1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini35 – 950916ExtracellularSequence analysisAdd
BLAST
Transmembranei951 – 97121HelicalSequence analysisAdd
BLAST
Topological domaini972 – 1574603CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Disruption phenotypei

No visible phenotype.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3434Sequence analysisAdd
BLAST
Chaini35 – 15741540Plexin-C1PRO_0000232750Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi64 ↔ 87PROSITE-ProRule annotation
Glycosylationi86 – 861N-linked (GlcNAc...)Sequence analysis
Glycosylationi143 – 1431N-linked (GlcNAc...)Sequence analysis
Glycosylationi149 – 1491N-linked (GlcNAc...)Sequence analysis
Disulfide bondi156 ↔ 194PROSITE-ProRule annotation
Glycosylationi252 – 2521N-linked (GlcNAc...)Sequence analysis
Disulfide bondi283 ↔ 329PROSITE-ProRule annotation
Glycosylationi386 – 3861N-linked (GlcNAc...)Sequence analysis
Glycosylationi407 – 4071N-linked (GlcNAc...)Sequence analysis
Disulfide bondi455 ↔ 472PROSITE-ProRule annotation
Disulfide bondi461 ↔ 506PROSITE-ProRule annotation
Disulfide bondi464 ↔ 481PROSITE-ProRule annotation
Disulfide bondi475 ↔ 487PROSITE-ProRule annotation
Glycosylationi694 – 6941N-linked (GlcNAc...)Sequence analysis
Glycosylationi773 – 7731N-linked (GlcNAc...)Sequence analysis
Glycosylationi802 – 8021N-linked (GlcNAc...)Sequence analysis
Modified residuei984 – 9841PhosphoserineCombined sources

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9QZC2.
MaxQBiQ9QZC2.
PaxDbiQ9QZC2.
PeptideAtlasiQ9QZC2.
PRIDEiQ9QZC2.

PTM databases

iPTMnetiQ9QZC2.
PhosphoSiteiQ9QZC2.

Expressioni

Tissue specificityi

Detected on dendritic cells, skin Langerhans cells and neutrophils (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000074785.
CleanExiMM_PLXNC1.
ExpressionAtlasiQ9QZC2. baseline and differential.
GenevisibleiQ9QZC2. MM.

Interactioni

Subunit structurei

Monomer. Homodimer. Interacts with SEMA7A (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000096939.

Structurei

3D structure databases

ProteinModelPortaliQ9QZC2.
SMRiQ9QZC2. Positions 1204-1311.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 452418SemaPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the plexin family.Curated
Contains 1 Sema domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410KCS7. Eukaryota.
ENOG41107MM. LUCA.
GeneTreeiENSGT00760000119048.
HOGENOMiHOG000115583.
HOVERGENiHBG082153.
InParanoidiQ9QZC2.
KOiK06572.
OMAiVANCNKH.
OrthoDBiEOG091G00EK.
PhylomeDBiQ9QZC2.
TreeFamiTF312962.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
2.60.40.10. 1 hit.
InterProiIPR013783. Ig-like_fold.
IPR002909. IPT.
IPR031148. Plexin.
IPR016201. Plexin-like_fold.
IPR013548. Plexin_cytoplasmic_RasGAP_dom.
IPR002165. Plexin_repeat.
IPR008936. Rho_GTPase_activation_prot.
IPR001627. Semap_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PANTHERiPTHR22625. PTHR22625. 1 hit.
PfamiPF08337. Plexin_cytopl. 1 hit.
PF01437. PSI. 1 hit.
PF01403. Sema. 1 hit.
PF01833. TIG. 2 hits.
[Graphical view]
SMARTiSM00429. IPT. 2 hits.
SM00423. PSI. 2 hits.
SM00630. Sema. 1 hit.
[Graphical view]
SUPFAMiSSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
SSF48350. SSF48350. 2 hits.
PROSITEiPS51004. SEMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QZC2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVSRRKTPP RPPYPAAPLP LIAYLLALAA PARGADEPVW RSEQAIGAIA
60 70 80 90 100
ASRADGVFVA SGSCLDQLDY SLKNRLSRLY RDQAGNCTEP VSLAPPARPR
110 120 130 140 150
PGSSFSKLLL PYREGATGLE GLLLTGWTFD RGACEVRPLG NLNRSSLRNG
160 170 180 190 200
TEVVSCHPQG STAGVVYRAS GTDLWYLAVA ATYVLPEPET ANRCNPAASD
210 220 230 240 250
RDTAIALKNT EGRSLATQEL GRLKLRGSAG SLHFVDAFLW NGSVYFPYYP
260 270 280 290 300
YNYTSGAATG WPSMARIAQS TEVLFQGQAA LDCDHGHPEG RRLLLSSSLV
310 320 330 340 350
EAVDIWAGVF SAATGEGQER RSPATTALCL FRMSEIQAHA RSCSWDFQAT
360 370 380 390 400
EHNCKEGDRP ERVQPIASST LIHSDLTSVY GTVVMNRTVL FLGTGDGQLL
410 420 430 440 450
KVVLGENLTS NCPEVIYEIK EETPVFYKLV PHPMKNIYIY LTAGKEVRRI
460 470 480 490 500
PVANCSKRKS CSECLAAADP HCGWCLPLQR CTFQGDCTHA GSFENWLDIS
510 520 530 540 550
SGPKKCPKIQ ILRSLRERTT VTIVGSISAR HSECVVKNAD TGKLLCQGRS
560 570 580 590 600
QLNWTCACNI PSRPSYNVLV VNATFSFPSW NLSERFNFTN CASLKECPAC
610 620 630 640 650
IRSGCAWCKR DKKCIHPFTP CEPSDYERNQ ELCQVAVEKS PKDSGGGRVK
660 670 680 690 700
ESKRNRTDGA VQVFYIKAIE PQKISTLGKS NVIVTGANFT QASNITMILR
710 720 730 740 750
GTSTCERDVI RVSHVLNDTH MKFSLPSSRK EMKDVCIQFD GGTCSSAGAL
760 770 780 790 800
SYIALPHCSL IVPATTWISG GQNITIMGRN FDVIDNLIIS HELKGNANVN
810 820 830 840 850
INVSEYCAAT FCRFLAPNLK SSKVRTNVAV KLRVQDTYLD CGTLQYLEDP
860 870 880 890 900
RFTGYRVESE IDTELEVKIQ KENDNFNISK DDIDITLFHG ENKQFNCSFE
910 920 930 940 950
NITRNQDLTT ILCKIKSIKN ANTIASSSKK VRVKLGNLEL YVEQESVPST
960 970 980 990 1000
WYFLIALPIL LAIVIVVAVV VTRYKSKELS RKQSQQLELL ESELRKEIRD
1010 1020 1030 1040 1050
GFAELQMDKL DVVDSFGTVP FLDYKHFALR TFFPESGGFT HIFTEDMHNR
1060 1070 1080 1090 1100
DANDKNESLT ALDALICNKS FLVTVIHTLE KQKNFSVKDR CLFASFLTIA
1110 1120 1130 1140 1150
LQTKLVYLTS ILEVLTRDLM EQCSNMQPKL MLRRTESVVE KLLTNWMSVC
1160 1170 1180 1190 1200
LSGFLRETVG EPFYLLVTTL NQKINKGPVD VITCKALYTL NEDWLLWQVP
1210 1220 1230 1240 1250
EFNTVALNVV FEKIPENESA DVCRNISVNV LDCDTIGQAK EKVFQAFLSK
1260 1270 1280 1290 1300
NGSPYGLQLN EIGLELQVGT RQKELLDIDS SSVILEDGIT KLNTIGHYEI
1310 1320 1330 1340 1350
SNGSTIKVFK KIANFTSDVE YSDDHCHLIL PDSEAFQVVQ GKRHRGKHKF
1360 1370 1380 1390 1400
KVKEMYLTKL LSTKVAIHSV LEKLFRSIWS LPNSRAPFAI KYFFDFLDAQ
1410 1420 1430 1440 1450
AENKKITDPD VVHIWKTNSL PLRFWVNILK NPQFVFDIKK TPHIDSCLSV
1460 1470 1480 1490 1500
IAQAFMDAFS LTEQQLGKEA PTNKLLYAKD IPTYKEEVKS YYKAIRDLPP
1510 1520 1530 1540 1550
LSSLEMEEFL TQESKKHENE FNEEVALTEI YKYIVKYFDE ILNKLERERG
1560 1570
LEEAQKQLLH VKVLFDEKKK CKWM
Length:1,574
Mass (Da):176,474
Last modified:May 1, 2000 - v1
Checksum:iFA8B5E5C6239FFEA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF190578 mRNA. Translation: AAF01334.1.
AE016773 Genomic DNA. Translation: AAN84620.1.
CCDSiCCDS48676.1.
RefSeqiNP_061267.1. NM_018797.2.
UniGeneiMm.256712.

Genome annotation databases

EnsembliENSMUST00000099337; ENSMUSP00000096939; ENSMUSG00000074785.
GeneIDi54712.
KEGGimmu:54712.
UCSCiuc007gvz.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF190578 mRNA. Translation: AAF01334.1.
AE016773 Genomic DNA. Translation: AAN84620.1.
CCDSiCCDS48676.1.
RefSeqiNP_061267.1. NM_018797.2.
UniGeneiMm.256712.

3D structure databases

ProteinModelPortaliQ9QZC2.
SMRiQ9QZC2. Positions 1204-1311.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000096939.

PTM databases

iPTMnetiQ9QZC2.
PhosphoSiteiQ9QZC2.

Proteomic databases

EPDiQ9QZC2.
MaxQBiQ9QZC2.
PaxDbiQ9QZC2.
PeptideAtlasiQ9QZC2.
PRIDEiQ9QZC2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000099337; ENSMUSP00000096939; ENSMUSG00000074785.
GeneIDi54712.
KEGGimmu:54712.
UCSCiuc007gvz.3. mouse.

Organism-specific databases

CTDi10154.
MGIiMGI:1890127. Plxnc1.

Phylogenomic databases

eggNOGiENOG410KCS7. Eukaryota.
ENOG41107MM. LUCA.
GeneTreeiENSGT00760000119048.
HOGENOMiHOG000115583.
HOVERGENiHBG082153.
InParanoidiQ9QZC2.
KOiK06572.
OMAiVANCNKH.
OrthoDBiEOG091G00EK.
PhylomeDBiQ9QZC2.
TreeFamiTF312962.

Enzyme and pathway databases

ReactomeiR-MMU-416700. Other semaphorin interactions.

Miscellaneous databases

PROiQ9QZC2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000074785.
CleanExiMM_PLXNC1.
ExpressionAtlasiQ9QZC2. baseline and differential.
GenevisibleiQ9QZC2. MM.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
2.60.40.10. 1 hit.
InterProiIPR013783. Ig-like_fold.
IPR002909. IPT.
IPR031148. Plexin.
IPR016201. Plexin-like_fold.
IPR013548. Plexin_cytoplasmic_RasGAP_dom.
IPR002165. Plexin_repeat.
IPR008936. Rho_GTPase_activation_prot.
IPR001627. Semap_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PANTHERiPTHR22625. PTHR22625. 1 hit.
PfamiPF08337. Plexin_cytopl. 1 hit.
PF01437. PSI. 1 hit.
PF01403. Sema. 1 hit.
PF01833. TIG. 2 hits.
[Graphical view]
SMARTiSM00429. IPT. 2 hits.
SM00423. PSI. 2 hits.
SM00630. Sema. 1 hit.
[Graphical view]
SUPFAMiSSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
SSF48350. SSF48350. 2 hits.
PROSITEiPS51004. SEMA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPLXC1_MOUSE
AccessioniPrimary (citable) accession number: Q9QZC2
Secondary accession number(s): Q8CGW1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: May 1, 2000
Last modified: September 7, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.