Short transient receptor potential channel 3

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Q9QZC1 (TRPC3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 101. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Short transient receptor potential channel 3
Short name=TrpC3

Alternative name(s):
Receptor-activated cation channel TRP3
Transient receptor protein 3
Short name=TRP-3
Short name=mTrp3
Trp-related protein 3

Gene names

Name:	Trpc3
Synonyms:	Trp3, Trrp3

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	836 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol 1,4,5-triphosphate receptors (ITPR) with bound IP3 By similarity. May also be activated by internal calcium store depletion.
Subunit structure	Interacts with TRPC1, ITPR1, ITPR3, MX1 and RNF24. Interacts with JPH2; the interaction is involved in maintaining Ca²⁺ homeostasis in skeletal muscle and is mediated by JPH2 'Ser-165' phosphorylation By similarity.
Subcellular location	Membrane; Multi-pass membrane protein Probable.
Tissue specificity	Abundantly expressed in brain. Concentrated in cerebellar Purkinje cells and sparsely localized in cerebellar granule lyer, pontine nuclei and thalamus. Lower levels detected in other tissues.
Sequence similarities	Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC3 sub-subfamily. [View classification] Contains 4 ANK repeats.

Ontologies

Keywords
Biological process	Calcium transport Ion transport Transport
Cellular component	Membrane
Domain	ANK repeat Repeat Transmembrane Transmembrane helix
Ligand	Calcium
Molecular function	Calcium channel Ion channel
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	calcium channel activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 836

836

Short transient receptor potential channel 3

PRO_0000215311

Regions

Topological domain

1 – 369

369

Cytoplasmic Potential

Transmembrane

370 – 390

Helical; Potential

Topological domain

391 – 418

Extracellular Potential

Transmembrane

419 – 439

Helical; Potential

Topological domain

440 – 451

Cytoplasmic Potential

Transmembrane

452 – 472

Helical; Potential

Topological domain

473 – 523

Extracellular Potential

Transmembrane

524 – 544

Helical; Potential

Topological domain

545 – 567

Cytoplasmic Potential

Transmembrane

568 – 588

Helical; Potential

Topological domain

589 – 637

Extracellular Potential

Transmembrane

638 – 658

Helical; Potential

Topological domain

659 – 836

178

Cytoplasmic Potential

Repeat

26 – 55

ANK 1

Repeat

61 – 90

ANK 2

Repeat

92 – 118

ANK 3

Repeat

147 – 176

ANK 4

Amino acid modifications

Glycosylation

404

N-linked (GlcNAc...) Potential

Sequences

Sequence

Length

Mass (Da)

Tools

Q9QZC1 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 7B863B209B9A25F8
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FASTA

836

95,672

        10         20         30         40         50         60 
MRDKGRRQAV RGPAFMFGAR GPSLTAEEER FLDAAEYGNI PVVRKMLEES RTLNVNCVDY 

        70         80         90        100        110        120 
MGQNALQLAV GNEHLEVTEL LLKKENLARI GDALLLAISK GYVRIVEAIL GHPGFAASRR 

       130        140        150        160        170        180 
LTLSPCEQEL RDDDFYAYDE DGTRFSPDIT PIILAAHCHK YEVVHLLLLK GARIERAHDY 

       190        200        210        220        230        240 
FCRCSDCAEK QRLDAFSHSR SRINAYKGLA SPAYLSLSSE DPVLTALELS NELAKLANIE 

       250        260        270        280        290        300 
KEFKNDYRKL SMQCKDFVVG VLDLCRDSEE VEAILNGDLE SAEPLERHGH KASLSRVKLA 

       310        320        330        340        350        360 
IKYEVKKFVA HPNCQQQLLT IWYENLSGLR EQTIAIKCLV VLVVALGLPF LAIGYWIAPC 

       370        380        390        400        410        420 
SRLGKILRSP FMKFVAHAAS FIIFLGLLVF NASDRFEGIT TLPNITVIDY PKQIFRVKTT 

       430        440        450        460        470        480 
QFTWTEMLIM VWVLGMMWSE CKELWLEGPR EYIVQLWNVL DFGMLSIFIA AFTARFLAFL 

       490        500        510        520        530        540 
QATKAQQYVD SHVQESDLSE VTLPPEVQYF TYARDKWLPS DPQIISEGLY AIAVVLSFSR 

       550        560        570        580        590        600 
IAYILPANES FGPLQISLGR TVKDIFKFMV LFIMVFLAFM IGMFILYSYY LGAKVNPAFT 

       610        620        630        640        650        660 
TVEESFKTLF WSIFGLSEVT SVVLKYDHKF IENIGYVLYG IYNVTMVVVL LNMLIAMINS 

       670        680        690        700        710        720 
SYQEIEDDSD VEWKFARSKL WLSYFDDGKT LPPPFSLVPS PKSFVYFIMR ITNFSKCRRR 

       730        740        750        760        770        780 
RLQKDLELGM GNSKSRLNLF TQSNSRVFES HSFNSILNQP TRYQQIMKRL IKRYVLKAQV 

       790        800        810        820        830 
DKENDEVNEG ELKEIKQDIS SLRYELLEDK SQATEELAIL IHKLSEKLNP SVLRCE

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References

[1]	"Differential distribution of TRP Ca2+ channel isoforms in mouse brain." Mori Y., Takada N., Okada T., Wakamori M., Imoto K., Wanifuchi H., Oka H., Oba A., Ikenaka K., Kurosaki T. NeuroReport 9:507-515(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[2]	"trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry." Zhu X., Jiang M., Peyton M., Boulay G., Hurst R., Stefani E., Birnbaumer L. Cell 85:661-671(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 563-671.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF190645 mRNA. Translation: AAF01468.1. U40982 mRNA. Translation: AAC52701.1.
IPI	IPI00137231.
UniGene	Mm.74363.
3D structure databases
ProteinModelPortal	Q9QZC1.
SMR	Q9QZC1. Positions 29-181.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000029271.
PTM databases
PhosphoSite	Q9QZC1.
Proteomic databases
PaxDb	Q9QZC1.
PRIDE	Q9QZC1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
MGI	MGI:109526. Trpc3.
Phylogenomic databases
eggNOG	NOG254238.
HOVERGEN	HBG068337.
InParanoid	Q9QZC1.
OrthoDB	EOG4V436Z.
Gene expression databases
Genevestigator	Q9QZC1.
GermOnline	ENSMUSG00000027716. Mus musculus.
Family and domain databases
Gene3D	1.25.40.20. 1 hit.
InterPro	IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. IPR005821. Ion_trans_dom. IPR004729. TRP_channel. IPR013555. TRP_dom. IPR005459. TRPC3_channel. IPR002153. TRPC_channel. [Graphical view]
PANTHER	PTHR10117. PTHR10117. 1 hit. PTHR10117:SF8. PTHR10117:SF8. 1 hit.
Pfam	PF12796. Ank_2. 1 hit. PF00520. Ion_trans. 1 hit. PF08344. TRP_2. 1 hit. [Graphical view]
PRINTS	PR01097. TRNSRECEPTRP. PR01644. TRPCHANNEL3.
SMART	SM00248. ANK. 3 hits. [Graphical view]
SUPFAM	SSF48403. ANK. 1 hit.
TIGRFAMs	TIGR00870. trp. 1 hit.
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. False negative. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

TRPC3_MOUSE

Accession

Primary (citable) accession number: Q9QZC1
Secondary accession number(s): Q61058

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	May 1, 2000
Last modified:	May 29, 2013
This is version 101 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents