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Protein

Short transient receptor potential channel 3

Gene

Trpc3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol 1,4,5-triphosphate receptors (ITPR) with bound IP3 (By similarity). May also be activated by internal calcium store depletion.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Short transient receptor potential channel 3
Short name:
TrpC3
Alternative name(s):
Receptor-activated cation channel TRP3
Transient receptor protein 3
Short name:
TRP-3
Short name:
mTrp3
Trp-related protein 3
Gene namesi
Name:Trpc3
Synonyms:Trp3, Trrp3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:109526. Trpc3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 369369CytoplasmicSequence analysisAdd
BLAST
Transmembranei370 – 39021HelicalSequence analysisAdd
BLAST
Topological domaini391 – 41828ExtracellularSequence analysisAdd
BLAST
Transmembranei419 – 43921HelicalSequence analysisAdd
BLAST
Topological domaini440 – 45112CytoplasmicSequence analysisAdd
BLAST
Transmembranei452 – 47221HelicalSequence analysisAdd
BLAST
Topological domaini473 – 52351ExtracellularSequence analysisAdd
BLAST
Transmembranei524 – 54421HelicalSequence analysisAdd
BLAST
Topological domaini545 – 56723CytoplasmicSequence analysisAdd
BLAST
Transmembranei568 – 58821HelicalSequence analysisAdd
BLAST
Topological domaini589 – 63749ExtracellularSequence analysisAdd
BLAST
Transmembranei638 – 65821HelicalSequence analysisAdd
BLAST
Topological domaini659 – 836178CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 836836Short transient receptor potential channel 3PRO_0000215311Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi404 – 4041N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9QZC1.
PRIDEiQ9QZC1.

PTM databases

PhosphoSiteiQ9QZC1.

Expressioni

Tissue specificityi

Abundantly expressed in brain. Concentrated in cerebellar Purkinje cells and sparsely localized in cerebellar granule lyer, pontine nuclei and thalamus. Lower levels detected in other tissues.

Interactioni

Subunit structurei

Interacts with TRPC1, ITPR1, ITPR3, MX1 and RNF24. Interacts with JPH2; the interaction is involved in maintaining Ca2+ homeostasis in skeletal muscle and is mediated by JPH2 'Ser-165' phosphorylation (By similarity).By similarity

Protein-protein interaction databases

DIPiDIP-61309N.
IntActiQ9QZC1. 1 interaction.
STRINGi10090.ENSMUSP00000029271.

Structurei

3D structure databases

ProteinModelPortaliQ9QZC1.
SMRiQ9QZC1. Positions 29-181.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati26 – 5530ANK 1Add
BLAST
Repeati61 – 9030ANK 2Add
BLAST
Repeati92 – 11827ANK 3Add
BLAST
Repeati147 – 17630ANK 4Add
BLAST

Sequence similaritiesi

Contains 4 ANK repeats.Curated

Keywords - Domaini

ANK repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3609. Eukaryota.
ENOG410XQ0Y. LUCA.
HOVERGENiHBG068337.
InParanoidiQ9QZC1.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
IPR004729. TRP_channel.
IPR013555. TRP_dom.
IPR005459. TRPC3_channel.
IPR002153. TRPC_channel.
[Graphical view]
PANTHERiPTHR10117. PTHR10117. 2 hits.
PTHR10117:SF8. PTHR10117:SF8. 2 hits.
PfamiPF12796. Ank_2. 1 hit.
PF00520. Ion_trans. 1 hit.
PF08344. TRP_2. 1 hit.
[Graphical view]
PRINTSiPR01097. TRNSRECEPTRP.
PR01644. TRPCHANNEL3.
SMARTiSM00248. ANK. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
TIGRFAMsiTIGR00870. trp. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9QZC1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRDKGRRQAV RGPAFMFGAR GPSLTAEEER FLDAAEYGNI PVVRKMLEES
60 70 80 90 100
RTLNVNCVDY MGQNALQLAV GNEHLEVTEL LLKKENLARI GDALLLAISK
110 120 130 140 150
GYVRIVEAIL GHPGFAASRR LTLSPCEQEL RDDDFYAYDE DGTRFSPDIT
160 170 180 190 200
PIILAAHCHK YEVVHLLLLK GARIERAHDY FCRCSDCAEK QRLDAFSHSR
210 220 230 240 250
SRINAYKGLA SPAYLSLSSE DPVLTALELS NELAKLANIE KEFKNDYRKL
260 270 280 290 300
SMQCKDFVVG VLDLCRDSEE VEAILNGDLE SAEPLERHGH KASLSRVKLA
310 320 330 340 350
IKYEVKKFVA HPNCQQQLLT IWYENLSGLR EQTIAIKCLV VLVVALGLPF
360 370 380 390 400
LAIGYWIAPC SRLGKILRSP FMKFVAHAAS FIIFLGLLVF NASDRFEGIT
410 420 430 440 450
TLPNITVIDY PKQIFRVKTT QFTWTEMLIM VWVLGMMWSE CKELWLEGPR
460 470 480 490 500
EYIVQLWNVL DFGMLSIFIA AFTARFLAFL QATKAQQYVD SHVQESDLSE
510 520 530 540 550
VTLPPEVQYF TYARDKWLPS DPQIISEGLY AIAVVLSFSR IAYILPANES
560 570 580 590 600
FGPLQISLGR TVKDIFKFMV LFIMVFLAFM IGMFILYSYY LGAKVNPAFT
610 620 630 640 650
TVEESFKTLF WSIFGLSEVT SVVLKYDHKF IENIGYVLYG IYNVTMVVVL
660 670 680 690 700
LNMLIAMINS SYQEIEDDSD VEWKFARSKL WLSYFDDGKT LPPPFSLVPS
710 720 730 740 750
PKSFVYFIMR ITNFSKCRRR RLQKDLELGM GNSKSRLNLF TQSNSRVFES
760 770 780 790 800
HSFNSILNQP TRYQQIMKRL IKRYVLKAQV DKENDEVNEG ELKEIKQDIS
810 820 830
SLRYELLEDK SQATEELAIL IHKLSEKLNP SVLRCE
Length:836
Mass (Da):95,672
Last modified:May 1, 2000 - v1
Checksum:i7B863B209B9A25F8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF190645 mRNA. Translation: AAF01468.1.
U40982 mRNA. Translation: AAC52701.1.
UniGeneiMm.74363.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF190645 mRNA. Translation: AAF01468.1.
U40982 mRNA. Translation: AAC52701.1.
UniGeneiMm.74363.

3D structure databases

ProteinModelPortaliQ9QZC1.
SMRiQ9QZC1. Positions 29-181.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-61309N.
IntActiQ9QZC1. 1 interaction.
STRINGi10090.ENSMUSP00000029271.

PTM databases

PhosphoSiteiQ9QZC1.

Proteomic databases

PaxDbiQ9QZC1.
PRIDEiQ9QZC1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:109526. Trpc3.

Phylogenomic databases

eggNOGiKOG3609. Eukaryota.
ENOG410XQ0Y. LUCA.
HOVERGENiHBG068337.
InParanoidiQ9QZC1.

Miscellaneous databases

PROiQ9QZC1.
SOURCEiSearch...

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
IPR004729. TRP_channel.
IPR013555. TRP_dom.
IPR005459. TRPC3_channel.
IPR002153. TRPC_channel.
[Graphical view]
PANTHERiPTHR10117. PTHR10117. 2 hits.
PTHR10117:SF8. PTHR10117:SF8. 2 hits.
PfamiPF12796. Ank_2. 1 hit.
PF00520. Ion_trans. 1 hit.
PF08344. TRP_2. 1 hit.
[Graphical view]
PRINTSiPR01097. TRNSRECEPTRP.
PR01644. TRPCHANNEL3.
SMARTiSM00248. ANK. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
TIGRFAMsiTIGR00870. trp. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Differential distribution of TRP Ca2+ channel isoforms in mouse brain."
    Mori Y., Takada N., Okada T., Wakamori M., Imoto K., Wanifuchi H., Oka H., Oba A., Ikenaka K., Kurosaki T.
    NeuroReport 9:507-515(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry."
    Zhu X., Jiang M., Peyton M., Boulay G., Hurst R., Stefani E., Birnbaumer L.
    Cell 85:661-671(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 563-671.

Entry informationi

Entry nameiTRPC3_MOUSE
AccessioniPrimary (citable) accession number: Q9QZC1
Secondary accession number(s): Q61058
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: May 11, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.