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Q9QZB9 (DCTN5_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Dynactin subunit 5
Alternative name(s):
Dynactin subunit p25
Gene names
Name:Dctn5
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length182 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Member of the pointed-end complex of the dynactin shoulder complex which contains DCTN4, DCTN5 and DCTN6 subunits and ACTR10. Within the complex DCTN6 forms a heterodimer with DCTN5. Ref.1

Subcellular location

Cytoplasmcytoskeleton By similarity. Chromosomecentromerekinetochore By similarity.

Sequence similarities

Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 182182Dynactin subunit 5
PRO_0000079828

Amino acid modifications

Modified residue11N-acetylmethionine By similarity

Experimental info

Sequence conflict111S → L in AAH10834. Ref.3
Sequence conflict951E → G in BAC36183. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9QZB9 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 476DAB4B7805D496

FASTA18220,141
        10         20         30         40         50         60 
MELGELLYNK SEYIETASGN KVSRQSVLCG SQNIVLNGKT IIMNDCIIRG DLANVRVGRH 

        70         80         90        100        110        120 
CVVKSRSVIR PPFKKFSKGV AFFPLHIGDH VFIEEDCVVN AAQIGSYVHV GKNCVIGRRC 

       130        140        150        160        170        180 
VLKDCCKILD NTVLPPETVV PPFTVFSGCP GLFSGELPEC TQELMIDVTK SYYQKFLPLT 


QV 

« Hide

References

« Hide 'large scale' references
[1]"Analysis of dynactin subcomplexes reveals a novel actin-related protein associated with the Arp1 minifilament pointed end."
Eckley D.M., Gill S.R., Melkonian K.A., Bingham J.B., Goodson H.V., Heuser J.E., Schroer T.A.
J. Cell Biol. 147:307-320(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBUNIT.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Amnion, Bone marrow, Embryo, Eye, Testis and Tongue.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Kidney and Mammary tumor.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF190795 mRNA. Translation: AAF05615.1.
AK010238 mRNA. Translation: BAB26789.1.
AK051957 mRNA. Translation: BAC34820.1.
AK076100 mRNA. Translation: BAC36183.1.
AK076738 mRNA. Translation: BAC36460.1.
AK151193 mRNA. Translation: BAE30190.1.
AK151876 mRNA. Translation: BAE30763.1.
AK168983 mRNA. Translation: BAE40783.1.
BC010834 mRNA. Translation: AAH10834.1.
BC005671 mRNA. Translation: AAH05671.1.
CCDSCCDS21811.1.
RefSeqNP_067621.3. NM_021608.3.
UniGeneMm.478285.

3D structure databases

ProteinModelPortalQ9QZB9.
SMRQ9QZB9. Positions 22-159.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid208544. 1 interaction.
IntActQ9QZB9. 1 interaction.

PTM databases

PhosphoSiteQ9QZB9.

Proteomic databases

MaxQBQ9QZB9.
PaxDbQ9QZB9.
PRIDEQ9QZB9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000033156; ENSMUSP00000033156; ENSMUSG00000030868.
GeneID59288.
KEGGmmu:59288.
UCSCuc009jon.2. mouse.

Organism-specific databases

CTD84516.
MGIMGI:1891689. Dctn5.

Phylogenomic databases

eggNOGNOG282896.
GeneTreeENSGT00390000015360.
HOGENOMHOG000198229.
HOVERGENHBG051325.
InParanoidQ9QZB9.
KOK10427.
OMAPPYKTYR.
OrthoDBEOG751NGQ.
PhylomeDBQ9QZB9.
TreeFamTF314194.

Gene expression databases

ArrayExpressQ9QZB9.
BgeeQ9QZB9.
GenevestigatorQ9QZB9.

Family and domain databases

InterProIPR001451. Hexapep_transf.
IPR011004. Trimer_LpxA-like.
[Graphical view]
PfamPF00132. Hexapep. 1 hit.
[Graphical view]
SUPFAMSSF51161. SSF51161. 1 hit.
ProtoNetSearch...

Other

NextBio314788.
PROQ9QZB9.
SOURCESearch...

Entry information

Entry nameDCTN5_MOUSE
AccessionPrimary (citable) accession number: Q9QZB9
Secondary accession number(s): Q3U9A4 expand/collapse secondary AC list , Q8BPE5, Q91XC6, Q99J17
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot