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Protein

Dynactin subunit 5

Gene

Dctn5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

ReactomeiREACT_196550. MHC class II antigen presentation.

Names & Taxonomyi

Protein namesi
Recommended name:
Dynactin subunit 5
Alternative name(s):
Dynactin subunit p25
Gene namesi
Name:Dctn5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:1891689. Dctn5.

Subcellular locationi

Cytoplasmcytoskeleton By similarity. Chromosomecentromerekinetochore By similarity

GO - Cellular componenti

  1. centrosome Source: MGI
  2. condensed chromosome kinetochore Source: UniProtKB-SubCell
  3. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Cytoskeleton, Kinetochore

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 182182Dynactin subunit 5PRO_0000079828Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9QZB9.
PaxDbiQ9QZB9.
PRIDEiQ9QZB9.

PTM databases

PhosphoSiteiQ9QZB9.

Expressioni

Gene expression databases

BgeeiQ9QZB9.
ExpressionAtlasiQ9QZB9. baseline and differential.
GenevestigatoriQ9QZB9.

Interactioni

Subunit structurei

Member of the pointed-end complex of the dynactin shoulder complex which contains DCTN4, DCTN5 and DCTN6 subunits and ACTR10. Within the complex DCTN6 forms a heterodimer with DCTN5.1 Publication

Protein-protein interaction databases

BioGridi208544. 1 interaction.
IntActiQ9QZB9. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ9QZB9.
SMRiQ9QZB9. Positions 22-159.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG282896.
GeneTreeiENSGT00390000015360.
HOGENOMiHOG000198229.
HOVERGENiHBG051325.
InParanoidiQ9QZB9.
KOiK10427.
OMAiPPYKTYR.
OrthoDBiEOG751NGQ.
PhylomeDBiQ9QZB9.
TreeFamiTF314194.

Family and domain databases

InterProiIPR001451. Hexapep_transf.
IPR011004. Trimer_LpxA-like.
[Graphical view]
PfamiPF00132. Hexapep. 1 hit.
[Graphical view]
SUPFAMiSSF51161. SSF51161. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9QZB9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELGELLYNK SEYIETASGN KVSRQSVLCG SQNIVLNGKT IIMNDCIIRG
60 70 80 90 100
DLANVRVGRH CVVKSRSVIR PPFKKFSKGV AFFPLHIGDH VFIEEDCVVN
110 120 130 140 150
AAQIGSYVHV GKNCVIGRRC VLKDCCKILD NTVLPPETVV PPFTVFSGCP
160 170 180
GLFSGELPEC TQELMIDVTK SYYQKFLPLT QV
Length:182
Mass (Da):20,141
Last modified:May 1, 2000 - v1
Checksum:i476DAB4B7805D496
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti11 – 111S → L in AAH10834 (PubMed:15489334).Curated
Sequence conflicti95 – 951E → G in BAC36183 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF190795 mRNA. Translation: AAF05615.1.
AK010238 mRNA. Translation: BAB26789.1.
AK051957 mRNA. Translation: BAC34820.1.
AK076100 mRNA. Translation: BAC36183.1.
AK076738 mRNA. Translation: BAC36460.1.
AK151193 mRNA. Translation: BAE30190.1.
AK151876 mRNA. Translation: BAE30763.1.
AK168983 mRNA. Translation: BAE40783.1.
BC010834 mRNA. Translation: AAH10834.1.
BC005671 mRNA. Translation: AAH05671.1.
CCDSiCCDS21811.1.
RefSeqiNP_067621.3. NM_021608.3.
UniGeneiMm.478285.

Genome annotation databases

EnsembliENSMUST00000033156; ENSMUSP00000033156; ENSMUSG00000030868.
GeneIDi59288.
KEGGimmu:59288.
UCSCiuc009jon.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF190795 mRNA. Translation: AAF05615.1.
AK010238 mRNA. Translation: BAB26789.1.
AK051957 mRNA. Translation: BAC34820.1.
AK076100 mRNA. Translation: BAC36183.1.
AK076738 mRNA. Translation: BAC36460.1.
AK151193 mRNA. Translation: BAE30190.1.
AK151876 mRNA. Translation: BAE30763.1.
AK168983 mRNA. Translation: BAE40783.1.
BC010834 mRNA. Translation: AAH10834.1.
BC005671 mRNA. Translation: AAH05671.1.
CCDSiCCDS21811.1.
RefSeqiNP_067621.3. NM_021608.3.
UniGeneiMm.478285.

3D structure databases

ProteinModelPortaliQ9QZB9.
SMRiQ9QZB9. Positions 22-159.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi208544. 1 interaction.
IntActiQ9QZB9. 2 interactions.

PTM databases

PhosphoSiteiQ9QZB9.

Proteomic databases

MaxQBiQ9QZB9.
PaxDbiQ9QZB9.
PRIDEiQ9QZB9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033156; ENSMUSP00000033156; ENSMUSG00000030868.
GeneIDi59288.
KEGGimmu:59288.
UCSCiuc009jon.2. mouse.

Organism-specific databases

CTDi84516.
MGIiMGI:1891689. Dctn5.

Phylogenomic databases

eggNOGiNOG282896.
GeneTreeiENSGT00390000015360.
HOGENOMiHOG000198229.
HOVERGENiHBG051325.
InParanoidiQ9QZB9.
KOiK10427.
OMAiPPYKTYR.
OrthoDBiEOG751NGQ.
PhylomeDBiQ9QZB9.
TreeFamiTF314194.

Enzyme and pathway databases

ReactomeiREACT_196550. MHC class II antigen presentation.

Miscellaneous databases

NextBioi314788.
PROiQ9QZB9.
SOURCEiSearch...

Gene expression databases

BgeeiQ9QZB9.
ExpressionAtlasiQ9QZB9. baseline and differential.
GenevestigatoriQ9QZB9.

Family and domain databases

InterProiIPR001451. Hexapep_transf.
IPR011004. Trimer_LpxA-like.
[Graphical view]
PfamiPF00132. Hexapep. 1 hit.
[Graphical view]
SUPFAMiSSF51161. SSF51161. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis of dynactin subcomplexes reveals a novel actin-related protein associated with the Arp1 minifilament pointed end."
    Eckley D.M., Gill S.R., Melkonian K.A., Bingham J.B., Goodson H.V., Heuser J.E., Schroer T.A.
    J. Cell Biol. 147:307-320(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBUNIT.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Amnion, Bone marrow, Embryo, Eye, Testis and Tongue.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Kidney and Mammary tumor.

Entry informationi

Entry nameiDCTN5_MOUSE
AccessioniPrimary (citable) accession number: Q9QZB9
Secondary accession number(s): Q3U9A4
, Q8BPE5, Q91XC6, Q99J17
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: May 1, 2000
Last modified: March 4, 2015
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.