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Protein

Dynactin subunit 5

Gene

Dctn5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • aorta development Source: MGI
  • coronary vasculature development Source: MGI
  • ventricular septum development Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-2132295. MHC class II antigen presentation.
R-MMU-6807878. COPI-mediated anterograde transport.
R-MMU-6811436. COPI-independent Golgi-to-ER retrograde traffic.

Names & Taxonomyi

Protein namesi
Recommended name:
Dynactin subunit 5
Alternative name(s):
Dynactin subunit p25
Gene namesi
Name:Dctn5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1891689. Dctn5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Cytoskeleton, Kinetochore

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000798281 – 182Dynactin subunit 5Add BLAST182

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9QZB9.
MaxQBiQ9QZB9.
PaxDbiQ9QZB9.
PeptideAtlasiQ9QZB9.
PRIDEiQ9QZB9.

PTM databases

iPTMnetiQ9QZB9.
PhosphoSitePlusiQ9QZB9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000030868.
ExpressionAtlasiQ9QZB9. baseline and differential.
GenevisibleiQ9QZB9. MM.

Interactioni

Subunit structurei

Member of the pointed-end complex of the dynactin shoulder complex which contains DCTN4, DCTN5 and DCTN6 subunits and ACTR10. Within the complex DCTN6 forms a heterodimer with DCTN5.1 Publication

Protein-protein interaction databases

BioGridi208544. 18 interactors.
IntActiQ9QZB9. 19 interactors.
STRINGi10090.ENSMUSP00000033156.

Structurei

3D structure databases

ProteinModelPortaliQ9QZB9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3121. Eukaryota.
ENOG410YENR. LUCA.
GeneTreeiENSGT00390000015360.
HOGENOMiHOG000198229.
HOVERGENiHBG051325.
InParanoidiQ9QZB9.
KOiK10427.
OMAiPPYKTYR.
OrthoDBiEOG091G0NK3.
PhylomeDBiQ9QZB9.
TreeFamiTF314194.

Family and domain databases

InterProiIPR001451. Hexapep.
IPR011004. Trimer_LpxA-like.
[Graphical view]
PfamiPF00132. Hexapep. 1 hit.
[Graphical view]
SUPFAMiSSF51161. SSF51161. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9QZB9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELGELLYNK SEYIETASGN KVSRQSVLCG SQNIVLNGKT IIMNDCIIRG
60 70 80 90 100
DLANVRVGRH CVVKSRSVIR PPFKKFSKGV AFFPLHIGDH VFIEEDCVVN
110 120 130 140 150
AAQIGSYVHV GKNCVIGRRC VLKDCCKILD NTVLPPETVV PPFTVFSGCP
160 170 180
GLFSGELPEC TQELMIDVTK SYYQKFLPLT QV
Length:182
Mass (Da):20,141
Last modified:May 1, 2000 - v1
Checksum:i476DAB4B7805D496
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti11S → L in AAH10834 (PubMed:15489334).Curated1
Sequence conflicti95E → G in BAC36183 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF190795 mRNA. Translation: AAF05615.1.
AK010238 mRNA. Translation: BAB26789.1.
AK051957 mRNA. Translation: BAC34820.1.
AK076100 mRNA. Translation: BAC36183.1.
AK076738 mRNA. Translation: BAC36460.1.
AK151193 mRNA. Translation: BAE30190.1.
AK151876 mRNA. Translation: BAE30763.1.
AK168983 mRNA. Translation: BAE40783.1.
BC010834 mRNA. Translation: AAH10834.1.
BC005671 mRNA. Translation: AAH05671.1.
CCDSiCCDS21811.1.
RefSeqiNP_067621.3. NM_021608.3.
UniGeneiMm.478285.

Genome annotation databases

EnsembliENSMUST00000033156; ENSMUSP00000033156; ENSMUSG00000030868.
GeneIDi59288.
KEGGimmu:59288.
UCSCiuc009jon.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF190795 mRNA. Translation: AAF05615.1.
AK010238 mRNA. Translation: BAB26789.1.
AK051957 mRNA. Translation: BAC34820.1.
AK076100 mRNA. Translation: BAC36183.1.
AK076738 mRNA. Translation: BAC36460.1.
AK151193 mRNA. Translation: BAE30190.1.
AK151876 mRNA. Translation: BAE30763.1.
AK168983 mRNA. Translation: BAE40783.1.
BC010834 mRNA. Translation: AAH10834.1.
BC005671 mRNA. Translation: AAH05671.1.
CCDSiCCDS21811.1.
RefSeqiNP_067621.3. NM_021608.3.
UniGeneiMm.478285.

3D structure databases

ProteinModelPortaliQ9QZB9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi208544. 18 interactors.
IntActiQ9QZB9. 19 interactors.
STRINGi10090.ENSMUSP00000033156.

PTM databases

iPTMnetiQ9QZB9.
PhosphoSitePlusiQ9QZB9.

Proteomic databases

EPDiQ9QZB9.
MaxQBiQ9QZB9.
PaxDbiQ9QZB9.
PeptideAtlasiQ9QZB9.
PRIDEiQ9QZB9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033156; ENSMUSP00000033156; ENSMUSG00000030868.
GeneIDi59288.
KEGGimmu:59288.
UCSCiuc009jon.2. mouse.

Organism-specific databases

CTDi84516.
MGIiMGI:1891689. Dctn5.

Phylogenomic databases

eggNOGiKOG3121. Eukaryota.
ENOG410YENR. LUCA.
GeneTreeiENSGT00390000015360.
HOGENOMiHOG000198229.
HOVERGENiHBG051325.
InParanoidiQ9QZB9.
KOiK10427.
OMAiPPYKTYR.
OrthoDBiEOG091G0NK3.
PhylomeDBiQ9QZB9.
TreeFamiTF314194.

Enzyme and pathway databases

ReactomeiR-MMU-2132295. MHC class II antigen presentation.
R-MMU-6807878. COPI-mediated anterograde transport.
R-MMU-6811436. COPI-independent Golgi-to-ER retrograde traffic.

Miscellaneous databases

PROiQ9QZB9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030868.
ExpressionAtlasiQ9QZB9. baseline and differential.
GenevisibleiQ9QZB9. MM.

Family and domain databases

InterProiIPR001451. Hexapep.
IPR011004. Trimer_LpxA-like.
[Graphical view]
PfamiPF00132. Hexapep. 1 hit.
[Graphical view]
SUPFAMiSSF51161. SSF51161. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDCTN5_MOUSE
AccessioniPrimary (citable) accession number: Q9QZB9
Secondary accession number(s): Q3U9A4
, Q8BPE5, Q91XC6, Q99J17
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: May 1, 2000
Last modified: November 2, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.