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Q9QZB9

- DCTN5_MOUSE

UniProt

Q9QZB9 - DCTN5_MOUSE

Protein

Dynactin subunit 5

Gene

Dctn5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Enzyme and pathway databases

    ReactomeiREACT_196550. MHC class II antigen presentation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dynactin subunit 5
    Alternative name(s):
    Dynactin subunit p25
    Gene namesi
    Name:Dctn5
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:1891689. Dctn5.

    Subcellular locationi

    Cytoplasmcytoskeleton By similarity. Chromosomecentromerekinetochore By similarity

    GO - Cellular componenti

    1. centrosome Source: Ensembl
    2. condensed chromosome kinetochore Source: UniProtKB-SubCell
    3. cytoplasm Source: UniProtKB-KW

    Keywords - Cellular componenti

    Centromere, Chromosome, Cytoplasm, Cytoskeleton, Kinetochore

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 182182Dynactin subunit 5PRO_0000079828Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ9QZB9.
    PaxDbiQ9QZB9.
    PRIDEiQ9QZB9.

    PTM databases

    PhosphoSiteiQ9QZB9.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9QZB9.
    BgeeiQ9QZB9.
    GenevestigatoriQ9QZB9.

    Interactioni

    Subunit structurei

    Member of the pointed-end complex of the dynactin shoulder complex which contains DCTN4, DCTN5 and DCTN6 subunits and ACTR10. Within the complex DCTN6 forms a heterodimer with DCTN5.1 Publication

    Protein-protein interaction databases

    BioGridi208544. 1 interaction.
    IntActiQ9QZB9. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9QZB9.
    SMRiQ9QZB9. Positions 22-159.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG282896.
    GeneTreeiENSGT00390000015360.
    HOGENOMiHOG000198229.
    HOVERGENiHBG051325.
    InParanoidiQ9QZB9.
    KOiK10427.
    OMAiPPYKTYR.
    OrthoDBiEOG751NGQ.
    PhylomeDBiQ9QZB9.
    TreeFamiTF314194.

    Family and domain databases

    InterProiIPR001451. Hexapep_transf.
    IPR011004. Trimer_LpxA-like.
    [Graphical view]
    PfamiPF00132. Hexapep. 1 hit.
    [Graphical view]
    SUPFAMiSSF51161. SSF51161. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9QZB9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MELGELLYNK SEYIETASGN KVSRQSVLCG SQNIVLNGKT IIMNDCIIRG    50
    DLANVRVGRH CVVKSRSVIR PPFKKFSKGV AFFPLHIGDH VFIEEDCVVN 100
    AAQIGSYVHV GKNCVIGRRC VLKDCCKILD NTVLPPETVV PPFTVFSGCP 150
    GLFSGELPEC TQELMIDVTK SYYQKFLPLT QV 182
    Length:182
    Mass (Da):20,141
    Last modified:May 1, 2000 - v1
    Checksum:i476DAB4B7805D496
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti11 – 111S → L in AAH10834. (PubMed:15489334)Curated
    Sequence conflicti95 – 951E → G in BAC36183. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF190795 mRNA. Translation: AAF05615.1.
    AK010238 mRNA. Translation: BAB26789.1.
    AK051957 mRNA. Translation: BAC34820.1.
    AK076100 mRNA. Translation: BAC36183.1.
    AK076738 mRNA. Translation: BAC36460.1.
    AK151193 mRNA. Translation: BAE30190.1.
    AK151876 mRNA. Translation: BAE30763.1.
    AK168983 mRNA. Translation: BAE40783.1.
    BC010834 mRNA. Translation: AAH10834.1.
    BC005671 mRNA. Translation: AAH05671.1.
    CCDSiCCDS21811.1.
    RefSeqiNP_067621.3. NM_021608.3.
    UniGeneiMm.478285.

    Genome annotation databases

    EnsembliENSMUST00000033156; ENSMUSP00000033156; ENSMUSG00000030868.
    GeneIDi59288.
    KEGGimmu:59288.
    UCSCiuc009jon.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF190795 mRNA. Translation: AAF05615.1 .
    AK010238 mRNA. Translation: BAB26789.1 .
    AK051957 mRNA. Translation: BAC34820.1 .
    AK076100 mRNA. Translation: BAC36183.1 .
    AK076738 mRNA. Translation: BAC36460.1 .
    AK151193 mRNA. Translation: BAE30190.1 .
    AK151876 mRNA. Translation: BAE30763.1 .
    AK168983 mRNA. Translation: BAE40783.1 .
    BC010834 mRNA. Translation: AAH10834.1 .
    BC005671 mRNA. Translation: AAH05671.1 .
    CCDSi CCDS21811.1.
    RefSeqi NP_067621.3. NM_021608.3.
    UniGenei Mm.478285.

    3D structure databases

    ProteinModelPortali Q9QZB9.
    SMRi Q9QZB9. Positions 22-159.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 208544. 1 interaction.
    IntActi Q9QZB9. 2 interactions.

    PTM databases

    PhosphoSitei Q9QZB9.

    Proteomic databases

    MaxQBi Q9QZB9.
    PaxDbi Q9QZB9.
    PRIDEi Q9QZB9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000033156 ; ENSMUSP00000033156 ; ENSMUSG00000030868 .
    GeneIDi 59288.
    KEGGi mmu:59288.
    UCSCi uc009jon.2. mouse.

    Organism-specific databases

    CTDi 84516.
    MGIi MGI:1891689. Dctn5.

    Phylogenomic databases

    eggNOGi NOG282896.
    GeneTreei ENSGT00390000015360.
    HOGENOMi HOG000198229.
    HOVERGENi HBG051325.
    InParanoidi Q9QZB9.
    KOi K10427.
    OMAi PPYKTYR.
    OrthoDBi EOG751NGQ.
    PhylomeDBi Q9QZB9.
    TreeFami TF314194.

    Enzyme and pathway databases

    Reactomei REACT_196550. MHC class II antigen presentation.

    Miscellaneous databases

    NextBioi 314788.
    PROi Q9QZB9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9QZB9.
    Bgeei Q9QZB9.
    Genevestigatori Q9QZB9.

    Family and domain databases

    InterProi IPR001451. Hexapep_transf.
    IPR011004. Trimer_LpxA-like.
    [Graphical view ]
    Pfami PF00132. Hexapep. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51161. SSF51161. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Analysis of dynactin subcomplexes reveals a novel actin-related protein associated with the Arp1 minifilament pointed end."
      Eckley D.M., Gill S.R., Melkonian K.A., Bingham J.B., Goodson H.V., Heuser J.E., Schroer T.A.
      J. Cell Biol. 147:307-320(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBUNIT.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Amnion, Bone marrow, Embryo, Eye, Testis and Tongue.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Kidney and Mammary tumor.

    Entry informationi

    Entry nameiDCTN5_MOUSE
    AccessioniPrimary (citable) accession number: Q9QZB9
    Secondary accession number(s): Q3U9A4
    , Q8BPE5, Q91XC6, Q99J17
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2005
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3