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Protein

Nuclear receptor subfamily 4 group A member 3

Gene

Nr4a3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Binds to the B1A response-element.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi290 – 36576Nuclear receptorPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri293 – 31321NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri329 – 35325NR C4-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Source: InterPro
  2. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: MGI
  3. sequence-specific DNA binding Source: MGI
  4. steroid hormone receptor activity Source: InterPro
  5. zinc ion binding Source: InterPro

GO - Biological processi

  1. adult behavior Source: MGI
  2. axon guidance Source: MGI
  3. hippocampus development Source: MGI
  4. inner ear morphogenesis Source: MGI
  5. mesoderm formation Source: MGI
  6. negative regulation of apoptotic process Source: MGI
  7. negative regulation of neuron apoptotic process Source: MGI
  8. neuromuscular process controlling balance Source: MGI
  9. organ regeneration Source: Ensembl
  10. positive regulation of cell cycle Source: MGI
  11. positive regulation of leukocyte apoptotic process Source: MGI
  12. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  13. response to hydrogen peroxide Source: MGI
  14. response to peptide hormone Source: Ensembl
  15. semicircular canal morphogenesis Source: MGI
  16. vestibular reflex Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_234105. Nuclear Receptor transcription pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear receptor subfamily 4 group A member 3
Alternative name(s):
Orphan nuclear receptor TEC
Translocated in extraskeletal chondrosarcoma
Gene namesi
Name:Nr4a3
Synonyms:Tec
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:1352457. Nr4a3.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
  2. transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 627627Nuclear receptor subfamily 4 group A member 3PRO_0000053723Add
BLAST

Proteomic databases

MaxQBiQ9QZB6.
PRIDEiQ9QZB6.

PTM databases

PhosphoSiteiQ9QZB6.

Expressioni

Tissue specificityi

Ubiquitous. Highest levels of expression in brain.

Gene expression databases

BgeeiQ9QZB6.
CleanExiMM_NR4A3.
ExpressionAtlasiQ9QZB6. baseline and differential.
GenevestigatoriQ9QZB6.

Interactioni

Subunit structurei

Interacts with SIX3(via homeobox); differentially regulates the transcriptional activities NR4A3.By similarity

Protein-protein interaction databases

BioGridi201804. 3 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ9QZB6.
SMRiQ9QZB6. Positions 291-627.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni441 – 49151Ligand-bindingSequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi99 – 11113Poly-HisAdd
BLAST
Compositional biasi112 – 1154Poly-Gln
Compositional biasi285 – 2884Poly-Ser

Sequence similaritiesi

Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri293 – 31321NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri329 – 35325NR C4-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG245120.
GeneTreeiENSGT00760000118887.
HOGENOMiHOG000230925.
HOVERGENiHBG052663.
InParanoidiQ9QZB6.
KOiK08559.
OrthoDBiEOG75XGKJ.
PhylomeDBiQ9QZB6.
TreeFamiTF315430.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR003072. NOR1_rcpt.
IPR003070. Nuc_orph_rcpt.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR01286. NORNUCRECPTR.
PR01284. NUCLEARECPTR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9QZB6-1) [UniParc]FASTAAdd to basket

Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPCVQAQYSP SPPGSTYATQ TYGSEYTTEI MNPDYTKLTM DLGSTGIMAT
60 70 80 90 100
ATTSLPSFST FMEGYPSSCE LKPSCLYQMP PSGPRPLIKM EEGREHGYHH
110 120 130 140 150
HHHHHHHHHH HQQQQPSIPP PSGPEDEVLP STSMYFKQSP PSTPTTPGFP
160 170 180 190 200
PQAGALWDDE LPSAPGCIAP GPLLDPQMKA VPPMAAAARF PIFFKPSPPH
210 220 230 240 250
PPAPSPAGGH HLGYDPTAAA ALSLPLGAAA AAGSQAAALE GHPYGLPLAK
260 270 280 290 300
RTATLTFPPL GLTASPTASS LLGESPSLPS PPNRSSSSGE GTCAVCGDNA
310 320 330 340 350
ACQHYGVRTC EGCKGFFKRT VQKNAKYVCL ANKNCPVDKR RRNRCQYCRF
360 370 380 390 400
QKCLSVGMVK EVVRTDSLKG RRGRLPSKPK SPLQQEPSQP SPPSPPICMM
410 420 430 440 450
NALVRALTDA TPRDLDYSRY CPTDQATAGT DAEHVQQFYN LLTASIDVSR
460 470 480 490 500
SWAEKIPGFT DLPKEDQTLL IESAFLELFV LRLSIRSNTA EDKFVFCNGL
510 520 530 540 550
VLHRLQCLRG FGEWLDSIKD FSLNLQSLNL DIQALACLSA LSMITERHGL
560 570 580 590 600
KEPKRVEELC TKITSSLKDH QRKGQALEPS EPKVLRALVE LRKICTQGLQ
610 620
RIFYLKLEDL VPPPSVIDKL FLDTLPF
Length:627
Mass (Da):68,454
Last modified:May 1, 2000 - v1
Checksum:i2F49CB4C8DE315A8
GO
Isoform 2 (identifier: Q9QZB6-2) [UniParc]FASTAAdd to basket

Also known as: Short, TECdeltaC

The sequence of this isoform differs from the canonical sequence as follows:
     420-429: YCPTDQATAG → VSSMNAFEPL
     430-627: Missing.

Show »
Length:429
Mass (Da):45,957
Checksum:i23CC2C4BF847668E
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei420 – 42910YCPTDQATAG → VSSMNAFEPL in isoform 2. 1 PublicationVSP_010083
Alternative sequencei430 – 627198Missing in isoform 2. 1 PublicationVSP_010084Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF191211 mRNA. Translation: AAF05622.1.
AF191212 mRNA. Translation: AAF05623.1.
CCDSiCCDS18163.1. [Q9QZB6-1]
RefSeqiNP_056558.1. NM_015743.2. [Q9QZB6-1]
XP_006537718.1. XM_006537655.1. [Q9QZB6-1]
XP_006537719.1. XM_006537656.1. [Q9QZB6-1]
XP_006537720.1. XM_006537657.1. [Q9QZB6-1]
XP_006537721.1. XM_006537658.1. [Q9QZB6-1]
UniGeneiMm.247261.
Mm.487935.

Genome annotation databases

EnsembliENSMUST00000030025; ENSMUSP00000030025; ENSMUSG00000028341. [Q9QZB6-1]
GeneIDi18124.
KEGGimmu:18124.
UCSCiuc008suu.1. mouse. [Q9QZB6-1]
uc008suv.1. mouse. [Q9QZB6-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF191211 mRNA. Translation: AAF05622.1.
AF191212 mRNA. Translation: AAF05623.1.
CCDSiCCDS18163.1. [Q9QZB6-1]
RefSeqiNP_056558.1. NM_015743.2. [Q9QZB6-1]
XP_006537718.1. XM_006537655.1. [Q9QZB6-1]
XP_006537719.1. XM_006537656.1. [Q9QZB6-1]
XP_006537720.1. XM_006537657.1. [Q9QZB6-1]
XP_006537721.1. XM_006537658.1. [Q9QZB6-1]
UniGeneiMm.247261.
Mm.487935.

3D structure databases

ProteinModelPortaliQ9QZB6.
SMRiQ9QZB6. Positions 291-627.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201804. 3 interactions.

PTM databases

PhosphoSiteiQ9QZB6.

Proteomic databases

MaxQBiQ9QZB6.
PRIDEiQ9QZB6.

Protocols and materials databases

DNASUi18124.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030025; ENSMUSP00000030025; ENSMUSG00000028341. [Q9QZB6-1]
GeneIDi18124.
KEGGimmu:18124.
UCSCiuc008suu.1. mouse. [Q9QZB6-1]
uc008suv.1. mouse. [Q9QZB6-2]

Organism-specific databases

CTDi8013.
MGIiMGI:1352457. Nr4a3.

Phylogenomic databases

eggNOGiNOG245120.
GeneTreeiENSGT00760000118887.
HOGENOMiHOG000230925.
HOVERGENiHBG052663.
InParanoidiQ9QZB6.
KOiK08559.
OrthoDBiEOG75XGKJ.
PhylomeDBiQ9QZB6.
TreeFamiTF315430.

Enzyme and pathway databases

ReactomeiREACT_234105. Nuclear Receptor transcription pathway.

Miscellaneous databases

NextBioi293340.
PROiQ9QZB6.
SOURCEiSearch...

Gene expression databases

BgeeiQ9QZB6.
CleanExiMM_NR4A3.
ExpressionAtlasiQ9QZB6. baseline and differential.
GenevestigatoriQ9QZB6.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR003072. NOR1_rcpt.
IPR003070. Nuc_orph_rcpt.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR01286. NORNUCRECPTR.
PR01284. NUCLEARECPTR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Structure and expression of the mouse gene encoding the orphan nuclear receptor TEC."
    Maltais A., Labelle Y.
    DNA Cell Biol. 19:121-130(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).

Entry informationi

Entry nameiNR4A3_MOUSE
AccessioniPrimary (citable) accession number: Q9QZB6
Secondary accession number(s): Q9QZB5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: May 1, 2000
Last modified: February 4, 2015
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.