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Q9QZB6

- NR4A3_MOUSE

UniProt

Q9QZB6 - NR4A3_MOUSE

Protein

Nuclear receptor subfamily 4 group A member 3

Gene

Nr4a3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Binds to the B1A response-element.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi290 – 36576Nuclear receptorPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri293 – 31321NR C4-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri329 – 35325NR C4-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Source: InterPro
    2. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: MGI
    3. sequence-specific DNA binding Source: MGI
    4. steroid hormone receptor activity Source: InterPro
    5. zinc ion binding Source: InterPro

    GO - Biological processi

    1. adult behavior Source: MGI
    2. axon guidance Source: MGI
    3. hippocampus development Source: MGI
    4. inner ear morphogenesis Source: MGI
    5. mesoderm formation Source: MGI
    6. negative regulation of apoptotic process Source: MGI
    7. negative regulation of neuron apoptotic process Source: MGI
    8. neuromuscular process controlling balance Source: MGI
    9. organ regeneration Source: Ensembl
    10. positive regulation of cell cycle Source: MGI
    11. positive regulation of leukocyte apoptotic process Source: MGI
    12. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    13. response to hydrogen peroxide Source: MGI
    14. response to peptide hormone Source: Ensembl
    15. semicircular canal morphogenesis Source: MGI
    16. vestibular reflex Source: MGI

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nuclear receptor subfamily 4 group A member 3
    Alternative name(s):
    Orphan nuclear receptor TEC
    Translocated in extraskeletal chondrosarcoma
    Gene namesi
    Name:Nr4a3
    Synonyms:Tec
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:1352457. Nr4a3.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell
    2. transcription factor complex Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 627627Nuclear receptor subfamily 4 group A member 3PRO_0000053723Add
    BLAST

    Proteomic databases

    PRIDEiQ9QZB6.

    PTM databases

    PhosphoSiteiQ9QZB6.

    Expressioni

    Tissue specificityi

    Ubiquitous. Highest levels of expression in brain.

    Gene expression databases

    ArrayExpressiQ9QZB6.
    BgeeiQ9QZB6.
    CleanExiMM_NR4A3.
    GenevestigatoriQ9QZB6.

    Interactioni

    Protein-protein interaction databases

    BioGridi201804. 3 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9QZB6.
    SMRiQ9QZB6. Positions 291-627.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni441 – 49151Ligand-bindingSequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi99 – 11113Poly-HisAdd
    BLAST
    Compositional biasi112 – 1154Poly-Gln
    Compositional biasi285 – 2884Poly-Ser

    Sequence similaritiesi

    Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri293 – 31321NR C4-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri329 – 35325NR C4-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiNOG245120.
    GeneTreeiENSGT00740000115375.
    HOGENOMiHOG000230925.
    HOVERGENiHBG052663.
    InParanoidiQ9QZB6.
    KOiK08559.
    OrthoDBiEOG75XGKJ.
    PhylomeDBiQ9QZB6.
    TreeFamiTF315430.

    Family and domain databases

    Gene3Di1.10.565.10. 1 hit.
    3.30.50.10. 1 hit.
    InterProiIPR003072. NOR1_rcpt.
    IPR003070. Nuc_orph_rcpt.
    IPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
    IPR001723. Str_hrmn_rcpt.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view]
    PfamiPF00104. Hormone_recep. 1 hit.
    PF00105. zf-C4. 1 hit.
    [Graphical view]
    PRINTSiPR01286. NORNUCRECPTR.
    PR01284. NUCLEARECPTR.
    PR00398. STRDHORMONER.
    PR00047. STROIDFINGER.
    SMARTiSM00430. HOLI. 1 hit.
    SM00399. ZnF_C4. 1 hit.
    [Graphical view]
    SUPFAMiSSF48508. SSF48508. 1 hit.
    PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9QZB6-1) [UniParc]FASTAAdd to Basket

    Also known as: Long

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPCVQAQYSP SPPGSTYATQ TYGSEYTTEI MNPDYTKLTM DLGSTGIMAT    50
    ATTSLPSFST FMEGYPSSCE LKPSCLYQMP PSGPRPLIKM EEGREHGYHH 100
    HHHHHHHHHH HQQQQPSIPP PSGPEDEVLP STSMYFKQSP PSTPTTPGFP 150
    PQAGALWDDE LPSAPGCIAP GPLLDPQMKA VPPMAAAARF PIFFKPSPPH 200
    PPAPSPAGGH HLGYDPTAAA ALSLPLGAAA AAGSQAAALE GHPYGLPLAK 250
    RTATLTFPPL GLTASPTASS LLGESPSLPS PPNRSSSSGE GTCAVCGDNA 300
    ACQHYGVRTC EGCKGFFKRT VQKNAKYVCL ANKNCPVDKR RRNRCQYCRF 350
    QKCLSVGMVK EVVRTDSLKG RRGRLPSKPK SPLQQEPSQP SPPSPPICMM 400
    NALVRALTDA TPRDLDYSRY CPTDQATAGT DAEHVQQFYN LLTASIDVSR 450
    SWAEKIPGFT DLPKEDQTLL IESAFLELFV LRLSIRSNTA EDKFVFCNGL 500
    VLHRLQCLRG FGEWLDSIKD FSLNLQSLNL DIQALACLSA LSMITERHGL 550
    KEPKRVEELC TKITSSLKDH QRKGQALEPS EPKVLRALVE LRKICTQGLQ 600
    RIFYLKLEDL VPPPSVIDKL FLDTLPF 627
    Length:627
    Mass (Da):68,454
    Last modified:May 1, 2000 - v1
    Checksum:i2F49CB4C8DE315A8
    GO
    Isoform 2 (identifier: Q9QZB6-2) [UniParc]FASTAAdd to Basket

    Also known as: Short, TECdeltaC

    The sequence of this isoform differs from the canonical sequence as follows:
         420-429: YCPTDQATAG → VSSMNAFEPL
         430-627: Missing.

    Show »
    Length:429
    Mass (Da):45,957
    Checksum:i23CC2C4BF847668E
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei420 – 42910YCPTDQATAG → VSSMNAFEPL in isoform 2. 1 PublicationVSP_010083
    Alternative sequencei430 – 627198Missing in isoform 2. 1 PublicationVSP_010084Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF191211 mRNA. Translation: AAF05622.1.
    AF191212 mRNA. Translation: AAF05623.1.
    CCDSiCCDS18163.1. [Q9QZB6-1]
    RefSeqiNP_056558.1. NM_015743.2. [Q9QZB6-1]
    XP_006537718.1. XM_006537655.1. [Q9QZB6-1]
    XP_006537719.1. XM_006537656.1. [Q9QZB6-1]
    XP_006537720.1. XM_006537657.1. [Q9QZB6-1]
    XP_006537721.1. XM_006537658.1. [Q9QZB6-1]
    UniGeneiMm.247261.
    Mm.487935.

    Genome annotation databases

    EnsembliENSMUST00000030025; ENSMUSP00000030025; ENSMUSG00000028341. [Q9QZB6-1]
    GeneIDi18124.
    KEGGimmu:18124.
    UCSCiuc008suu.1. mouse. [Q9QZB6-1]
    uc008suv.1. mouse. [Q9QZB6-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF191211 mRNA. Translation: AAF05622.1 .
    AF191212 mRNA. Translation: AAF05623.1 .
    CCDSi CCDS18163.1. [Q9QZB6-1 ]
    RefSeqi NP_056558.1. NM_015743.2. [Q9QZB6-1 ]
    XP_006537718.1. XM_006537655.1. [Q9QZB6-1 ]
    XP_006537719.1. XM_006537656.1. [Q9QZB6-1 ]
    XP_006537720.1. XM_006537657.1. [Q9QZB6-1 ]
    XP_006537721.1. XM_006537658.1. [Q9QZB6-1 ]
    UniGenei Mm.247261.
    Mm.487935.

    3D structure databases

    ProteinModelPortali Q9QZB6.
    SMRi Q9QZB6. Positions 291-627.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 201804. 3 interactions.

    PTM databases

    PhosphoSitei Q9QZB6.

    Proteomic databases

    PRIDEi Q9QZB6.

    Protocols and materials databases

    DNASUi 18124.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000030025 ; ENSMUSP00000030025 ; ENSMUSG00000028341 . [Q9QZB6-1 ]
    GeneIDi 18124.
    KEGGi mmu:18124.
    UCSCi uc008suu.1. mouse. [Q9QZB6-1 ]
    uc008suv.1. mouse. [Q9QZB6-2 ]

    Organism-specific databases

    CTDi 8013.
    MGIi MGI:1352457. Nr4a3.

    Phylogenomic databases

    eggNOGi NOG245120.
    GeneTreei ENSGT00740000115375.
    HOGENOMi HOG000230925.
    HOVERGENi HBG052663.
    InParanoidi Q9QZB6.
    KOi K08559.
    OrthoDBi EOG75XGKJ.
    PhylomeDBi Q9QZB6.
    TreeFami TF315430.

    Miscellaneous databases

    NextBioi 293340.
    PROi Q9QZB6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9QZB6.
    Bgeei Q9QZB6.
    CleanExi MM_NR4A3.
    Genevestigatori Q9QZB6.

    Family and domain databases

    Gene3Di 1.10.565.10. 1 hit.
    3.30.50.10. 1 hit.
    InterProi IPR003072. NOR1_rcpt.
    IPR003070. Nuc_orph_rcpt.
    IPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
    IPR001723. Str_hrmn_rcpt.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view ]
    Pfami PF00104. Hormone_recep. 1 hit.
    PF00105. zf-C4. 1 hit.
    [Graphical view ]
    PRINTSi PR01286. NORNUCRECPTR.
    PR01284. NUCLEARECPTR.
    PR00398. STRDHORMONER.
    PR00047. STROIDFINGER.
    SMARTi SM00430. HOLI. 1 hit.
    SM00399. ZnF_C4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48508. SSF48508. 1 hit.
    PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure and expression of the mouse gene encoding the orphan nuclear receptor TEC."
      Maltais A., Labelle Y.
      DNA Cell Biol. 19:121-130(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).

    Entry informationi

    Entry nameiNR4A3_MOUSE
    AccessioniPrimary (citable) accession number: Q9QZB6
    Secondary accession number(s): Q9QZB5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2004
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3