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Q9QZB6

- NR4A3_MOUSE

UniProt

Q9QZB6 - NR4A3_MOUSE

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Protein

Nuclear receptor subfamily 4 group A member 3

Gene
Nr4a3, Tec
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Binds to the B1A response-element By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi290 – 36576Nuclear receptorAdd
BLAST
Zinc fingeri293 – 31321NR C4-typeAdd
BLAST
Zinc fingeri329 – 35325NR C4-typeAdd
BLAST

GO - Molecular functioni

  1. ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Source: InterPro
  2. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: MGI
  3. sequence-specific DNA binding Source: MGI
  4. steroid hormone receptor activity Source: InterPro
  5. zinc ion binding Source: InterPro

GO - Biological processi

  1. adult behavior Source: MGI
  2. axon guidance Source: MGI
  3. hippocampus development Source: MGI
  4. inner ear morphogenesis Source: MGI
  5. mesoderm formation Source: MGI
  6. negative regulation of apoptotic process Source: MGI
  7. negative regulation of neuron apoptotic process Source: MGI
  8. neuromuscular process controlling balance Source: MGI
  9. organ regeneration Source: Ensembl
  10. positive regulation of cell cycle Source: MGI
  11. positive regulation of leukocyte apoptotic process Source: MGI
  12. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  13. response to hydrogen peroxide Source: MGI
  14. response to peptide hormone Source: Ensembl
  15. semicircular canal morphogenesis Source: MGI
  16. vestibular reflex Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear receptor subfamily 4 group A member 3
Alternative name(s):
Orphan nuclear receptor TEC
Translocated in extraskeletal chondrosarcoma
Gene namesi
Name:Nr4a3
Synonyms:Tec
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:1352457. Nr4a3.

Subcellular locationi

Nucleus Reviewed prediction

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
  2. transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 627627Nuclear receptor subfamily 4 group A member 3PRO_0000053723Add
BLAST

Proteomic databases

PRIDEiQ9QZB6.

PTM databases

PhosphoSiteiQ9QZB6.

Expressioni

Tissue specificityi

Ubiquitous. Highest levels of expression in brain.

Gene expression databases

ArrayExpressiQ9QZB6.
BgeeiQ9QZB6.
CleanExiMM_NR4A3.
GenevestigatoriQ9QZB6.

Interactioni

Protein-protein interaction databases

BioGridi201804. 3 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ9QZB6.
SMRiQ9QZB6. Positions 291-627.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni441 – 49151Ligand-binding Reviewed predictionAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi99 – 11113Poly-HisAdd
BLAST
Compositional biasi112 – 1154Poly-Gln
Compositional biasi285 – 2884Poly-Ser

Sequence similaritiesi

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG245120.
GeneTreeiENSGT00740000115375.
HOGENOMiHOG000230925.
HOVERGENiHBG052663.
InParanoidiQ9QZB6.
KOiK08559.
OrthoDBiEOG75XGKJ.
PhylomeDBiQ9QZB6.
TreeFamiTF315430.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR003072. NOR1_rcpt.
IPR003070. Nuc_orph_rcpt.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR01286. NORNUCRECPTR.
PR01284. NUCLEARECPTR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9QZB6-1) [UniParc]FASTAAdd to Basket

Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MPCVQAQYSP SPPGSTYATQ TYGSEYTTEI MNPDYTKLTM DLGSTGIMAT    50
ATTSLPSFST FMEGYPSSCE LKPSCLYQMP PSGPRPLIKM EEGREHGYHH 100
HHHHHHHHHH HQQQQPSIPP PSGPEDEVLP STSMYFKQSP PSTPTTPGFP 150
PQAGALWDDE LPSAPGCIAP GPLLDPQMKA VPPMAAAARF PIFFKPSPPH 200
PPAPSPAGGH HLGYDPTAAA ALSLPLGAAA AAGSQAAALE GHPYGLPLAK 250
RTATLTFPPL GLTASPTASS LLGESPSLPS PPNRSSSSGE GTCAVCGDNA 300
ACQHYGVRTC EGCKGFFKRT VQKNAKYVCL ANKNCPVDKR RRNRCQYCRF 350
QKCLSVGMVK EVVRTDSLKG RRGRLPSKPK SPLQQEPSQP SPPSPPICMM 400
NALVRALTDA TPRDLDYSRY CPTDQATAGT DAEHVQQFYN LLTASIDVSR 450
SWAEKIPGFT DLPKEDQTLL IESAFLELFV LRLSIRSNTA EDKFVFCNGL 500
VLHRLQCLRG FGEWLDSIKD FSLNLQSLNL DIQALACLSA LSMITERHGL 550
KEPKRVEELC TKITSSLKDH QRKGQALEPS EPKVLRALVE LRKICTQGLQ 600
RIFYLKLEDL VPPPSVIDKL FLDTLPF 627
Length:627
Mass (Da):68,454
Last modified:May 1, 2000 - v1
Checksum:i2F49CB4C8DE315A8
GO
Isoform 2 (identifier: Q9QZB6-2) [UniParc]FASTAAdd to Basket

Also known as: Short, TECdeltaC

The sequence of this isoform differs from the canonical sequence as follows:
     420-429: YCPTDQATAG → VSSMNAFEPL
     430-627: Missing.

Show »
Length:429
Mass (Da):45,957
Checksum:i23CC2C4BF847668E
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei420 – 42910YCPTDQATAG → VSSMNAFEPL in isoform 2. VSP_010083
Alternative sequencei430 – 627198Missing in isoform 2. VSP_010084Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF191211 mRNA. Translation: AAF05622.1.
AF191212 mRNA. Translation: AAF05623.1.
CCDSiCCDS18163.1. [Q9QZB6-1]
RefSeqiNP_056558.1. NM_015743.2. [Q9QZB6-1]
XP_006537718.1. XM_006537655.1. [Q9QZB6-1]
XP_006537719.1. XM_006537656.1. [Q9QZB6-1]
XP_006537720.1. XM_006537657.1. [Q9QZB6-1]
XP_006537721.1. XM_006537658.1. [Q9QZB6-1]
UniGeneiMm.247261.
Mm.487935.

Genome annotation databases

EnsembliENSMUST00000030025; ENSMUSP00000030025; ENSMUSG00000028341. [Q9QZB6-1]
GeneIDi18124.
KEGGimmu:18124.
UCSCiuc008suu.1. mouse. [Q9QZB6-1]
uc008suv.1. mouse. [Q9QZB6-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF191211 mRNA. Translation: AAF05622.1 .
AF191212 mRNA. Translation: AAF05623.1 .
CCDSi CCDS18163.1. [Q9QZB6-1 ]
RefSeqi NP_056558.1. NM_015743.2. [Q9QZB6-1 ]
XP_006537718.1. XM_006537655.1. [Q9QZB6-1 ]
XP_006537719.1. XM_006537656.1. [Q9QZB6-1 ]
XP_006537720.1. XM_006537657.1. [Q9QZB6-1 ]
XP_006537721.1. XM_006537658.1. [Q9QZB6-1 ]
UniGenei Mm.247261.
Mm.487935.

3D structure databases

ProteinModelPortali Q9QZB6.
SMRi Q9QZB6. Positions 291-627.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 201804. 3 interactions.

PTM databases

PhosphoSitei Q9QZB6.

Proteomic databases

PRIDEi Q9QZB6.

Protocols and materials databases

DNASUi 18124.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000030025 ; ENSMUSP00000030025 ; ENSMUSG00000028341 . [Q9QZB6-1 ]
GeneIDi 18124.
KEGGi mmu:18124.
UCSCi uc008suu.1. mouse. [Q9QZB6-1 ]
uc008suv.1. mouse. [Q9QZB6-2 ]

Organism-specific databases

CTDi 8013.
MGIi MGI:1352457. Nr4a3.

Phylogenomic databases

eggNOGi NOG245120.
GeneTreei ENSGT00740000115375.
HOGENOMi HOG000230925.
HOVERGENi HBG052663.
InParanoidi Q9QZB6.
KOi K08559.
OrthoDBi EOG75XGKJ.
PhylomeDBi Q9QZB6.
TreeFami TF315430.

Miscellaneous databases

NextBioi 293340.
PROi Q9QZB6.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9QZB6.
Bgeei Q9QZB6.
CleanExi MM_NR4A3.
Genevestigatori Q9QZB6.

Family and domain databases

Gene3Di 1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProi IPR003072. NOR1_rcpt.
IPR003070. Nuc_orph_rcpt.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view ]
Pfami PF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view ]
PRINTSi PR01286. NORNUCRECPTR.
PR01284. NUCLEARECPTR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTi SM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view ]
SUPFAMi SSF48508. SSF48508. 1 hit.
PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Structure and expression of the mouse gene encoding the orphan nuclear receptor TEC."
    Maltais A., Labelle Y.
    DNA Cell Biol. 19:121-130(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).

Entry informationi

Entry nameiNR4A3_MOUSE
AccessioniPrimary (citable) accession number: Q9QZB6
Secondary accession number(s): Q9QZB5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi