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Protein

Regulator of G-protein signaling 20

Gene

Rgs20

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G-protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins.3 Publications

GO - Molecular functioni

  • armadillo repeat domain binding Source: GO_Central
  • beta-catenin binding Source: GO_Central
  • GTPase activator activity Source: MGI
  • protein kinase binding Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Signal transduction inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 20
Short name:
RGS20
Alternative name(s):
Regulator of G-protein signaling Z1
Gene namesi
Name:Rgs20
Synonyms:Rgsz1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1929866. Rgs20.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 239239Regulator of G-protein signaling 20PRO_0000204234Add
BLAST

Post-translational modificationi

Fatty acylated. Heavily palmitoylated in the cysteine string motif (By similarity).By similarity
N- and O-glycosylated in synapsomal membranes.1 Publication
Serine phosphorylated in synapsomal membranes.1 Publication
Sumoylated with SUMO1, SUMO2 and SUMO3. Sumoylation increases binding to the G-proteins, G(alpha)-i2 and G(z), and interaction with mu-opioid receptors.1 Publication

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ9QZB1.
PeptideAtlasiQ9QZB1.
PRIDEiQ9QZB1.

PTM databases

iPTMnetiQ9QZB1.
PhosphoSiteiQ9QZB1.
SwissPalmiQ9QZB1.

Expressioni

Gene expression databases

BgeeiENSMUSG00000002459.
CleanExiMM_RGS20.
ExpressionAtlasiQ9QZB1. baseline and differential.
GenevisibleiQ9QZB1. MM.

Interactioni

Subunit structurei

Forms a complex with G(alpha)z/i2 subunits and mu-opioid receptors; the formation of this complex results in mu-opioid receptor desensitization. Interacts with OPRM1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9QZB1. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ9QZB1.
SMRiQ9QZB1. Positions 102-229.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini113 – 229117RGSPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi59 – 7113Poly-CysAdd
BLAST

Sequence similaritiesi

Contains 1 RGS domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00760000118903.
HOGENOMiHOG000233513.
HOVERGENiHBG013233.
InParanoidiQ9QZB1.
KOiK16449.
PhylomeDBiQ9QZB1.

Family and domain databases

Gene3Di1.10.196.10. 1 hit.
InterProiIPR016137. RGS.
IPR024066. RGS_subdom1.
[Graphical view]
PfamiPF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
PROSITEiPS50132. RGS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9QZB1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTANGGPRA RASPSASPAD PGLPEGSERT EMRMRQMCGG SETQGPAPSQ
60 70 80 90 100
QGGRGSNACC FCWCCCCTCS CLTVRNQEDQ RPQRASHEIR TDIPACEESP
110 120 130 140 150
TPTLEEVCAW AQSFDNLMVT PAGRNAFREF LRTEFSEENM LFWMACEELK
160 170 180 190 200
REANKSTIEE KARIIYEDYI SILSPKEVSL DSRVREVINR NMVDPSQHIF
210 220 230
DDAQLQIYTL MHRDSYPRFM NSTVYKDLLT SLAEKTVEA
Length:239
Mass (Da):26,986
Last modified:May 1, 2000 - v1
Checksum:iF383923163A44D18
GO

Sequence cautioni

The sequence BAB28987 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti32 – 321M → R in strain: BALB/c. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF191554 mRNA. Translation: AAF05757.1.
AF191552 mRNA. Translation: AAF05756.1.
AK013773 mRNA. Translation: BAB28987.2. Different initiation.
AK158864 mRNA. Translation: BAE34700.1.
BC116925 mRNA. Translation: AAI16926.1.
BC116929 mRNA. Translation: AAI16930.1.
CCDSiCCDS14807.1.
RefSeqiNP_001277301.1. NM_001290372.1.
NP_067349.2. NM_021374.5.
XP_011236702.1. XM_011238400.1.
UniGeneiMm.103771.

Genome annotation databases

EnsembliENSMUST00000002533; ENSMUSP00000002533; ENSMUSG00000002459.
GeneIDi58175.
KEGGimmu:58175.
UCSCiuc007afk.3. mouse.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF191554 mRNA. Translation: AAF05757.1.
AF191552 mRNA. Translation: AAF05756.1.
AK013773 mRNA. Translation: BAB28987.2. Different initiation.
AK158864 mRNA. Translation: BAE34700.1.
BC116925 mRNA. Translation: AAI16926.1.
BC116929 mRNA. Translation: AAI16930.1.
CCDSiCCDS14807.1.
RefSeqiNP_001277301.1. NM_001290372.1.
NP_067349.2. NM_021374.5.
XP_011236702.1. XM_011238400.1.
UniGeneiMm.103771.

3D structure databases

ProteinModelPortaliQ9QZB1.
SMRiQ9QZB1. Positions 102-229.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9QZB1. 1 interaction.

PTM databases

iPTMnetiQ9QZB1.
PhosphoSiteiQ9QZB1.
SwissPalmiQ9QZB1.

Proteomic databases

MaxQBiQ9QZB1.
PeptideAtlasiQ9QZB1.
PRIDEiQ9QZB1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000002533; ENSMUSP00000002533; ENSMUSG00000002459.
GeneIDi58175.
KEGGimmu:58175.
UCSCiuc007afk.3. mouse.

Organism-specific databases

CTDi8601.
MGIiMGI:1929866. Rgs20.

Phylogenomic databases

GeneTreeiENSGT00760000118903.
HOGENOMiHOG000233513.
HOVERGENiHBG013233.
InParanoidiQ9QZB1.
KOiK16449.
PhylomeDBiQ9QZB1.

Miscellaneous databases

PROiQ9QZB1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000002459.
CleanExiMM_RGS20.
ExpressionAtlasiQ9QZB1. baseline and differential.
GenevisibleiQ9QZB1. MM.

Family and domain databases

Gene3Di1.10.196.10. 1 hit.
InterProiIPR016137. RGS.
IPR024066. RGS_subdom1.
[Graphical view]
PfamiPF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
PROSITEiPS50132. RGS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRGS20_MOUSE
AccessioniPrimary (citable) accession number: Q9QZB1
Secondary accession number(s): Q14A97
, Q3TY63, Q9CUV8, Q9QZB2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: May 1, 2000
Last modified: September 7, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.