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Protein

CD151 antigen

Gene

Cd151

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential for the proper assembly of the glomerular and tubular basement membranes in kidney.By similarity

GO - Molecular functioni

  • integrin binding Source: RGD

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-RNO-2022090 Assembly of collagen fibrils and other multimeric structures
R-RNO-446107 Type I hemidesmosome assembly

Names & Taxonomyi

Protein namesi
Recommended name:
CD151 antigen
Alternative name(s):
Platelet-endothelial tetraspan antigen 3
Short name:
PETA-3
CD_antigen: CD151
Gene namesi
Name:Cd151
Synonyms:Peta3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi621290 Cd151

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 18CytoplasmicSequence analysisAdd BLAST18
Transmembranei19 – 39HelicalSequence analysisAdd BLAST21
Topological domaini40 – 57ExtracellularSequence analysisAdd BLAST18
Transmembranei58 – 78HelicalSequence analysisAdd BLAST21
Topological domaini79 – 91CytoplasmicSequence analysisAdd BLAST13
Transmembranei92 – 112HelicalSequence analysisAdd BLAST21
Topological domaini113 – 221ExtracellularSequence analysisAdd BLAST109
Transmembranei222 – 242HelicalSequence analysisAdd BLAST21
Topological domaini243 – 253CytoplasmicSequence analysisAdd BLAST11

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002192331 – 253CD151 antigenAdd BLAST253

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi11S-palmitoyl cysteineBy similarity1
Lipidationi15S-palmitoyl cysteineBy similarity1
Glycosylationi159N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi242S-palmitoyl cysteineBy similarity1
Lipidationi243S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ9QZA6
PRIDEiQ9QZA6

PTM databases

iPTMnetiQ9QZA6
PhosphoSitePlusiQ9QZA6
UniCarbKBiQ9QZA6

Expressioni

Gene expression databases

BgeeiENSRNOG00000019215
GenevisibleiQ9QZA6 RN

Interactioni

GO - Molecular functioni

  • integrin binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000066223

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882 Eukaryota
ENOG4111IRY LUCA
GeneTreeiENSGT00880000137851
HOGENOMiHOG000230651
HOVERGENiHBG107306
InParanoidiQ9QZA6
KOiK06537
OMAiCKTVVAG
OrthoDBiEOG091G0CQO
PhylomeDBiQ9QZA6
TreeFamiTF352892

Family and domain databases

Gene3Di1.10.1450.10, 1 hit
InterProiView protein in InterPro
IPR000301 Tetraspanin
IPR018499 Tetraspanin/Peripherin
IPR018503 Tetraspanin_CS
IPR008952 Tetraspanin_EC2_sf
PfamiView protein in Pfam
PF00335 Tetraspannin, 1 hit
PIRSFiPIRSF002419 Tetraspanin, 1 hit
PRINTSiPR00259 TMFOUR
SUPFAMiSSF48652 SSF48652, 1 hit
PROSITEiView protein in PROSITE
PS00421 TM4_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q9QZA6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGEFNEKKAT CGTVCLKYLL FTYNCCFWLA GLAVMAVGIW TLALKSDYIS
60 70 80 90 100
LLASSTYLAT AYILVVAGVV VMVTGVLGCC ATFKERRNLL RLYFILLLII
110 120 130 140 150
FLLEIIAGIL AYVYYQQLNT ELKENLKDTM IKRYHQSGHE GVTNAVDKLQ
160 170 180 190 200
QEFHCCGSNN SRDWRDSEWI RSGEADSRVV PDSCCKTVVT GCGKREHASN
210 220 230 240 250
IYKVEGGCIT KLESFIQEHL RVIGAVGIGI ACVQVFGMIF TCCLYRSLKL

EHY
Length:253
Mass (Da):28,355
Last modified:October 1, 2000 - v2
Checksum:i51876AF31B4DCB2B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF192547 mRNA Translation: AAF05763.2
BC072515 mRNA Translation: AAH72515.1
RefSeqiNP_071968.1, NM_022523.1
XP_003749065.1, XM_003749017.4
XP_006230638.1, XM_006230576.3
XP_006230660.1, XM_006230598.3
XP_017445147.1, XM_017589658.1
XP_017445148.1, XM_017589659.1
XP_017445742.1, XM_017590253.1
XP_017445743.1, XM_017590254.1
XP_017459719.1, XM_017604230.1
XP_017459724.1, XM_017604235.1
XP_017459725.1, XM_017604236.1
XP_017459726.1, XM_017604237.1
UniGeneiRn.1465

Genome annotation databases

EnsembliENSRNOT00000026079; ENSRNOP00000026080; ENSRNOG00000019215
ENSRNOT00000072434; ENSRNOP00000066223; ENSRNOG00000046094
ENSRNOT00000089241; ENSRNOP00000073673; ENSRNOG00000019215
GeneIDi100911730
64315
KEGGirno:100911730
rno:64315
UCSCiRGD:621290 rat

Similar proteinsi

Entry informationi

Entry nameiCD151_RAT
AccessioniPrimary (citable) accession number: Q9QZA6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: October 1, 2000
Last modified: March 28, 2018
This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health