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Protein

CD151 antigen

Gene

Cd151

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Essential for the proper assembly of the glomerular and tubular basement membranes in kidney.By similarity

GO - Molecular functioni

  • integrin binding Source: RGD

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-RNO-2022090. Assembly of collagen fibrils and other multimeric structures.
R-RNO-446107. Type I hemidesmosome assembly.

Names & Taxonomyi

Protein namesi
Recommended name:
CD151 antigen
Alternative name(s):
Platelet-endothelial tetraspan antigen 3
Short name:
PETA-3
CD_antigen: CD151
Gene namesi
Name:Cd151
Synonyms:Peta3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi621290. Cd151.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1818CytoplasmicSequence analysisAdd
BLAST
Transmembranei19 – 3921HelicalSequence analysisAdd
BLAST
Topological domaini40 – 5718ExtracellularSequence analysisAdd
BLAST
Transmembranei58 – 7821HelicalSequence analysisAdd
BLAST
Topological domaini79 – 9113CytoplasmicSequence analysisAdd
BLAST
Transmembranei92 – 11221HelicalSequence analysisAdd
BLAST
Topological domaini113 – 221109ExtracellularSequence analysisAdd
BLAST
Transmembranei222 – 24221HelicalSequence analysisAdd
BLAST
Topological domaini243 – 25311CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 253253CD151 antigenPRO_0000219233Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi11 – 111S-palmitoyl cysteineBy similarity
Lipidationi15 – 151S-palmitoyl cysteineBy similarity
Glycosylationi159 – 1591N-linked (GlcNAc...)Sequence analysis
Lipidationi242 – 2421S-palmitoyl cysteineBy similarity
Lipidationi243 – 2431S-palmitoyl cysteineBy similarity

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ9QZA6.
PRIDEiQ9QZA6.

PTM databases

iPTMnetiQ9QZA6.
PhosphoSiteiQ9QZA6.
UniCarbKBiQ9QZA6.

Expressioni

Gene expression databases

BgeeiENSRNOG00000019215.
GenevisibleiQ9QZA6. RN.

Interactioni

GO - Molecular functioni

  • integrin binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000066223.

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00760000118875.
HOGENOMiHOG000230651.
HOVERGENiHBG107306.
InParanoidiQ9QZA6.
KOiK06537.
OMAiHEGVTNA.
OrthoDBiEOG091G0CQO.
PhylomeDBiQ9QZA6.
TreeFamiTF352892.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9QZA6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGEFNEKKAT CGTVCLKYLL FTYNCCFWLA GLAVMAVGIW TLALKSDYIS
60 70 80 90 100
LLASSTYLAT AYILVVAGVV VMVTGVLGCC ATFKERRNLL RLYFILLLII
110 120 130 140 150
FLLEIIAGIL AYVYYQQLNT ELKENLKDTM IKRYHQSGHE GVTNAVDKLQ
160 170 180 190 200
QEFHCCGSNN SRDWRDSEWI RSGEADSRVV PDSCCKTVVT GCGKREHASN
210 220 230 240 250
IYKVEGGCIT KLESFIQEHL RVIGAVGIGI ACVQVFGMIF TCCLYRSLKL

EHY
Length:253
Mass (Da):28,355
Last modified:October 1, 2000 - v2
Checksum:i51876AF31B4DCB2B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF192547 mRNA. Translation: AAF05763.2.
BC072515 mRNA. Translation: AAH72515.1.
RefSeqiNP_071968.1. NM_022523.1.
XP_003749065.1. XM_003749017.3.
XP_006230638.1. XM_006230576.2.
XP_006230660.1. XM_006230598.2.
UniGeneiRn.1465.

Genome annotation databases

EnsembliENSRNOT00000026079; ENSRNOP00000026080; ENSRNOG00000019215.
ENSRNOT00000072434; ENSRNOP00000066223; ENSRNOG00000046094.
ENSRNOT00000089241; ENSRNOP00000073673; ENSRNOG00000019215.
GeneIDi100911730.
64315.
KEGGirno:100911730.
rno:64315.
UCSCiRGD:621290. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF192547 mRNA. Translation: AAF05763.2.
BC072515 mRNA. Translation: AAH72515.1.
RefSeqiNP_071968.1. NM_022523.1.
XP_003749065.1. XM_003749017.3.
XP_006230638.1. XM_006230576.2.
XP_006230660.1. XM_006230598.2.
UniGeneiRn.1465.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000066223.

PTM databases

iPTMnetiQ9QZA6.
PhosphoSiteiQ9QZA6.
UniCarbKBiQ9QZA6.

Proteomic databases

PaxDbiQ9QZA6.
PRIDEiQ9QZA6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000026079; ENSRNOP00000026080; ENSRNOG00000019215.
ENSRNOT00000072434; ENSRNOP00000066223; ENSRNOG00000046094.
ENSRNOT00000089241; ENSRNOP00000073673; ENSRNOG00000019215.
GeneIDi100911730.
64315.
KEGGirno:100911730.
rno:64315.
UCSCiRGD:621290. rat.

Organism-specific databases

CTDi977.
RGDi621290. Cd151.

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00760000118875.
HOGENOMiHOG000230651.
HOVERGENiHBG107306.
InParanoidiQ9QZA6.
KOiK06537.
OMAiHEGVTNA.
OrthoDBiEOG091G0CQO.
PhylomeDBiQ9QZA6.
TreeFamiTF352892.

Enzyme and pathway databases

ReactomeiR-RNO-2022090. Assembly of collagen fibrils and other multimeric structures.
R-RNO-446107. Type I hemidesmosome assembly.

Miscellaneous databases

PROiQ9QZA6.

Gene expression databases

BgeeiENSRNOG00000019215.
GenevisibleiQ9QZA6. RN.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCD151_RAT
AccessioniPrimary (citable) accession number: Q9QZA6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: October 1, 2000
Last modified: September 7, 2016
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.