Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9QZ86 (NOP58_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nucleolar protein 58
Alternative name(s):
Nopp140-associated protein of 65 kDa
Nucleolar protein 5
Gene names
Name:Nop58
Synonyms:Nap65, Nol5, Nop5
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length534 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required for 60S ribosomal subunit biogenesis By similarity. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such as U3, U8 and U14 snoRNAs By similarity.

Subunit structure

Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles; the core proteins NHP2L1, NOP56, NOP58 and FBL assemble stepwise onto the snoRNA. Interacts with NOLC1/Nopp140. Interacts with NUFIP1, RUVBL1 AND RUVBL2; RUVBL1:RUVBL2 seem to bridge the association of NOP58 with NUFIP1. Ref.1

Subcellular location

Nucleusnucleolus By similarity. Nucleusnucleoplasm By similarity.

Post-translational modification

Sumoylation is essential for high-affinity binding to snoRNAs By similarity.

Sequence similarities

Belongs to the NOP5/NOP56 family.

Contains 1 Nop domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 534534Nucleolar protein 58
PRO_0000219024

Regions

Domain282 – 400119Nop
Compositional bias441 – 53090Lys-rich

Amino acid modifications

Modified residue1091Phosphoserine By similarity
Modified residue3511Phosphoserine By similarity
Modified residue5071Phosphoserine By similarity
Modified residue5191Phosphoserine By similarity
Cross-link467Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) By similarity
Cross-link502Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) By similarity

Experimental info

Sequence conflict3961R → K in AAC23535. Ref.2
Sequence conflict4591A → K in AAC23535. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9QZ86 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 4B9585FA14E67799

FASTA53460,071
        10         20         30         40         50         60 
MLVLFETSVG YAIFKVLNEK KLQEVDSLWK EFETPEKANK IVKLKHFEKF QDTAEALAAF 

        70         80         90        100        110        120 
TALMEGKINK QLKKVLKKIV KEAHEPLAVA DAKLGGVIKE KLNLSCIHSP VVNELMRGIR 

       130        140        150        160        170        180 
SQMDGLIPGV EPREMAAMCL GLAHSLSRYR LKFSADKVDT MIVQAISLLD DLDKELNNYI 

       190        200        210        220        230        240 
MRCREWYGWH FPELGKIISD NLTYCKCLQK VGDRKNYASA TLSEFLSEEV EAEVKAAAEI 

       250        260        270        280        290        300 
SMGTEVSEED ICNILHLCTQ VIEISEYRTQ LYEYLQNRMM AIAPNVTVMV GELVGARLIA 

       310        320        330        340        350        360 
HAGSLLNLAK HAASTVQILG AEKALFRALK SRRDTPKYGL IYHASLVGQT SPKHKGKISR 

       370        380        390        400        410        420 
MLAAKTVLAI RYDAFGEDSS SAMGAENRAK LEARLRILED RGIRKISGTG KALAKAEKYE 

       430        440        450        460        470        480 
HKSEVKTYDP SGDSTLPTCS KKRKIEEVDK EDEITEKKAK KAKIKIKAEV EEEMEEAEEE 

       490        500        510        520        530 
QVVEEEPTVK KKKKKDKKKH IKEEPLSEEE PCTSTAVPSP EKKKKKKKKK DAED 

« Hide

References

[1]"Conserved composition of mammalian box H/ACA and box C/D small nucleolar ribonucleoprotein particles and their interaction with the common factor Nopp140."
Yang Y., Isaac C., Wang C., Dragon F., Pogacic V., Meier U.T.
Mol. Biol. Cell 11:567-577(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 1-22, INTERACTION WITH NOLC1.
[2]Hatton D., Gray J.C.
Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-461.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF194371 mRNA. Translation: AAF05769.1.
AF069782 mRNA. Translation: AAC23535.1.
RefSeqNP_068522.1. NM_021754.1.
UniGeneRn.43930.

3D structure databases

ProteinModelPortalQ9QZ86.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid248802. 1 interaction.

PTM databases

PhosphoSiteQ9QZ86.

Proteomic databases

PaxDbQ9QZ86.
PRIDEQ9QZ86.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000022676; ENSRNOP00000022676; ENSRNOG00000016486.
GeneID60373.
KEGGrno:60373.
UCSCRGD:620484. rat.

Organism-specific databases

CTD51602.
RGD620484. Nop58.

Phylogenomic databases

eggNOGCOG1498.
GeneTreeENSGT00550000074998.
HOGENOMHOG000196310.
InParanoidQ9QZ86.
KOK14565.
OMACENETLA.
OrthoDBEOG7T7GT0.
PhylomeDBQ9QZ86.
TreeFamTF105688.

Gene expression databases

GenevestigatorQ9QZ86.

Family and domain databases

InterProIPR012974. NOP5_N.
IPR002687. Nop_dom.
IPR012976. NOSIC.
[Graphical view]
PfamPF01798. Nop. 1 hit.
PF08156. NOP5NT. 1 hit.
PF08060. NOSIC. 1 hit.
[Graphical view]
SMARTSM00931. NOSIC. 1 hit.
[Graphical view]
PROSITEPS51358. NOP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio612047.
PROQ9QZ86.

Entry information

Entry nameNOP58_RAT
AccessionPrimary (citable) accession number: Q9QZ86
Secondary accession number(s): O88525
Entry history
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: May 1, 2000
Last modified: May 14, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families