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Q9QZ86

- NOP58_RAT

UniProt

Q9QZ86 - NOP58_RAT

Protein

Nucleolar protein 58

Gene

Nop58

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Required for 60S ribosomal subunit biogenesis By similarity. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such as U3, U8 and U14 snoRNAs By similarity.By similarity

    GO - Molecular functioni

    1. rRNA methyltransferase activity Source: RGD
    2. snoRNA binding Source: Ensembl
    3. snoRNP binding Source: UniProtKB
    4. unfolded protein binding Source: UniProtKB

    GO - Biological processi

    1. rRNA methylation Source: GOC
    2. rRNA modification Source: RGD
    3. snRNP protein import into nucleus Source: UniProtKB

    Keywords - Molecular functioni

    Ribonucleoprotein

    Keywords - Biological processi

    Ribosome biogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nucleolar protein 58
    Alternative name(s):
    Nopp140-associated protein of 65 kDa
    Nucleolar protein 5
    Gene namesi
    Name:Nop58
    Synonyms:Nap65, Nol5, Nop5
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 9

    Organism-specific databases

    RGDi620484. Nop58.

    Subcellular locationi

    Nucleusnucleolus By similarity. Nucleusnucleoplasm By similarity

    GO - Cellular componenti

    1. Cajal body Source: Ensembl
    2. cytoplasm Source: Ensembl
    3. nucleolus Source: UniProtKB-SubCell
    4. pre-snoRNP complex Source: Ensembl
    5. small nucleolar ribonucleoprotein complex Source: RGD

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 534534Nucleolar protein 58PRO_0000219024Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei109 – 1091PhosphoserineBy similarity
    Modified residuei351 – 3511PhosphoserineBy similarity
    Cross-linki467 – 467Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
    Cross-linki502 – 502Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
    Modified residuei507 – 5071PhosphoserineBy similarity
    Modified residuei519 – 5191PhosphoserineBy similarity

    Post-translational modificationi

    Sumoylation is essential for high-affinity binding to snoRNAs.By similarity

    Keywords - PTMi

    Isopeptide bond, Phosphoprotein, Ubl conjugation

    Proteomic databases

    PaxDbiQ9QZ86.
    PRIDEiQ9QZ86.

    PTM databases

    PhosphoSiteiQ9QZ86.

    Expressioni

    Gene expression databases

    GenevestigatoriQ9QZ86.

    Interactioni

    Subunit structurei

    Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles; the core proteins NHP2L1, NOP56, NOP58 and FBL assemble stepwise onto the snoRNA. Interacts with NOLC1/Nopp140. Interacts with NUFIP1, RUVBL1 AND RUVBL2; RUVBL1:RUVBL2 seem to bridge the association of NOP58 with NUFIP1.1 Publication

    Protein-protein interaction databases

    BioGridi248802. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9QZ86.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini282 – 400119NopPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi441 – 53090Lys-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the NOP5/NOP56 family.Curated
    Contains 1 Nop domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG1498.
    GeneTreeiENSGT00550000074998.
    HOGENOMiHOG000196310.
    InParanoidiQ9QZ86.
    KOiK14565.
    OMAiCENETLA.
    OrthoDBiEOG7T7GT0.
    PhylomeDBiQ9QZ86.
    TreeFamiTF105688.

    Family and domain databases

    InterProiIPR012974. NOP5_N.
    IPR002687. Nop_dom.
    IPR012976. NOSIC.
    [Graphical view]
    PfamiPF01798. Nop. 1 hit.
    PF08156. NOP5NT. 1 hit.
    PF08060. NOSIC. 1 hit.
    [Graphical view]
    SMARTiSM00931. NOSIC. 1 hit.
    [Graphical view]
    PROSITEiPS51358. NOP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9QZ86-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLVLFETSVG YAIFKVLNEK KLQEVDSLWK EFETPEKANK IVKLKHFEKF    50
    QDTAEALAAF TALMEGKINK QLKKVLKKIV KEAHEPLAVA DAKLGGVIKE 100
    KLNLSCIHSP VVNELMRGIR SQMDGLIPGV EPREMAAMCL GLAHSLSRYR 150
    LKFSADKVDT MIVQAISLLD DLDKELNNYI MRCREWYGWH FPELGKIISD 200
    NLTYCKCLQK VGDRKNYASA TLSEFLSEEV EAEVKAAAEI SMGTEVSEED 250
    ICNILHLCTQ VIEISEYRTQ LYEYLQNRMM AIAPNVTVMV GELVGARLIA 300
    HAGSLLNLAK HAASTVQILG AEKALFRALK SRRDTPKYGL IYHASLVGQT 350
    SPKHKGKISR MLAAKTVLAI RYDAFGEDSS SAMGAENRAK LEARLRILED 400
    RGIRKISGTG KALAKAEKYE HKSEVKTYDP SGDSTLPTCS KKRKIEEVDK 450
    EDEITEKKAK KAKIKIKAEV EEEMEEAEEE QVVEEEPTVK KKKKKDKKKH 500
    IKEEPLSEEE PCTSTAVPSP EKKKKKKKKK DAED 534
    Length:534
    Mass (Da):60,071
    Last modified:May 1, 2000 - v1
    Checksum:i4B9585FA14E67799
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti396 – 3961R → K in AAC23535. 1 PublicationCurated
    Sequence conflicti459 – 4591A → K in AAC23535. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF194371 mRNA. Translation: AAF05769.1.
    AF069782 mRNA. Translation: AAC23535.1.
    RefSeqiNP_068522.1. NM_021754.1.
    UniGeneiRn.43930.

    Genome annotation databases

    EnsembliENSRNOT00000022676; ENSRNOP00000022676; ENSRNOG00000016486.
    GeneIDi60373.
    KEGGirno:60373.
    UCSCiRGD:620484. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF194371 mRNA. Translation: AAF05769.1 .
    AF069782 mRNA. Translation: AAC23535.1 .
    RefSeqi NP_068522.1. NM_021754.1.
    UniGenei Rn.43930.

    3D structure databases

    ProteinModelPortali Q9QZ86.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 248802. 1 interaction.

    PTM databases

    PhosphoSitei Q9QZ86.

    Proteomic databases

    PaxDbi Q9QZ86.
    PRIDEi Q9QZ86.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000022676 ; ENSRNOP00000022676 ; ENSRNOG00000016486 .
    GeneIDi 60373.
    KEGGi rno:60373.
    UCSCi RGD:620484. rat.

    Organism-specific databases

    CTDi 51602.
    RGDi 620484. Nop58.

    Phylogenomic databases

    eggNOGi COG1498.
    GeneTreei ENSGT00550000074998.
    HOGENOMi HOG000196310.
    InParanoidi Q9QZ86.
    KOi K14565.
    OMAi CENETLA.
    OrthoDBi EOG7T7GT0.
    PhylomeDBi Q9QZ86.
    TreeFami TF105688.

    Miscellaneous databases

    NextBioi 612047.
    PROi Q9QZ86.

    Gene expression databases

    Genevestigatori Q9QZ86.

    Family and domain databases

    InterProi IPR012974. NOP5_N.
    IPR002687. Nop_dom.
    IPR012976. NOSIC.
    [Graphical view ]
    Pfami PF01798. Nop. 1 hit.
    PF08156. NOP5NT. 1 hit.
    PF08060. NOSIC. 1 hit.
    [Graphical view ]
    SMARTi SM00931. NOSIC. 1 hit.
    [Graphical view ]
    PROSITEi PS51358. NOP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Conserved composition of mammalian box H/ACA and box C/D small nucleolar ribonucleoprotein particles and their interaction with the common factor Nopp140."
      Yang Y., Isaac C., Wang C., Dragon F., Pogacic V., Meier U.T.
      Mol. Biol. Cell 11:567-577(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 1-22, INTERACTION WITH NOLC1.
    2. Hatton D., Gray J.C.
      Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-461.

    Entry informationi

    Entry nameiNOP58_RAT
    AccessioniPrimary (citable) accession number: Q9QZ86
    Secondary accession number(s): O88525
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 26, 2001
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3