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Q9QZ86

- NOP58_RAT

UniProt

Q9QZ86 - NOP58_RAT

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Protein

Nucleolar protein 58

Gene

Nop58

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Required for 60S ribosomal subunit biogenesis (By similarity). Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such as U3, U8 and U14 snoRNAs (By similarity).By similarity

GO - Molecular functioni

  1. poly(A) RNA binding Source: Ensembl
  2. rRNA methyltransferase activity Source: RGD
  3. snoRNA binding Source: Ensembl
  4. snoRNP binding Source: UniProtKB
  5. unfolded protein binding Source: UniProtKB

GO - Biological processi

  1. rRNA methylation Source: GOC
  2. rRNA modification Source: RGD
  3. snRNP protein import into nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

Ribosome biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleolar protein 58
Alternative name(s):
Nopp140-associated protein of 65 kDa
Nucleolar protein 5
Gene namesi
Name:Nop58
Synonyms:Nap65, Nol5, Nop5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 9

Organism-specific databases

RGDi620484. Nop58.

Subcellular locationi

Nucleusnucleolus By similarity. Nucleusnucleoplasm By similarity

GO - Cellular componenti

  1. Cajal body Source: Ensembl
  2. cytoplasm Source: Ensembl
  3. nucleolus Source: Ensembl
  4. pre-snoRNP complex Source: Ensembl
  5. small nucleolar ribonucleoprotein complex Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 534534Nucleolar protein 58PRO_0000219024Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei109 – 1091PhosphoserineBy similarity
Modified residuei351 – 3511PhosphoserineBy similarity
Cross-linki467 – 467Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
Cross-linki502 – 502Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
Modified residuei507 – 5071PhosphoserineBy similarity
Modified residuei519 – 5191PhosphoserineBy similarity

Post-translational modificationi

Sumoylation is essential for high-affinity binding to snoRNAs.By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ9QZ86.
PRIDEiQ9QZ86.

PTM databases

PhosphoSiteiQ9QZ86.

Expressioni

Gene expression databases

GenevestigatoriQ9QZ86.

Interactioni

Subunit structurei

Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles; the core proteins NHP2L1, NOP56, NOP58 and FBL assemble stepwise onto the snoRNA. Interacts with NOLC1/Nopp140. Interacts with NUFIP1, RUVBL1 AND RUVBL2; RUVBL1:RUVBL2 seem to bridge the association of NOP58 with NUFIP1.1 Publication

Protein-protein interaction databases

BioGridi248802. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ9QZ86.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini282 – 400119NopPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi441 – 53090Lys-richAdd
BLAST

Sequence similaritiesi

Belongs to the NOP5/NOP56 family.Curated
Contains 1 Nop domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG1498.
GeneTreeiENSGT00550000074998.
HOGENOMiHOG000196310.
InParanoidiQ9QZ86.
KOiK14565.
OMAiCENETLA.
OrthoDBiEOG7T7GT0.
PhylomeDBiQ9QZ86.
TreeFamiTF105688.

Family and domain databases

InterProiIPR012974. NOP5_N.
IPR002687. Nop_dom.
IPR012976. NOSIC.
[Graphical view]
PfamiPF01798. Nop. 1 hit.
PF08156. NOP5NT. 1 hit.
PF08060. NOSIC. 1 hit.
[Graphical view]
SMARTiSM00931. NOSIC. 1 hit.
[Graphical view]
PROSITEiPS51358. NOP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9QZ86-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLVLFETSVG YAIFKVLNEK KLQEVDSLWK EFETPEKANK IVKLKHFEKF
60 70 80 90 100
QDTAEALAAF TALMEGKINK QLKKVLKKIV KEAHEPLAVA DAKLGGVIKE
110 120 130 140 150
KLNLSCIHSP VVNELMRGIR SQMDGLIPGV EPREMAAMCL GLAHSLSRYR
160 170 180 190 200
LKFSADKVDT MIVQAISLLD DLDKELNNYI MRCREWYGWH FPELGKIISD
210 220 230 240 250
NLTYCKCLQK VGDRKNYASA TLSEFLSEEV EAEVKAAAEI SMGTEVSEED
260 270 280 290 300
ICNILHLCTQ VIEISEYRTQ LYEYLQNRMM AIAPNVTVMV GELVGARLIA
310 320 330 340 350
HAGSLLNLAK HAASTVQILG AEKALFRALK SRRDTPKYGL IYHASLVGQT
360 370 380 390 400
SPKHKGKISR MLAAKTVLAI RYDAFGEDSS SAMGAENRAK LEARLRILED
410 420 430 440 450
RGIRKISGTG KALAKAEKYE HKSEVKTYDP SGDSTLPTCS KKRKIEEVDK
460 470 480 490 500
EDEITEKKAK KAKIKIKAEV EEEMEEAEEE QVVEEEPTVK KKKKKDKKKH
510 520 530
IKEEPLSEEE PCTSTAVPSP EKKKKKKKKK DAED
Length:534
Mass (Da):60,071
Last modified:May 1, 2000 - v1
Checksum:i4B9585FA14E67799
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti396 – 3961R → K in AAC23535. 1 PublicationCurated
Sequence conflicti459 – 4591A → K in AAC23535. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF194371 mRNA. Translation: AAF05769.1.
AF069782 mRNA. Translation: AAC23535.1.
RefSeqiNP_068522.1. NM_021754.1.
UniGeneiRn.43930.

Genome annotation databases

EnsembliENSRNOT00000022676; ENSRNOP00000022676; ENSRNOG00000016486.
GeneIDi60373.
KEGGirno:60373.
UCSCiRGD:620484. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF194371 mRNA. Translation: AAF05769.1 .
AF069782 mRNA. Translation: AAC23535.1 .
RefSeqi NP_068522.1. NM_021754.1.
UniGenei Rn.43930.

3D structure databases

ProteinModelPortali Q9QZ86.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 248802. 1 interaction.

PTM databases

PhosphoSitei Q9QZ86.

Proteomic databases

PaxDbi Q9QZ86.
PRIDEi Q9QZ86.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000022676 ; ENSRNOP00000022676 ; ENSRNOG00000016486 .
GeneIDi 60373.
KEGGi rno:60373.
UCSCi RGD:620484. rat.

Organism-specific databases

CTDi 51602.
RGDi 620484. Nop58.

Phylogenomic databases

eggNOGi COG1498.
GeneTreei ENSGT00550000074998.
HOGENOMi HOG000196310.
InParanoidi Q9QZ86.
KOi K14565.
OMAi CENETLA.
OrthoDBi EOG7T7GT0.
PhylomeDBi Q9QZ86.
TreeFami TF105688.

Miscellaneous databases

NextBioi 612047.
PROi Q9QZ86.

Gene expression databases

Genevestigatori Q9QZ86.

Family and domain databases

InterProi IPR012974. NOP5_N.
IPR002687. Nop_dom.
IPR012976. NOSIC.
[Graphical view ]
Pfami PF01798. Nop. 1 hit.
PF08156. NOP5NT. 1 hit.
PF08060. NOSIC. 1 hit.
[Graphical view ]
SMARTi SM00931. NOSIC. 1 hit.
[Graphical view ]
PROSITEi PS51358. NOP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Conserved composition of mammalian box H/ACA and box C/D small nucleolar ribonucleoprotein particles and their interaction with the common factor Nopp140."
    Yang Y., Isaac C., Wang C., Dragon F., Pogacic V., Meier U.T.
    Mol. Biol. Cell 11:567-577(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 1-22, INTERACTION WITH NOLC1.
  2. Hatton D., Gray J.C.
    Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-461.

Entry informationi

Entry nameiNOP58_RAT
AccessioniPrimary (citable) accession number: Q9QZ86
Secondary accession number(s): O88525
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3