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Q9QZ82

- CP11A_MOUSE

UniProt

Q9QZ82 - CP11A_MOUSE

Protein

Cholesterol side-chain cleavage enzyme, mitochondrial

Gene

Cyp11a1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone.By similarity

    Catalytic activityi

    Cholesterol + 6 reduced adrenodoxin + 3 O2 = pregnenolone + 4-methylpentanal + 6 oxidized adrenodoxin + 4 H2O.

    Cofactori

    Heme group.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi458 – 4581Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. cholesterol binding Source: Ensembl
    2. cholesterol monooxygenase (side-chain-cleaving) activity Source: MGI
    3. heme binding Source: UniProtKB
    4. iron ion binding Source: InterPro

    GO - Biological processi

    1. biphenyl metabolic process Source: Ensembl
    2. C21-steroid hormone biosynthetic process Source: MGI
    3. cellular response to antibiotic Source: Ensembl
    4. cellular response to cadmium ion Source: Ensembl
    5. cellular response to cAMP Source: Ensembl
    6. cellular response to fibroblast growth factor stimulus Source: Ensembl
    7. cellular response to follicle-stimulating hormone stimulus Source: Ensembl
    8. cellular response to interleukin-1 Source: Ensembl
    9. cellular response to lipopolysaccharide Source: Ensembl
    10. cellular response to peptide hormone stimulus Source: Ensembl
    11. cellular response to transforming growth factor beta stimulus Source: Ensembl
    12. cellular response to tumor necrosis factor Source: Ensembl
    13. cerebellum development Source: Ensembl
    14. cholesterol metabolic process Source: UniProtKB
    15. dibenzo-p-dioxin metabolic process Source: Ensembl
    16. estrogen biosynthetic process Source: Ensembl
    17. fractalkine metabolic process Source: Ensembl
    18. granulosa cell differentiation Source: Ensembl
    19. hippocampus development Source: Ensembl
    20. Leydig cell differentiation Source: Ensembl
    21. maternal process involved in female pregnancy Source: Ensembl
    22. mating behavior Source: Ensembl
    23. phenol-containing compound metabolic process Source: Ensembl
    24. phthalate metabolic process Source: Ensembl
    25. progesterone biosynthetic process Source: Ensembl
    26. response to alkaloid Source: Ensembl
    27. response to corticosterone Source: Ensembl
    28. response to drug Source: Ensembl
    29. response to fungicide Source: Ensembl
    30. response to gamma radiation Source: Ensembl
    31. response to genistein Source: Ensembl
    32. response to hydrogen peroxide Source: Ensembl
    33. response to insecticide Source: Ensembl
    34. response to L-ascorbic acid Source: Ensembl
    35. response to salt stress Source: Ensembl
    36. response to vitamin E Source: Ensembl
    37. Schwann cell differentiation Source: Ensembl
    38. testosterone biosynthetic process Source: Ensembl

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Biological processi

    Cholesterol metabolism, Lipid metabolism, Steroid metabolism, Steroidogenesis, Sterol metabolism

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_223561. Pregnenolone biosynthesis.
    REACT_227038. Endogenous sterols.
    UniPathwayiUPA00229.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cholesterol side-chain cleavage enzyme, mitochondrial (EC:1.14.15.6)
    Alternative name(s):
    CYPXIA1
    Cholesterol desmolase
    Cytochrome P450 11A1
    Cytochrome P450(scc)
    Gene namesi
    Name:Cyp11a1
    Synonyms:Cyp11a
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:88582. Cyp11a1.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial crista Source: Ensembl
    2. mitochondrion Source: MGI
    3. perikaryon Source: Ensembl

    Keywords - Cellular componenti

    Membrane, Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 3636MitochondrionBy similarityAdd
    BLAST
    Chaini37 – 526490Cholesterol side-chain cleavage enzyme, mitochondrialPRO_0000003587Add
    BLAST

    Proteomic databases

    MaxQBiQ9QZ82.
    PaxDbiQ9QZ82.
    PRIDEiQ9QZ82.

    PTM databases

    PhosphoSiteiQ9QZ82.

    Expressioni

    Gene expression databases

    BgeeiQ9QZ82.
    GenevestigatoriQ9QZ82.

    Interactioni

    Subunit structurei

    Interacts with FDX1/adrenodoxin.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9QZ82.
    SMRiQ9QZ82. Positions 41-510.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG2124.
    GeneTreeiENSGT00750000117408.
    HOGENOMiHOG000013161.
    HOVERGENiHBG051098.
    InParanoidiQ9QZ82.
    KOiK00498.
    OMAiYQRPIGV.
    OrthoDBiEOG7MKW5S.
    PhylomeDBiQ9QZ82.
    TreeFamiTF105094.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9QZ82-1 [UniParc]FASTAAdd to Basket

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    MLAKGLSLRS VLVKGCQPFL SPTWQGPVLS TGKGAGTSTS SPRSFNEIPS    50
    PGDNGWLNLY HFWRESGTQK IHYHQMQSFQ KYGPIYREKL GTLESVYIVD 100
    PKDASILFSC EGPNPERFLV PPWVAYHQYY QRPIGVLFKS SDAWKKDRIV 150
    LNQEVMAPGA IKNFVPLLEG VAQDFIKVLH RRIKQQNSGN FSGVISDDLF 200
    RFSFESISSV IFGERMGMLE EIVDPEAQRF INAVYQMFHT SVPMLNLPPD 250
    FFRLLRTKTW KDHAAAWDVI FNKADEYTQN FYWDLRQKRD FSQYPGVLYS 300
    LLGGNKLPFK NIQANITEML AGGVDTTSMT LQWNLYEMAH NLKVQEMLRA 350
    EVLAARRQAQ GDMAKMVQLV PLLKASIKET LRLHPISVTL QRYTVNDLVL 400
    RNYKIPAKTL VQVASFAMGR DPGFFPNPNK FDPTRWLEKS QNTTHFRYLG 450
    FGWGVRQCLG RRIAELEMTI LLINLLENFR IEVQNLRDVG TKFSLILMPE 500
    NPILFNFQPL KQDLGPAVTR KDNTVN 526
    Length:526
    Mass (Da):60,315
    Last modified:May 1, 2000 - v1
    Checksum:iE5029738EE4ECB71
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF195119 mRNA. Translation: AAF03897.1.
    CCDSiCCDS40653.1.
    RefSeqiNP_062753.3. NM_019779.3.
    UniGeneiMm.302865.

    Genome annotation databases

    EnsembliENSMUST00000034874; ENSMUSP00000034874; ENSMUSG00000032323.
    GeneIDi13070.
    KEGGimmu:13070.
    UCSCiuc009pwa.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF195119 mRNA. Translation: AAF03897.1 .
    CCDSi CCDS40653.1.
    RefSeqi NP_062753.3. NM_019779.3.
    UniGenei Mm.302865.

    3D structure databases

    ProteinModelPortali Q9QZ82.
    SMRi Q9QZ82. Positions 41-510.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9QZ82.

    Proteomic databases

    MaxQBi Q9QZ82.
    PaxDbi Q9QZ82.
    PRIDEi Q9QZ82.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000034874 ; ENSMUSP00000034874 ; ENSMUSG00000032323 .
    GeneIDi 13070.
    KEGGi mmu:13070.
    UCSCi uc009pwa.1. mouse.

    Organism-specific databases

    CTDi 1583.
    MGIi MGI:88582. Cyp11a1.

    Phylogenomic databases

    eggNOGi COG2124.
    GeneTreei ENSGT00750000117408.
    HOGENOMi HOG000013161.
    HOVERGENi HBG051098.
    InParanoidi Q9QZ82.
    KOi K00498.
    OMAi YQRPIGV.
    OrthoDBi EOG7MKW5S.
    PhylomeDBi Q9QZ82.
    TreeFami TF105094.

    Enzyme and pathway databases

    UniPathwayi UPA00229 .
    Reactomei REACT_223561. Pregnenolone biosynthesis.
    REACT_227038. Endogenous sterols.

    Miscellaneous databases

    NextBioi 283004.
    PROi Q9QZ82.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9QZ82.
    Genevestigatori Q9QZ82.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Tanaka M., Hennebold J.H., Adashi E.Y.
      Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6.

    Entry informationi

    Entry nameiCP11A_MOUSE
    AccessioniPrimary (citable) accession number: Q9QZ82
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 4, 2001
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 111 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3