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Q9QZ82 (CP11A_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cholesterol side-chain cleavage enzyme, mitochondrial

EC=1.14.15.6
Alternative name(s):
CYPXIA1
Cholesterol desmolase
Cytochrome P450 11A1
Cytochrome P450(scc)
Gene names
Name:Cyp11a1
Synonyms:Cyp11a
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length526 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone By similarity.

Catalytic activity

Cholesterol + 6 reduced adrenodoxin + 3 O2 = pregnenolone + 4-methylpentanal + 6 oxidized adrenodoxin + 4 H2O.

Cofactor

Heme group By similarity.

Pathway

Lipid metabolism; C21-steroid hormone metabolism.

Subunit structure

Interacts with FDX1/adrenodoxin By similarity.

Subcellular location

Mitochondrion membrane.

Sequence similarities

Belongs to the cytochrome P450 family.

Ontologies

Keywords
   Biological processCholesterol metabolism
Lipid metabolism
Steroid metabolism
Steroidogenesis
Sterol metabolism
   Cellular componentMembrane
Mitochondrion
   DomainTransit peptide
   LigandHeme
Iron
Metal-binding
   Molecular functionMonooxygenase
Oxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processC21-steroid hormone biosynthetic process

Inferred from direct assay PubMed 7527351. Source: MGI

Leydig cell differentiation

Inferred from electronic annotation. Source: Ensembl

Schwann cell differentiation

Inferred from electronic annotation. Source: Ensembl

biphenyl metabolic process

Inferred from electronic annotation. Source: Ensembl

cellular response to antibiotic

Inferred from electronic annotation. Source: Ensembl

cellular response to cAMP

Inferred from electronic annotation. Source: Ensembl

cellular response to cadmium ion

Inferred from electronic annotation. Source: Ensembl

cellular response to fibroblast growth factor stimulus

Inferred from electronic annotation. Source: Ensembl

cellular response to follicle-stimulating hormone stimulus

Inferred from electronic annotation. Source: Ensembl

cellular response to interleukin-1

Inferred from electronic annotation. Source: Ensembl

cellular response to lipopolysaccharide

Inferred from electronic annotation. Source: Ensembl

cellular response to peptide hormone stimulus

Inferred from electronic annotation. Source: Ensembl

cellular response to transforming growth factor beta stimulus

Inferred from electronic annotation. Source: Ensembl

cellular response to tumor necrosis factor

Inferred from electronic annotation. Source: Ensembl

cerebellum development

Inferred from electronic annotation. Source: Ensembl

cholesterol metabolic process

Inferred from sequence or structural similarity. Source: UniProtKB

dibenzo-p-dioxin metabolic process

Inferred from electronic annotation. Source: Ensembl

estrogen biosynthetic process

Inferred from electronic annotation. Source: Ensembl

fractalkine metabolic process

Inferred from electronic annotation. Source: Ensembl

granulosa cell differentiation

Inferred from electronic annotation. Source: Ensembl

hippocampus development

Inferred from electronic annotation. Source: Ensembl

maternal process involved in female pregnancy

Inferred from electronic annotation. Source: Ensembl

mating behavior

Inferred from electronic annotation. Source: Ensembl

phenol-containing compound metabolic process

Inferred from electronic annotation. Source: Ensembl

phthalate metabolic process

Inferred from electronic annotation. Source: Ensembl

progesterone biosynthetic process

Inferred from electronic annotation. Source: Ensembl

response to L-ascorbic acid

Inferred from electronic annotation. Source: Ensembl

response to alkaloid

Inferred from electronic annotation. Source: Ensembl

response to corticosterone

Inferred from electronic annotation. Source: Ensembl

response to drug

Inferred from electronic annotation. Source: Ensembl

response to fungicide

Inferred from electronic annotation. Source: Ensembl

response to gamma radiation

Inferred from electronic annotation. Source: Ensembl

response to genistein

Inferred from electronic annotation. Source: Ensembl

response to hydrogen peroxide

Inferred from electronic annotation. Source: Ensembl

response to insecticide

Inferred from electronic annotation. Source: Ensembl

response to salt stress

Inferred from electronic annotation. Source: Ensembl

response to vitamin E

Inferred from electronic annotation. Source: Ensembl

testosterone biosynthetic process

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentmitochondrial crista

Inferred from electronic annotation. Source: Ensembl

mitochondrion

Inferred from direct assay PubMed 14651853PubMed 18614015PubMed 8111631. Source: MGI

perikaryon

Inferred from electronic annotation. Source: Ensembl

   Molecular_functioncholesterol binding

Inferred from electronic annotation. Source: Ensembl

cholesterol monooxygenase (side-chain-cleaving) activity

Inferred from direct assay PubMed 7527351. Source: MGI

heme binding

Inferred from sequence or structural similarity. Source: UniProtKB

iron ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 3636Mitochondrion By similarity
Chain37 – 526490Cholesterol side-chain cleavage enzyme, mitochondrial
PRO_0000003587

Sites

Metal binding4581Iron (heme axial ligand) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9QZ82 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: E5029738EE4ECB71

FASTA52660,315
        10         20         30         40         50         60 
MLAKGLSLRS VLVKGCQPFL SPTWQGPVLS TGKGAGTSTS SPRSFNEIPS PGDNGWLNLY 

        70         80         90        100        110        120 
HFWRESGTQK IHYHQMQSFQ KYGPIYREKL GTLESVYIVD PKDASILFSC EGPNPERFLV 

       130        140        150        160        170        180 
PPWVAYHQYY QRPIGVLFKS SDAWKKDRIV LNQEVMAPGA IKNFVPLLEG VAQDFIKVLH 

       190        200        210        220        230        240 
RRIKQQNSGN FSGVISDDLF RFSFESISSV IFGERMGMLE EIVDPEAQRF INAVYQMFHT 

       250        260        270        280        290        300 
SVPMLNLPPD FFRLLRTKTW KDHAAAWDVI FNKADEYTQN FYWDLRQKRD FSQYPGVLYS 

       310        320        330        340        350        360 
LLGGNKLPFK NIQANITEML AGGVDTTSMT LQWNLYEMAH NLKVQEMLRA EVLAARRQAQ 

       370        380        390        400        410        420 
GDMAKMVQLV PLLKASIKET LRLHPISVTL QRYTVNDLVL RNYKIPAKTL VQVASFAMGR 

       430        440        450        460        470        480 
DPGFFPNPNK FDPTRWLEKS QNTTHFRYLG FGWGVRQCLG RRIAELEMTI LLINLLENFR 

       490        500        510        520 
IEVQNLRDVG TKFSLILMPE NPILFNFQPL KQDLGPAVTR KDNTVN 

« Hide

References

[1]Tanaka M., Hennebold J.H., Adashi E.Y.
Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF195119 mRNA. Translation: AAF03897.1.
CCDSCCDS40653.1.
RefSeqNP_062753.3. NM_019779.3.
UniGeneMm.302865.

3D structure databases

ProteinModelPortalQ9QZ82.
SMRQ9QZ82. Positions 41-510.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ9QZ82.

Proteomic databases

MaxQBQ9QZ82.
PaxDbQ9QZ82.
PRIDEQ9QZ82.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000034874; ENSMUSP00000034874; ENSMUSG00000032323.
GeneID13070.
KEGGmmu:13070.
UCSCuc009pwa.1. mouse.

Organism-specific databases

CTD1583.
MGIMGI:88582. Cyp11a1.

Phylogenomic databases

eggNOGCOG2124.
GeneTreeENSGT00750000117408.
HOGENOMHOG000013161.
HOVERGENHBG051098.
InParanoidQ9QZ82.
KOK00498.
OMAYQRPIGV.
OrthoDBEOG7MKW5S.
PhylomeDBQ9QZ82.
TreeFamTF105094.

Enzyme and pathway databases

UniPathwayUPA00229.

Gene expression databases

BgeeQ9QZ82.
GenevestigatorQ9QZ82.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio283004.
PROQ9QZ82.
SOURCESearch...

Entry information

Entry nameCP11A_MOUSE
AccessionPrimary (citable) accession number: Q9QZ82
Entry history
Integrated into UniProtKB/Swiss-Prot: May 4, 2001
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot