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Protein

Myoglobin

Gene

Mb

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi65Iron (heme distal ligand)1
Metal bindingi94Iron (heme proximal ligand)1

GO - Molecular functioni

  • heme binding Source: RGD
  • metal ion binding Source: UniProtKB-KW
  • oxygen binding Source: RGD
  • oxygen transporter activity Source: UniProtKB-KW

GO - Biological processi

  • brown fat cell differentiation Source: Ensembl
  • enucleate erythrocyte differentiation Source: Ensembl
  • heart development Source: Ensembl
  • oxygen transport Source: RGD
  • response to hormone Source: RGD
  • response to hydrogen peroxide Source: RGD
  • response to hypoxia Source: Ensembl
  • slow-twitch skeletal muscle fiber contraction Source: RGD

Keywordsi

Molecular functionMuscle protein
Biological processOxygen transport, Transport
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-RNO-8981607. Intracellular oxygen transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Myoglobin
Gene namesi
Name:Mb
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi620411. Mb.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000533411 – 154MyoglobinAdd BLAST154

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei4PhosphoserineCombined sources1
Modified residuei32PhosphoserineCombined sources1
Modified residuei68PhosphothreonineBy similarity1
Modified residuei121PhosphoserineCombined sources1
Modified residuei133PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9QZ76.
PRIDEiQ9QZ76.

PTM databases

iPTMnetiQ9QZ76.
PhosphoSitePlusiQ9QZ76.

Expressioni

Gene expression databases

BgeeiENSRNOG00000004583.
GenevisibleiQ9QZ76. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006184.

Structurei

3D structure databases

ProteinModelPortaliQ9QZ76.
SMRiQ9QZ76.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3378. Eukaryota.
COG1018. LUCA.
GeneTreeiENSGT00730000110844.
HOGENOMiHOG000070111.
HOVERGENiHBG107340.
InParanoidiQ9QZ76.
OMAiLFRNDIA.
OrthoDBiEOG091G0OAO.
PhylomeDBiQ9QZ76.
TreeFamiTF332967.

Family and domain databases

InterProiView protein in InterPro
IPR000971. Globin.
IPR009050. Globin-like.
IPR002335. Myoglobin.
PANTHERiPTHR11442:SF57. PTHR11442:SF57. 1 hit.
PfamiView protein in Pfam
PF00042. Globin. 1 hit.
PRINTSiPR00613. MYOGLOBIN.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiView protein in PROSITE
PS01033. GLOBIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9QZ76-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLSDGEWQM VLNIWGKVEG DLAGHGQEVL ISLFKAHPET LEKFDKFKNL
60 70 80 90 100
KSEEEMKSSE DLKKHGCTVL TALGTILKKK GQHAAEIQPL AQSHATKHKI
110 120 130 140 150
PVKYLEFISE VIIQVLKKRY SGDFGADAQG AMSKALELFR NDIAAKYKEL

GFQG
Length:154
Mass (Da):17,157
Last modified:January 23, 2007 - v3
Checksum:i98B31BE57FA020DA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF197916 mRNA. Translation: AAF05848.1.
BC070511 mRNA. Translation: AAH70511.1.
RefSeqiNP_067599.1. NM_021588.2.
UniGeneiRn.40511.

Genome annotation databases

EnsembliENSRNOT00000006184; ENSRNOP00000006184; ENSRNOG00000004583.
GeneIDi59108.
KEGGirno:59108.
UCSCiRGD:620411. rat.

Similar proteinsi

Entry informationi

Entry nameiMYG_RAT
AccessioniPrimary (citable) accession number: Q9QZ76
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: January 23, 2007
Last modified: September 27, 2017
This is version 113 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families