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Q9QZ67

- PPM1D_MOUSE

UniProt

Q9QZ67 - PPM1D_MOUSE

Protein

Protein phosphatase 1D

Gene

Ppm1d

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-18' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins By similarity.By similarity

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 2 magnesium or manganese ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi98 – 981Manganese 1By similarity
    Metal bindingi98 – 981Manganese 2By similarity
    Metal bindingi99 – 991Manganese 1; via carbonyl oxygenBy similarity
    Metal bindingi307 – 3071Manganese 2By similarity
    Metal bindingi359 – 3591Manganese 2By similarity

    GO - Molecular functioni

    1. magnesium-dependent protein serine/threonine phosphatase activity Source: MGI
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. G2/M transition of mitotic cell cycle Source: MGI
    2. peptidyl-threonine dephosphorylation Source: Ensembl
    3. response to bacterium Source: MGI

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Biological processi

    Cell cycle

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein phosphatase 1D (EC:3.1.3.16)
    Alternative name(s):
    Protein phosphatase 2C isoform delta
    Short name:
    PP2C-delta
    Protein phosphatase magnesium-dependent 1 delta
    p53-induced protein phosphatase 1
    Gene namesi
    Name:Ppm1d
    Synonyms:Wip1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:1858214. Ppm1d.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 598598Protein phosphatase 1DPRO_0000057753Add
    BLAST

    Proteomic databases

    PaxDbiQ9QZ67.
    PRIDEiQ9QZ67.

    PTM databases

    PhosphoSiteiQ9QZ67.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed.1 Publication

    Inductioni

    By p53.

    Gene expression databases

    ArrayExpressiQ9QZ67.
    BgeeiQ9QZ67.
    GenevestigatoriQ9QZ67.

    Interactioni

    Subunit structurei

    Interacts with CHEK1 and CHEK2; dephosphorylates them.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000020835.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9QZ67.
    SMRiQ9QZ67. Positions 92-367.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini15 – 371357PP2C-likeAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 9494Interaction with CHEK1By similarityAdd
    BLAST

    Sequence similaritiesi

    Belongs to the PP2C family.Curated
    Contains 1 PP2C-like domain.Curated

    Phylogenomic databases

    eggNOGiCOG0631.
    GeneTreeiENSGT00730000110861.
    HOVERGENiHBG058897.
    InParanoidiB1B0B0.
    KOiK10147.
    OMAiVIPSKDP.
    OrthoDBiEOG7Z95M0.
    TreeFamiTF313481.

    Family and domain databases

    Gene3Di3.60.40.10. 2 hits.
    InterProiIPR001932. PP2C-like_dom.
    IPR000222. PP2C_Mn2_Asp60_BS.
    IPR015655. Protein_Pase_2C.
    [Graphical view]
    PANTHERiPTHR13832. PTHR13832. 1 hit.
    PfamiPF00481. PP2C. 1 hit.
    [Graphical view]
    SMARTiSM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view]
    SUPFAMiSSF81606. SSF81606. 2 hits.
    PROSITEiPS01032. PP2C. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9QZ67-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGLYSLGVS VFSDQGGRKY MEDVTQIVVE PEPAAEDKPA PVPRRALGLP    50
    ATPTLAGVGP SEKGPAAARD PAPDAAASLP AGRCCRRRSS VAFFAVCDGH 100
    GGREAAQFAR EHLWGFIKKQ KGFTSSEPAK VCAAIRKGFL ACHLAMWKKL 150
    AEWPKTMTGL PSTSGTTASV VIIRGMKMYV AHVGDSGVVL GIQDDPKDDF 200
    VRAVEVTQDH KPELPKERER IEGLGGSVMN KSGVNRVVWK RPRLTHSGPV 250
    RRSTVIDQIP FLAVARALGD LWSYDFFSGK FVVSPEPDTS VHTLDPRKHK 300
    YIILGSDGLW NMVPPQDAIS MCQDQEEKKY LMGEQGQSCA KMLVNRALGR 350
    WRQRMLRADN TSAIVICISP EVDNQGNFTN EDELFLNLTD SPTYNSQETC 400
    VMTSSPSSTP PIKSPEEDAW PRLSSKDHIP ALVRSNAFSE KFLEVPAEIA 450
    RGNIQTVVMT SKDSETLEEN CPKALTLRIH DSLNNTLSVG LIPTNSTNTI 500
    MDQKNLKMST PGQMKAQEVE RTPPANFKRT LEESNSGPLM KKHRRNGLSR 550
    SSGAQASSLP TASQRRHSVK LTLRRRLRGQ RKMGNPLLHQ HRKTVCVC 598
    Length:598
    Mass (Da):65,723
    Last modified:July 27, 2011 - v2
    Checksum:i4DB70375685BBC15
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti532 – 5321E → K in AAF09251. (PubMed:10756097)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF200464 mRNA. Translation: AAF09251.1.
    BX323026 Genomic DNA. Translation: CAI26197.1.
    CCDSiCCDS25194.1.
    RefSeqiNP_058606.3. NM_016910.3.
    UniGeneiMm.45609.

    Genome annotation databases

    EnsembliENSMUST00000020835; ENSMUSP00000020835; ENSMUSG00000020525.
    GeneIDi53892.
    KEGGimmu:53892.
    UCSCiuc007krl.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF200464 mRNA. Translation: AAF09251.1 .
    BX323026 Genomic DNA. Translation: CAI26197.1 .
    CCDSi CCDS25194.1.
    RefSeqi NP_058606.3. NM_016910.3.
    UniGenei Mm.45609.

    3D structure databases

    ProteinModelPortali Q9QZ67.
    SMRi Q9QZ67. Positions 92-367.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000020835.

    PTM databases

    PhosphoSitei Q9QZ67.

    Proteomic databases

    PaxDbi Q9QZ67.
    PRIDEi Q9QZ67.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000020835 ; ENSMUSP00000020835 ; ENSMUSG00000020525 .
    GeneIDi 53892.
    KEGGi mmu:53892.
    UCSCi uc007krl.2. mouse.

    Organism-specific databases

    CTDi 8493.
    MGIi MGI:1858214. Ppm1d.

    Phylogenomic databases

    eggNOGi COG0631.
    GeneTreei ENSGT00730000110861.
    HOVERGENi HBG058897.
    InParanoidi B1B0B0.
    KOi K10147.
    OMAi VIPSKDP.
    OrthoDBi EOG7Z95M0.
    TreeFami TF313481.

    Miscellaneous databases

    NextBioi 310783.
    PROi Q9QZ67.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9QZ67.
    Bgeei Q9QZ67.
    Genevestigatori Q9QZ67.

    Family and domain databases

    Gene3Di 3.60.40.10. 2 hits.
    InterProi IPR001932. PP2C-like_dom.
    IPR000222. PP2C_Mn2_Asp60_BS.
    IPR015655. Protein_Pase_2C.
    [Graphical view ]
    PANTHERi PTHR13832. PTHR13832. 1 hit.
    Pfami PF00481. PP2C. 1 hit.
    [Graphical view ]
    SMARTi SM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81606. SSF81606. 2 hits.
    PROSITEi PS01032. PP2C. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The structure and expression of the murine wildtype p53-induced phosphatase 1 (Wip1) gene."
      Choi J., Appella E., Donehower L.A.
      Genomics 64:298-306(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Strain: 129/SvJ.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.

    Entry informationi

    Entry nameiPPM1D_MOUSE
    AccessioniPrimary (citable) accession number: Q9QZ67
    Secondary accession number(s): B1B0B0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 110 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3