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Protein

Heat shock protein beta-3

Gene

Hspb3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Inhibitor of actin polymerization.By similarity

Keywordsi

Biological processStress response

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein beta-3
Short name:
HspB3
Gene namesi
Name:Hspb3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1928479. Hspb3.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: Translocates to nuclear foci during heat shock.By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001259371 – 154Heat shock protein beta-3Add BLAST154

Proteomic databases

PaxDbiQ9QZ57.
PRIDEiQ9QZ57.

PTM databases

PhosphoSitePlusiQ9QZ57.

Expressioni

Gene expression databases

BgeeiENSMUSG00000051456.
CleanExiMM_HSPB3.
GenevisibleiQ9QZ57. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000054193.

Structurei

3D structure databases

ProteinModelPortaliQ9QZ57.
SMRiQ9QZ57.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini57 – 154sHSPPROSITE-ProRule annotationAdd BLAST98

Sequence similaritiesi

Belongs to the small heat shock protein (HSP20) family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3591. Eukaryota.
ENOG410YERS. LUCA.
GeneTreeiENSGT00760000119238.
HOGENOMiHOG000286024.
HOVERGENiHBG052039.
InParanoidiQ9QZ57.
KOiK09544.
OMAiFCHDGIL.
OrthoDBiEOG091G0USC.
PhylomeDBiQ9QZ57.
TreeFamiTF105049.

Family and domain databases

CDDicd06477. ACD_HspB3_Like. 1 hit.
Gene3Di2.60.40.790. 1 hit.
InterProiView protein in InterPro
IPR002068. A-crystallin/Hsp20_dom.
IPR001436. Alpha-crystallin/HSP.
IPR031107. HSP20.
IPR008978. HSP20-like_chaperone.
IPR033894. HSPB3.
PANTHERiPTHR11527. PTHR11527. 1 hit.
PfamiView protein in Pfam
PF00011. HSP20. 1 hit.
PRINTSiPR00299. ACRYSTALLIN.
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiView protein in PROSITE
PS01031. SHSP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9QZ57-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKIILRHLI ETPVRYQEEF EARGLEDCRL DHTLYALPGP TIEDLSKARG
60 70 80 90 100
AGTPQALAED SASTEKPPGE GKSRFQILLD VVQFLPEDII IQTFEGWLLI
110 120 130 140 150
KAQHGTRMDE HGFISRSFTR QYKLPDGVET KDLSAILCHD GILVVEVKDS

LGTK
Length:154
Mass (Da):17,230
Last modified:May 1, 2000 - v1
Checksum:iECBAAD45221FE2E3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF203375 mRNA. Translation: AAF09589.1.
AK009633 mRNA. Translation: BAB26404.1.
BC065388 mRNA. Translation: AAH65388.1.
BC092376 mRNA. Translation: AAH92376.1.
CCDSiCCDS26785.1.
RefSeqiNP_064344.1. NM_019960.2.
UniGeneiMm.41410.

Genome annotation databases

EnsembliENSMUST00000054650; ENSMUSP00000054193; ENSMUSG00000051456.
GeneIDi56534.
KEGGimmu:56534.
UCSCiuc007rxi.2. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiHSPB3_MOUSE
AccessioniPrimary (citable) accession number: Q9QZ57
Secondary accession number(s): Q569N3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: May 1, 2000
Last modified: May 10, 2017
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families