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Protein

UBX domain-containing protein 8

Gene

Ubxn8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins, possibly by tethering VCP to the endoplasmic reticulum membrane. May play a role in reproduction (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
UBX domain-containing protein 8
Alternative name(s):
Reproduction 8 protein
Short name:
Rep-8 protein
UBX domain-containing protein 6
Gene namesi
Name:Ubxn8
Synonyms:D0H8S2298E, Rep8, Ubxd6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1337129. Ubxn8.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 11CytoplasmicSequence analysis
Transmembranei2 – 2221HelicalSequence analysisAdd
BLAST
Topological domaini23 – 3311LumenalSequence analysisAdd
BLAST
Transmembranei34 – 5421HelicalSequence analysisAdd
BLAST
Topological domaini55 – 277223CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 277277UBX domain-containing protein 8PRO_0000211034Add
BLAST

Proteomic databases

EPDiQ9QZ49.
PaxDbiQ9QZ49.
PRIDEiQ9QZ49.

PTM databases

iPTMnetiQ9QZ49.
PhosphoSiteiQ9QZ49.

Expressioni

Tissue specificityi

Highly expressed in gonads. In testis, expressed in post-meiotic round spermatids, while in ovaries it is expressed in granulosa cells.1 Publication

Developmental stagei

Expressed in both the early and late embryonic stages of development.1 Publication

Interactioni

Subunit structurei

Interacts with SYVN1 and VCP.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000092992.

Structurei

Secondary structure

1
277
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi195 – 2039Combined sources
Beta strandi209 – 21911Combined sources
Helixi221 – 23010Combined sources
Turni234 – 2363Combined sources
Beta strandi237 – 2404Combined sources
Beta strandi242 – 2443Combined sources
Helixi256 – 2594Combined sources
Beta strandi265 – 2717Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2CR5NMR-A182-277[»]
ProteinModelPortaliQ9QZ49.
SMRiQ9QZ49. Positions 182-273.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9QZ49.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini193 – 26977UBXPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 UBX domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1363. Eukaryota.
ENOG410XSFS. LUCA.
HOGENOMiHOG000132969.
HOVERGENiHBG010843.
InParanoidiQ9QZ49.
PhylomeDBiQ9QZ49.

Family and domain databases

InterProiIPR029071. Ubiquitin-rel_dom.
IPR001012. UBX_dom.
IPR017247. UBXN8.
[Graphical view]
PfamiPF00789. UBX. 1 hit.
[Graphical view]
PIRSFiPIRSF037632. UBX_Rep6. 1 hit.
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS50033. UBX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9QZ49-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASRGVVGLF LLSALPLLCL ELRRGIPSLG IKDLILLSGR IFLLLALLTL
60 70 80 90 100
VISVTTSWFN SLKPSQGHLK EGEKENEKRR RLVRERQQEA QGEKASRYIE
110 120 130 140 150
NVLKPQQEMK LKKLEERFYQ MTGETWKLTA GHRLLEGDED SEFENSSQAS
160 170 180 190 200
FETINGEAAR RQNLPKFSTE ISPAARPLLR KEVPDLPEEP SETAEEVVTV
210 220 230 240 250
ALRCPNGRVL RRRFFKSWNS QVLLDWMMKV GYHKSLYRLS TSFPRRALEV
260 270
EGGSSLEDIG ITVDTVLNVE EKEQSSQ
Length:277
Mass (Da):31,555
Last modified:May 1, 2000 - v1
Checksum:i0AC63ACC5C4F5FF9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D88447 mRNA. Translation: BAA84495.1.
BC024492 mRNA. Translation: AAH24492.1.
CCDSiCCDS22234.1.
UniGeneiMm.29301.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D88447 mRNA. Translation: BAA84495.1.
BC024492 mRNA. Translation: AAH24492.1.
CCDSiCCDS22234.1.
UniGeneiMm.29301.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2CR5NMR-A182-277[»]
ProteinModelPortaliQ9QZ49.
SMRiQ9QZ49. Positions 182-273.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000092992.

PTM databases

iPTMnetiQ9QZ49.
PhosphoSiteiQ9QZ49.

Proteomic databases

EPDiQ9QZ49.
PaxDbiQ9QZ49.
PRIDEiQ9QZ49.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1337129. Ubxn8.

Phylogenomic databases

eggNOGiKOG1363. Eukaryota.
ENOG410XSFS. LUCA.
HOGENOMiHOG000132969.
HOVERGENiHBG010843.
InParanoidiQ9QZ49.
PhylomeDBiQ9QZ49.

Miscellaneous databases

EvolutionaryTraceiQ9QZ49.
PROiQ9QZ49.
SOURCEiSearch...

Family and domain databases

InterProiIPR029071. Ubiquitin-rel_dom.
IPR001012. UBX_dom.
IPR017247. UBXN8.
[Graphical view]
PfamiPF00789. UBX. 1 hit.
[Graphical view]
PIRSFiPIRSF037632. UBX_Rep6. 1 hit.
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS50033. UBX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUBXN8_MOUSE
AccessioniPrimary (citable) accession number: Q9QZ49
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: May 1, 2000
Last modified: May 11, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.