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Protein

Zinc finger and BTB domain-containing protein 7A

Gene

Zbtb7a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a key role in the instruction of early lymphoid progenitors to develop into B lineage by repressing T-cell instructive Notch signals (By similarity). Specifically represses the transcription of the CDKN2A gene. Efficiently abrogates E2F1-dependent CDKN2A transactivation/de-repression. Binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3' (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri376 – 39823C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri404 – 42623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri432 – 45423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri460 – 48425C2H2-type 4; atypicalPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • DNA binding Source: UniProtKB
  • histone acetyltransferase binding Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW
  • transcription factor activity, sequence-specific DNA binding Source: RGD

GO - Biological processi

  • cell differentiation Source: UniProtKB-KW
  • multicellular organism development Source: UniProtKB-KW
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • regulation of osteoclast differentiation Source: RGD
  • regulation of transcription, DNA-templated Source: RGD
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Repressor

Keywords - Biological processi

Differentiation, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 7A
Alternative name(s):
Leukemia/lymphoma-related factor
Osteoclast-derived zinc finger protein
Gene namesi
Name:Zbtb7a
Synonyms:Lrf, Oczf, Zbtb7
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620946. Zbtb7a.

Subcellular locationi

  • Nucleus 1 Publication

GO - Cellular componenti

  • nucleus Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 569569Zinc finger and BTB domain-containing protein 7APRO_0000047717Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei331 – 3311PhosphoserineCombined sources
Modified residuei335 – 3351PhosphoserineBy similarity
Cross-linki527 – 527Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei537 – 5371PhosphoserineBy similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ9QZ48.
PRIDEiQ9QZ48.

PTM databases

iPTMnetiQ9QZ48.
PhosphoSiteiQ9QZ48.

Expressioni

Tissue specificityi

Expressed in osteoclasts and kidney cells.

Interactioni

Subunit structurei

Interacts with BCL6.By similarity

GO - Molecular functioni

  • histone acetyltransferase binding Source: UniProtKB

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027323.

Structurei

3D structure databases

ProteinModelPortaliQ9QZ48.
SMRiQ9QZ48. Positions 7-129.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 10168BTBPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni480 – 49617Nuclear targeting sequenceSequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 4 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri376 – 39823C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri404 – 42623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri432 – 45423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri460 – 48425C2H2-type 4; atypicalPROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
HOGENOMiHOG000082521.
HOVERGENiHBG106747.
InParanoidiQ9QZ48.
KOiK10494.
PhylomeDBiQ9QZ48.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 4 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9QZ48-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGGVDGPIG IPFPDHSSDI LSGLNEQRTQ GLLCDVVILV EGREFPTHRS
60 70 80 90 100
VLAACSQYFK KLFTSGAVVD QQNVYEIDFV SAEALTALMD FAYTATLTVS
110 120 130 140 150
TANVGDILSA ARLLEIPAVS RVCTDLLERQ ILAADDVGDA GQPDGAGPTD
160 170 180 190 200
QRNLLRAKEY LEFFRSNPMN SLPPTAFQWP GFSAPDDDLD ATKEAVAAAV
210 220 230 240 250
AAVAAGDCNG LDFYGPGPPA DRPPTGDGEE GDSTPGLWPE RDEDAPPGGL
260 270 280 290 300
FPPPTAPPAT TQNGHYGRAG ASTGEEEAVA LSEAAPEPGD SPGFLSGAAE
310 320 330 340 350
GEDGDAADVD GLAASTLLQQ MMSSVGRAGD SDEESRPDDK GVMDYYLKYF
360 370 380 390 400
SGAHEGDVYP AWSQKGEKKI RAKAFQKCPI CEKVIQGAGK LPRHIRTHTG
410 420 430 440 450
EKPYECNICK VRFTRQDKLK VHMRKHTGEK PYLCQQCGAA FAHNYDLKNH
460 470 480 490 500
MRVHTGLRPY QCDSCCKTFV RSDHLHRHLK KDGCNGVPSR RGRKPRVRGV
510 520 530 540 550
PPDVPSGAGA PPGLPDAPRN GQEKHFKDEE DDEEEASLDG LGRLNVAGSG
560
GDDGAGGPTV AATEGNFAT
Length:569
Mass (Da):60,543
Last modified:May 1, 2000 - v1
Checksum:iC1114B303B0D0F0D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D88450 mRNA. Translation: BAA86393.1.
RefSeqiNP_446454.1. NM_054002.1.
UniGeneiRn.162908.
Rn.23192.

Genome annotation databases

GeneIDi117107.
KEGGirno:117107.
UCSCiRGD:620946. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D88450 mRNA. Translation: BAA86393.1.
RefSeqiNP_446454.1. NM_054002.1.
UniGeneiRn.162908.
Rn.23192.

3D structure databases

ProteinModelPortaliQ9QZ48.
SMRiQ9QZ48. Positions 7-129.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027323.

PTM databases

iPTMnetiQ9QZ48.
PhosphoSiteiQ9QZ48.

Proteomic databases

PaxDbiQ9QZ48.
PRIDEiQ9QZ48.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi117107.
KEGGirno:117107.
UCSCiRGD:620946. rat.

Organism-specific databases

CTDi51341.
RGDi620946. Zbtb7a.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
HOGENOMiHOG000082521.
HOVERGENiHBG106747.
InParanoidiQ9QZ48.
KOiK10494.
PhylomeDBiQ9QZ48.

Miscellaneous databases

PROiQ9QZ48.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 4 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Osteoclast-derived zinc finger (OCZF) protein with POZ domain, a possible transcriptional repressor, is involved in osteoclastogenesis."
    Kukita A., Kukita T., Ouchida M., Maeda H., Yatsuki H., Kohashi O.
    Blood 94:1987-1997(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION.
    Strain: Sprague-Dawley.
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-331, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiZBT7A_RAT
AccessioniPrimary (citable) accession number: Q9QZ48
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: May 1, 2000
Last modified: June 8, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.