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Protein

Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1

Gene

St6galnac1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Transfers CMP-NeuAc with an alpha-2,6-linkage to the GalNAc residues of GalNAc-O-Ser/Thr, Gal-beta-1,3-GalNAc-O-Ser/Thr and NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc-O-Ser/Thr are substrates. Higher activity towards GalNAc-O-Ser/Thr.1 Publication

Catalytic activityi

CMP-N-acetylneuraminate + glycano-(1->3)-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein = CMP + glycano-((2->6)-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein.

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

  • alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity Source: MGI

GO - Biological processi

  • ganglioside biosynthetic process Source: MGI
  • oligosaccharide biosynthetic process Source: MGI
  • protein N-linked glycosylation via asparagine Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

ReactomeiR-MMU-4085001. Sialic acid metabolism.
UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT29. Glycosyltransferase Family 29.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 (EC:2.4.99.3)
Alternative name(s):
GalNAc alpha-2,6-sialyltransferase I
ST6GalNAc I
Short name:
ST6GalNAcI
Sialyltransferase 7A
Short name:
SIAT7-A
Gene namesi
Name:St6galnac1
Synonyms:Siat7a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1341826. St6galnac1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 12CytoplasmicSequence analysisAdd BLAST12
Transmembranei13 – 33Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini34 – 526LumenalSequence analysisAdd BLAST493

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001492701 – 526Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1Add BLAST526

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi206N-linked (GlcNAc...)Sequence analysis1
Glycosylationi228N-linked (GlcNAc...)Sequence analysis1
Glycosylationi259N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi293 ↔ 461By similarity
Glycosylationi303N-linked (GlcNAc...)Sequence analysis1
Glycosylationi388N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9QZ39.
PaxDbiQ9QZ39.
PRIDEiQ9QZ39.

PTM databases

iPTMnetiQ9QZ39.
PhosphoSitePlusiQ9QZ39.

Expressioni

Tissue specificityi

Submaxillary gland, mammary gland, spleen and colon.

Gene expression databases

BgeeiENSMUSG00000009588.
GenevisibleiQ9QZ39. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000009732.

Structurei

3D structure databases

ProteinModelPortaliQ9QZ39.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 29 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2692. Eukaryota.
ENOG410XT8P. LUCA.
GeneTreeiENSGT00760000119095.
HOGENOMiHOG000231097.
HOVERGENiHBG073351.
InParanoidiQ9QZ39.
KOiK03479.
OMAiWLQNIFL.
OrthoDBiEOG091G07XX.
TreeFamiTF354325.

Family and domain databases

InterProiIPR001675. Glyco_trans_29.
[Graphical view]
PfamiPF00777. Glyco_transf_29. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9QZ39-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRYCRGLSQ RQAFLLLTVL ALLFILLFVV KDPRAKDSRC QFIWKNDASA
60 70 80 90 100
QENQQKAEPQ VPIMTLSPRV HNKETTSVSS KDLKKQEREA VQGEQAEGKE
110 120 130 140 150
KRKLETIRPA PENPQSKAEP AAKTPVSEHL DKLPRAPGAL STRKTPMATG
160 170 180 190 200
AVPAKKKVVQ ATKSPASSPH PTTRRRQRLK ASEFKSEPRW DFEEEYSLDM
210 220 230 240 250
SSLQTNCSAS VKIKASKSPW LQNIFLPNIT LFLDSGRFTQ SEWNRLEHFA
260 270 280 290 300
PPFGFMELNQ SLVQKVVTRF PPVRQQQLLL ASLPTGYSKC ITCAVVGNGG
310 320 330 340 350
ILNDSRVGRE IDSHDYVFRL SGAVIKGYEQ DVGTRTSFYG FTAFSLTQSI
360 370 380 390 400
LILGRRGFQH VPLGKDVRYL HFLEGTRDYE WLEAMFLNQT LAKTHLSWFR
410 420 430 440 450
HRPQEAFRNA LDLDRYLLLH PDFLRYMKNR FLRSKTLDTA HWRIYRPTTG
460 470 480 490 500
ALLLLTALHL CDKVSAYGFI TEGHQRFSDH YYDTSWKRLI FYINHDFRLE
510 520
RMVWKRLHDE GIIWLYQRPQ SDKAKN
Length:526
Mass (Da):60,734
Last modified:July 27, 2011 - v2
Checksum:i682A5E35E3C142D6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti40C → R in CAA72137 (PubMed:10788794).Curated1
Sequence conflicti44 – 45WK → LN in CAA72137 (PubMed:10788794).Curated2
Sequence conflicti48A → S in CAA72137 (PubMed:10788794).Curated1
Sequence conflicti53 – 54NQ → IL in CAA72137 (PubMed:10788794).Curated2
Sequence conflicti61V → G in CAA72137 (PubMed:10788794).Curated1
Sequence conflicti75T → A in CAA72137 (PubMed:10788794).Curated1
Sequence conflicti133L → V in CAA72137 (PubMed:10788794).Curated1
Sequence conflicti136A → T in CAA72137 (PubMed:10788794).Curated1
Sequence conflicti378D → N in CAA72137 (PubMed:10788794).Curated1
Sequence conflicti475Q → E in CAA72137 (PubMed:10788794).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11274 mRNA. Translation: CAA72137.1.
Y10294 Genomic DNA. Translation: CAA71341.1.
AL645542 Genomic DNA. Translation: CAM25277.1.
BC141095 mRNA. Translation: AAI41096.1.
BC145373 mRNA. Translation: AAI45374.1.
CCDSiCCDS36380.1.
PIRiJC7248.
RefSeqiNP_035501.2. NM_011371.2.
UniGeneiMm.436887.
Mm.491644.

Genome annotation databases

EnsembliENSMUST00000009732; ENSMUSP00000009732; ENSMUSG00000009588.
GeneIDi20445.
KEGGimmu:20445.
UCSCiuc007mme.1. mouse.

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - GTase

ST6GalNAc I

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11274 mRNA. Translation: CAA72137.1.
Y10294 Genomic DNA. Translation: CAA71341.1.
AL645542 Genomic DNA. Translation: CAM25277.1.
BC141095 mRNA. Translation: AAI41096.1.
BC145373 mRNA. Translation: AAI45374.1.
CCDSiCCDS36380.1.
PIRiJC7248.
RefSeqiNP_035501.2. NM_011371.2.
UniGeneiMm.436887.
Mm.491644.

3D structure databases

ProteinModelPortaliQ9QZ39.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000009732.

Protein family/group databases

CAZyiGT29. Glycosyltransferase Family 29.

PTM databases

iPTMnetiQ9QZ39.
PhosphoSitePlusiQ9QZ39.

Proteomic databases

MaxQBiQ9QZ39.
PaxDbiQ9QZ39.
PRIDEiQ9QZ39.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000009732; ENSMUSP00000009732; ENSMUSG00000009588.
GeneIDi20445.
KEGGimmu:20445.
UCSCiuc007mme.1. mouse.

Organism-specific databases

CTDi55808.
MGIiMGI:1341826. St6galnac1.

Phylogenomic databases

eggNOGiKOG2692. Eukaryota.
ENOG410XT8P. LUCA.
GeneTreeiENSGT00760000119095.
HOGENOMiHOG000231097.
HOVERGENiHBG073351.
InParanoidiQ9QZ39.
KOiK03479.
OMAiWLQNIFL.
OrthoDBiEOG091G07XX.
TreeFamiTF354325.

Enzyme and pathway databases

UniPathwayiUPA00378.
ReactomeiR-MMU-4085001. Sialic acid metabolism.

Miscellaneous databases

ChiTaRSiSt6galnac1. mouse.
PROiQ9QZ39.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000009588.
GenevisibleiQ9QZ39. MM.

Family and domain databases

InterProiIPR001675. Glyco_trans_29.
[Graphical view]
PfamiPF00777. Glyco_transf_29. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSIA7A_MOUSE
AccessioniPrimary (citable) accession number: Q9QZ39
Secondary accession number(s): A2AA23, Q9JJP5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.