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Protein

Homeobox protein SIX6

Gene

Six6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in eye development.3 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi126 – 18661HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein SIX6
Alternative name(s):
Optic homeobox 2
Sine oculis homeobox homolog 6
Six9 protein
Gene namesi
Name:Six6
Synonyms:Optx2, Six9
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1341840. Six6.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 246246Homeobox protein SIX6PRO_0000049308Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei212 – 2121PhosphothreonineBy similarity
Modified residuei221 – 2211PhosphoserineBy similarity
Modified residuei225 – 2251PhosphoserineBy similarity
Modified residuei227 – 2271PhosphoserineBy similarity
Modified residuei228 – 2281PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9QZ28.
PRIDEiQ9QZ28.

PTM databases

PhosphoSiteiQ9QZ28.

Expressioni

Tissue specificityi

In the developing embryo, expressed mainly in the ventral optic stalk, optic chiasma, the neural retina and the primordial tissues that give rise to the pituitary/hypothalamus axis. Not expressed in the lens placode.2 Publications

Developmental stagei

Expression is first detected in the embryo at E8.1 Publication

Gene expression databases

BgeeiQ9QZ28.
ExpressionAtlasiQ9QZ28. baseline and differential.
GenevisibleiQ9QZ28. MM.

Interactioni

Subunit structurei

Interacts with TLE4 and AES.1 Publication

Protein-protein interaction databases

BioGridi203264. 5 interactions.
IntActiQ9QZ28. 3 interactions.
STRINGi10090.ENSMUSP00000021519.

Structurei

3D structure databases

ProteinModelPortaliQ9QZ28.
SMRiQ9QZ28. Positions 1-189.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SIX/Sine oculis homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0775. Eukaryota.
ENOG410XRPB. LUCA.
GeneTreeiENSGT00540000070251.
HOGENOMiHOG000261680.
HOVERGENiHBG003609.
InParanoidiQ9QZ28.
KOiK19473.
OMAiTASMFQL.
OrthoDBiEOG7C5M8Z.
PhylomeDBiQ9QZ28.
TreeFamiTF315545.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR031701. SIX1_SD.
IPR032947. SIX6.
[Graphical view]
PANTHERiPTHR10390:SF12. PTHR10390:SF12. 1 hit.
PfamiPF00046. Homeobox. 1 hit.
PF16878. SIX1_SD. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9QZ28-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFQLPILNFS PQQVAGVCET LEESGDVERL GRFLWSLPVA PAACEALNKN
60 70 80 90 100
ESVLRARAIV AFHGGNYREL YHILENHKFT KESHAKLQAL WLEAHYQEAE
110 120 130 140 150
KLRGRPLGPV DKYRVRKKFP LPRTIWDGEQ KTHCFKERTR HLLREWYLQD
160 170 180 190 200
PYPNPSKKRE LAQATGLTPT QVGNWFKNRR QRDRAAAAKN RLQQQVLSQG
210 220 230 240
PGRVLRSEGE GTPEVLGVAS SPAASLSSKA ATSAISITSS DSECDI
Length:246
Mass (Da):27,741
Last modified:June 1, 2002 - v2
Checksum:iF1332D5E617B2CF1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti141 – 1411H → N in CAA09775 (PubMed:10381575).Curated
Sequence conflicti220 – 2201S → T in CAA09775 (PubMed:10381575).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF050130 mRNA. Translation: AAC33850.1.
AF135267 mRNA. Translation: AAD48911.1.
AJ011787 mRNA. Translation: CAA09775.1.
AK017544 mRNA. No translation available.
AK029309 mRNA. Translation: BAC26387.1.
CCDSiCCDS25972.1.
RefSeqiNP_035514.1. NM_011384.5.
UniGeneiMm.57138.

Genome annotation databases

EnsembliENSMUST00000021519; ENSMUSP00000021519; ENSMUSG00000021099.
GeneIDi20476.
KEGGimmu:20476.
UCSCiuc007nvy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF050130 mRNA. Translation: AAC33850.1.
AF135267 mRNA. Translation: AAD48911.1.
AJ011787 mRNA. Translation: CAA09775.1.
AK017544 mRNA. No translation available.
AK029309 mRNA. Translation: BAC26387.1.
CCDSiCCDS25972.1.
RefSeqiNP_035514.1. NM_011384.5.
UniGeneiMm.57138.

3D structure databases

ProteinModelPortaliQ9QZ28.
SMRiQ9QZ28. Positions 1-189.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203264. 5 interactions.
IntActiQ9QZ28. 3 interactions.
STRINGi10090.ENSMUSP00000021519.

PTM databases

PhosphoSiteiQ9QZ28.

Proteomic databases

PaxDbiQ9QZ28.
PRIDEiQ9QZ28.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021519; ENSMUSP00000021519; ENSMUSG00000021099.
GeneIDi20476.
KEGGimmu:20476.
UCSCiuc007nvy.1. mouse.

Organism-specific databases

CTDi4990.
MGIiMGI:1341840. Six6.

Phylogenomic databases

eggNOGiKOG0775. Eukaryota.
ENOG410XRPB. LUCA.
GeneTreeiENSGT00540000070251.
HOGENOMiHOG000261680.
HOVERGENiHBG003609.
InParanoidiQ9QZ28.
KOiK19473.
OMAiTASMFQL.
OrthoDBiEOG7C5M8Z.
PhylomeDBiQ9QZ28.
TreeFamiTF315545.

Miscellaneous databases

PROiQ9QZ28.
SOURCEiSearch...

Gene expression databases

BgeeiQ9QZ28.
ExpressionAtlasiQ9QZ28. baseline and differential.
GenevisibleiQ9QZ28. MM.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR031701. SIX1_SD.
IPR032947. SIX6.
[Graphical view]
PANTHERiPTHR10390:SF12. PTHR10390:SF12. 1 hit.
PfamiPF00046. Homeobox. 1 hit.
PF16878. SIX1_SD. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The optx2 homeobox gene is expressed in early precursors of the eye and activates retina-specific genes."
    Toy J., Yang J.-M., Leppert G.S., Sundin O.H.
    Proc. Natl. Acad. Sci. U.S.A. 95:10643-10648(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
  2. "Six6 (Optx2) is a novel murine Six3-related homeobox gene that demarcates the presumptive pituitary/hypothalamic axis and the ventral optic stalk."
    Jean D., Bernier G., Gruss P.
    Mech. Dev. 84:31-40(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Eye.
  3. "Six9 (Optx2), a new member of the Six gene family of transcription factors, is expressed at early stages of vertebrate ocular and pituitary development."
    Lopez-Rios J., Gallardo E., Rodriguez de Cordoba S., Bovolenta P.
    Mech. Dev. 83:155-159(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Strain: BALB/cJ.
    Tissue: Embryonic head.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Head.
  5. "Six3-mediated auto repression and eye development requires its interaction with members of the Groucho-related family of co-repressors."
    Zhu C.C., Dyer M.A., Uchikawa M., Kondoh H., Lagutin O.V., Oliver G.
    Development 129:2835-2849(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH AES AND TLE4.

Entry informationi

Entry nameiSIX6_MOUSE
AccessioniPrimary (citable) accession number: Q9QZ28
Secondary accession number(s): O88423
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: June 1, 2002
Last modified: July 6, 2016
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.