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Protein

C-type lectin domain family 4 member A

Gene

Clec4a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in regulating immune reactivity. May play a role in modulating dendritic cells (DC) differentiation and/or maturation (By similarity). May be involved in the inhibition of B-cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation.By similarity1 Publication

GO - Molecular functioni

  • carbohydrate binding Source: MGI

GO - Biological processi

Keywordsi

Biological processAdaptive immunity, Immunity, Innate immunity
LigandLectin

Names & Taxonomyi

Protein namesi
Recommended name:
C-type lectin domain family 4 member A
Alternative name(s):
C-type lectin superfamily member 6
Dendritic cell immunoreceptor
Gene namesi
Name:Clec4a
Synonyms:Clec4a2, Clecsf6, Dcir
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1349412. Clec4a2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 48CytoplasmicSequence analysisAdd BLAST48
Transmembranei49 – 69Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini70 – 238ExtracellularSequence analysisAdd BLAST169

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: MGI

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi7Y → F: Loss of inhibition of B-cell calcium mobilization. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000466131 – 238C-type lectin domain family 4 member AAdd BLAST238

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi91N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi107 ↔ 118PROSITE-ProRule annotation
Glycosylationi131N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi136N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi137 ↔ 231PROSITE-ProRule annotation
Disulfide bondi205 ↔ 223PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9QZ15.
PRIDEiQ9QZ15.

PTM databases

iPTMnetiQ9QZ15.
PhosphoSitePlusiQ9QZ15.

Expressioni

Tissue specificityi

Expressed in splenic antigen-presenting cells including B-cells, monocytes/macrophages, and dendritic cells (at protein level). Expressed in spleen and lymph node and slightly increased with dendritic cell maturation.1 Publication

Gene expression databases

BgeeiENSMUSG00000030148.
CleanExiMM_CLEC4A2.
ExpressionAtlasiQ9QZ15. baseline and differential.
GenevisibleiQ9QZ15. MM.

Interactioni

Subunit structurei

May interact with PTPN6 via its ITIM site.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9QZ15.
SMRiQ9QZ15.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini126 – 233C-type lectinPROSITE-ProRule annotationAdd BLAST108

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi5 – 10ITIM motif6

Domaini

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00760000118924.
HOGENOMiHOG000059556.
HOVERGENiHBG050992.
InParanoidiQ9QZ15.
KOiK10057.
PhylomeDBiQ9QZ15.

Family and domain databases

CDDicd03590. CLECT_DC-SIGN_like. 1 hit.
Gene3Di3.10.100.10. 1 hit.
InterProiView protein in InterPro
IPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR018378. C-type_lectin_CS.
IPR033989. CD209-like_CTLD.
IPR016187. CTDL_fold.
PfamiView protein in Pfam
PF00059. Lectin_C. 1 hit.
SMARTiView protein in SMART
SM00034. CLECT. 1 hit.
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiView protein in PROSITE
PS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9QZ15-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASEITYAEV KFKNESNSLH TYSESPAAPR EKPIRDLRKP GSPSLLLTSL
60 70 80 90 100
MLLLLLLAIT FLVAFIIYFQ KYSQLLEEKK AAKNIMHNEL NCTKSVSPME
110 120 130 140 150
DKVWSCCPKD WRLFGSHCYL VPTVSSSASW NKSEENCSRM GAHLVVIQSQ
160 170 180 190 200
EEQDFITGIL DTHAAYFIGL WDTGHRQWQW VDQTPYEESI TFWHNGEPSS
210 220 230
GNEKCATIIY RWKTGWGWND ISCSLKQKSV CQMKKINL
Length:238
Mass (Da):27,323
Last modified:May 1, 2000 - v1
Checksum:i2DB8AE0E11B18A56
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ133533 mRNA. Translation: CAB57870.1.
AF387099 mRNA. Translation: AAM22402.1.
AK049002 mRNA. Translation: BAC33509.1.
BC075729 mRNA. Translation: AAH75729.1.
BC096565 mRNA. Translation: AAH96565.1.
CCDSiCCDS20510.1.
RefSeqiNP_001163803.1. NM_001170332.1.
NP_001163804.1. NM_001170333.1.
NP_036129.1. NM_011999.4.
UniGeneiMm.47384.

Genome annotation databases

EnsembliENSMUST00000041779; ENSMUSP00000045781; ENSMUSG00000030148.
ENSMUST00000161365; ENSMUSP00000124615; ENSMUSG00000030148.
GeneIDi26888.
KEGGimmu:26888.
UCSCiuc009dqa.1. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCLC4A_MOUSE
AccessioniPrimary (citable) accession number: Q9QZ15
Secondary accession number(s): Q4VA33
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: May 1, 2000
Last modified: July 5, 2017
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot