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Q9QZ08

- NAGK_MOUSE

UniProt

Q9QZ08 - NAGK_MOUSE

Protein

N-acetyl-D-glucosamine kinase

Gene

Nagk

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway. Also has ManNAc kinase activity.1 Publication

    Catalytic activityi

    ATP + N-acetyl-D-glucosamine = ADP + N-acetyl-D-glucosamine 6-phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei36 – 361SubstrateBy similarity
    Binding sitei107 – 1071SubstrateBy similarity
    Binding sitei152 – 1521SubstrateBy similarity
    Binding sitei271 – 2711ATPBy similarity
    Binding sitei275 – 2751ATPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi6 – 138ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. N-acetylglucosamine kinase activity Source: MGI
    3. N-acylmannosamine kinase activity Source: MGI

    GO - Biological processi

    1. carbohydrate phosphorylation Source: GOC
    2. N-acetylglucosamine metabolic process Source: MGI
    3. N-acetylneuraminate catabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.1.59. 3474.
    SABIO-RKQ9QZ08.
    UniPathwayiUPA00629.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    N-acetyl-D-glucosamine kinase (EC:2.7.1.59)
    Short name:
    N-acetylglucosamine kinase
    Alternative name(s):
    GlcNAc kinase
    Gene namesi
    Name:Nagk
    Synonyms:Gnk
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:1860418. Nagk.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 343342N-acetyl-D-glucosamine kinasePRO_0000096697Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei76 – 761PhosphoserineBy similarity
    Modified residuei205 – 2051PhosphotyrosineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ9QZ08.
    PaxDbiQ9QZ08.
    PRIDEiQ9QZ08.

    2D gel databases

    REPRODUCTION-2DPAGEQ9QZ08.

    PTM databases

    PhosphoSiteiQ9QZ08.

    Expressioni

    Tissue specificityi

    Ubiquitous.1 Publication

    Gene expression databases

    ArrayExpressiQ9QZ08.
    BgeeiQ9QZ08.
    CleanExiMM_NAGK.
    GenevestigatoriQ9QZ08.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    IntActiQ9QZ08. 1 interaction.
    MINTiMINT-224654.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9QZ08.
    SMRiQ9QZ08. Positions 2-343.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni129 – 1302Substrate bindingBy similarity
    Regioni145 – 1473Substrate bindingBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG2971.
    GeneTreeiENSGT00510000047418.
    HOGENOMiHOG000007248.
    HOVERGENiHBG052570.
    KOiK00884.
    OrthoDBiEOG7V1FR7.
    PhylomeDBiQ9QZ08.
    TreeFamiTF314158.

    Family and domain databases

    InterProiIPR002731. ATPase_BadF.
    [Graphical view]
    PfamiPF01869. BcrAD_BadFG. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9QZ08-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAALYGGVEG GGTRSKVLLL SEDGQILAEA DGLSTNHWLI GTDQCVERIN    50
    EMVDRAKQKA GVDPLVPLRS LGLSLSGGEQ EDAVRLLIEE LRHRFPNLSE 100
    NYLITTDAAG SIATATPDGG IVLISGTGSN CRLINPDGSE SGCGGWGHMM 150
    GDEGSAYWIA HQAVKIVFDS IDNLEAAPHD IGHVKQAMFD YFQVPDRLGI 200
    LTHLYRDFDK CKFAGFCQKI AEGAHQGDPL SRYIFRKAGE MLGRHVVAVL 250
    PEIDPVLFQG ELGLPILCVG SVWKSWELLK EGFLLALTLG REQQAQNSFS 300
    SFTLMKLRHS SALGGASLGA RHIGYHLPMD YSINAIAFYS YTF 343
    Length:343
    Mass (Da):37,268
    Last modified:January 23, 2007 - v3
    Checksum:iA3832E98C9B3228E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ242909 mRNA. Translation: CAB61849.1.
    BC004689 mRNA. Translation: AAH04689.1.
    CCDSiCCDS20286.1.
    RefSeqiNP_062415.1. NM_019542.2.
    UniGeneiMm.190650.

    Genome annotation databases

    EnsembliENSMUST00000037376; ENSMUSP00000042026; ENSMUSG00000034744.
    GeneIDi56174.
    KEGGimmu:56174.
    UCSCiuc009coh.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ242909 mRNA. Translation: CAB61849.1 .
    BC004689 mRNA. Translation: AAH04689.1 .
    CCDSi CCDS20286.1.
    RefSeqi NP_062415.1. NM_019542.2.
    UniGenei Mm.190650.

    3D structure databases

    ProteinModelPortali Q9QZ08.
    SMRi Q9QZ08. Positions 2-343.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9QZ08. 1 interaction.
    MINTi MINT-224654.

    PTM databases

    PhosphoSitei Q9QZ08.

    2D gel databases

    REPRODUCTION-2DPAGE Q9QZ08.

    Proteomic databases

    MaxQBi Q9QZ08.
    PaxDbi Q9QZ08.
    PRIDEi Q9QZ08.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000037376 ; ENSMUSP00000042026 ; ENSMUSG00000034744 .
    GeneIDi 56174.
    KEGGi mmu:56174.
    UCSCi uc009coh.2. mouse.

    Organism-specific databases

    CTDi 55577.
    MGIi MGI:1860418. Nagk.

    Phylogenomic databases

    eggNOGi COG2971.
    GeneTreei ENSGT00510000047418.
    HOGENOMi HOG000007248.
    HOVERGENi HBG052570.
    KOi K00884.
    OrthoDBi EOG7V1FR7.
    PhylomeDBi Q9QZ08.
    TreeFami TF314158.

    Enzyme and pathway databases

    UniPathwayi UPA00629 .
    BRENDAi 2.7.1.59. 3474.
    SABIO-RK Q9QZ08.

    Miscellaneous databases

    NextBioi 311940.
    PROi Q9QZ08.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9QZ08.
    Bgeei Q9QZ08.
    CleanExi MM_NAGK.
    Genevestigatori Q9QZ08.

    Family and domain databases

    InterProi IPR002731. ATPase_BadF.
    [Graphical view ]
    Pfami PF01869. BcrAD_BadFG. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of murine and human N-acetylglucosamine kinase."
      Hinderlich S., Berger M., Schwarzkopf M., Effertz K., Reutter W.
      Eur. J. Biochem. 267:3301-3308(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "Metabolism of vertebrate amino sugars with N-glycolyl groups: elucidating the intracellular fate of the non-human sialic acid N-glycolylneuraminic acid."
      Bergfeld A.K., Pearce O.M., Diaz S.L., Pham T., Varki A.
      J. Biol. Chem. 287:28865-28881(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: PATHWAY.

    Entry informationi

    Entry nameiNAGK_MOUSE
    AccessioniPrimary (citable) accession number: Q9QZ08
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 2002
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 84 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3