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Q9QZ08

- NAGK_MOUSE

UniProt

Q9QZ08 - NAGK_MOUSE

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Protein

N-acetyl-D-glucosamine kinase

Gene

Nagk

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway. Also has ManNAc kinase activity.1 Publication

Catalytic activityi

ATP + N-acetyl-D-glucosamine = ADP + N-acetyl-D-glucosamine 6-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei36 – 361SubstrateBy similarity
Binding sitei107 – 1071SubstrateBy similarity
Binding sitei152 – 1521SubstrateBy similarity
Binding sitei271 – 2711ATPBy similarity
Binding sitei275 – 2751ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi6 – 138ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. N-acetylglucosamine kinase activity Source: MGI
  3. N-acylmannosamine kinase activity Source: MGI

GO - Biological processi

  1. carbohydrate phosphorylation Source: GOC
  2. N-acetylglucosamine metabolic process Source: MGI
  3. N-acetylneuraminate catabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.1.59. 3474.
SABIO-RKQ9QZ08.
UniPathwayiUPA00629.

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetyl-D-glucosamine kinase (EC:2.7.1.59)
Short name:
N-acetylglucosamine kinase
Alternative name(s):
GlcNAc kinase
Gene namesi
Name:Nagk
Synonyms:Gnk
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:1860418. Nagk.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 343342N-acetyl-D-glucosamine kinasePRO_0000096697Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei76 – 761PhosphoserineBy similarity
Modified residuei205 – 2051PhosphotyrosineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9QZ08.
PaxDbiQ9QZ08.
PRIDEiQ9QZ08.

2D gel databases

REPRODUCTION-2DPAGEQ9QZ08.

PTM databases

PhosphoSiteiQ9QZ08.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiQ9QZ08.
CleanExiMM_NAGK.
ExpressionAtlasiQ9QZ08. baseline and differential.
GenevestigatoriQ9QZ08.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

IntActiQ9QZ08. 1 interaction.
MINTiMINT-224654.

Structurei

3D structure databases

ProteinModelPortaliQ9QZ08.
SMRiQ9QZ08. Positions 2-343.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni129 – 1302Substrate bindingBy similarity
Regioni145 – 1473Substrate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2971.
GeneTreeiENSGT00510000047418.
HOGENOMiHOG000007248.
HOVERGENiHBG052570.
InParanoidiQ9QZ08.
KOiK00884.
OrthoDBiEOG7V1FR7.
PhylomeDBiQ9QZ08.
TreeFamiTF314158.

Family and domain databases

InterProiIPR002731. ATPase_BadF.
[Graphical view]
PfamiPF01869. BcrAD_BadFG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QZ08-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAALYGGVEG GGTRSKVLLL SEDGQILAEA DGLSTNHWLI GTDQCVERIN
60 70 80 90 100
EMVDRAKQKA GVDPLVPLRS LGLSLSGGEQ EDAVRLLIEE LRHRFPNLSE
110 120 130 140 150
NYLITTDAAG SIATATPDGG IVLISGTGSN CRLINPDGSE SGCGGWGHMM
160 170 180 190 200
GDEGSAYWIA HQAVKIVFDS IDNLEAAPHD IGHVKQAMFD YFQVPDRLGI
210 220 230 240 250
LTHLYRDFDK CKFAGFCQKI AEGAHQGDPL SRYIFRKAGE MLGRHVVAVL
260 270 280 290 300
PEIDPVLFQG ELGLPILCVG SVWKSWELLK EGFLLALTLG REQQAQNSFS
310 320 330 340
SFTLMKLRHS SALGGASLGA RHIGYHLPMD YSINAIAFYS YTF
Length:343
Mass (Da):37,268
Last modified:January 23, 2007 - v3
Checksum:iA3832E98C9B3228E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ242909 mRNA. Translation: CAB61849.1.
BC004689 mRNA. Translation: AAH04689.1.
CCDSiCCDS20286.1.
RefSeqiNP_062415.1. NM_019542.2.
UniGeneiMm.190650.

Genome annotation databases

EnsembliENSMUST00000037376; ENSMUSP00000042026; ENSMUSG00000034744.
GeneIDi56174.
KEGGimmu:56174.
UCSCiuc009coh.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ242909 mRNA. Translation: CAB61849.1 .
BC004689 mRNA. Translation: AAH04689.1 .
CCDSi CCDS20286.1.
RefSeqi NP_062415.1. NM_019542.2.
UniGenei Mm.190650.

3D structure databases

ProteinModelPortali Q9QZ08.
SMRi Q9QZ08. Positions 2-343.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9QZ08. 1 interaction.
MINTi MINT-224654.

PTM databases

PhosphoSitei Q9QZ08.

2D gel databases

REPRODUCTION-2DPAGE Q9QZ08.

Proteomic databases

MaxQBi Q9QZ08.
PaxDbi Q9QZ08.
PRIDEi Q9QZ08.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000037376 ; ENSMUSP00000042026 ; ENSMUSG00000034744 .
GeneIDi 56174.
KEGGi mmu:56174.
UCSCi uc009coh.2. mouse.

Organism-specific databases

CTDi 55577.
MGIi MGI:1860418. Nagk.

Phylogenomic databases

eggNOGi COG2971.
GeneTreei ENSGT00510000047418.
HOGENOMi HOG000007248.
HOVERGENi HBG052570.
InParanoidi Q9QZ08.
KOi K00884.
OrthoDBi EOG7V1FR7.
PhylomeDBi Q9QZ08.
TreeFami TF314158.

Enzyme and pathway databases

UniPathwayi UPA00629 .
BRENDAi 2.7.1.59. 3474.
SABIO-RK Q9QZ08.

Miscellaneous databases

NextBioi 311940.
PROi Q9QZ08.
SOURCEi Search...

Gene expression databases

Bgeei Q9QZ08.
CleanExi MM_NAGK.
ExpressionAtlasi Q9QZ08. baseline and differential.
Genevestigatori Q9QZ08.

Family and domain databases

InterProi IPR002731. ATPase_BadF.
[Graphical view ]
Pfami PF01869. BcrAD_BadFG. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of murine and human N-acetylglucosamine kinase."
    Hinderlich S., Berger M., Schwarzkopf M., Effertz K., Reutter W.
    Eur. J. Biochem. 267:3301-3308(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Metabolism of vertebrate amino sugars with N-glycolyl groups: elucidating the intracellular fate of the non-human sialic acid N-glycolylneuraminic acid."
    Bergfeld A.K., Pearce O.M., Diaz S.L., Pham T., Varki A.
    J. Biol. Chem. 287:28865-28881(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PATHWAY.

Entry informationi

Entry nameiNAGK_MOUSE
AccessioniPrimary (citable) accession number: Q9QZ08
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 85 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3