Reviewed,
UniProtKB/Swiss-Prot Q9QZ06 (TOLIP_MOUSE)
Last modified
January 19, 2010.
Version 68.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Toll-interacting protein | ||
| Gene names |
| ||
| Organism | Mus musculus (Mouse) | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 274 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity. |
| Subunit structure | Oligomerizes. Binds to TLR2 and the TLR4-MD2 complex via its C-terminus. Exists as complex with IRAK1 in unstimulated cells. Upon IL-1 signaling, Tollip binds to the activated IL-1 receptor complex containing IL-1RI, IL-1RacP and the adapter protein MyD88, where it interacts with the TIR domain of IL-1RacP. MyD88 then triggers IRAK1 autophosphorylation, which in turn leads to the dissociation of IRAK1 from Tollip and IL-1RAcP. Interacts with TOM1L2 By similarity. |
| Subcellular location | Cytoplasm Probable. |
| Tissue specificity | Detected in heart, brain, spleen, lung, liver, skeletal muscle, kidney, thymus, pancreas and testis. |
| Sequence similarities | Belongs to the tollip family. Contains 1 C2 domain. Contains 1 CUE domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Immune response Inflammatory response |
| Cellular component | Cytoplasm |
| PTM | Acetylation Phosphoprotein |
| Gene Ontology (GO) | |
| Biological process | immune response Inferred from electronic annotation. Source: UniProtKB-KW inflammatory responseInferred from electronic annotation. Source: UniProtKB-KW phosphorylationInferred from sequence or structural similarity. Source: UniProtKB |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | protein binding Ref.1 Inferred from physical interaction. Source: IntAct |
| Complete GO annotation... | |
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| Il1rap | Q61730 | 1 | EBI-74272,EBI-525035 | |
| Il1rl1 | P14719 | 1 | EBI-74272,EBI-525078 | |
| Irak1 | Q62406 | 2 | EBI-74272,EBI-448533 | |
| Tom1 | O88746 | 1 | EBI-74272,EBI-74264 |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Initiator methionine | 1 | 1 | Removed By similarity | ||||||
| Chain | 2 – 274 | 273 | Toll-interacting protein | PRO_0000072626 | |||||
Regions | |||||||||
| Domain | 40 – 135 | 96 | C2 | ||||||
| Domain | 229 – 272 | 44 | CUE | ||||||
| Compositional bias | 28 – 44 | 17 | Gln-rich | ||||||
Amino acid modifications | |||||||||
| Modified residue | 2 | 1 | N-acetylalanine By similarity | ||||||
| Modified residue | 83 | 1 | Phosphotyrosine By similarity | ||||||
Sequences
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References
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AJ242971 mRNA. Translation: CAB58121.1. AK015062 mRNA. No translation available. AK016482 mRNA. Translation: BAB30262.1. AK045422 mRNA. Translation: BAC32357.1. AK049263 mRNA. Translation: BAC33643.1. AK161312 mRNA. Translation: BAE36316.1. BC062139 mRNA. Translation: AAH62139.1. |
| IPI | IPI00136618. |
| RefSeq | NP_076253.1. |
| UniGene | Mm.103551 |
3D structure databases | |
| SMR | Q9QZ06. Positions 47-175, 231-273. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q9QZ06. 4 interactions. |
| STRING | Q9QZ06. |
Proteomic databases | |
| PRIDE | Q9QZ06. |
Genome annotation databases | |
| Ensembl | ENSMUST00000001950; ENSMUSP00000001950; ENSMUSG00000025139; Mus musculus. [Genome view] |
| GeneID | 54473. |
| KEGG | mmu:54473. |
| UCSC | uc009kmd.1. mouse. |
Organism-specific databases | |
| CTD | 54473. |
| MGI | MGI:1891808. Tollip. |
Phylogenomic databases | |
| eggNOG | roNOG15441. |
| HOGENOM | HBG315923. |
| HOVERGEN | Q9QZ06. |
| InParanoid | Q9QZ06. |
| OMA | HVTIPES. |
| PhylomeDB | Q9QZ06. |
Gene expression databases | |
| ArrayExpress | Q9QZ06. |
| Bgee | Q9QZ06. |
| CleanEx | MM_TOLLIP. |
| Genevestigator | Q9QZ06. |
| GermOnline | ENSMUSG00000025139. Mus musculus. |
Family and domain databases | |
| InterPro | IPR000008. C2_Ca-dep. IPR008973. C2_Ca/lipid-bd_dom_CaLB. IPR003892. CUE. IPR009060. UBA-like. [Graphical view] |
| Pfam | PF00168. C2. 1 hit. PF02845. CUE. 1 hit. [Graphical view] |
| SMART | SM00239. C2. 1 hit. SM00546. CUE. 1 hit. [Graphical view] |
| PROSITE | PS50004. C2. False negative. PS51140. CUE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 311336. |
| SOURCE | Search... |
Entry information
| Entry name | TOLIP_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q9QZ06 Secondary accession number(s): Q543N1, Q9D5P5 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


