ID   S39A1_MOUSE             Reviewed;         324 AA.
AC   Q9QZ03; A2RTD4; Q99K44;
DT   26-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT   27-JUL-2011, sequence version 3.
DT   24-JAN-2024, entry version 153.
DE   RecName: Full=Zinc transporter ZIP1;
DE   AltName: Full=Solute carrier family 39 member 1;
DE   AltName: Full=Zinc-iron-regulated transporter-like;
DE   AltName: Full=Zrt- and Irt-like protein 1;
DE            Short=ZIP-1;
DE            Short=mZIP1;
GN   Name=Slc39a1; Synonyms=Zip1, Zirtl;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP   STAGE.
RX   PubMed=10610721; DOI=10.1006/geno.1999.5993;
RA   Lioumi M., Ferguson C.A., Sharpe P.T., Freeman T., Marenholz I.,
RA   Mischke D., Heizmann C., Ragoussis J.;
RT   "Isolation and characterization of human and mouse ZIRTL, a member of the
RT   IRT1 family of transporters, mapping within the epidermal differentiation
RT   complex.";
RL   Genomics 62:272-280(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain, and Mammary tumor;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   FUNCTION, TRANSPORTER ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, AND TISSUE
RP   SPECIFICITY.
RX   PubMed=14525987; DOI=10.1074/jbc.m304163200;
RA   Dufner-Beattie J., Langmade S.J., Wang F., Eide D., Andrews G.K.;
RT   "Structure, function, and regulation of a subfamily of mouse zinc
RT   transporter genes.";
RL   J. Biol. Chem. 278:50142-50150(2003).
CC   -!- FUNCTION: Transporter for the divalent cation Zn(2+). Mediates the
CC       influx of Zn(2+) into cells from extracellular space.
CC       {ECO:0000269|PubMed:14525987}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Zn(2+)(in) = Zn(2+)(out); Xref=Rhea:RHEA:29351,
CC         ChEBI:CHEBI:29105; Evidence={ECO:0000269|PubMed:14525987};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:29352;
CC         Evidence={ECO:0000305|PubMed:14525987};
CC   -!- BIOPHYSICOCHEMICAL PROPERTIES:
CC       Kinetic parameters:
CC         KM=1.7 uM for Zn(2+) {ECO:0000269|PubMed:14525987};
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9NY26};
CC       Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum
CC       membrane {ECO:0000250|UniProtKB:Q9NY26}; Multi-pass membrane protein
CC       {ECO:0000255}. Note=Shows a vesicular localization corresponding
CC       partially to the endoplasmic reticulum in several epithelial cell
CC       lines. {ECO:0000250|UniProtKB:Q9NY26}.
CC   -!- TISSUE SPECIFICITY: Ubiquitous, except in the pancreas
CC       (PubMed:10610721, PubMed:14525987). Highest levels seen in kidney,
CC       salivary gland and placenta. {ECO:0000269|PubMed:10610721,
CC       ECO:0000269|PubMed:14525987}.
CC   -!- DEVELOPMENTAL STAGE: Found to be developmentally regulated in the skin
CC       where it is expressed in the epidermal layer, excluding the dermis, at
CC       embryonic day 17.5 dpc but not in 10.5 dpc and 15.5 dpc. In the small
CC       intestine found toward the base of the intestinal villi from 17.5 dpc.
CC       In the pancreas, expression was detected from 17.5 dpc and no
CC       expression was found in the liver. Also expressed in osteoblasts of
CC       developing bone from 15.5 dpc. {ECO:0000269|PubMed:10610721}.
CC   -!- SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAB59982.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AJ243651; CAB59982.1; ALT_FRAME; Genomic_DNA.
DR   EMBL; CH466547; EDL15152.1; -; Genomic_DNA.
DR   EMBL; BC005474; AAH05474.1; -; mRNA.
DR   EMBL; BC132461; AAI32462.1; -; mRNA.
DR   EMBL; BC138459; AAI38460.1; -; mRNA.
DR   EMBL; BC147738; AAI47739.1; -; mRNA.
DR   EMBL; BC147744; AAI47745.1; -; mRNA.
DR   CCDS; CCDS17525.1; -.
DR   RefSeq; NP_038929.2; NM_013901.2.
DR   RefSeq; XP_006501623.1; XM_006501560.3.
DR   AlphaFoldDB; Q9QZ03; -.
DR   SMR; Q9QZ03; -.
DR   BioGRID; 205964; 3.
DR   STRING; 10090.ENSMUSP00000076012; -.
DR   iPTMnet; Q9QZ03; -.
DR   PhosphoSitePlus; Q9QZ03; -.
DR   SwissPalm; Q9QZ03; -.
DR   MaxQB; Q9QZ03; -.
DR   PaxDb; 10090-ENSMUSP00000076012; -.
DR   ProteomicsDB; 256572; -.
DR   Pumba; Q9QZ03; -.
DR   Antibodypedia; 20389; 121 antibodies from 27 providers.
DR   DNASU; 30791; -.
DR   Ensembl; ENSMUST00000015467.9; ENSMUSP00000076012.7; ENSMUSG00000052310.10.
DR   GeneID; 30791; -.
DR   KEGG; mmu:30791; -.
DR   UCSC; uc012csu.1; mouse.
DR   AGR; MGI:1353474; -.
DR   CTD; 27173; -.
DR   MGI; MGI:1353474; Slc39a1.
DR   VEuPathDB; HostDB:ENSMUSG00000052310; -.
DR   eggNOG; KOG1558; Eukaryota.
DR   GeneTree; ENSGT00940000157062; -.
DR   HOGENOM; CLU_040462_1_0_1; -.
DR   InParanoid; Q9QZ03; -.
DR   OMA; FGFAPLC; -.
DR   OrthoDB; 5482951at2759; -.
DR   PhylomeDB; Q9QZ03; -.
DR   TreeFam; TF317098; -.
DR   Reactome; R-MMU-442380; Zinc influx into cells by the SLC39 gene family.
DR   BioGRID-ORCS; 30791; 5 hits in 76 CRISPR screens.
DR   ChiTaRS; Slc39a1; mouse.
DR   PRO; PR:Q9QZ03; -.
DR   Proteomes; UP000000589; Chromosome 3.
DR   RNAct; Q9QZ03; Protein.
DR   Bgee; ENSMUSG00000052310; Expressed in prostate gland and 152 other cell types or tissues.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0005102; F:signaling receptor binding; ISO:MGI.
DR   GO; GO:0005385; F:zinc ion transmembrane transporter activity; IDA:MGI.
DR   GO; GO:0048701; P:embryonic cranial skeleton morphogenesis; IMP:MGI.
DR   GO; GO:0001701; P:in utero embryonic development; IMP:MGI.
DR   GO; GO:0060173; P:limb development; IMP:MGI.
DR   GO; GO:0071577; P:zinc ion transmembrane transport; ISO:MGI.
DR   GO; GO:0006829; P:zinc ion transport; IDA:MGI.
DR   InterPro; IPR003689; ZIP.
DR   PANTHER; PTHR11040:SF58; ZINC TRANSPORTER ZIP1; 1.
DR   PANTHER; PTHR11040; ZINC/IRON TRANSPORTER; 1.
DR   Pfam; PF02535; Zip; 1.
DR   Genevisible; Q9QZ03; MM.
PE   1: Evidence at protein level;
KW   Cell membrane; Endoplasmic reticulum; Ion transport; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport; Zinc;
KW   Zinc transport.
FT   CHAIN           1..324
FT                   /note="Zinc transporter ZIP1"
FT                   /id="PRO_0000068764"
FT   TOPO_DOM        1..30
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        31..51
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        52..68
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        69..89
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        90..104
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        105..125
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        126..179
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        180..200
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        201..206
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        207..227
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        228..237
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        238..258
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        259..272
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        273..293
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        294..303
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        304..324
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        19
FT                   /note="S -> L (in Ref. 1; CAB59982)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        29
FT                   /note="V -> G (in Ref. 1; CAB59982)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        36
FT                   /note="Missing (in Ref. 1; CAB59982)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        44
FT                   /note="C -> G (in Ref. 1; CAB59982)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        137
FT                   /note="T -> S (in Ref. 1; CAB59982 and 3; AAH05474)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        142..143
FT                   /note="PE -> SK (in Ref. 1; CAB59982)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        177
FT                   /note="A -> T (in Ref. 1; CAB59982)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        183
FT                   /note="L -> P (in Ref. 1; CAB59982)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        200..203
FT                   /note="LQRD -> FQPN (in Ref. 1; CAB59982)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        209..210
FT                   /note="EL -> DC (in Ref. 1; CAB59982)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        279
FT                   /note="A -> E (in Ref. 1; CAB59982)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        288
FT                   /note="F -> Y (in Ref. 1; CAB59982)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   324 AA;  34293 MW;  E7962CDB4726D6B3 CRC64;
     MGPWGEPELL VWRPEAVASE PSVPVGLEVK LGALVLLLLL TLICSLVPVC VLRRSGANHE
     ASASGQKALS LVSCFAGGVF LATCLLDLLP DYLAAIDEAL EALHVTLQFP LQEFILAMGF
     FLVLVMEQIT LAYKEQTSPP HPEETRALLG TVNGGPQHWH DGPGIPQAGG TPAAPSALRA
     CVLVFSLALH SVFEGLAVGL QRDRARAMEL CLALLLHKGI LAVSLSLRLL QSHLRVQVVA
     GCGILFSCMT PLGIGLGAAL AESAGPLHQL AQSVLEGMAA GTFLYITFLE ILPQELATSE
     QRILKVILLL AGFALLTGLL FVQI
//