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Q9QZ03 (S39A1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc transporter ZIP1
Alternative name(s):
Solute carrier family 39 member 1
Zinc-iron-regulated transporter-like
Zrt- and Irt-like protein 1
Short name=ZIP-1
Short name=mZIP1
Gene names
Name:Slc39a1
Synonyms:Zip1, Zirtl
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length324 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Mediates zinc uptake. May function as a major endogenous zinc uptake transporter in many cells of the body By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity.

Tissue specificity

Ubiquitous. Highest levels seen in kidney, salivary gland and placenta. Ref.1

Developmental stage

Found to be developmentally regulated in the skin where it is expressed in the epidermal layer, excluding the dermis, at embryonic day E17.5 but not in E10.5 and E15.5. In the small intestine found toward the base of the intestinal villi from E17.5. In the pancreas, expression was detected from E17.5 and no expression was found in the liver. Also expressed in osteoblats of developing bone from E15.5. Ref.1

Sequence similarities

Belongs to the ZIP transporter (TC 2.A.5) family. [View classification]

Sequence caution

The sequence CAB59982.1 differs from that shown. Reason: Frameshift at positions 4 and 291.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 324324Zinc transporter ZIP1
PRO_0000068764

Regions

Topological domain1 – 3030Extracellular Potential
Transmembrane31 – 5121Helical; Potential
Topological domain52 – 6817Cytoplasmic Potential
Transmembrane69 – 8921Helical; Potential
Topological domain90 – 10415Extracellular Potential
Transmembrane105 – 12521Helical; Potential
Topological domain126 – 17954Cytoplasmic Potential
Transmembrane180 – 20021Helical; Potential
Topological domain201 – 2066Extracellular Potential
Transmembrane207 – 22721Helical; Potential
Topological domain228 – 23710Cytoplasmic Potential
Transmembrane238 – 25821Helical; Potential
Topological domain259 – 27214Extracellular Potential
Transmembrane273 – 29321Helical; Potential
Topological domain294 – 30310Cytoplasmic Potential
Transmembrane304 – 32421Helical; Potential
Region190 – 1912Heavy metals binding By similarity

Experimental info

Sequence conflict191S → L in CAB59982. Ref.1
Sequence conflict291V → G in CAB59982. Ref.1
Sequence conflict361Missing in CAB59982. Ref.1
Sequence conflict441C → G in CAB59982. Ref.1
Sequence conflict1371T → S in CAB59982. Ref.1
Sequence conflict1371T → S in AAH05474. Ref.3
Sequence conflict142 – 1432PE → SK in CAB59982. Ref.1
Sequence conflict1771A → T in CAB59982. Ref.1
Sequence conflict1831L → P in CAB59982. Ref.1
Sequence conflict200 – 2034LQRD → FQPN in CAB59982. Ref.1
Sequence conflict209 – 2102EL → DC in CAB59982. Ref.1
Sequence conflict2791A → E in CAB59982. Ref.1
Sequence conflict2881F → Y in CAB59982. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9QZ03 [UniParc].

Last modified July 27, 2011. Version 3.
Checksum: E7962CDB4726D6B3

FASTA32434,293
        10         20         30         40         50         60 
MGPWGEPELL VWRPEAVASE PSVPVGLEVK LGALVLLLLL TLICSLVPVC VLRRSGANHE 

        70         80         90        100        110        120 
ASASGQKALS LVSCFAGGVF LATCLLDLLP DYLAAIDEAL EALHVTLQFP LQEFILAMGF 

       130        140        150        160        170        180 
FLVLVMEQIT LAYKEQTSPP HPEETRALLG TVNGGPQHWH DGPGIPQAGG TPAAPSALRA 

       190        200        210        220        230        240 
CVLVFSLALH SVFEGLAVGL QRDRARAMEL CLALLLHKGI LAVSLSLRLL QSHLRVQVVA 

       250        260        270        280        290        300 
GCGILFSCMT PLGIGLGAAL AESAGPLHQL AQSVLEGMAA GTFLYITFLE ILPQELATSE 

       310        320 
QRILKVILLL AGFALLTGLL FVQI 

« Hide

References

« Hide 'large scale' references
[1]"Isolation and characterization of human and mouse ZIRTL, a member of the IRT1 family of transporters, mapping within the epidermal differentiation complex."
Lioumi M., Ferguson C.A., Sharpe P.T., Freeman T., Marenholz I., Mischke D., Heizmann C., Ragoussis J.
Genomics 62:272-280(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
[2]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain and Mammary tumor.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ243651 Genomic DNA. Translation: CAB59982.1. Frameshift.
CH466547 Genomic DNA. Translation: EDL15152.1.
BC005474 mRNA. Translation: AAH05474.1.
BC132461 mRNA. Translation: AAI32462.1.
BC138459 mRNA. Translation: AAI38460.1.
BC147738 mRNA. Translation: AAI47739.1.
BC147744 mRNA. Translation: AAI47745.1.
RefSeqNP_038929.2. NM_013901.2.
XP_006501623.1. XM_006501560.1.
UniGeneMm.294709.

3D structure databases

ProteinModelPortalQ9QZ03.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000076012.

PTM databases

PhosphoSiteQ9QZ03.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000015467; ENSMUSP00000076012; ENSMUSG00000052310.
GeneID30791.
KEGGmmu:30791.
UCSCuc012csu.1. mouse.

Organism-specific databases

CTD27173.
MGIMGI:1353474. Slc39a1.

Phylogenomic databases

eggNOGNOG84653.
GeneTreeENSGT00530000063242.
HOGENOMHOG000236331.
HOVERGENHBG015174.
InParanoidA2RTD4.
KOK14709.
OMASGANHEA.
OrthoDBEOG74R1RF.
TreeFamTF317098.

Gene expression databases

ArrayExpressQ9QZ03.
BgeeQ9QZ03.
GenevestigatorQ9QZ03.

Family and domain databases

InterProIPR003689. ZIP.
[Graphical view]
PfamPF02535. Zip. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio307206.
PROQ9QZ03.
SOURCESearch...

Entry information

Entry nameS39A1_MOUSE
AccessionPrimary (citable) accession number: Q9QZ03
Secondary accession number(s): A2RTD4, Q99K44
Entry history
Integrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: July 27, 2011
Last modified: April 16, 2014
This is version 101 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot