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Q9QZ03

- S39A1_MOUSE

UniProt

Q9QZ03 - S39A1_MOUSE

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Protein

Zinc transporter ZIP1

Gene

Slc39a1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Mediates zinc uptake. May function as a major endogenous zinc uptake transporter in many cells of the body (By similarity).By similarity

GO - Molecular functioni

  1. zinc ion transmembrane transporter activity Source: MGI

GO - Biological processi

  1. zinc ion transmembrane transport Source: GOC
  2. zinc ion transport Source: MGI
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport, Zinc transport

Keywords - Ligandi

Zinc

Enzyme and pathway databases

ReactomeiREACT_198240. Zinc influx into cells by the SLC39 gene family.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter ZIP1
Alternative name(s):
Solute carrier family 39 member 1
Zinc-iron-regulated transporter-like
Zrt- and Irt-like protein 1
Short name:
ZIP-1
Short name:
mZIP1
Gene namesi
Name:Slc39a1
Synonyms:Zip1, Zirtl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:1353474. Slc39a1.

Subcellular locationi

Cell membrane By similarity; Multi-pass membrane protein By similarity

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 324324Zinc transporter ZIP1PRO_0000068764Add
BLAST

PTM databases

PhosphoSiteiQ9QZ03.

Expressioni

Tissue specificityi

Ubiquitous. Highest levels seen in kidney, salivary gland and placenta.1 Publication

Developmental stagei

Found to be developmentally regulated in the skin where it is expressed in the epidermal layer, excluding the dermis, at embryonic day E17.5 but not in E10.5 and E15.5. In the small intestine found toward the base of the intestinal villi from E17.5. In the pancreas, expression was detected from E17.5 and no expression was found in the liver. Also expressed in osteoblats of developing bone from E15.5.1 Publication

Gene expression databases

BgeeiQ9QZ03.
ExpressionAtlasiQ9QZ03. baseline and differential.
GenevestigatoriQ9QZ03.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000076012.

Structurei

3D structure databases

ProteinModelPortaliQ9QZ03.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3030ExtracellularSequence AnalysisAdd
BLAST
Topological domaini52 – 6817CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini90 – 10415ExtracellularSequence AnalysisAdd
BLAST
Topological domaini126 – 17954CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini201 – 2066ExtracellularSequence Analysis
Topological domaini228 – 23710CytoplasmicSequence Analysis
Topological domaini259 – 27214ExtracellularSequence AnalysisAdd
BLAST
Topological domaini294 – 30310CytoplasmicSequence Analysis

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei31 – 5121HelicalSequence AnalysisAdd
BLAST
Transmembranei69 – 8921HelicalSequence AnalysisAdd
BLAST
Transmembranei105 – 12521HelicalSequence AnalysisAdd
BLAST
Transmembranei180 – 20021HelicalSequence AnalysisAdd
BLAST
Transmembranei207 – 22721HelicalSequence AnalysisAdd
BLAST
Transmembranei238 – 25821HelicalSequence AnalysisAdd
BLAST
Transmembranei273 – 29321HelicalSequence AnalysisAdd
BLAST
Transmembranei304 – 32421HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni190 – 1912Heavy metals bindingBy similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG84653.
GeneTreeiENSGT00530000063242.
HOGENOMiHOG000236331.
HOVERGENiHBG015174.
InParanoidiQ9QZ03.
KOiK14709.
OMAiQSHLRVQ.
OrthoDBiEOG74R1RF.
TreeFamiTF317098.

Family and domain databases

InterProiIPR003689. ZIP.
[Graphical view]
PfamiPF02535. Zip. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9QZ03-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGPWGEPELL VWRPEAVASE PSVPVGLEVK LGALVLLLLL TLICSLVPVC
60 70 80 90 100
VLRRSGANHE ASASGQKALS LVSCFAGGVF LATCLLDLLP DYLAAIDEAL
110 120 130 140 150
EALHVTLQFP LQEFILAMGF FLVLVMEQIT LAYKEQTSPP HPEETRALLG
160 170 180 190 200
TVNGGPQHWH DGPGIPQAGG TPAAPSALRA CVLVFSLALH SVFEGLAVGL
210 220 230 240 250
QRDRARAMEL CLALLLHKGI LAVSLSLRLL QSHLRVQVVA GCGILFSCMT
260 270 280 290 300
PLGIGLGAAL AESAGPLHQL AQSVLEGMAA GTFLYITFLE ILPQELATSE
310 320
QRILKVILLL AGFALLTGLL FVQI
Length:324
Mass (Da):34,293
Last modified:July 27, 2011 - v3
Checksum:iE7962CDB4726D6B3
GO

Sequence cautioni

The sequence CAB59982.1 differs from that shown. Reason: Frameshift at positions 4 and 291.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti19 – 191S → L in CAB59982. (PubMed:10610721)Curated
Sequence conflicti29 – 291V → G in CAB59982. (PubMed:10610721)Curated
Sequence conflicti36 – 361Missing in CAB59982. (PubMed:10610721)Curated
Sequence conflicti44 – 441C → G in CAB59982. (PubMed:10610721)Curated
Sequence conflicti137 – 1371T → S in CAB59982. (PubMed:10610721)Curated
Sequence conflicti137 – 1371T → S in AAH05474. (PubMed:15489334)Curated
Sequence conflicti142 – 1432PE → SK in CAB59982. (PubMed:10610721)Curated
Sequence conflicti177 – 1771A → T in CAB59982. (PubMed:10610721)Curated
Sequence conflicti183 – 1831L → P in CAB59982. (PubMed:10610721)Curated
Sequence conflicti200 – 2034LQRD → FQPN in CAB59982. (PubMed:10610721)Curated
Sequence conflicti209 – 2102EL → DC in CAB59982. (PubMed:10610721)Curated
Sequence conflicti279 – 2791A → E in CAB59982. (PubMed:10610721)Curated
Sequence conflicti288 – 2881F → Y in CAB59982. (PubMed:10610721)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ243651 Genomic DNA. Translation: CAB59982.1. Frameshift.
CH466547 Genomic DNA. Translation: EDL15152.1.
BC005474 mRNA. Translation: AAH05474.1.
BC132461 mRNA. Translation: AAI32462.1.
BC138459 mRNA. Translation: AAI38460.1.
BC147738 mRNA. Translation: AAI47739.1.
BC147744 mRNA. Translation: AAI47745.1.
CCDSiCCDS17525.1.
RefSeqiNP_038929.2. NM_013901.2.
XP_006501623.1. XM_006501560.1.
UniGeneiMm.294709.

Genome annotation databases

EnsembliENSMUST00000015467; ENSMUSP00000076012; ENSMUSG00000052310.
GeneIDi30791.
KEGGimmu:30791.
UCSCiuc012csu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ243651 Genomic DNA. Translation: CAB59982.1 . Frameshift.
CH466547 Genomic DNA. Translation: EDL15152.1 .
BC005474 mRNA. Translation: AAH05474.1 .
BC132461 mRNA. Translation: AAI32462.1 .
BC138459 mRNA. Translation: AAI38460.1 .
BC147738 mRNA. Translation: AAI47739.1 .
BC147744 mRNA. Translation: AAI47745.1 .
CCDSi CCDS17525.1.
RefSeqi NP_038929.2. NM_013901.2.
XP_006501623.1. XM_006501560.1.
UniGenei Mm.294709.

3D structure databases

ProteinModelPortali Q9QZ03.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000076012.

PTM databases

PhosphoSitei Q9QZ03.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000015467 ; ENSMUSP00000076012 ; ENSMUSG00000052310 .
GeneIDi 30791.
KEGGi mmu:30791.
UCSCi uc012csu.1. mouse.

Organism-specific databases

CTDi 27173.
MGIi MGI:1353474. Slc39a1.

Phylogenomic databases

eggNOGi NOG84653.
GeneTreei ENSGT00530000063242.
HOGENOMi HOG000236331.
HOVERGENi HBG015174.
InParanoidi Q9QZ03.
KOi K14709.
OMAi QSHLRVQ.
OrthoDBi EOG74R1RF.
TreeFami TF317098.

Enzyme and pathway databases

Reactomei REACT_198240. Zinc influx into cells by the SLC39 gene family.

Miscellaneous databases

NextBioi 307206.
PROi Q9QZ03.
SOURCEi Search...

Gene expression databases

Bgeei Q9QZ03.
ExpressionAtlasi Q9QZ03. baseline and differential.
Genevestigatori Q9QZ03.

Family and domain databases

InterProi IPR003689. ZIP.
[Graphical view ]
Pfami PF02535. Zip. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of human and mouse ZIRTL, a member of the IRT1 family of transporters, mapping within the epidermal differentiation complex."
    Lioumi M., Ferguson C.A., Sharpe P.T., Freeman T., Marenholz I., Mischke D., Heizmann C., Ragoussis J.
    Genomics 62:272-280(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Mammary tumor.

Entry informationi

Entry nameiS39A1_MOUSE
AccessioniPrimary (citable) accession number: Q9QZ03
Secondary accession number(s): A2RTD4, Q99K44
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 106 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3