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Protein

Zinc transporter ZIP1

Gene

Slc39a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Mediates zinc uptake. May function as a major endogenous zinc uptake transporter in many cells of the body (By similarity).By similarity

GO - Molecular functioni

  1. zinc ion transmembrane transporter activity Source: MGI

GO - Biological processi

  1. embryonic cranial skeleton morphogenesis Source: MGI
  2. in utero embryonic development Source: MGI
  3. limb development Source: MGI
  4. zinc II ion transmembrane transport Source: MGI
  5. zinc II ion transport Source: MGI
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport, Zinc transport

Keywords - Ligandi

Zinc

Enzyme and pathway databases

ReactomeiREACT_339629. Zinc influx into cells by the SLC39 gene family.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter ZIP1
Alternative name(s):
Solute carrier family 39 member 1
Zinc-iron-regulated transporter-like
Zrt- and Irt-like protein 1
Short name:
ZIP-1
Short name:
mZIP1
Gene namesi
Name:Slc39a1
Synonyms:Zip1, Zirtl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1353474. Slc39a1.

Subcellular locationi

  1. Cell membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3030ExtracellularSequence AnalysisAdd
BLAST
Transmembranei31 – 5121HelicalSequence AnalysisAdd
BLAST
Topological domaini52 – 6817CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei69 – 8921HelicalSequence AnalysisAdd
BLAST
Topological domaini90 – 10415ExtracellularSequence AnalysisAdd
BLAST
Transmembranei105 – 12521HelicalSequence AnalysisAdd
BLAST
Topological domaini126 – 17954CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei180 – 20021HelicalSequence AnalysisAdd
BLAST
Topological domaini201 – 2066ExtracellularSequence Analysis
Transmembranei207 – 22721HelicalSequence AnalysisAdd
BLAST
Topological domaini228 – 23710CytoplasmicSequence Analysis
Transmembranei238 – 25821HelicalSequence AnalysisAdd
BLAST
Topological domaini259 – 27214ExtracellularSequence AnalysisAdd
BLAST
Transmembranei273 – 29321HelicalSequence AnalysisAdd
BLAST
Topological domaini294 – 30310CytoplasmicSequence Analysis
Transmembranei304 – 32421HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 324324Zinc transporter ZIP1PRO_0000068764Add
BLAST

PTM databases

PhosphoSiteiQ9QZ03.

Expressioni

Tissue specificityi

Ubiquitous. Highest levels seen in kidney, salivary gland and placenta.1 Publication

Developmental stagei

Found to be developmentally regulated in the skin where it is expressed in the epidermal layer, excluding the dermis, at embryonic day E17.5 but not in E10.5 and E15.5. In the small intestine found toward the base of the intestinal villi from E17.5. In the pancreas, expression was detected from E17.5 and no expression was found in the liver. Also expressed in osteoblats of developing bone from E15.5.1 Publication

Gene expression databases

BgeeiQ9QZ03.
ExpressionAtlasiQ9QZ03. baseline and differential.
GenevestigatoriQ9QZ03.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000076012.

Structurei

3D structure databases

ProteinModelPortaliQ9QZ03.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni190 – 1912Heavy metals bindingBy similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG84653.
GeneTreeiENSGT00530000063242.
HOGENOMiHOG000236331.
HOVERGENiHBG015174.
InParanoidiQ9QZ03.
KOiK14709.
OMAiCHAVAHE.
OrthoDBiEOG74R1RF.
TreeFamiTF317098.

Family and domain databases

InterProiIPR003689. ZIP.
[Graphical view]
PfamiPF02535. Zip. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9QZ03-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPWGEPELL VWRPEAVASE PSVPVGLEVK LGALVLLLLL TLICSLVPVC
60 70 80 90 100
VLRRSGANHE ASASGQKALS LVSCFAGGVF LATCLLDLLP DYLAAIDEAL
110 120 130 140 150
EALHVTLQFP LQEFILAMGF FLVLVMEQIT LAYKEQTSPP HPEETRALLG
160 170 180 190 200
TVNGGPQHWH DGPGIPQAGG TPAAPSALRA CVLVFSLALH SVFEGLAVGL
210 220 230 240 250
QRDRARAMEL CLALLLHKGI LAVSLSLRLL QSHLRVQVVA GCGILFSCMT
260 270 280 290 300
PLGIGLGAAL AESAGPLHQL AQSVLEGMAA GTFLYITFLE ILPQELATSE
310 320
QRILKVILLL AGFALLTGLL FVQI
Length:324
Mass (Da):34,293
Last modified:July 27, 2011 - v3
Checksum:iE7962CDB4726D6B3
GO

Sequence cautioni

The sequence CAB59982.1 differs from that shown. Reason: Frameshift at positions 4 and 291. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti19 – 191S → L in CAB59982 (PubMed:10610721).Curated
Sequence conflicti29 – 291V → G in CAB59982 (PubMed:10610721).Curated
Sequence conflicti36 – 361Missing in CAB59982 (PubMed:10610721).Curated
Sequence conflicti44 – 441C → G in CAB59982 (PubMed:10610721).Curated
Sequence conflicti137 – 1371T → S in CAB59982 (PubMed:10610721).Curated
Sequence conflicti137 – 1371T → S in AAH05474 (PubMed:15489334).Curated
Sequence conflicti142 – 1432PE → SK in CAB59982 (PubMed:10610721).Curated
Sequence conflicti177 – 1771A → T in CAB59982 (PubMed:10610721).Curated
Sequence conflicti183 – 1831L → P in CAB59982 (PubMed:10610721).Curated
Sequence conflicti200 – 2034LQRD → FQPN in CAB59982 (PubMed:10610721).Curated
Sequence conflicti209 – 2102EL → DC in CAB59982 (PubMed:10610721).Curated
Sequence conflicti279 – 2791A → E in CAB59982 (PubMed:10610721).Curated
Sequence conflicti288 – 2881F → Y in CAB59982 (PubMed:10610721).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ243651 Genomic DNA. Translation: CAB59982.1. Frameshift.
CH466547 Genomic DNA. Translation: EDL15152.1.
BC005474 mRNA. Translation: AAH05474.1.
BC132461 mRNA. Translation: AAI32462.1.
BC138459 mRNA. Translation: AAI38460.1.
BC147738 mRNA. Translation: AAI47739.1.
BC147744 mRNA. Translation: AAI47745.1.
CCDSiCCDS17525.1.
RefSeqiNP_038929.2. NM_013901.2.
XP_006501623.1. XM_006501560.2.
UniGeneiMm.294709.

Genome annotation databases

EnsembliENSMUST00000015467; ENSMUSP00000076012; ENSMUSG00000052310.
GeneIDi30791.
KEGGimmu:30791.
UCSCiuc012csu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ243651 Genomic DNA. Translation: CAB59982.1. Frameshift.
CH466547 Genomic DNA. Translation: EDL15152.1.
BC005474 mRNA. Translation: AAH05474.1.
BC132461 mRNA. Translation: AAI32462.1.
BC138459 mRNA. Translation: AAI38460.1.
BC147738 mRNA. Translation: AAI47739.1.
BC147744 mRNA. Translation: AAI47745.1.
CCDSiCCDS17525.1.
RefSeqiNP_038929.2. NM_013901.2.
XP_006501623.1. XM_006501560.2.
UniGeneiMm.294709.

3D structure databases

ProteinModelPortaliQ9QZ03.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000076012.

PTM databases

PhosphoSiteiQ9QZ03.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000015467; ENSMUSP00000076012; ENSMUSG00000052310.
GeneIDi30791.
KEGGimmu:30791.
UCSCiuc012csu.1. mouse.

Organism-specific databases

CTDi27173.
MGIiMGI:1353474. Slc39a1.

Phylogenomic databases

eggNOGiNOG84653.
GeneTreeiENSGT00530000063242.
HOGENOMiHOG000236331.
HOVERGENiHBG015174.
InParanoidiQ9QZ03.
KOiK14709.
OMAiCHAVAHE.
OrthoDBiEOG74R1RF.
TreeFamiTF317098.

Enzyme and pathway databases

ReactomeiREACT_339629. Zinc influx into cells by the SLC39 gene family.

Miscellaneous databases

NextBioi307206.
PROiQ9QZ03.
SOURCEiSearch...

Gene expression databases

BgeeiQ9QZ03.
ExpressionAtlasiQ9QZ03. baseline and differential.
GenevestigatoriQ9QZ03.

Family and domain databases

InterProiIPR003689. ZIP.
[Graphical view]
PfamiPF02535. Zip. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of human and mouse ZIRTL, a member of the IRT1 family of transporters, mapping within the epidermal differentiation complex."
    Lioumi M., Ferguson C.A., Sharpe P.T., Freeman T., Marenholz I., Mischke D., Heizmann C., Ragoussis J.
    Genomics 62:272-280(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Mammary tumor.

Entry informationi

Entry nameiS39A1_MOUSE
AccessioniPrimary (citable) accession number: Q9QZ03
Secondary accession number(s): A2RTD4, Q99K44
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: July 27, 2011
Last modified: April 29, 2015
This is version 110 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.