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Q9QZ03

- S39A1_MOUSE

UniProt

Q9QZ03 - S39A1_MOUSE

Protein

Zinc transporter ZIP1

Gene

Slc39a1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 3 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Mediates zinc uptake. May function as a major endogenous zinc uptake transporter in many cells of the body By similarity.By similarity

    GO - Molecular functioni

    1. zinc ion transmembrane transporter activity Source: MGI

    GO - Biological processi

    1. zinc ion transport Source: MGI

    Keywords - Biological processi

    Ion transport, Transport, Zinc transport

    Keywords - Ligandi

    Zinc

    Enzyme and pathway databases

    ReactomeiREACT_198240. Zinc influx into cells by the SLC39 gene family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc transporter ZIP1
    Alternative name(s):
    Solute carrier family 39 member 1
    Zinc-iron-regulated transporter-like
    Zrt- and Irt-like protein 1
    Short name:
    ZIP-1
    Short name:
    mZIP1
    Gene namesi
    Name:Slc39a1
    Synonyms:Zip1, Zirtl
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:1353474. Slc39a1.

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 324324Zinc transporter ZIP1PRO_0000068764Add
    BLAST

    PTM databases

    PhosphoSiteiQ9QZ03.

    Expressioni

    Tissue specificityi

    Ubiquitous. Highest levels seen in kidney, salivary gland and placenta.1 Publication

    Developmental stagei

    Found to be developmentally regulated in the skin where it is expressed in the epidermal layer, excluding the dermis, at embryonic day E17.5 but not in E10.5 and E15.5. In the small intestine found toward the base of the intestinal villi from E17.5. In the pancreas, expression was detected from E17.5 and no expression was found in the liver. Also expressed in osteoblats of developing bone from E15.5.1 Publication

    Gene expression databases

    ArrayExpressiQ9QZ03.
    BgeeiQ9QZ03.
    GenevestigatoriQ9QZ03.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000076012.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9QZ03.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3030ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini52 – 6817CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini90 – 10415ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini126 – 17954CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini201 – 2066ExtracellularSequence Analysis
    Topological domaini228 – 23710CytoplasmicSequence Analysis
    Topological domaini259 – 27214ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini294 – 30310CytoplasmicSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei31 – 5121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei69 – 8921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei105 – 12521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei180 – 20021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei207 – 22721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei238 – 25821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei273 – 29321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei304 – 32421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni190 – 1912Heavy metals bindingBy similarity

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG84653.
    GeneTreeiENSGT00530000063242.
    HOGENOMiHOG000236331.
    HOVERGENiHBG015174.
    InParanoidiA2RTD4.
    KOiK14709.
    OMAiQSHLRVQ.
    OrthoDBiEOG74R1RF.
    TreeFamiTF317098.

    Family and domain databases

    InterProiIPR003689. ZIP.
    [Graphical view]
    PfamiPF02535. Zip. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9QZ03-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGPWGEPELL VWRPEAVASE PSVPVGLEVK LGALVLLLLL TLICSLVPVC    50
    VLRRSGANHE ASASGQKALS LVSCFAGGVF LATCLLDLLP DYLAAIDEAL 100
    EALHVTLQFP LQEFILAMGF FLVLVMEQIT LAYKEQTSPP HPEETRALLG 150
    TVNGGPQHWH DGPGIPQAGG TPAAPSALRA CVLVFSLALH SVFEGLAVGL 200
    QRDRARAMEL CLALLLHKGI LAVSLSLRLL QSHLRVQVVA GCGILFSCMT 250
    PLGIGLGAAL AESAGPLHQL AQSVLEGMAA GTFLYITFLE ILPQELATSE 300
    QRILKVILLL AGFALLTGLL FVQI 324
    Length:324
    Mass (Da):34,293
    Last modified:July 27, 2011 - v3
    Checksum:iE7962CDB4726D6B3
    GO

    Sequence cautioni

    The sequence CAB59982.1 differs from that shown. Reason: Frameshift at positions 4 and 291.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti19 – 191S → L in CAB59982. (PubMed:10610721)Curated
    Sequence conflicti29 – 291V → G in CAB59982. (PubMed:10610721)Curated
    Sequence conflicti36 – 361Missing in CAB59982. (PubMed:10610721)Curated
    Sequence conflicti44 – 441C → G in CAB59982. (PubMed:10610721)Curated
    Sequence conflicti137 – 1371T → S in CAB59982. (PubMed:10610721)Curated
    Sequence conflicti137 – 1371T → S in AAH05474. (PubMed:15489334)Curated
    Sequence conflicti142 – 1432PE → SK in CAB59982. (PubMed:10610721)Curated
    Sequence conflicti177 – 1771A → T in CAB59982. (PubMed:10610721)Curated
    Sequence conflicti183 – 1831L → P in CAB59982. (PubMed:10610721)Curated
    Sequence conflicti200 – 2034LQRD → FQPN in CAB59982. (PubMed:10610721)Curated
    Sequence conflicti209 – 2102EL → DC in CAB59982. (PubMed:10610721)Curated
    Sequence conflicti279 – 2791A → E in CAB59982. (PubMed:10610721)Curated
    Sequence conflicti288 – 2881F → Y in CAB59982. (PubMed:10610721)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ243651 Genomic DNA. Translation: CAB59982.1. Frameshift.
    CH466547 Genomic DNA. Translation: EDL15152.1.
    BC005474 mRNA. Translation: AAH05474.1.
    BC132461 mRNA. Translation: AAI32462.1.
    BC138459 mRNA. Translation: AAI38460.1.
    BC147738 mRNA. Translation: AAI47739.1.
    BC147744 mRNA. Translation: AAI47745.1.
    CCDSiCCDS17525.1.
    RefSeqiNP_038929.2. NM_013901.2.
    XP_006501623.1. XM_006501560.1.
    UniGeneiMm.294709.

    Genome annotation databases

    EnsembliENSMUST00000015467; ENSMUSP00000076012; ENSMUSG00000052310.
    GeneIDi30791.
    KEGGimmu:30791.
    UCSCiuc012csu.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ243651 Genomic DNA. Translation: CAB59982.1 . Frameshift.
    CH466547 Genomic DNA. Translation: EDL15152.1 .
    BC005474 mRNA. Translation: AAH05474.1 .
    BC132461 mRNA. Translation: AAI32462.1 .
    BC138459 mRNA. Translation: AAI38460.1 .
    BC147738 mRNA. Translation: AAI47739.1 .
    BC147744 mRNA. Translation: AAI47745.1 .
    CCDSi CCDS17525.1.
    RefSeqi NP_038929.2. NM_013901.2.
    XP_006501623.1. XM_006501560.1.
    UniGenei Mm.294709.

    3D structure databases

    ProteinModelPortali Q9QZ03.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000076012.

    PTM databases

    PhosphoSitei Q9QZ03.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000015467 ; ENSMUSP00000076012 ; ENSMUSG00000052310 .
    GeneIDi 30791.
    KEGGi mmu:30791.
    UCSCi uc012csu.1. mouse.

    Organism-specific databases

    CTDi 27173.
    MGIi MGI:1353474. Slc39a1.

    Phylogenomic databases

    eggNOGi NOG84653.
    GeneTreei ENSGT00530000063242.
    HOGENOMi HOG000236331.
    HOVERGENi HBG015174.
    InParanoidi A2RTD4.
    KOi K14709.
    OMAi QSHLRVQ.
    OrthoDBi EOG74R1RF.
    TreeFami TF317098.

    Enzyme and pathway databases

    Reactomei REACT_198240. Zinc influx into cells by the SLC39 gene family.

    Miscellaneous databases

    NextBioi 307206.
    PROi Q9QZ03.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9QZ03.
    Bgeei Q9QZ03.
    Genevestigatori Q9QZ03.

    Family and domain databases

    InterProi IPR003689. ZIP.
    [Graphical view ]
    Pfami PF02535. Zip. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of human and mouse ZIRTL, a member of the IRT1 family of transporters, mapping within the epidermal differentiation complex."
      Lioumi M., Ferguson C.A., Sharpe P.T., Freeman T., Marenholz I., Mischke D., Heizmann C., Ragoussis J.
      Genomics 62:272-280(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain and Mammary tumor.

    Entry informationi

    Entry nameiS39A1_MOUSE
    AccessioniPrimary (citable) accession number: Q9QZ03
    Secondary accession number(s): A2RTD4, Q99K44
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 26, 2003
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 105 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3