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Protein

Dickkopf-related protein 2

Gene

Dkk2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.1 Publication

GO - Molecular functioni

  • co-receptor binding Source: ParkinsonsUK-UCL

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Dickkopf-related protein 2
Short name:
Dickkopf-2
Short name:
Dkk-2
Short name:
mDkk-2
Gene namesi
Name:Dkk2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1890663. Dkk2.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: MGI
  • extracellular space Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3333Sequence analysisAdd
BLAST
Chaini34 – 259226Dickkopf-related protein 2PRO_0000007221Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi52 – 521N-linked (GlcNAc...)Sequence analysis
Disulfide bondi183 ↔ 1951 Publication
Disulfide bondi189 ↔ 2041 Publication
Disulfide bondi194 ↔ 2311 Publication
Disulfide bondi214 ↔ 2391 Publication
Disulfide bondi233 ↔ 2561 Publication

Post-translational modificationi

May be proteolytically processed by a furin-like protease.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9QYZ8.
PaxDbiQ9QYZ8.
PRIDEiQ9QYZ8.

PTM databases

PhosphoSiteiQ9QYZ8.

Expressioni

Gene expression databases

BgeeiENSMUSG00000028031.
CleanExiMM_DKK2.
GenevisibleiQ9QYZ8. MM.

Interactioni

Subunit structurei

Interacts with LRP5 and LRP6.1 Publication

GO - Molecular functioni

  • co-receptor binding Source: ParkinsonsUK-UCL

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029665.

Structurei

Secondary structure

1
259
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi178 – 1803Combined sources
Beta strandi193 – 1964Combined sources
Beta strandi199 – 2013Combined sources
Beta strandi203 – 2064Combined sources
Beta strandi212 – 2143Combined sources
Beta strandi222 – 2243Combined sources
Beta strandi237 – 2415Combined sources
Helixi247 – 2493Combined sources
Beta strandi254 – 2585Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2JTKNMR-A172-259[»]
ProteinModelPortaliQ9QYZ8.
SMRiQ9QYZ8. Positions 172-259.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9QYZ8.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni78 – 12750DKK-type Cys-1Add
BLAST
Regioni183 – 25674DKK-type Cys-2Add
BLAST

Domaini

The C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6.

Sequence similaritiesi

Belongs to the dickkopf family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1218. Eukaryota.
ENOG410XQWV. LUCA.
GeneTreeiENSGT00390000007000.
HOGENOMiHOG000246998.
HOVERGENiHBG000441.
InParanoidiQ9QYZ8.
KOiK02165.
OMAiGTRCNNG.
OrthoDBiEOG091G0H13.
TreeFamiTF330916.

Family and domain databases

InterProiIPR006796. Dickkopf_N.
[Graphical view]
PfamiPF04706. Dickkopf_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QYZ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALMRVKDS SRCLLLLAAV LMVESSQLGS SRAKLNSIKS SLGGETPAQS
60 70 80 90 100
ANRSAGMNQG LAFGGSKKGK SLGQAYPCSS DKECEVGRYC HSPHQGSSAC
110 120 130 140 150
MLCRRKKKRC HRDGMCCPGT RCNNGICIPV TESILTPHIP ALDGTRHRDR
160 170 180 190 200
NHGHYSNHDL GWQNLGRPHS KMPHIKGHEG DPCLRSSDCI DGFCCARHFW
210 220 230 240 250
TKICKPVLHQ GEVCTKQRKK GSHGLEIFQR CDCAKGLSCK VWKDATYSSK

ARLHVCQKI
Length:259
Mass (Da):28,432
Last modified:October 3, 2012 - v2
Checksum:iE649ED8E3BC7E8E4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti35 – 351L → P in CAB60110 (PubMed:10495270).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ243963 mRNA. Translation: CAB60110.1.
AK028225 mRNA. Translation: BAC25824.1.
AK031749 mRNA. Translation: BAC27536.1.
AC127260 Genomic DNA. No translation available.
CH466532 Genomic DNA. Translation: EDL12195.1.
BC096448 mRNA. Translation: AAH96448.1.
CCDSiCCDS17844.1.
RefSeqiNP_064661.2. NM_020265.4.
UniGeneiMm.103593.

Genome annotation databases

EnsembliENSMUST00000029665; ENSMUSP00000029665; ENSMUSG00000028031.
GeneIDi56811.
KEGGimmu:56811.
UCSCiuc008rjw.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ243963 mRNA. Translation: CAB60110.1.
AK028225 mRNA. Translation: BAC25824.1.
AK031749 mRNA. Translation: BAC27536.1.
AC127260 Genomic DNA. No translation available.
CH466532 Genomic DNA. Translation: EDL12195.1.
BC096448 mRNA. Translation: AAH96448.1.
CCDSiCCDS17844.1.
RefSeqiNP_064661.2. NM_020265.4.
UniGeneiMm.103593.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2JTKNMR-A172-259[»]
ProteinModelPortaliQ9QYZ8.
SMRiQ9QYZ8. Positions 172-259.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029665.

PTM databases

PhosphoSiteiQ9QYZ8.

Proteomic databases

MaxQBiQ9QYZ8.
PaxDbiQ9QYZ8.
PRIDEiQ9QYZ8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029665; ENSMUSP00000029665; ENSMUSG00000028031.
GeneIDi56811.
KEGGimmu:56811.
UCSCiuc008rjw.2. mouse.

Organism-specific databases

CTDi27123.
MGIiMGI:1890663. Dkk2.

Phylogenomic databases

eggNOGiKOG1218. Eukaryota.
ENOG410XQWV. LUCA.
GeneTreeiENSGT00390000007000.
HOGENOMiHOG000246998.
HOVERGENiHBG000441.
InParanoidiQ9QYZ8.
KOiK02165.
OMAiGTRCNNG.
OrthoDBiEOG091G0H13.
TreeFamiTF330916.

Miscellaneous databases

EvolutionaryTraceiQ9QYZ8.
PROiQ9QYZ8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028031.
CleanExiMM_DKK2.
GenevisibleiQ9QYZ8. MM.

Family and domain databases

InterProiIPR006796. Dickkopf_N.
[Graphical view]
PfamiPF04706. Dickkopf_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDKK2_MOUSE
AccessioniPrimary (citable) accession number: Q9QYZ8
Secondary accession number(s): Q8BFW0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: October 3, 2012
Last modified: September 7, 2016
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.