Q9QYZ4 (SMOK1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Sperm motility kinase 1
EC=2.7.11.1

Gene names

Name:

Smok1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	484 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May play a role in sperm motility, especially in the regulation of flagellar function. Ref.1
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Tissue specificity	Testis-specific. Expressed in the testis from 22 days postpartum (22 dpp). Ref.1
Miscellaneous	Tw12 allele. Encoded on the T-complex, a region of 20-30 Mb on proximal third of mouse chromosome 17. Naturally occurring variant forms of the T-complex, known as complete t-haplotypes, are found in wild mouse populations. The t-haplotypes contain at least four nonoverlapping inversions that suppress recombination with the wild-type chromosome, and lock into strong linkage disequilibrium loci affecting normal transmission of the chromosome, male gametogenesis and embryonic development.
Sequence similarities	Belongs to the protein kinase superfamily. Tyr protein kinase family. Smok subfamily. Contains 1 protein kinase domain. Contains 1 UBA domain.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase Tyrosine-protein kinase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW protein tyrosine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 484	484	Sperm motility kinase 1		PRO_0000307870
Regions
	Domain	8 – 256	249	Protein kinase
	Domain	274 – 314	41	UBA
	Nucleotide binding	14 – 22	9	ATP By similarity
Sites
	Active site	127	1	Proton acceptor By similarity
	Binding site	37	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9QYZ4 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 4244F91CF74D50AA	FASTA	484	54,794
	10 20 30 40 50 60 MEKFHAQYEM LETIGQGGCA KVKLARHRLT GTHVAVKMIP KREYWCKLLM FEAELLMMFN 70 80 90 100 110 120 HPNIISLLQV IETKKKVYLI MELCEGKSLY QHIQNAGYLQ EDEARPLFKQ LLSAMNYCHN 130 140 150 160 170 180 QGIVHRDLTP DNIMVEKDGR VKNIDFGLST HVKPGQKLNL FCGTYPFSAP EVLLSRPYGG 190 200 210 220 230 240 PKIDVWTLGV VLYFMVIGKI PFDAASIEKL RKQIVAGKYS APCRLSVKLQ HLINLLMTDN 250 260 270 280 290 300 PELRPTVAEV MVHPWITKGS GVFPDPCEEQ IPLKPDPAIV KPMGHIGFQA QDIEDSLRQR 310 320 330 340 350 360 KFNETMASYC LLKKQILKEC DRPIRDQPMN PSVTPFPSLV DTPTFHLGLR RRETEPTGLR 370 380 390 400 410 420 LSANRQVSVC GKSTSKKRDR SFIWPGVLSR PINTTPTMDQ THTRTRSVPC IYSNVCTIHP 430 440 450 460 470 480 NSIDESTEGH TSASAEDKPV HSRGWPRGIK GWTRKIGNAM RKLCCCIPSK ETSHLGQSRV CPKK

References

[1]

"A protein kinase encoded by the t complex responder gene causes non-Mendelian inheritance." Herrmann B.G., Koschorz B., Wertz K., McLaughlin K.J., Kispert A. Nature 402:141-146(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY, FUNCTION. Tissue: Testis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ245455 Genomic DNA. Translation: CAB61343.1.
IPI	IPI00474421.
3D structure databases
HSSP	HSSP built from PDB template 2EUE based on UniProtKB P06782.
ProteinModelPortal	Q9QYZ4.
SMR	Q9QYZ4. Positions 6-322.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000094432.
Proteomic databases
PRIDE	Q9QYZ4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
UCSC	uc012akl.1. mouse.
Organism-specific databases
MGI	MGI:1351488. Smok1.
Phylogenomic databases
HOVERGEN	HBG108494.
InParanoid	Q9QYZ4.
Gene expression databases
Genevestigator	Q9QYZ4.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR002290. Ser/Thr_dual-sp_kinase_dom. IPR008266. Tyr_kinase_AS. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. False negative. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. PS50030. UBA. False negative. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

SMOK1_MOUSE

Accession

Primary (citable) accession number: Q9QYZ4

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
Last sequence update:	May 1, 2000
Last modified:	May 1, 2013
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program