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Q9QYZ4 (SMOK1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sperm motility kinase 1

EC=2.7.11.1
Gene names
Name:Smok1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length484 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May play a role in sperm motility, especially in the regulation of flagellar function. Ref.1

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Tissue specificity

Testis-specific. Expressed in the testis from 22 days postpartum (22 dpp). Ref.1

Miscellaneous

Tw12 allele.

Encoded on the T-complex, a region of 20-30 Mb on proximal third of mouse chromosome 17. Naturally occurring variant forms of the T-complex, known as complete t-haplotypes, are found in wild mouse populations. The t-haplotypes contain at least four nonoverlapping inversions that suppress recombination with the wild-type chromosome, and lock into strong linkage disequilibrium loci affecting normal transmission of the chromosome, male gametogenesis and embryonic development.

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. Smok subfamily.

Contains 1 protein kinase domain.

Contains 1 UBA domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 484484Sperm motility kinase 1
PRO_0000307870

Regions

Domain8 – 256249Protein kinase
Domain274 – 31441UBA
Nucleotide binding14 – 229ATP By similarity

Sites

Active site1271Proton acceptor By similarity
Binding site371ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9QYZ4 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 4244F91CF74D50AA

FASTA48454,794
        10         20         30         40         50         60 
MEKFHAQYEM LETIGQGGCA KVKLARHRLT GTHVAVKMIP KREYWCKLLM FEAELLMMFN 

        70         80         90        100        110        120 
HPNIISLLQV IETKKKVYLI MELCEGKSLY QHIQNAGYLQ EDEARPLFKQ LLSAMNYCHN 

       130        140        150        160        170        180 
QGIVHRDLTP DNIMVEKDGR VKNIDFGLST HVKPGQKLNL FCGTYPFSAP EVLLSRPYGG 

       190        200        210        220        230        240 
PKIDVWTLGV VLYFMVIGKI PFDAASIEKL RKQIVAGKYS APCRLSVKLQ HLINLLMTDN 

       250        260        270        280        290        300 
PELRPTVAEV MVHPWITKGS GVFPDPCEEQ IPLKPDPAIV KPMGHIGFQA QDIEDSLRQR 

       310        320        330        340        350        360 
KFNETMASYC LLKKQILKEC DRPIRDQPMN PSVTPFPSLV DTPTFHLGLR RRETEPTGLR 

       370        380        390        400        410        420 
LSANRQVSVC GKSTSKKRDR SFIWPGVLSR PINTTPTMDQ THTRTRSVPC IYSNVCTIHP 

       430        440        450        460        470        480 
NSIDESTEGH TSASAEDKPV HSRGWPRGIK GWTRKIGNAM RKLCCCIPSK ETSHLGQSRV 


CPKK 

« Hide

References

[1]"A protein kinase encoded by the t complex responder gene causes non-Mendelian inheritance."
Herrmann B.G., Koschorz B., Wertz K., McLaughlin K.J., Kispert A.
Nature 402:141-146(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY, FUNCTION.
Tissue: Testis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ245455 Genomic DNA. Translation: CAB61343.1.

3D structure databases

ProteinModelPortalQ9QYZ4.
SMRQ9QYZ4. Positions 6-352.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000094432.

Proteomic databases

PRIDEQ9QYZ4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:1351488. Smok1.

Phylogenomic databases

HOVERGENHBG108494.
InParanoidQ9QYZ4.

Gene expression databases

GenevestigatorQ9QYZ4.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008266. Tyr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ9QYZ4.
SOURCESearch...

Entry information

Entry nameSMOK1_MOUSE
AccessionPrimary (citable) accession number: Q9QYZ4
Entry history
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: May 1, 2000
Last modified: June 11, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot