Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9QYZ4

- SMOK1_MOUSE

UniProt

Q9QYZ4 - SMOK1_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Sperm motility kinase 1

Gene

Smok1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

May play a role in sperm motility, especially in the regulation of flagellar function.1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei37 – 371ATPPROSITE-ProRule annotation
Active sitei127 – 1271Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi14 – 229ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein serine/threonine kinase activity Source: UniProtKB-KW
  3. protein tyrosine kinase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sperm motility kinase 1 (EC:2.7.11.1)
Gene namesi
Name:Smok1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:1351488. Smok1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 484484Sperm motility kinase 1PRO_0000307870Add
BLAST

Proteomic databases

PRIDEiQ9QYZ4.

Expressioni

Tissue specificityi

Testis-specific. Expressed in the testis from 22 days postpartum (22 dpp).1 Publication

Gene expression databases

GenevestigatoriQ9QYZ4.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000094432.

Structurei

3D structure databases

ProteinModelPortaliQ9QYZ4.
SMRiQ9QYZ4. Positions 6-352.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 256249Protein kinasePROSITE-ProRule annotationAdd
BLAST
Domaini274 – 31441UBAAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. Smok subfamily.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 1 UBA domain.Curated

Phylogenomic databases

HOVERGENiHBG108494.
InParanoidiQ9QYZ4.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008266. Tyr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9QYZ4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEKFHAQYEM LETIGQGGCA KVKLARHRLT GTHVAVKMIP KREYWCKLLM
60 70 80 90 100
FEAELLMMFN HPNIISLLQV IETKKKVYLI MELCEGKSLY QHIQNAGYLQ
110 120 130 140 150
EDEARPLFKQ LLSAMNYCHN QGIVHRDLTP DNIMVEKDGR VKNIDFGLST
160 170 180 190 200
HVKPGQKLNL FCGTYPFSAP EVLLSRPYGG PKIDVWTLGV VLYFMVIGKI
210 220 230 240 250
PFDAASIEKL RKQIVAGKYS APCRLSVKLQ HLINLLMTDN PELRPTVAEV
260 270 280 290 300
MVHPWITKGS GVFPDPCEEQ IPLKPDPAIV KPMGHIGFQA QDIEDSLRQR
310 320 330 340 350
KFNETMASYC LLKKQILKEC DRPIRDQPMN PSVTPFPSLV DTPTFHLGLR
360 370 380 390 400
RRETEPTGLR LSANRQVSVC GKSTSKKRDR SFIWPGVLSR PINTTPTMDQ
410 420 430 440 450
THTRTRSVPC IYSNVCTIHP NSIDESTEGH TSASAEDKPV HSRGWPRGIK
460 470 480
GWTRKIGNAM RKLCCCIPSK ETSHLGQSRV CPKK
Length:484
Mass (Da):54,794
Last modified:May 1, 2000 - v1
Checksum:i4244F91CF74D50AA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ245455 Genomic DNA. Translation: CAB61343.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ245455 Genomic DNA. Translation: CAB61343.1 .

3D structure databases

ProteinModelPortali Q9QYZ4.
SMRi Q9QYZ4. Positions 6-352.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000094432.

Proteomic databases

PRIDEi Q9QYZ4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:1351488. Smok1.

Phylogenomic databases

HOVERGENi HBG108494.
InParanoidi Q9QYZ4.

Miscellaneous databases

PROi Q9QYZ4.
SOURCEi Search...

Gene expression databases

Genevestigatori Q9QYZ4.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008266. Tyr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A protein kinase encoded by the t complex responder gene causes non-Mendelian inheritance."
    Herrmann B.G., Koschorz B., Wertz K., McLaughlin K.J., Kispert A.
    Nature 402:141-146(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY, FUNCTION.
    Tissue: Testis.

Entry informationi

Entry nameiSMOK1_MOUSE
AccessioniPrimary (citable) accession number: Q9QYZ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Tw12 allele.
Encoded on the T-complex, a region of 20-30 Mb on proximal third of mouse chromosome 17. Naturally occurring variant forms of the T-complex, known as complete t-haplotypes, are found in wild mouse populations. The t-haplotypes contain at least four nonoverlapping inversions that suppress recombination with the wild-type chromosome, and lock into strong linkage disequilibrium loci affecting normal transmission of the chromosome, male gametogenesis and embryonic development.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3