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Q9QYZ4

- SMOK1_MOUSE

UniProt

Q9QYZ4 - SMOK1_MOUSE

Protein

Sperm motility kinase 1

Gene

Smok1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    May play a role in sperm motility, especially in the regulation of flagellar function.1 Publication

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei37 – 371ATPPROSITE-ProRule annotation
    Active sitei127 – 1271Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi14 – 229ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein serine/threonine kinase activity Source: UniProtKB-KW
    3. protein tyrosine kinase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sperm motility kinase 1 (EC:2.7.11.1)
    Gene namesi
    Name:Smok1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:1351488. Smok1.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 484484Sperm motility kinase 1PRO_0000307870Add
    BLAST

    Proteomic databases

    PRIDEiQ9QYZ4.

    Expressioni

    Tissue specificityi

    Testis-specific. Expressed in the testis from 22 days postpartum (22 dpp).1 Publication

    Gene expression databases

    GenevestigatoriQ9QYZ4.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000094432.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9QYZ4.
    SMRiQ9QYZ4. Positions 6-352.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini8 – 256249Protein kinasePROSITE-ProRule annotationAdd
    BLAST
    Domaini274 – 31441UBAAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Tyr protein kinase family. Smok subfamily.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation
    Contains 1 UBA domain.Curated

    Phylogenomic databases

    HOVERGENiHBG108494.
    InParanoidiQ9QYZ4.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008266. Tyr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9QYZ4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEKFHAQYEM LETIGQGGCA KVKLARHRLT GTHVAVKMIP KREYWCKLLM    50
    FEAELLMMFN HPNIISLLQV IETKKKVYLI MELCEGKSLY QHIQNAGYLQ 100
    EDEARPLFKQ LLSAMNYCHN QGIVHRDLTP DNIMVEKDGR VKNIDFGLST 150
    HVKPGQKLNL FCGTYPFSAP EVLLSRPYGG PKIDVWTLGV VLYFMVIGKI 200
    PFDAASIEKL RKQIVAGKYS APCRLSVKLQ HLINLLMTDN PELRPTVAEV 250
    MVHPWITKGS GVFPDPCEEQ IPLKPDPAIV KPMGHIGFQA QDIEDSLRQR 300
    KFNETMASYC LLKKQILKEC DRPIRDQPMN PSVTPFPSLV DTPTFHLGLR 350
    RRETEPTGLR LSANRQVSVC GKSTSKKRDR SFIWPGVLSR PINTTPTMDQ 400
    THTRTRSVPC IYSNVCTIHP NSIDESTEGH TSASAEDKPV HSRGWPRGIK 450
    GWTRKIGNAM RKLCCCIPSK ETSHLGQSRV CPKK 484
    Length:484
    Mass (Da):54,794
    Last modified:May 1, 2000 - v1
    Checksum:i4244F91CF74D50AA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ245455 Genomic DNA. Translation: CAB61343.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ245455 Genomic DNA. Translation: CAB61343.1 .

    3D structure databases

    ProteinModelPortali Q9QYZ4.
    SMRi Q9QYZ4. Positions 6-352.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000094432.

    Proteomic databases

    PRIDEi Q9QYZ4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:1351488. Smok1.

    Phylogenomic databases

    HOVERGENi HBG108494.
    InParanoidi Q9QYZ4.

    Miscellaneous databases

    PROi Q9QYZ4.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q9QYZ4.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008266. Tyr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A protein kinase encoded by the t complex responder gene causes non-Mendelian inheritance."
      Herrmann B.G., Koschorz B., Wertz K., McLaughlin K.J., Kispert A.
      Nature 402:141-146(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY, FUNCTION.
      Tissue: Testis.

    Entry informationi

    Entry nameiSMOK1_MOUSE
    AccessioniPrimary (citable) accession number: Q9QYZ4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 23, 2007
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Tw12 allele.
    Encoded on the T-complex, a region of 20-30 Mb on proximal third of mouse chromosome 17. Naturally occurring variant forms of the T-complex, known as complete t-haplotypes, are found in wild mouse populations. The t-haplotypes contain at least four nonoverlapping inversions that suppress recombination with the wild-type chromosome, and lock into strong linkage disequilibrium loci affecting normal transmission of the chromosome, male gametogenesis and embryonic development.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3