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Protein

Sperm motility kinase 2B

Gene

Smok2b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in sperm motility, especially in the regulation of flagellar function.1 Publication

Miscellaneous

Encoded on the T-complex, a region of 20-30 Mb on proximal third of mouse chromosome 17. Naturally occurring variant forms of the T-complex, known as complete t-haplotypes, are found in wild mouse populations. The t-haplotypes contain at least four nonoverlapping inversions that suppress recombination with the wild-type chromosome, and lock into strong linkage disequilibrium loci affecting normal transmission of the chromosome, male gametogenesis and embryonic development.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei37ATPPROSITE-ProRule annotation1
Active sitei127Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi14 – 22ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sperm motility kinase 2BImported (EC:2.7.11.11 Publication)
Gene namesi
Name:Smok2bImported
Synonyms:Gm1847
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:3037705. Smok2b.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003078681 – 484Sperm motility kinase 2BAdd BLAST484

Proteomic databases

PaxDbiQ9QYZ3.
PRIDEiQ9QYZ3.

Expressioni

Tissue specificityi

Testis-specific. Expressed in the testis from 22 days postpartum (22 dpp).1 Publication

Gene expression databases

BgeeiENSMUSG00000073457.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000061516.

Structurei

3D structure databases

ProteinModelPortaliQ9QYZ3.
SMRiQ9QYZ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 256Protein kinasePROSITE-ProRule annotationAdd BLAST249
Domaini272 – 314UBAAdd BLAST43

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0586. Eukaryota.
ENOG410XNQ0. LUCA.
GeneTreeiENSGT00900000140875.
HOGENOMiHOG000154351.
HOVERGENiHBG108494.
InParanoidiQ9QYZ3.
OMAiCWEREPR.
OrthoDBiEOG091G0ASZ.
PhylomeDBiQ9QYZ3.
TreeFamiTF338820.

Family and domain databases

InterProiView protein in InterPro
IPR011009. Kinase-like_dom_sf.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
PfamiView protein in Pfam
PF00069. Pkinase. 1 hit.
SMARTiView protein in SMART
SM00220. S_TKc. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9QYZ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENFHAQYVM LETIGHGGCS KVMLARHRLT GSHVAVKMIR KSECWCNPVM
60 70 80 90 100
SEVELLMMAD HPNIISLLQV IETKKKVYLI MELCEGKSLY QHIRNAGYLQ
110 120 130 140 150
EDEARALFKQ LLSAMNYCHN QGIVHRDLKP DNIMVEKDGK VKIIDFGLGT
160 170 180 190 200
QVKPGQKLNL FCGTYPFSAP EVLLSRPYDG PKIDVWTLGV VLYFMVTGKV
210 220 230 240 250
PFDAASIQKL VRQILAGKYF VPSRLSVELR DLISLLMTAN PKLRPTVAEV
260 270 280 290 300
MVHPWVTEGS GVFPDPCEEQ MPLKPNPAIV KAMGYIGFQA QDIEDSLRQR
310 320 330 340 350
KFNETMASYC LLKKQILKEC DRPIRAQPMN PSVTPFPSLV DTSTFHLGLR
360 370 380 390 400
RRETEPTSLR LSANRQMSVC GRSTSKKRDR RFSWPSVSGR PLHTTHTMDH
410 420 430 440 450
THTRTRSVPC IYSMFCTIQP NSSDDSTEGH TSASAEDKPV RSRGWPRGIK
460 470 480
GWTRKIGNVM RKLCCCIPSK ETSHVGHSRV SPKK
Length:484
Mass (Da):54,698
Last modified:May 1, 2000 - v1
Checksum:iC53B0ABEEB97364C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ245456 Genomic DNA. Translation: CAB61344.1.
CCDSiCCDS49952.1.
RefSeqiNP_001161385.1. NM_001167913.2.

Genome annotation databases

EnsembliENSMUST00000059824; ENSMUSP00000061516; ENSMUSG00000073457.
ENSMUST00000162940; ENSMUSP00000124967; ENSMUSG00000073457.
GeneIDi236574.
KEGGimmu:236574.
UCSCiuc012akm.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiSMK2B_MOUSE
AccessioniPrimary (citable) accession number: Q9QYZ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: May 1, 2000
Last modified: November 22, 2017
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families