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Protein

Endothelial cell-specific molecule 1

Gene

Esm1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in angiogenesis; promotes angiogenic sprouting. May have potent implications in lung endothelial cell-leukocyte interactions (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Angiogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelial cell-specific molecule 1
Short name:
ESM-1
Gene namesi
Name:Esm1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1918940. Esm1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 184163Endothelial cell-specific molecule 1PRO_0000014395Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi157 – 1571O-linked (Xyl...) (chondroitin sulfate)By similarity

Post-translational modificationi

O-glycosylated; contains chondroitin sulfate and dermatan sulfate.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9QYY7.
PaxDbiQ9QYY7.
PRIDEiQ9QYY7.

Expressioni

Gene expression databases

BgeeiQ9QYY7.
CleanExiMM_ESM1.
ExpressionAtlasiQ9QYY7. baseline and differential.
GenevisibleiQ9QYY7. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000040187.

Structurei

3D structure databases

ProteinModelPortaliQ9QYY7.
SMRiQ9QYY7. Positions 20-136.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 10279IGFBP N-terminalPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 IGFBP N-terminal domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1218. Eukaryota.
ENOG410XQWV. LUCA.
GeneTreeiENSGT00390000018810.
HOGENOMiHOG000273901.
HOVERGENiHBG005610.
InParanoidiQ9QYY7.
OMAiSTKYAVD.
OrthoDBiEOG7BW0M2.
PhylomeDBiQ9QYY7.

Family and domain databases

InterProiIPR009030. Growth_fac_rcpt_.
IPR000867. IGFBP-like.
[Graphical view]
PfamiPF00219. IGFBP. 1 hit.
[Graphical view]
SMARTiSM00121. IB. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
PROSITEiPS51323. IGFBP_N_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QYY7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSLLLLTTL LVPLHLGMAW SAKYAVDCPE HCDKTECRSS LRCKRTVLDD
60 70 80 90 100
CGCCQVCAAG PGETCYRTVS GMDGVKCGPG LKCHFYSEED DFGDEFGICK
110 120 130 140 150
DCPYGTFGME CKETCNCQSG ICDRVTGRCL DFPFFQYAAA KSPSRTSASH
160 170 180
TERDSASGDG NAVREEIGEG NAARPSVMKW LNPR
Length:184
Mass (Da):20,043
Last modified:May 1, 2000 - v1
Checksum:i0F54F7629678D278
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ249354 mRNA. Translation: CAB60730.1.
AK002913 mRNA. Translation: BAB22452.1.
BC051919 mRNA. Translation: AAH51919.1.
CCDSiCCDS26784.1.
RefSeqiNP_076101.1. NM_023612.3.
UniGeneiMm.38929.

Genome annotation databases

EnsembliENSMUST00000038144; ENSMUSP00000040187; ENSMUSG00000042379.
GeneIDi71690.
KEGGimmu:71690.
UCSCiuc007rxe.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ249354 mRNA. Translation: CAB60730.1.
AK002913 mRNA. Translation: BAB22452.1.
BC051919 mRNA. Translation: AAH51919.1.
CCDSiCCDS26784.1.
RefSeqiNP_076101.1. NM_023612.3.
UniGeneiMm.38929.

3D structure databases

ProteinModelPortaliQ9QYY7.
SMRiQ9QYY7. Positions 20-136.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000040187.

Proteomic databases

EPDiQ9QYY7.
PaxDbiQ9QYY7.
PRIDEiQ9QYY7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038144; ENSMUSP00000040187; ENSMUSG00000042379.
GeneIDi71690.
KEGGimmu:71690.
UCSCiuc007rxe.1. mouse.

Organism-specific databases

CTDi11082.
MGIiMGI:1918940. Esm1.

Phylogenomic databases

eggNOGiKOG1218. Eukaryota.
ENOG410XQWV. LUCA.
GeneTreeiENSGT00390000018810.
HOGENOMiHOG000273901.
HOVERGENiHBG005610.
InParanoidiQ9QYY7.
OMAiSTKYAVD.
OrthoDBiEOG7BW0M2.
PhylomeDBiQ9QYY7.

Miscellaneous databases

PROiQ9QYY7.
SOURCEiSearch...

Gene expression databases

BgeeiQ9QYY7.
CleanExiMM_ESM1.
ExpressionAtlasiQ9QYY7. baseline and differential.
GenevisibleiQ9QYY7. MM.

Family and domain databases

InterProiIPR009030. Growth_fac_rcpt_.
IPR000867. IGFBP-like.
[Graphical view]
PfamiPF00219. IGFBP. 1 hit.
[Graphical view]
SMARTiSM00121. IB. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
PROSITEiPS51323. IGFBP_N_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Lassalle P.
    Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/cJ.
    Tissue: Lung.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Kidney.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain.

Entry informationi

Entry nameiESM1_MOUSE
AccessioniPrimary (citable) accession number: Q9QYY7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 2000
Last modified: June 8, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.