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Reviewed, UniProtKB/Swiss-Prot Q9QYY1 (IL1F5_MOUSE)

Last modified July 13, 2010. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
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Names and originHide

Protein namesRecommended name:
Interleukin-1 family member 5

Short name=IL-1F5
Alternative name(s):
Interleukin-1 delta
Short name=IL-1 delta
Interleukin-1-like protein 1
Short name=IL-1L1
Interleukin-1 HY1
Short name=IL-1HY1
Interleukin-1 homolog 3
Short name=IL-1H3
Gene names
Name:Il1f5
Synonyms:Fil1d, Il1h3, Il1hy1
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMus
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Protein attributesHide

Sequence length156 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level.
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General annotation (Comments)Hide

Function

Is a highly and a specific antagonist of the IL-1 receptor-related protein 2-mediated response to interleukin 1 family member 9 (IL1F9). Could constitute part of an independent signaling system analogous to interleukin-1 alpha (IL-1A), beta (IL-1B) receptor agonist and interleukin-1 receptor type I (IL-1R1), that is present in epithelial barriers and takes part in local inflammatory response By similarity.

Subcellular location

Secreted By similarity.

Tissue specificity

Highly abundant in embryonic tissue and tissues containing epithelial cells.

Sequence similarities

Belongs to the IL-1 family.

Sequence caution

The sequence CAB59831.1 differs from that shown. Reason: Erroneous initiation.

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OntologiesHide

Keywords
   Cellular componentSecreted
   Molecular functionCytokine
   PTMDisulfide bond
   Technical term3D-structure
Gene Ontology (GO)
   Cellular componentextracellular space

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functioncytokine activity

Inferred from electronic annotation. Source: UniProtKB-KW

interleukin-1 receptor antagonist activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...
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Sequence annotation (Features)Hide

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 156156Interleukin-1 family member 5
PRO_0000153643

Amino acid modifications

Disulfide bond9 ↔ 155 Ref.5

Experimental info

Sequence conflict21Missing Ref.3

Secondary structure

..................................... 156
Helix Strand Turn

Details...

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SequencesHide

Sequence LengthMass (Da)Tools
Q9QYY1-1 [UniParc].

Last modified November 8, 2002. Version 2.
Checksum: A4D1EE2F93CF77A7

FASTA15617,136
        10         20         30         40         50         60 
MMVLSGALCF RMKDSALKVL YLHNNQLLAG GLHAEKVIKG EEISVVPNRA LDASLSPVIL 

        70         80         90        100        110        120 
GVQGGSQCLS CGTEKGPILK LEPVNIMELY LGAKESKSFT FYRRDMGLTS SFESAAYPGW 

       130        140        150 
FLCTSPEADQ PVRLTQIPED PAWDAPITDF YFQQCD 

« Hide

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ReferencesHide

« Hide 'large scale' references
[1]"Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2."
Debets R., Timans J.C., Homey B., Zurawski S., Sana T.R., Lo S., Wagner J., Edwards G., Clifford T., Menon S., Bazan J.F., Kastelein R.A.
J. Immunol. 167:1440-1446(2001) [PubMed: 11466363] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"A tissue specific IL-1 receptor antagonist homolog from the IL-1 cluster lacks IL-1, IL-1ra, IL-18 and IL-18 antagonist activities."
Barton J.L., Herbst R., Bosisio D., Higgins L., Nicklin M.J.H.
Eur. J. Immunol. 30:3299-3308(2000) [PubMed: 11093146] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Identification and initial characterization of four novel members of the interleukin-1 family."
Kumar S., McDonnell P.C., Lehr R., Tierney L., Tzimas M.N., Griswold D.E., Capper E.A., Tal-Singer R., Wells G.I., Doyle M.L., Young P.R.
J. Biol. Chem. 275:10308-10314(2000) [PubMed: 10744718] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Stomach and Tongue.
[5]"High-resolution structure of murine interleukin 1 homologue IL-1F5 reveals unique loop conformations for receptor binding specificity."
Dunn E.F., Gay N.J., Bristow A.F., Gearing D.P., O'Neill L.A.J., Pei X.Y.
Biochemistry 42:10938-10944(2003) [PubMed: 12974628] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS) OF 3-156, DISULFIDE BOND.
+Additional computationally mapped references.
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Cross-referencesHide

Sequence databases

EMBL
GenBank
DDBJ
AF230378 mRNA. Translation: AAF91275.1.
AK009741 mRNA. Translation: BAB26471.1.
AK008977 mRNA. Translation: BAB26002.1.
AJ250429 mRNA. Translation: CAB59831.1. Different initiation.
AF200495 mRNA. Translation: AAF69251.1.
IPIIPI00120531.
RefSeqNP_001139559.1.
NP_001139560.1.
NP_062324.2.
UniGeneMm.29261

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1MD6X-ray1.60A3-156[»]
ModBaseSearch...

Protein-protein interaction databases

STRINGQ9QYY1.

Proteomic databases

PRIDEQ9QYY1.

Genome annotation databases

EnsemblENSMUST00000028360; ENSMUSP00000028360; ENSMUSG00000026983; Mus musculus. [Genome view]
ENSMUST00000114490; ENSMUSP00000110134; ENSMUSG00000026983; Mus musculus. [Genome view]
GeneID54450.
KEGGmmu:54450.
UCSCuc008ios.1. mouse.

Organism-specific databases

CTD54450.
MGIMGI:1859325. Il1f5.

Phylogenomic databases

HOGENOMHBG282870.
HOVERGENHBG052099.
InParanoidQ9QYY1.
OMASVVPNRS.
OrthoDBEOG9XH2JD.
PhylomeDBQ9QYY1.

Gene expression databases

ArrayExpressQ9QYY1.
BgeeQ9QYY1.
CleanExMM_IL1F5.
GenevestigatorQ9QYY1.
GermOnlineENSMUSG00000026983. Mus musculus.

Family and domain databases

InterProIPR008996. Cytokine_IL1-like.
IPR003297. IL_rcpt_IL1RA.
IPR020877. Interleukin-1_CS.
IPR000975. Interleukin_1.
[Graphical view]
PfamPF00340. IL1. 1 hit.
[Graphical view]
PRINTSPR00264. INTERLEUKIN1.
PR01360. INTRLEUKIN1X.
SMARTSM00125. IL1. 1 hit.
[Graphical view]
SUPFAMSSF50353. Cytok_IL1_like. 1 hit.
PROSITEPS00253. INTERLEUKIN_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio311328.
SOURCESearch...
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Entry informationHide

Entry nameIL1F5_MOUSE
AccessionPrimary (citable) accession number: Q9QYY1
Secondary accession number(s): Q9JIG2
Entry history
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: November 8, 2002
Last modified: July 13, 2010
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
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Relevant documentsHide

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents