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Protein

Interleukin-36 receptor antagonist protein

Gene

IL36RN

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2/IL-36R and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens. May activate an anti-inflammatory signaling pathway by recruiting SIGIRR.4 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Immunity, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-36 receptor antagonist protein
Short name:
IL-36Ra1 Publication
Alternative name(s):
Interleukin-1 HY1
Short name:
IL-1HY1
Interleukin-1 delta
Short name:
IL-1 delta
Interleukin-1 family member 5
Short name:
IL-1F5
Interleukin-1 homolog 3
Short name:
IL-1H3
Interleukin-1-like protein 1
Short name:
IL-1L1
Gene namesi
Name:IL36RN
Synonyms:Fil1d, Il1f5, Il1h3, Il1hy1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1859325. Il1f5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Disruption phenotypei

In combination with transgenic IL36A exacerbates skin abnormalities (acanthosis, hyperkeratosis, presence of a mixed inflammatory cell infiltrate and increased cytokine and chemokine expression).1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001536432 – 156Interleukin-36 receptor antagonist proteinAdd BLAST155

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi9 ↔ 1551 Publication

Post-translational modificationi

Removal of N-terminal methionine is necessary for full antagonistic activity.1 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiQ9QYY1.
PaxDbiQ9QYY1.
PRIDEiQ9QYY1.

PTM databases

PhosphoSitePlusiQ9QYY1.

Expressioni

Tissue specificityi

Highly abundant in embryonic tissue and tissues containing epithelial cells.

Gene expression databases

BgeeiENSMUSG00000026983.
CleanExiMM_IL1F5.
ExpressionAtlasiQ9QYY1. baseline and differential.
GenevisibleiQ9QYY1. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028360.

Structurei

Secondary structure

1156
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi8 – 14Combined sources7
Beta strandi19 – 23Combined sources5
Beta strandi26 – 29Combined sources4
Helixi32 – 35Combined sources4
Beta strandi43 – 47Combined sources5
Helixi53 – 55Combined sources3
Beta strandi57 – 62Combined sources6
Turni63 – 66Combined sources4
Beta strandi67 – 70Combined sources4
Beta strandi73 – 76Combined sources4
Beta strandi80 – 83Combined sources4
Helixi86 – 91Combined sources6
Beta strandi92 – 94Combined sources3
Helixi97 – 99Combined sources3
Beta strandi100 – 105Combined sources6
Beta strandi110 – 117Combined sources8
Beta strandi121 – 124Combined sources4
Beta strandi126 – 131Combined sources6
Beta strandi133 – 135Combined sources3
Beta strandi150 – 154Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MD6X-ray1.60A3-156[»]
ProteinModelPortaliQ9QYY1.
SMRiQ9QYY1.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9QYY1.

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-1 family.Curated

Phylogenomic databases

eggNOGiENOG410IZIW. Eukaryota.
ENOG41116AA. LUCA.
GeneTreeiENSGT00530000062899.
HOVERGENiHBG052099.
InParanoidiQ9QYY1.
KOiK05483.
OMAiMKDSALK.
OrthoDBiEOG091G0PWA.
PhylomeDBiQ9QYY1.
TreeFamiTF300203.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR020877. IL-1_CS.
IPR000975. IL-1_fam.
IPR003297. IL-1RA/IL-36.
IPR027171. IL-36RA.
[Graphical view]
PANTHERiPTHR10078:SF7. PTHR10078:SF7. 1 hit.
PfamiPF00340. IL1. 1 hit.
[Graphical view]
PRINTSiPR00264. INTERLEUKIN1.
PR01360. INTRLEUKIN1X.
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00253. INTERLEUKIN_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QYY1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMVLSGALCF RMKDSALKVL YLHNNQLLAG GLHAEKVIKG EEISVVPNRA
60 70 80 90 100
LDASLSPVIL GVQGGSQCLS CGTEKGPILK LEPVNIMELY LGAKESKSFT
110 120 130 140 150
FYRRDMGLTS SFESAAYPGW FLCTSPEADQ PVRLTQIPED PAWDAPITDF

YFQQCD
Length:156
Mass (Da):17,136
Last modified:November 8, 2002 - v2
Checksum:iA4D1EE2F93CF77A7
GO

Sequence cautioni

The sequence CAB59831 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2Missing in AAF69251 (PubMed:11466363).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ250429 mRNA. Translation: CAB59831.1. Different initiation.
AF200495 mRNA. Translation: AAF69251.1.
AF230378 mRNA. Translation: AAF91275.1.
AK008977 mRNA. Translation: BAB26002.1.
AK009741 mRNA. Translation: BAB26471.1.
CCDSiCCDS50519.1.
RefSeqiNP_001139559.1. NM_001146087.1.
NP_001139560.1. NM_001146088.1.
NP_062324.2. NM_019451.2.
UniGeneiMm.29261.

Genome annotation databases

EnsembliENSMUST00000028360; ENSMUSP00000028360; ENSMUSG00000026983.
ENSMUST00000114490; ENSMUSP00000110134; ENSMUSG00000026983.
ENSMUST00000168941; ENSMUSP00000126028; ENSMUSG00000026983.
GeneIDi54450.
KEGGimmu:54450.
UCSCiuc008ios.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ250429 mRNA. Translation: CAB59831.1. Different initiation.
AF200495 mRNA. Translation: AAF69251.1.
AF230378 mRNA. Translation: AAF91275.1.
AK008977 mRNA. Translation: BAB26002.1.
AK009741 mRNA. Translation: BAB26471.1.
CCDSiCCDS50519.1.
RefSeqiNP_001139559.1. NM_001146087.1.
NP_001139560.1. NM_001146088.1.
NP_062324.2. NM_019451.2.
UniGeneiMm.29261.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MD6X-ray1.60A3-156[»]
ProteinModelPortaliQ9QYY1.
SMRiQ9QYY1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028360.

PTM databases

PhosphoSitePlusiQ9QYY1.

Proteomic databases

MaxQBiQ9QYY1.
PaxDbiQ9QYY1.
PRIDEiQ9QYY1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028360; ENSMUSP00000028360; ENSMUSG00000026983.
ENSMUST00000114490; ENSMUSP00000110134; ENSMUSG00000026983.
ENSMUST00000168941; ENSMUSP00000126028; ENSMUSG00000026983.
GeneIDi54450.
KEGGimmu:54450.
UCSCiuc008ios.2. mouse.

Organism-specific databases

CTDi54450.
MGIiMGI:1859325. Il1f5.

Phylogenomic databases

eggNOGiENOG410IZIW. Eukaryota.
ENOG41116AA. LUCA.
GeneTreeiENSGT00530000062899.
HOVERGENiHBG052099.
InParanoidiQ9QYY1.
KOiK05483.
OMAiMKDSALK.
OrthoDBiEOG091G0PWA.
PhylomeDBiQ9QYY1.
TreeFamiTF300203.

Miscellaneous databases

EvolutionaryTraceiQ9QYY1.
PROiQ9QYY1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026983.
CleanExiMM_IL1F5.
ExpressionAtlasiQ9QYY1. baseline and differential.
GenevisibleiQ9QYY1. MM.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR020877. IL-1_CS.
IPR000975. IL-1_fam.
IPR003297. IL-1RA/IL-36.
IPR027171. IL-36RA.
[Graphical view]
PANTHERiPTHR10078:SF7. PTHR10078:SF7. 1 hit.
PfamiPF00340. IL1. 1 hit.
[Graphical view]
PRINTSiPR00264. INTERLEUKIN1.
PR01360. INTRLEUKIN1X.
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00253. INTERLEUKIN_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiI36RA_MOUSE
AccessioniPrimary (citable) accession number: Q9QYY1
Secondary accession number(s): Q9JIG2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: November 8, 2002
Last modified: November 2, 2016
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Bioactive (processed) recombinant IL36RN inhibits effects of IL-36 when used in 100- 1000-fold molar excess.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.