Q9QYY1 (I36RA_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Interleukin-36 receptor antagonist protein

Alternative name(s):
Interleukin-1 HY1
Short name=IL-1HY1
Interleukin-1 delta
Short name=IL-1 delta
Interleukin-1 family member 5
Short name=IL-1F5
Interleukin-1 homolog 3
Short name=IL-1H3
Interleukin-1-like protein 1
Short name=IL-1L1

Gene names

Name:	IL36RN
Synonyms:	Fil1d, Il1f5, Il1h3, Il1hy1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	156 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Is a highly and a specific antagonist of the IL-1 receptor-related protein 2-mediated response to interleukin 1 family member 9 (IL1F9). Could constitute part of an independent signaling system analogous to interleukin-1 alpha (IL-1A), beta (IL-1B) receptor agonist and interleukin-1 receptor type I (IL-1R1), that is present in epithelial barriers and takes part in local inflammatory response By similarity.
Subcellular location	Secreted By similarity.
Tissue specificity	Highly abundant in embryonic tissue and tissues containing epithelial cells.
Sequence similarities	Belongs to the IL-1 family.
Sequence caution	The sequence CAB59831.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Cellular component	Secreted
Molecular function	Cytokine
PTM	Disulfide bond
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	negative regulation of cytokine-mediated signaling pathway Inferred from electronic annotation. Source: GOC negative regulation of interleukin-6 production Inferred from genetic interaction PubMed 21860022. Source: MGI
Cellular_component	extracellular space Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 156

156

Interleukin-36 receptor antagonist protein

PRO_0000153643

Amino acid modifications

Disulfide bond

9 ↔ 155

Ref.5

Experimental info

Sequence conflict

2

1

Missing in AAF69251. Ref.3

Secondary structure

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156

Helix Strand Turn

Details...

Beta strand

8 – 14

7

Beta strand

19 – 23

5

Beta strand

26 – 29

4

Helix

32 – 35

4

Beta strand

43 – 47

5

Helix

53 – 55

3

Beta strand

57 – 62

6

Turn

63 – 66

4

Beta strand

67 – 70

4

Beta strand

73 – 76

4

Beta strand

80 – 83

4

Helix

86 – 91

6

Beta strand

92 – 94

3

Helix

97 – 99

3

Beta strand

100 – 105

6

Beta strand

110 – 117

8

Beta strand

121 – 124

4

Beta strand

126 – 131

6

Beta strand

133 – 135

3

Beta strand

150 – 154

5

Sequences

	Sequence		Length	Mass (Da)
	Q9QYY1 [UniParc]. Last modified November 8, 2002. Version 2. Checksum: A4D1EE2F93CF77A7	FASTA	156	17,136
	10 20 30 40 50 60 MMVLSGALCF RMKDSALKVL YLHNNQLLAG GLHAEKVIKG EEISVVPNRA LDASLSPVIL 70 80 90 100 110 120 GVQGGSQCLS CGTEKGPILK LEPVNIMELY LGAKESKSFT FYRRDMGLTS SFESAAYPGW 130 140 150 FLCTSPEADQ PVRLTQIPED PAWDAPITDF YFQQCD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A tissue specific IL-1 receptor antagonist homolog from the IL-1 cluster lacks IL-1, IL-1ra, IL-18 and IL-18 antagonist activities." Barton J.L., Herbst R., Bosisio D., Higgins L., Nicklin M.J.H. Eur. J. Immunol. 30:3299-3308(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Identification and initial characterization of four novel members of the interleukin-1 family." Kumar S., McDonnell P.C., Lehr R., Tierney L., Tzimas M.N., Griswold D.E., Capper E.A., Tal-Singer R., Wells G.I., Doyle M.L., Young P.R. J. Biol. Chem. 275:10308-10314(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2." Debets R., Timans J.C., Homey B., Zurawski S., Sana T.R., Lo S., Wagner J., Edwards G., Clifford T., Menon S., Bazan J.F., Kastelein R.A. J. Immunol. 167:1440-1446(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Stomach and Tongue.
[5]	"High-resolution structure of murine interleukin 1 homologue IL-1F5 reveals unique loop conformations for receptor binding specificity." Dunn E.F., Gay N.J., Bristow A.F., Gearing D.P., O'Neill L.A.J., Pei X.Y. Biochemistry 42:10938-10944(2003) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS) OF 3-156, DISULFIDE BOND.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AJ250429 mRNA. Translation: CAB59831.1. Different initiation.
AF200495 mRNA. Translation: AAF69251.1.
AF230378 mRNA. Translation: AAF91275.1.
AK008977 mRNA. Translation: BAB26002.1.
AK009741 mRNA. Translation: BAB26471.1.

IPI

IPI00120531.

RefSeq

NP_001139559.1. NM_001146087.1.
NP_001139560.1. NM_001146088.1.
NP_062324.2. NM_019451.2.

UniGene

Mm.29261.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1MD6	X-ray	1.60	A	3-156	[»]

ProteinModelPortal

Q9QYY1.

SMR

Q9QYY1. Positions 3-156.

ModBase

Search...

Proteomic databases

PRIDE

Q9QYY1.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENSMUST00000028360; ENSMUSP00000028360; ENSMUSG00000026983.
ENSMUST00000114490; ENSMUSP00000110134; ENSMUSG00000026983.
ENSMUST00000168941; ENSMUSP00000126028; ENSMUSG00000026983.

GeneID

54450.

KEGG

mmu:54450.

Organism-specific databases

CTD

54450.

MGI

MGI:1859325. Il1f5.

Phylogenomic databases

eggNOG

NOG46537.

GeneTree

ENSGT00530000062899.

HOVERGEN

HBG052099.

InParanoid

Q9QYY1.

KO

K05483.

OMA

TLEPVNI.

OrthoDB

EOG4MKNHG.

Gene expression databases

ArrayExpress

Q9QYY1.

Bgee

Q9QYY1.

CleanEx

MM_IL1F5.

Genevestigator

Q9QYY1.

GermOnline

ENSMUSG00000026983. Mus musculus.

Family and domain databases

InterPro

IPR008996. Cytokine_IL1-like.
IPR003297. IL-1RA/IL-36.
IPR020877. Interleukin-1_CS.
IPR027171. Interleukin-36RA.
IPR000975. Interleukin_1.
[Graphical view]

PANTHER

PTHR10078:SF7. PTHR10078:SF7. 1 hit.

Pfam

PF00340. IL1. 1 hit.
[Graphical view]

PRINTS

PR00264. INTERLEUKIN1.
PR01360. INTRLEUKIN1X.

SMART

SM00125. IL1. 1 hit.
[Graphical view]

SUPFAM

SSF50353. Cytok_IL1_like. 1 hit.

PROSITE

PS00253. INTERLEUKIN_1. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q9QYY1.

NextBio

311328.

SOURCE

Search...

Entry information

Entry name

I36RA_MOUSE

Accession

Primary (citable) accession number: Q9QYY1
Secondary accession number(s): Q9JIG2

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 8, 2002
Last sequence update:	November 8, 2002
Last modified:	April 3, 2013
This is version 98 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program