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Q9QYY1

- I36RA_MOUSE

UniProt

Q9QYY1 - I36RA_MOUSE

Protein

Interleukin-36 receptor antagonist protein

Gene

IL36RN

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Is a highly and a specific antagonist of the IL-1 receptor-related protein 2/IL1RL2-mediated response to interleukin IL36G. Could constitute part of an independent signaling system analogous to interleukin-1 alpha (IL-1A), beta (IL-1B) receptor agonist and interleukin-1 receptor type I (IL-1R1), that is present in epithelial barriers and takes part in local inflammatory response By similarity.By similarity

    GO - Biological processi

    1. negative regulation of cytokine-mediated signaling pathway Source: GOC
    2. negative regulation of interleukin-6 production Source: MGI

    Keywords - Molecular functioni

    Cytokine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interleukin-36 receptor antagonist protein
    Alternative name(s):
    Interleukin-1 HY1
    Short name:
    IL-1HY1
    Interleukin-1 delta
    Short name:
    IL-1 delta
    Interleukin-1 family member 5
    Short name:
    IL-1F5
    Interleukin-1 homolog 3
    Short name:
    IL-1H3
    Interleukin-1-like protein 1
    Short name:
    IL-1L1
    Gene namesi
    Name:IL36RN
    Synonyms:Fil1d, Il1f5, Il1h3, Il1hy1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:1859325. Il1f5.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 156156Interleukin-36 receptor antagonist proteinPRO_0000153643Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi9 ↔ 1551 Publication

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    MaxQBiQ9QYY1.
    PRIDEiQ9QYY1.

    Expressioni

    Tissue specificityi

    Highly abundant in embryonic tissue and tissues containing epithelial cells.

    Gene expression databases

    BgeeiQ9QYY1.
    CleanExiMM_IL1F5.
    GenevestigatoriQ9QYY1.

    Structurei

    Secondary structure

    1
    156
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi8 – 147
    Beta strandi19 – 235
    Beta strandi26 – 294
    Helixi32 – 354
    Beta strandi43 – 475
    Helixi53 – 553
    Beta strandi57 – 626
    Turni63 – 664
    Beta strandi67 – 704
    Beta strandi73 – 764
    Beta strandi80 – 834
    Helixi86 – 916
    Beta strandi92 – 943
    Helixi97 – 993
    Beta strandi100 – 1056
    Beta strandi110 – 1178
    Beta strandi121 – 1244
    Beta strandi126 – 1316
    Beta strandi133 – 1353
    Beta strandi150 – 1545

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1MD6X-ray1.60A3-156[»]
    ProteinModelPortaliQ9QYY1.
    SMRiQ9QYY1. Positions 3-156.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9QYY1.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the IL-1 family.Curated

    Phylogenomic databases

    eggNOGiNOG46537.
    GeneTreeiENSGT00530000062899.
    HOVERGENiHBG052099.
    InParanoidiQ9QYY1.
    KOiK05483.
    OMAiFYRRDMG.
    OrthoDBiEOG7QG45K.
    PhylomeDBiQ9QYY1.
    TreeFamiTF300203.

    Family and domain databases

    InterProiIPR008996. Cytokine_IL1-like.
    IPR020877. IL-1_CS.
    IPR000975. IL-1_fam.
    IPR003297. IL-1RA/IL-36.
    IPR027171. IL-36RA.
    [Graphical view]
    PANTHERiPTHR10078:SF7. PTHR10078:SF7. 1 hit.
    PfamiPF00340. IL1. 1 hit.
    [Graphical view]
    PRINTSiPR00264. INTERLEUKIN1.
    PR01360. INTRLEUKIN1X.
    SUPFAMiSSF50353. SSF50353. 1 hit.
    PROSITEiPS00253. INTERLEUKIN_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9QYY1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMVLSGALCF RMKDSALKVL YLHNNQLLAG GLHAEKVIKG EEISVVPNRA    50
    LDASLSPVIL GVQGGSQCLS CGTEKGPILK LEPVNIMELY LGAKESKSFT 100
    FYRRDMGLTS SFESAAYPGW FLCTSPEADQ PVRLTQIPED PAWDAPITDF 150
    YFQQCD 156
    Length:156
    Mass (Da):17,136
    Last modified:November 8, 2002 - v2
    Checksum:iA4D1EE2F93CF77A7
    GO

    Sequence cautioni

    The sequence CAB59831.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti2 – 21Missing in AAF69251. (PubMed:11466363)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ250429 mRNA. Translation: CAB59831.1. Different initiation.
    AF200495 mRNA. Translation: AAF69251.1.
    AF230378 mRNA. Translation: AAF91275.1.
    AK008977 mRNA. Translation: BAB26002.1.
    AK009741 mRNA. Translation: BAB26471.1.
    CCDSiCCDS50519.1.
    RefSeqiNP_001139559.1. NM_001146087.1.
    NP_001139560.1. NM_001146088.1.
    NP_062324.2. NM_019451.2.
    UniGeneiMm.29261.

    Genome annotation databases

    EnsembliENSMUST00000028360; ENSMUSP00000028360; ENSMUSG00000026983.
    ENSMUST00000114490; ENSMUSP00000110134; ENSMUSG00000026983.
    ENSMUST00000168941; ENSMUSP00000126028; ENSMUSG00000026983.
    GeneIDi54450.
    KEGGimmu:54450.
    UCSCiuc008ios.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ250429 mRNA. Translation: CAB59831.1 . Different initiation.
    AF200495 mRNA. Translation: AAF69251.1 .
    AF230378 mRNA. Translation: AAF91275.1 .
    AK008977 mRNA. Translation: BAB26002.1 .
    AK009741 mRNA. Translation: BAB26471.1 .
    CCDSi CCDS50519.1.
    RefSeqi NP_001139559.1. NM_001146087.1.
    NP_001139560.1. NM_001146088.1.
    NP_062324.2. NM_019451.2.
    UniGenei Mm.29261.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1MD6 X-ray 1.60 A 3-156 [» ]
    ProteinModelPortali Q9QYY1.
    SMRi Q9QYY1. Positions 3-156.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    MaxQBi Q9QYY1.
    PRIDEi Q9QYY1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000028360 ; ENSMUSP00000028360 ; ENSMUSG00000026983 .
    ENSMUST00000114490 ; ENSMUSP00000110134 ; ENSMUSG00000026983 .
    ENSMUST00000168941 ; ENSMUSP00000126028 ; ENSMUSG00000026983 .
    GeneIDi 54450.
    KEGGi mmu:54450.
    UCSCi uc008ios.2. mouse.

    Organism-specific databases

    CTDi 54450.
    MGIi MGI:1859325. Il1f5.

    Phylogenomic databases

    eggNOGi NOG46537.
    GeneTreei ENSGT00530000062899.
    HOVERGENi HBG052099.
    InParanoidi Q9QYY1.
    KOi K05483.
    OMAi FYRRDMG.
    OrthoDBi EOG7QG45K.
    PhylomeDBi Q9QYY1.
    TreeFami TF300203.

    Miscellaneous databases

    EvolutionaryTracei Q9QYY1.
    NextBioi 311328.
    PROi Q9QYY1.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9QYY1.
    CleanExi MM_IL1F5.
    Genevestigatori Q9QYY1.

    Family and domain databases

    InterProi IPR008996. Cytokine_IL1-like.
    IPR020877. IL-1_CS.
    IPR000975. IL-1_fam.
    IPR003297. IL-1RA/IL-36.
    IPR027171. IL-36RA.
    [Graphical view ]
    PANTHERi PTHR10078:SF7. PTHR10078:SF7. 1 hit.
    Pfami PF00340. IL1. 1 hit.
    [Graphical view ]
    PRINTSi PR00264. INTERLEUKIN1.
    PR01360. INTRLEUKIN1X.
    SUPFAMi SSF50353. SSF50353. 1 hit.
    PROSITEi PS00253. INTERLEUKIN_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A tissue specific IL-1 receptor antagonist homolog from the IL-1 cluster lacks IL-1, IL-1ra, IL-18 and IL-18 antagonist activities."
      Barton J.L., Herbst R., Bosisio D., Higgins L., Nicklin M.J.H.
      Eur. J. Immunol. 30:3299-3308(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Identification and initial characterization of four novel members of the interleukin-1 family."
      Kumar S., McDonnell P.C., Lehr R., Tierney L., Tzimas M.N., Griswold D.E., Capper E.A., Tal-Singer R., Wells G.I., Doyle M.L., Young P.R.
      J. Biol. Chem. 275:10308-10314(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2."
      Debets R., Timans J.C., Homey B., Zurawski S., Sana T.R., Lo S., Wagner J., Edwards G., Clifford T., Menon S., Bazan J.F., Kastelein R.A.
      J. Immunol. 167:1440-1446(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Stomach and Tongue.
    5. "High-resolution structure of murine interleukin 1 homologue IL-1F5 reveals unique loop conformations for receptor binding specificity."
      Dunn E.F., Gay N.J., Bristow A.F., Gearing D.P., O'Neill L.A.J., Pei X.Y.
      Biochemistry 42:10938-10944(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS) OF 3-156, DISULFIDE BOND.

    Entry informationi

    Entry nameiI36RA_MOUSE
    AccessioniPrimary (citable) accession number: Q9QYY1
    Secondary accession number(s): Q9JIG2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 8, 2002
    Last sequence update: November 8, 2002
    Last modified: October 1, 2014
    This is version 110 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3