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Q9QYY0

- GAB1_MOUSE

UniProt

Q9QYY0 - GAB1_MOUSE

Protein

GRB2-associated-binding protein 1

Gene

Gab1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 2 (13 Apr 2004)
      Previous versions | rss
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    Functioni

    Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR) By similarity.By similarity

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. signal transducer activity Source: MGI

    GO - Biological processi

    1. activation of JUN kinase activity Source: MGI
    2. activation of MAPK activity Source: MGI
    3. epidermal growth factor receptor signaling pathway Source: MGI
    4. epidermis development Source: MGI
    5. heart development Source: MGI
    6. interleukin-6-mediated signaling pathway Source: MGI
    7. labyrinthine layer development Source: MGI
    8. platelet-derived growth factor receptor signaling pathway Source: MGI
    9. positive regulation of MAPK cascade Source: MGI
    10. regulation of cell migration Source: MGI
    11. response to oxidative stress Source: MGI
    12. signal transduction Source: MGI

    Enzyme and pathway databases

    ReactomeiREACT_196455. Signaling by FGFR mutants.
    REACT_196588. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_199123. Signaling by constitutively active EGFR.
    REACT_206286. GAB1 signalosome.
    REACT_215348. PI3K events in ERBB2 signaling.
    REACT_223993. PI-3K cascade.
    REACT_226341. PIP3 activates AKT signaling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GRB2-associated-binding protein 1
    Alternative name(s):
    GRB2-associated binder 1
    Growth factor receptor bound protein 2-associated protein 1
    Gene namesi
    Name:Gab1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:108088. Gab1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: MGI

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 695694GRB2-associated-binding protein 1PRO_0000050284Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserineBy similarity
    Modified residuei628 – 6281PhosphotyrosineBy similarity
    Modified residuei660 – 6601Phosphotyrosine1 Publication

    Post-translational modificationi

    Phosphorylated on tyrosine residue(s) by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Tyrosine phosphorylation of GAB1 mediates interaction with several proteins that contain SH2 domains. Phosphorylated on tyrosine residues by HCK upon IL6 signaling By similarity. Phosphorylated in response to FGFR1 activation.By similarity1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ9QYY0.
    PaxDbiQ9QYY0.
    PRIDEiQ9QYY0.

    PTM databases

    PhosphoSiteiQ9QYY0.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9QYY0.
    BgeeiQ9QYY0.
    GenevestigatoriQ9QYY0.

    Interactioni

    Subunit structurei

    Interacts with GRB2 and with other SH2-containing proteins. Interacts with phosphorylated LAT2. Interacts with PTPRJ By similarity. Interacts (phosphorylated) with PTPN11. Interacts with HCK By similarity. Identified in a complex containing FRS2, GRB2, GAB1, PIK3R1 and SOS1.By similarity1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Grb2Q606318EBI-644784,EBI-1688

    Protein-protein interaction databases

    BioGridi199793. 6 interactions.
    DIPiDIP-39377N.
    IntActiQ9QYY0. 11 interactions.
    MINTiMINT-137191.
    STRINGi10090.ENSMUSP00000034150.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9QYY0.
    SMRiQ9QYY0. Positions 26-111.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini5 – 116112PHPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi450 – 54192Pro-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the GAB family.Curated
    Contains 1 PH domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG80382.
    GeneTreeiENSGT00510000046662.
    HOGENOMiHOG000236270.
    HOVERGENiHBG051685.
    InParanoidiQ9QYY0.
    KOiK09593.
    OMAiQIPRTFP.
    OrthoDBiEOG7T4MJJ.
    PhylomeDBiQ9QYY0.
    TreeFamiTF329487.

    Family and domain databases

    Gene3Di2.30.29.30. 1 hit.
    InterProiIPR001849. PH_domain.
    IPR011993. PH_like_dom.
    [Graphical view]
    PfamiPF00169. PH. 1 hit.
    [Graphical view]
    SMARTiSM00233. PH. 1 hit.
    [Graphical view]
    PROSITEiPS50003. PH_DOMAIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9QYY0-1 [UniParc]FASTAAdd to Basket

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    MSGGEVVCSG WLRKSPPEKK LKRYAWKRRW FVLRSGRLTG DPDVLEYYKN    50
    DHAKKPIRII DLNLCQQVDA GLTFNKKEFE NSYIFDINTI DRIFYLVADS 100
    EEDMNKWVRC ICDICGFNPT EEDPVKPLTG SSQAPVDSPF AISTAPASSQ 150
    MEASSVALPP PYQVISLPPH PDTLGLQDDP QDYLLLINCQ SKKPEPNRTL 200
    FDSAKPTFSE TDCNDNVPSH QTPASSQSKH GMNGFFQQQM MYDCPPSRLT 250
    SVSGESSLYN LPRSYSHDVL PKESPSSTEA DGELYTFNTP SGTAGVETQM 300
    RHVSISYDIP PTPGNTYQIP RTFPESTLGQ SSKLDTIPDI PPPRPPKPHP 350
    THDRSPVETC GVPRTASDTD SSYCIPPPAG MTPSRSNTIS TVDLNKLRKD 400
    ASSQDCYDIP RTFPSDRSSS LEGFHSQYKI KSVLTAGGVS GEELDENYVP 450
    MNPNSPPRQH SGSFTEPIQE PNYVPMTPGT FDFSSFGMQV PPPAHMGFRS 500
    SPKTPPRRPV PVADCEPPPV DRNLKPDRKV KPAPLDIKPL SEWEELQAPV 550
    RSPITRSFAR DSSRFPMSPR PDSVHSTTSS SDSHDSEENY VPMNPNLSGE 600
    DPNLFASNSL DGGSSPMNKP KGDKQVEYLD LDLDSGKSTP PRKQKSSGSG 650
    SSMADERVDY VVVDQQKTLA LKSTREAWTD GRQSTESETP TKNVK 695
    Length:695
    Mass (Da):76,812
    Last modified:April 13, 2004 - v2
    Checksum:iF0A567896E058C58
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti236 – 2361F → L in CAB59832. 1 PublicationCurated
    Sequence conflicti351 – 3511T → S in CAB59832. 1 PublicationCurated
    Sequence conflicti379 – 3791A → V in CAB59832. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ250669 mRNA. Translation: CAB59832.1.
    BC007483 mRNA. Translation: AAH07483.1.
    CCDSiCCDS22443.1.
    RefSeqiNP_067331.2. NM_021356.2.
    UniGeneiMm.277409.

    Genome annotation databases

    EnsembliENSMUST00000034150; ENSMUSP00000034150; ENSMUSG00000031714.
    GeneIDi14388.
    KEGGimmu:14388.
    UCSCiuc009mjb.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ250669 mRNA. Translation: CAB59832.1 .
    BC007483 mRNA. Translation: AAH07483.1 .
    CCDSi CCDS22443.1.
    RefSeqi NP_067331.2. NM_021356.2.
    UniGenei Mm.277409.

    3D structure databases

    ProteinModelPortali Q9QYY0.
    SMRi Q9QYY0. Positions 26-111.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 199793. 6 interactions.
    DIPi DIP-39377N.
    IntActi Q9QYY0. 11 interactions.
    MINTi MINT-137191.
    STRINGi 10090.ENSMUSP00000034150.

    PTM databases

    PhosphoSitei Q9QYY0.

    Proteomic databases

    MaxQBi Q9QYY0.
    PaxDbi Q9QYY0.
    PRIDEi Q9QYY0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000034150 ; ENSMUSP00000034150 ; ENSMUSG00000031714 .
    GeneIDi 14388.
    KEGGi mmu:14388.
    UCSCi uc009mjb.1. mouse.

    Organism-specific databases

    CTDi 2549.
    MGIi MGI:108088. Gab1.

    Phylogenomic databases

    eggNOGi NOG80382.
    GeneTreei ENSGT00510000046662.
    HOGENOMi HOG000236270.
    HOVERGENi HBG051685.
    InParanoidi Q9QYY0.
    KOi K09593.
    OMAi QIPRTFP.
    OrthoDBi EOG7T4MJJ.
    PhylomeDBi Q9QYY0.
    TreeFami TF329487.

    Enzyme and pathway databases

    Reactomei REACT_196455. Signaling by FGFR mutants.
    REACT_196588. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_199123. Signaling by constitutively active EGFR.
    REACT_206286. GAB1 signalosome.
    REACT_215348. PI3K events in ERBB2 signaling.
    REACT_223993. PI-3K cascade.
    REACT_226341. PIP3 activates AKT signaling.

    Miscellaneous databases

    NextBioi 285905.
    PROi Q9QYY0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9QYY0.
    Bgeei Q9QYY0.
    Genevestigatori Q9QYY0.

    Family and domain databases

    Gene3Di 2.30.29.30. 1 hit.
    InterProi IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    [Graphical view ]
    Pfami PF00169. PH. 1 hit.
    [Graphical view ]
    SMARTi SM00233. PH. 1 hit.
    [Graphical view ]
    PROSITEi PS50003. PH_DOMAIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Sachs M.
      Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary tumor.
    3. "Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins."
      Ong S.H., Hadari Y.R., Gotoh N., Guy G.R., Schlessinger J., Lax I.
      Proc. Natl. Acad. Sci. U.S.A. 98:6074-6079(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION IN RESPONSE TO FGFR1 SIGNALING, INTERACTION WITH GRB2.
    4. "Fibroblast growth factor signalling: from development to cancer."
      Turner N., Grose R.
      Nat. Rev. Cancer 10:116-129(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW ON FUNCTION IN FGF SIGNALING.

    Entry informationi

    Entry nameiGAB1_MOUSE
    AccessioniPrimary (citable) accession number: Q9QYY0
    Secondary accession number(s): Q91VW7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 13, 2004
    Last sequence update: April 13, 2004
    Last modified: October 1, 2014
    This is version 107 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3