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Q9QYY0 (GAB1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GRB2-associated-binding protein 1
Alternative name(s):
GRB2-associated binder 1
Growth factor receptor bound protein 2-associated protein 1
Gene names
Name:Gab1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length695 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR) By similarity.

Subunit structure

Interacts with GRB2 and with other SH2-containing proteins. Interacts with phosphorylated LAT2. Interacts with PTPRJ By similarity. Interacts (phosphorylated) with PTPN11. Interacts with HCK By similarity. Identified in a complex containing FRS2, GRB2, GAB1, PIK3R1 and SOS1. Ref.3

Post-translational modification

Phosphorylated on tyrosine residue(s) by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Tyrosine phosphorylation of GAB1 mediates interaction with several proteins that contain SH2 domains. Phosphorylated on tyrosine residues by HCK upon IL6 signaling By similarity. Phosphorylated in response to FGFR1 activation. Ref.3

Sequence similarities

Belongs to the GAB family.

Contains 1 PH domain.

Ontologies

Keywords
   PTMAcetylation
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processactivation of JUN kinase activity

Inferred from mutant phenotype PubMed 12808090. Source: MGI

activation of MAPK activity

Inferred from direct assay PubMed 11940581. Source: MGI

epidermal growth factor receptor signaling pathway

Inferred from mutant phenotype PubMed 10779359. Source: MGI

epidermis development

Inferred from mutant phenotype PubMed 10779359. Source: MGI

heart development

Inferred from mutant phenotype PubMed 10779359. Source: MGI

interleukin-6-mediated signaling pathway

Inferred from mutant phenotype PubMed 10779359. Source: MGI

labyrinthine layer development

Inferred from mutant phenotype PubMed 10779359. Source: MGI

platelet-derived growth factor receptor signaling pathway

Inferred from mutant phenotype PubMed 10779359. Source: MGI

positive regulation of MAPK cascade

Inferred from mutant phenotype PubMed 10779359. Source: MGI

regulation of cell migration

Inferred from genetic interaction PubMed 16166380. Source: MGI

response to oxidative stress

Inferred from direct assay PubMed 12808090. Source: MGI

signal transduction

Inferred from direct assay PubMed 11940581. Source: MGI

   Cellular_componentcytoplasm

Inferred from direct assay PubMed 15736129. Source: MGI

   Molecular_functionprotein binding

Inferred from physical interaction PubMed 10871282PubMed 11445578PubMed 15102471PubMed 23452850. Source: IntAct

signal transducer activity

Inferred from direct assay PubMed 11940581. Source: MGI

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Grb2Q606318EBI-644784,EBI-1688

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 695694GRB2-associated-binding protein 1
PRO_0000050284

Regions

Domain5 – 116112PH
Compositional bias450 – 54192Pro-rich

Amino acid modifications

Modified residue21N-acetylserine By similarity
Modified residue6281Phosphotyrosine By similarity
Modified residue6601Phosphotyrosine

Experimental info

Sequence conflict2361F → L in CAB59832. Ref.1
Sequence conflict3511T → S in CAB59832. Ref.1
Sequence conflict3791A → V in CAB59832. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9QYY0 [UniParc].

Last modified April 13, 2004. Version 2.
Checksum: F0A567896E058C58

FASTA69576,812
        10         20         30         40         50         60 
MSGGEVVCSG WLRKSPPEKK LKRYAWKRRW FVLRSGRLTG DPDVLEYYKN DHAKKPIRII 

        70         80         90        100        110        120 
DLNLCQQVDA GLTFNKKEFE NSYIFDINTI DRIFYLVADS EEDMNKWVRC ICDICGFNPT 

       130        140        150        160        170        180 
EEDPVKPLTG SSQAPVDSPF AISTAPASSQ MEASSVALPP PYQVISLPPH PDTLGLQDDP 

       190        200        210        220        230        240 
QDYLLLINCQ SKKPEPNRTL FDSAKPTFSE TDCNDNVPSH QTPASSQSKH GMNGFFQQQM 

       250        260        270        280        290        300 
MYDCPPSRLT SVSGESSLYN LPRSYSHDVL PKESPSSTEA DGELYTFNTP SGTAGVETQM 

       310        320        330        340        350        360 
RHVSISYDIP PTPGNTYQIP RTFPESTLGQ SSKLDTIPDI PPPRPPKPHP THDRSPVETC 

       370        380        390        400        410        420 
GVPRTASDTD SSYCIPPPAG MTPSRSNTIS TVDLNKLRKD ASSQDCYDIP RTFPSDRSSS 

       430        440        450        460        470        480 
LEGFHSQYKI KSVLTAGGVS GEELDENYVP MNPNSPPRQH SGSFTEPIQE PNYVPMTPGT 

       490        500        510        520        530        540 
FDFSSFGMQV PPPAHMGFRS SPKTPPRRPV PVADCEPPPV DRNLKPDRKV KPAPLDIKPL 

       550        560        570        580        590        600 
SEWEELQAPV RSPITRSFAR DSSRFPMSPR PDSVHSTTSS SDSHDSEENY VPMNPNLSGE 

       610        620        630        640        650        660 
DPNLFASNSL DGGSSPMNKP KGDKQVEYLD LDLDSGKSTP PRKQKSSGSG SSMADERVDY 

       670        680        690 
VVVDQQKTLA LKSTREAWTD GRQSTESETP TKNVK 

« Hide

References

« Hide 'large scale' references
[1]Sachs M.
Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Mammary tumor.
[3]"Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins."
Ong S.H., Hadari Y.R., Gotoh N., Guy G.R., Schlessinger J., Lax I.
Proc. Natl. Acad. Sci. U.S.A. 98:6074-6079(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION IN RESPONSE TO FGFR1 SIGNALING, INTERACTION WITH GRB2.
[4]"Fibroblast growth factor signalling: from development to cancer."
Turner N., Grose R.
Nat. Rev. Cancer 10:116-129(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW ON FUNCTION IN FGF SIGNALING.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ250669 mRNA. Translation: CAB59832.1.
BC007483 mRNA. Translation: AAH07483.1.
CCDSCCDS22443.1.
RefSeqNP_067331.2. NM_021356.2.
UniGeneMm.277409.

3D structure databases

ProteinModelPortalQ9QYY0.
SMRQ9QYY0. Positions 26-111.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid199793. 6 interactions.
DIPDIP-39377N.
IntActQ9QYY0. 11 interactions.
MINTMINT-137191.
STRING10090.ENSMUSP00000034150.

PTM databases

PhosphoSiteQ9QYY0.

Proteomic databases

MaxQBQ9QYY0.
PaxDbQ9QYY0.
PRIDEQ9QYY0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000034150; ENSMUSP00000034150; ENSMUSG00000031714.
GeneID14388.
KEGGmmu:14388.
UCSCuc009mjb.1. mouse.

Organism-specific databases

CTD2549.
MGIMGI:108088. Gab1.

Phylogenomic databases

eggNOGNOG80382.
GeneTreeENSGT00510000046662.
HOGENOMHOG000236270.
HOVERGENHBG051685.
InParanoidQ9QYY0.
KOK09593.
OMAQIPRTFP.
OrthoDBEOG7T4MJJ.
PhylomeDBQ9QYY0.
TreeFamTF329487.

Gene expression databases

ArrayExpressQ9QYY0.
BgeeQ9QYY0.
GenevestigatorQ9QYY0.

Family and domain databases

Gene3D2.30.29.30. 1 hit.
InterProIPR011993. PH_like_dom.
IPR001849. Pleckstrin_homology.
[Graphical view]
PfamPF00169. PH. 1 hit.
[Graphical view]
SMARTSM00233. PH. 1 hit.
[Graphical view]
PROSITEPS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio285905.
PROQ9QYY0.
SOURCESearch...

Entry information

Entry nameGAB1_MOUSE
AccessionPrimary (citable) accession number: Q9QYY0
Secondary accession number(s): Q91VW7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: July 9, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot