GRB2-associated-binding protein 1 - Mus musculus (Mouse)

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Q9QYY0 (GAB1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 94. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
GRB2-associated-binding protein 1

Alternative name(s):
GRB2-associated binder 1
Growth factor receptor bound protein 2-associated protein 1

Gene names

Name:

Gab1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	695 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR) By similarity.
Subunit structure	Interacts with GRB2 and with other SH2-containing proteins. Interacts with phosphorylated LAT2. Interacts with PTPRJ By similarity. Interacts (phosphorylated) with PTPN11. Interacts with HCK By similarity. Identified in a complex containing FRS2, GRB2, GAB1, PIK3R1 and SOS1. Ref.3
Post-translational modification	Phosphorylated on tyrosine residue(s) by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Tyrosine phosphorylation of GAB1 mediates interaction with several proteins that contain SH2 domains. Phosphorylated on tyrosine residues by HCK upon IL6 signaling By similarity. Phosphorylated in response to FGFR1 activation. Ref.3
Sequence similarities	Belongs to the GAB family. Contains 1 PH domain.

Ontologies

Keywords
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	activation of JUN kinase activity Inferred from mutant phenotype PubMed 12808090. Source: MGI epidermal growth factor receptor signaling pathway Inferred from mutant phenotype PubMed 10779359. Source: MGI epidermis development Inferred from mutant phenotype PubMed 10779359. Source: MGI heart development Inferred from mutant phenotype PubMed 10779359. Source: MGI interleukin-6-mediated signaling pathway Inferred from mutant phenotype PubMed 10779359. Source: MGI labyrinthine layer development Inferred from mutant phenotype PubMed 10779359. Source: MGI platelet-derived growth factor receptor signaling pathway Inferred from mutant phenotype PubMed 10779359. Source: MGI regulation of cell migration Inferred from genetic interaction PubMed 16166380. Source: MGI response to oxidative stress Inferred from direct assay PubMed 12808090. Source: MGI
Cellular_component	cytoplasm Inferred from direct assay PubMed 15736129. Source: MGI
Molecular_function	phospholipid binding Inferred from electronic annotation. Source: InterPro signal transducer activity Inferred from direct assay PubMed 11940581. Source: MGI
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
Grb2	Q60631	5	EBI-644784,EBI-1688

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 695

695

GRB2-associated-binding protein 1

PRO_0000050284

Regions

Domain

5 – 116

112

Compositional bias

450 – 541

Pro-rich

Amino acid modifications

Modified residue

266

Phosphoserine Ref.5

Modified residue

504

Phosphothreonine Ref.4

Modified residue

628

Phosphotyrosine By similarity

Modified residue

660

Phosphotyrosine

Experimental info

Sequence conflict

236

F → L in CAB59832. Ref.1

Sequence conflict

351

T → S in CAB59832. Ref.1

Sequence conflict

379

A → V in CAB59832. Ref.1

Sequences

Sequence

Length

Mass (Da)

Tools

Q9QYY0 [UniParc].

Last modified April 13, 2004. Version 2.
Checksum: F0A567896E058C58
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FASTA

695

76,812

        10         20         30         40         50         60 
MSGGEVVCSG WLRKSPPEKK LKRYAWKRRW FVLRSGRLTG DPDVLEYYKN DHAKKPIRII 

        70         80         90        100        110        120 
DLNLCQQVDA GLTFNKKEFE NSYIFDINTI DRIFYLVADS EEDMNKWVRC ICDICGFNPT 

       130        140        150        160        170        180 
EEDPVKPLTG SSQAPVDSPF AISTAPASSQ MEASSVALPP PYQVISLPPH PDTLGLQDDP 

       190        200        210        220        230        240 
QDYLLLINCQ SKKPEPNRTL FDSAKPTFSE TDCNDNVPSH QTPASSQSKH GMNGFFQQQM 

       250        260        270        280        290        300 
MYDCPPSRLT SVSGESSLYN LPRSYSHDVL PKESPSSTEA DGELYTFNTP SGTAGVETQM 

       310        320        330        340        350        360 
RHVSISYDIP PTPGNTYQIP RTFPESTLGQ SSKLDTIPDI PPPRPPKPHP THDRSPVETC 

       370        380        390        400        410        420 
GVPRTASDTD SSYCIPPPAG MTPSRSNTIS TVDLNKLRKD ASSQDCYDIP RTFPSDRSSS 

       430        440        450        460        470        480 
LEGFHSQYKI KSVLTAGGVS GEELDENYVP MNPNSPPRQH SGSFTEPIQE PNYVPMTPGT 

       490        500        510        520        530        540 
FDFSSFGMQV PPPAHMGFRS SPKTPPRRPV PVADCEPPPV DRNLKPDRKV KPAPLDIKPL 

       550        560        570        580        590        600 
SEWEELQAPV RSPITRSFAR DSSRFPMSPR PDSVHSTTSS SDSHDSEENY VPMNPNLSGE 

       610        620        630        640        650        660 
DPNLFASNSL DGGSSPMNKP KGDKQVEYLD LDLDSGKSTP PRKQKSSGSG SSMADERVDY 

       670        680        690 
VVVDQQKTLA LKSTREAWTD GRQSTESETP TKNVK

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Sachs M. Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Mammary tumor.
[3]	"Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins." Ong S.H., Hadari Y.R., Gotoh N., Guy G.R., Schlessinger J., Lax I. Proc. Natl. Acad. Sci. U.S.A. 98:6074-6079(2001) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION IN RESPONSE TO FGFR1 SIGNALING, INTERACTION WITH GRB2.
[4]	"Large-scale phosphorylation analysis of mouse liver." Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-504, MASS SPECTROMETRY. Tissue: Liver.
[5]	"Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry." Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J., Faessler R., Mann M. J. Proteome Res. 7:5314-5326(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-266, MASS SPECTROMETRY. Tissue: Melanoma.
[6]	"Fibroblast growth factor signalling: from development to cancer." Turner N., Grose R. Nat. Rev. Cancer 10:116-129(2010) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW ON FUNCTION IN FGF SIGNALING.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ250669 mRNA. Translation: CAB59832.1. BC007483 mRNA. Translation: AAH07483.1.
IPI	IPI00406794.
RefSeq	NP_067331.2. NM_021356.2.
UniGene	Mm.277409.
3D structure databases
ProteinModelPortal	Q9QYY0.
SMR	Q9QYY0. Positions 26-111.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9QYY0. 4 interactions.
MINT	MINT-137191.
STRING	10090.ENSMUSP00000034150.
PTM databases
PhosphoSite	Q9QYY0.
Proteomic databases
PaxDb	Q9QYY0.
PRIDE	Q9QYY0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000034150; ENSMUSP00000034150; ENSMUSG00000031714.
GeneID	14388.
KEGG	mmu:14388.
Organism-specific databases
CTD	2549.
MGI	MGI:108088. Gab1.
Phylogenomic databases
eggNOG	NOG80382.
GeneTree	ENSGT00510000046662.
HOGENOM	HOG000236270.
HOVERGEN	HBG051685.
InParanoid	Q9QYY0.
KO	K09593.
OMA	ETDCNDN.
OrthoDB	EOG4KSPJ6.
Gene expression databases
ArrayExpress	Q9QYY0.
Bgee	Q9QYY0.
Genevestigator	Q9QYY0.
GermOnline	ENSMUSG00000031714. Mus musculus.
Family and domain databases
Gene3D	2.30.29.30. 1 hit.
InterPro	IPR011993. PH_like_dom. IPR001849. Pleckstrin_homology. [Graphical view]
Pfam	PF00169. PH. 1 hit. [Graphical view]
SMART	SM00233. PH. 1 hit. [Graphical view]
PROSITE	PS50003. PH_DOMAIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	285905.
SOURCE	Search...

Entry information

Entry name

GAB1_MOUSE

Accession

Primary (citable) accession number: Q9QYY0
Secondary accession number(s): Q91VW7

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 13, 2004
Last sequence update:	April 13, 2004
Last modified:	May 1, 2013
This is version 94 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents