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Protein

GRB2-associated-binding protein 1

Gene

Gab1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR) (By similarity).By similarity

GO - Molecular functioni

  • signal transducer activity Source: MGI

GO - Biological processi

  • activation of JUN kinase activity Source: MGI
  • activation of MAPK activity Source: MGI
  • epidermal growth factor receptor signaling pathway Source: MGI
  • epidermis development Source: MGI
  • heart development Source: MGI
  • interleukin-6-mediated signaling pathway Source: MGI
  • labyrinthine layer development Source: MGI
  • platelet-derived growth factor receptor signaling pathway Source: MGI
  • positive regulation of MAPK cascade Source: MGI
  • regulation of cell migration Source: MGI
  • response to oxidative stress Source: MGI
  • signal transduction Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-109704. PI3K Cascade.
R-MMU-1257604. PIP3 activates AKT signaling.
R-MMU-180292. GAB1 signalosome.
R-MMU-1963642. PI3K events in ERBB2 signaling.
R-MMU-5654689. PI-3K cascade:FGFR1.
R-MMU-5654695. PI-3K cascade:FGFR2.
R-MMU-5654710. PI-3K cascade:FGFR3.
R-MMU-5654720. PI-3K cascade:FGFR4.
R-MMU-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
R-MMU-8851907. MET activates PI3K/AKT signaling.
R-MMU-8853659. RET signaling.
R-MMU-8865999. MET activates PTPN11.
R-MMU-8875555. MET activates RAP1 and RAC1.
R-MMU-8875656. MET receptor recycling.

Names & Taxonomyi

Protein namesi
Recommended name:
GRB2-associated-binding protein 1
Alternative name(s):
GRB2-associated binder 1
Growth factor receptor bound protein 2-associated protein 1
Gene namesi
Name:Gab1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:108088. Gab1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000502842 – 695GRB2-associated-binding protein 1Add BLAST694

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei251PhosphoserineBy similarity1
Modified residuei253PhosphoserineBy similarity1
Modified residuei266PhosphoserineBy similarity1
Modified residuei304PhosphoserineBy similarity1
Modified residuei388PhosphothreonineBy similarity1
Modified residuei403PhosphoserineBy similarity1
Modified residuei455PhosphoserineCombined sources1
Modified residuei628PhosphotyrosineBy similarity1
Modified residuei639PhosphothreonineBy similarity1
Modified residuei652PhosphoserineBy similarity1
Modified residuei660PhosphotyrosineBy similarity1
Modified residuei684PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated on tyrosine residue(s) by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Tyrosine phosphorylation of GAB1 mediates interaction with several proteins that contain SH2 domains. Phosphorylated on tyrosine residues by HCK upon IL6 signaling (By similarity). Phosphorylated in response to FGFR1 activation.By similarity1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9QYY0.
PaxDbiQ9QYY0.
PRIDEiQ9QYY0.

PTM databases

iPTMnetiQ9QYY0.
PhosphoSitePlusiQ9QYY0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000031714.
ExpressionAtlasiQ9QYY0. baseline and differential.
GenevisibleiQ9QYY0. MM.

Interactioni

Subunit structurei

Interacts with GRB2 and with other SH2-containing proteins. Interacts with phosphorylated LAT2. Interacts with PTPRJ (By similarity). Interacts (phosphorylated) with PTPN11. Interacts with HCK (By similarity). Identified in a complex containing FRS2, GRB2, GAB1, PIK3R1 and SOS1.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Grb2Q606318EBI-644784,EBI-1688

Protein-protein interaction databases

BioGridi199793. 6 interactors.
DIPiDIP-39377N.
IntActiQ9QYY0. 11 interactors.
MINTiMINT-137191.
STRINGi10090.ENSMUSP00000034150.

Structurei

3D structure databases

ProteinModelPortaliQ9QYY0.
SMRiQ9QYY0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 116PHPROSITE-ProRule annotationAdd BLAST112

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi450 – 541Pro-richAdd BLAST92

Sequence similaritiesi

Belongs to the GAB family.Curated
Contains 1 PH domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IEIX. Eukaryota.
ENOG4111RDE. LUCA.
GeneTreeiENSGT00510000046662.
HOGENOMiHOG000236270.
HOVERGENiHBG051685.
InParanoidiQ9QYY0.
KOiK09593.
OMAiDTDSSYC.
OrthoDBiEOG091G03BY.
PhylomeDBiQ9QYY0.
TreeFamiTF329487.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QYY0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGGEVVCSG WLRKSPPEKK LKRYAWKRRW FVLRSGRLTG DPDVLEYYKN
60 70 80 90 100
DHAKKPIRII DLNLCQQVDA GLTFNKKEFE NSYIFDINTI DRIFYLVADS
110 120 130 140 150
EEDMNKWVRC ICDICGFNPT EEDPVKPLTG SSQAPVDSPF AISTAPASSQ
160 170 180 190 200
MEASSVALPP PYQVISLPPH PDTLGLQDDP QDYLLLINCQ SKKPEPNRTL
210 220 230 240 250
FDSAKPTFSE TDCNDNVPSH QTPASSQSKH GMNGFFQQQM MYDCPPSRLT
260 270 280 290 300
SVSGESSLYN LPRSYSHDVL PKESPSSTEA DGELYTFNTP SGTAGVETQM
310 320 330 340 350
RHVSISYDIP PTPGNTYQIP RTFPESTLGQ SSKLDTIPDI PPPRPPKPHP
360 370 380 390 400
THDRSPVETC GVPRTASDTD SSYCIPPPAG MTPSRSNTIS TVDLNKLRKD
410 420 430 440 450
ASSQDCYDIP RTFPSDRSSS LEGFHSQYKI KSVLTAGGVS GEELDENYVP
460 470 480 490 500
MNPNSPPRQH SGSFTEPIQE PNYVPMTPGT FDFSSFGMQV PPPAHMGFRS
510 520 530 540 550
SPKTPPRRPV PVADCEPPPV DRNLKPDRKV KPAPLDIKPL SEWEELQAPV
560 570 580 590 600
RSPITRSFAR DSSRFPMSPR PDSVHSTTSS SDSHDSEENY VPMNPNLSGE
610 620 630 640 650
DPNLFASNSL DGGSSPMNKP KGDKQVEYLD LDLDSGKSTP PRKQKSSGSG
660 670 680 690
SSMADERVDY VVVDQQKTLA LKSTREAWTD GRQSTESETP TKNVK
Length:695
Mass (Da):76,812
Last modified:April 13, 2004 - v2
Checksum:iF0A567896E058C58
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti236F → L in CAB59832 (Ref. 1) Curated1
Sequence conflicti351T → S in CAB59832 (Ref. 1) Curated1
Sequence conflicti379A → V in CAB59832 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ250669 mRNA. Translation: CAB59832.1.
BC007483 mRNA. Translation: AAH07483.1.
CCDSiCCDS22443.1.
RefSeqiNP_067331.2. NM_021356.2.
UniGeneiMm.277409.

Genome annotation databases

EnsembliENSMUST00000034150; ENSMUSP00000034150; ENSMUSG00000031714.
GeneIDi14388.
KEGGimmu:14388.
UCSCiuc009mjb.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ250669 mRNA. Translation: CAB59832.1.
BC007483 mRNA. Translation: AAH07483.1.
CCDSiCCDS22443.1.
RefSeqiNP_067331.2. NM_021356.2.
UniGeneiMm.277409.

3D structure databases

ProteinModelPortaliQ9QYY0.
SMRiQ9QYY0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199793. 6 interactors.
DIPiDIP-39377N.
IntActiQ9QYY0. 11 interactors.
MINTiMINT-137191.
STRINGi10090.ENSMUSP00000034150.

PTM databases

iPTMnetiQ9QYY0.
PhosphoSitePlusiQ9QYY0.

Proteomic databases

MaxQBiQ9QYY0.
PaxDbiQ9QYY0.
PRIDEiQ9QYY0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034150; ENSMUSP00000034150; ENSMUSG00000031714.
GeneIDi14388.
KEGGimmu:14388.
UCSCiuc009mjb.2. mouse.

Organism-specific databases

CTDi2549.
MGIiMGI:108088. Gab1.

Phylogenomic databases

eggNOGiENOG410IEIX. Eukaryota.
ENOG4111RDE. LUCA.
GeneTreeiENSGT00510000046662.
HOGENOMiHOG000236270.
HOVERGENiHBG051685.
InParanoidiQ9QYY0.
KOiK09593.
OMAiDTDSSYC.
OrthoDBiEOG091G03BY.
PhylomeDBiQ9QYY0.
TreeFamiTF329487.

Enzyme and pathway databases

ReactomeiR-MMU-109704. PI3K Cascade.
R-MMU-1257604. PIP3 activates AKT signaling.
R-MMU-180292. GAB1 signalosome.
R-MMU-1963642. PI3K events in ERBB2 signaling.
R-MMU-5654689. PI-3K cascade:FGFR1.
R-MMU-5654695. PI-3K cascade:FGFR2.
R-MMU-5654710. PI-3K cascade:FGFR3.
R-MMU-5654720. PI-3K cascade:FGFR4.
R-MMU-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
R-MMU-8851907. MET activates PI3K/AKT signaling.
R-MMU-8853659. RET signaling.
R-MMU-8865999. MET activates PTPN11.
R-MMU-8875555. MET activates RAP1 and RAC1.
R-MMU-8875656. MET receptor recycling.

Miscellaneous databases

ChiTaRSiGab1. mouse.
PROiQ9QYY0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031714.
ExpressionAtlasiQ9QYY0. baseline and differential.
GenevisibleiQ9QYY0. MM.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGAB1_MOUSE
AccessioniPrimary (citable) accession number: Q9QYY0
Secondary accession number(s): Q91VW7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: November 30, 2016
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.