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Protein

GRB2-associated-binding protein 1

Gene

Gab1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR) (By similarity).By similarity

GO - Biological processi

  • actin cytoskeleton reorganization Source: MGI
  • activation of JUN kinase activity Source: MGI
  • activation of MAPK activity Source: MGI
  • angiogenesis Source: MGI
  • cellular response to vascular endothelial growth factor stimulus Source: BHF-UCL
  • endothelial cell chemotaxis to vascular endothelial growth factor Source: MGI
  • epidermal growth factor receptor signaling pathway Source: MGI
  • epidermis development Source: MGI
  • heart development Source: MGI
  • interleukin-6-mediated signaling pathway Source: MGI
  • labyrinthine layer development Source: MGI
  • platelet-derived growth factor receptor signaling pathway Source: MGI
  • positive regulation of angiogenesis Source: MGI
  • positive regulation of cell migration by vascular endothelial growth factor signaling pathway Source: BHF-UCL
  • positive regulation of MAPK cascade Source: MGI
  • regulation of cell migration Source: MGI
  • response to hepatocyte growth factor Source: MGI
  • response to oxidative stress Source: MGI
  • signal transduction Source: MGI
  • vascular endothelial growth factor signaling pathway Source: MGI

Enzyme and pathway databases

ReactomeiR-MMU-109704 PI3K Cascade
R-MMU-1257604 PIP3 activates AKT signaling
R-MMU-180292 GAB1 signalosome
R-MMU-1963642 PI3K events in ERBB2 signaling
R-MMU-5654689 PI-3K cascade:FGFR1
R-MMU-5654695 PI-3K cascade:FGFR2
R-MMU-5654710 PI-3K cascade:FGFR3
R-MMU-5654720 PI-3K cascade:FGFR4
R-MMU-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-MMU-8851907 MET activates PI3K/AKT signaling
R-MMU-8853659 RET signaling
R-MMU-8865999 MET activates PTPN11
R-MMU-8875555 MET activates RAP1 and RAC1
R-MMU-8875656 MET receptor recycling
R-MMU-9032759 NTRK2 activates RAC1

Names & Taxonomyi

Protein namesi
Recommended name:
GRB2-associated-binding protein 1
Alternative name(s):
GRB2-associated binder 1
Growth factor receptor bound protein 2-associated protein 1
Gene namesi
Name:Gab1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:108088 Gab1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000502842 – 695GRB2-associated-binding protein 1Add BLAST694

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei251PhosphoserineBy similarity1
Modified residuei253PhosphoserineBy similarity1
Modified residuei266PhosphoserineBy similarity1
Modified residuei304PhosphoserineBy similarity1
Modified residuei388PhosphothreonineBy similarity1
Modified residuei403PhosphoserineBy similarity1
Modified residuei455PhosphoserineCombined sources1
Modified residuei628PhosphotyrosineBy similarity1
Modified residuei639PhosphothreonineBy similarity1
Modified residuei652PhosphoserineBy similarity1
Modified residuei660PhosphotyrosineBy similarity1
Modified residuei684PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated on tyrosine residue(s) by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Tyrosine phosphorylation of GAB1 mediates interaction with several proteins that contain SH2 domains. Phosphorylated on tyrosine residues by HCK upon IL6 signaling (By similarity). Phosphorylated in response to FGFR1 activation.By similarity1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9QYY0
PaxDbiQ9QYY0
PRIDEiQ9QYY0

PTM databases

iPTMnetiQ9QYY0
PhosphoSitePlusiQ9QYY0

Expressioni

Gene expression databases

BgeeiENSMUSG00000031714
ExpressionAtlasiQ9QYY0 baseline and differential
GenevisibleiQ9QYY0 MM

Interactioni

Subunit structurei

Interacts with GRB2 and with other SH2-containing proteins. Interacts with phosphorylated LAT2. Interacts with PTPRJ (By similarity). Interacts (phosphorylated) with PTPN11. Interacts with HCK (By similarity). Identified in a complex containing FRS2, GRB2, GAB1, PIK3R1 and SOS1.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Grb2Q606318EBI-644784,EBI-1688

Protein-protein interaction databases

BioGridi199793, 8 interactors
DIPiDIP-39377N
IntActiQ9QYY0, 12 interactors
MINTiQ9QYY0
STRINGi10090.ENSMUSP00000034150

Structurei

3D structure databases

ProteinModelPortaliQ9QYY0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 116PHPROSITE-ProRule annotationAdd BLAST112

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi450 – 541Pro-richAdd BLAST92

Sequence similaritiesi

Belongs to the GAB family.Curated

Phylogenomic databases

eggNOGiENOG410IEIX Eukaryota
ENOG4111RDE LUCA
GeneTreeiENSGT00510000046662
HOGENOMiHOG000236270
HOVERGENiHBG051685
InParanoidiQ9QYY0
KOiK09593
OrthoDBiEOG091G03BY
PhylomeDBiQ9QYY0
TreeFamiTF329487

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PfamiView protein in Pfam
PF00169 PH, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QYY0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGGEVVCSG WLRKSPPEKK LKRYAWKRRW FVLRSGRLTG DPDVLEYYKN
60 70 80 90 100
DHAKKPIRII DLNLCQQVDA GLTFNKKEFE NSYIFDINTI DRIFYLVADS
110 120 130 140 150
EEDMNKWVRC ICDICGFNPT EEDPVKPLTG SSQAPVDSPF AISTAPASSQ
160 170 180 190 200
MEASSVALPP PYQVISLPPH PDTLGLQDDP QDYLLLINCQ SKKPEPNRTL
210 220 230 240 250
FDSAKPTFSE TDCNDNVPSH QTPASSQSKH GMNGFFQQQM MYDCPPSRLT
260 270 280 290 300
SVSGESSLYN LPRSYSHDVL PKESPSSTEA DGELYTFNTP SGTAGVETQM
310 320 330 340 350
RHVSISYDIP PTPGNTYQIP RTFPESTLGQ SSKLDTIPDI PPPRPPKPHP
360 370 380 390 400
THDRSPVETC GVPRTASDTD SSYCIPPPAG MTPSRSNTIS TVDLNKLRKD
410 420 430 440 450
ASSQDCYDIP RTFPSDRSSS LEGFHSQYKI KSVLTAGGVS GEELDENYVP
460 470 480 490 500
MNPNSPPRQH SGSFTEPIQE PNYVPMTPGT FDFSSFGMQV PPPAHMGFRS
510 520 530 540 550
SPKTPPRRPV PVADCEPPPV DRNLKPDRKV KPAPLDIKPL SEWEELQAPV
560 570 580 590 600
RSPITRSFAR DSSRFPMSPR PDSVHSTTSS SDSHDSEENY VPMNPNLSGE
610 620 630 640 650
DPNLFASNSL DGGSSPMNKP KGDKQVEYLD LDLDSGKSTP PRKQKSSGSG
660 670 680 690
SSMADERVDY VVVDQQKTLA LKSTREAWTD GRQSTESETP TKNVK
Length:695
Mass (Da):76,812
Last modified:April 13, 2004 - v2
Checksum:iF0A567896E058C58
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti236F → L in CAB59832 (Ref. 1) Curated1
Sequence conflicti351T → S in CAB59832 (Ref. 1) Curated1
Sequence conflicti379A → V in CAB59832 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ250669 mRNA Translation: CAB59832.1
BC007483 mRNA Translation: AAH07483.1
CCDSiCCDS22443.1
RefSeqiNP_067331.2, NM_021356.2
UniGeneiMm.277409

Genome annotation databases

EnsembliENSMUST00000034150; ENSMUSP00000034150; ENSMUSG00000031714
GeneIDi14388
KEGGimmu:14388
UCSCiuc009mjb.2 mouse

Similar proteinsi

Entry informationi

Entry nameiGAB1_MOUSE
AccessioniPrimary (citable) accession number: Q9QYY0
Secondary accession number(s): Q91VW7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: June 20, 2018
This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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