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Q9QYX7

- PCLO_MOUSE

UniProt

Q9QYX7 - PCLO_MOUSE

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Protein

Protein piccolo

Gene

Pclo

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May act as a scaffolding protein involved in the organization of synaptic active zones and in synaptic vesicle trafficking.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri532 – 55625C4-typeSequence AnalysisAdd
BLAST
Zinc fingeri997 – 102024C4-typeSequence AnalysisAdd
BLAST

GO - Molecular functioni

  1. calcium-dependent phospholipid binding Source: UniProtKB
  2. calcium ion binding Source: UniProtKB
  3. profilin binding Source: UniProtKB

GO - Biological processi

  1. cAMP-mediated signaling Source: MGI
  2. cytoskeleton organization Source: MGI
  3. insulin secretion Source: MGI
  4. regulation of exocytosis Source: MGI
  5. synaptic vesicle targeting Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Calcium, Calcium/phospholipid-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein piccolo
Alternative name(s):
Aczonin
Brain-derived HLMN protein
Multidomain presynaptic cytomatrix protein
Gene namesi
Name:Pclo
Synonyms:Acz
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:1349390. Pclo.

Subcellular locationi

Cell junctionsynapse 1 Publication
Note: Concentrated at the presynaptic side of synaptic junctions.

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. postsynaptic density Source: MGI
  3. synapse Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 50685068Protein piccoloPRO_0000058251Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1766 – 17661Phosphoserine1 Publication
Glycosylationi2686 – 26861O-linked (GlcNAc)1 Publication
Glycosylationi2960 – 29601O-linked (GlcNAc)1 Publication
Modified residuei3358 – 33581Phosphoserine1 Publication
Modified residuei3376 – 33761Phosphothreonine1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9QYX7.
PaxDbiQ9QYX7.
PRIDEiQ9QYX7.

PTM databases

PhosphoSiteiQ9QYX7.

Expressioni

Tissue specificityi

Highly expressed in brain. Moderately expressed in pituitary gland and pancreatic islets. Low levels found in stomach.2 Publications

Gene expression databases

CleanExiMM_PCLO.
GenevestigatoriQ9QYX7.

Interactioni

Subunit structurei

Interacts with RABAC1/PRA1, RIMS2 and profilin.2 Publications

Protein-protein interaction databases

BioGridi205033. 3 interactions.
IntActiQ9QYX7. 2 interactions.
MINTiMINT-4106700.
STRINGi10090.ENSMUSP00000030691.

Structurei

3D structure databases

ProteinModelPortaliQ9QYX7.
SMRiQ9QYX7. Positions 4412-4520, 4618-4759.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4424 – 451895PDZPROSITE-ProRule annotationAdd
BLAST
Domaini4637 – 473599C2 1PROSITE-ProRule annotationAdd
BLAST
Domaini4952 – 504291C2 2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni401 – 50010010 X 10 AA tandem approximate repeats of P-A-K-P-Q-P-Q-Q-P-XAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi2335 – 235925Poly-ProAdd
BLAST

Domaini

C2 domain 1 is involved in binding calcium and phospholipids. Calcium binds with low affinity but with high specificity and induces a large conformational change.By similarity

Sequence similaritiesi

Contains 2 C2 domains.PROSITE-ProRule annotation
Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri532 – 55625C4-typeSequence AnalysisAdd
BLAST
Zinc fingeri997 – 102024C4-typeSequence AnalysisAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG12793.
GeneTreeiENSGT00620000087961.
HOGENOMiHOG000168263.
HOVERGENiHBG031058.
InParanoidiQ9QYX7.
KOiK16882.
OMAiIDYPEEV.
OrthoDBiEOG73805D.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
2.60.40.150. 2 hits.
3.30.40.10. 2 hits.
InterProiIPR000008. C2_dom.
IPR001478. PDZ.
IPR011011. Znf_FYVE_PHD.
IPR008899. Znf_piccolo.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00168. C2. 2 hits.
PF00595. PDZ. 1 hit.
PF05715. zf-piccolo. 2 hits.
[Graphical view]
SMARTiSM00239. C2. 2 hits.
SM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 2 hits.
SSF50156. SSF50156. 1 hit.
SSF57903. SSF57903. 2 hits.
PROSITEiPS50004. C2. 2 hits.
PS50106. PDZ. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9QYX7) [UniParc]FASTAAdd to Basket

Also known as: L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGNEASLEGE GLPEGLAAAA GGAGGSGSAL HPGIPAGMEA DLSQLSEEER
60 70 80 90 100
RQIAAVMSRA QGLPKGSVPA AAAESPSMHR KQELDSSQAP QQPGKPPDPG
110 120 130 140 150
RPPQHGLSKS RTTDTFRSEQ KLPGRSPSTI SLKESKSRTD FKEEYKSSMM
160 170 180 190 200
PGFFSDVNPL SAVSSVVNKF NPFDLISDSE AVQEETTKKQ KVAQKDQGKS
210 220 230 240 250
EGITKPSLQQ PSPKLIPKQQ GPGKEVIPQD IPSKSVSSQQ AEKTKPQAPG
260 270 280 290 300
TAKPSQQSPA QTPAQQAKPV AQQPGPAKAT VQQPGPAKSP AQPAGTGKSP
310 320 330 340 350
AQPPVTAKPP AQQAGLEKTS LQQPGPKSLA QTPGQGKVPP GPAKSPAQQP
360 370 380 390 400
GTAKLPAQQP GPQTAAKVPG PTKTPAQLSG PGKTPAQQPG PTKPSPQQPI
410 420 430 440 450
PAKPQPQQPV ATKPQPQQPA PAKPQPQHPT PAKPQPQHPT PAKPQPQQPT
460 470 480 490 500
PAKPQPQQPT PAKPQPQQPT PAKPQPQHPT PAKPQPQQPG LGKPSAQQPS
510 520 530 540 550
KSISQTVTGR PLQAPPTSAA QAPAQGLSKT ICPLCNTTEL LLHTPEKANF
560 570 580 590 600
NTCTECQSTV CSLCGFNPNP HLTEIKEWLC LNCQMQRALG GELAAIPSSP
610 620 630 640 650
QPTPKAASVQ PATASKSPVP SQQASPKKEL PSKQDSPKAP ESKKPPPLVK
660 670 680 690 700
QPTLHGPTPA TAPQPPVAEA LPKPAPPKKP SAALPEQAKA PVADVEPKQP
710 720 730 740 750
KTTETLTDSP SSAAATSKPA ILSSQVQAQA QVTTAPPLKT DSAKTSQSFP
760 770 780 790 800
PTGDTITPLD SKAMPRPASD SKIVSHPGPT SESKDPVQKK EEPKKAQTKV
810 820 830 840 850
TPKPDTKPVP KGSPTPSGTR PTTGQATPQS QQPPKPPEQS RRFSLNLGGI
860 870 880 890 900
ADAPKSQPTT PQETVTGKLF GFGASIFSQA SNLISTAGQQ APHPQTGPAA
910 920 930 940 950
PSKQAPPPSQ TLAAQGPPKS TGPHPSAPAK TTAVKKETKG PAAENLEAKP
960 970 980 990 1000
VQAPTVKKAE KDKKPPPGKV SKPPPTEPEK AVLAQKPDKT TKPKPACPLC
1010 1020 1030 1040 1050
RTELNVGSQD PPNFNTCTEC KNQVCNLCGF NPTPHLTEIQ EWLCLNCQTQ
1060 1070 1080 1090 1100
RAISGQLGDM DKMPPASSGP KASPVPAPAE PPPQKTPTAA HAKGKKKETE
1110 1120 1130 1140 1150
VKAETEKQIP EKETPSIEKT PPAVATDQKL EESEVTKSLV SVLPEKKPSE
1160 1170 1180 1190 1200
EEKALPADKK EKKPPAAEAP PLEEKKPIPD DQKLPPDAKP SASEGEEKRD
1210 1220 1230 1240 1250
LLKAHVQIPE EGPIGKVASL ACEGEQQPDT RPEDLPGATP QTLPKDRQKE
1260 1270 1280 1290 1300
SRDVTQPQAE GTAKEGRGEP SKDRTEKEED KSDTSSSQQP KSPQGLSDTG
1310 1320 1330 1340 1350
YSSDGISGSL GEIPSLIPSD EKDLLKGLKK DSFSQESSPS SPSDLAKLES
1360 1370 1380 1390 1400
TVLSILEAQA STLVGEKAEK KTQPQKVSPE QPQDQQKTQT PSETRDISIS
1410 1420 1430 1440 1450
EEEIKESQEK KVTSKKDSAQ GFPSRKEHKE NPELVDDLSP RRASYDSVED
1460 1470 1480 1490 1500
SSESENSPVA RRKRRTSIGS SSSEEYKQED SQGSGEDEDF IRKQIIEMSA
1510 1520 1530 1540 1550
DEDASGSEDE EFIRSQLKEI GGVTESQKRE ETKGKGKSPA GKHRRLTRKS
1560 1570 1580 1590 1600
STSFDDDAGR RHSWHDEDDE TFDESPELKF RETKSQESEE LVVAGGGGLR
1610 1620 1630 1640 1650
RFKTIELNST VTDKYSAESS QKKTTLYFDE EPELEMESLT DSPEDRSRGE
1660 1670 1680 1690 1700
GSSSLHASSF TPGTSPTSVS SLDEDSDSSP SHKKGESKQQ RKARHRSHGP
1710 1720 1730 1740 1750
LLPTIEDSSE EEELREEEEL LKEQEKQREL EQQQRKSSSK KSKKDKDELR
1760 1770 1780 1790 1800
AQRRRERPKT PPSNLSPIED ASPTEELRQA AEMEELHRSS CSEYSPSIES
1810 1820 1830 1840 1850
DPEGFEISPE KIIEVQKVYK LPTAVSLYSP TDEQSVMQKE GAQKALKSAE
1860 1870 1880 1890 1900
EMYEEMMHKP HKYKAFPAAN ERDEVFEKEP LYGGMLIEDY IYESLVEDTY
1910 1920 1930 1940 1950
NGSVDGSLLT RQDEQNGFMQ QRGREQKIRL QEQIYDDPMQ KITDLQKEFY
1960 1970 1980 1990 2000
ELESLHSIVP QEDIVSSSYI IPESHEIVDL GSMVTSTSEE KKLLDADAAY
2010 2020 2030 2040 2050
EELMKRQQMQ VTDGSSLIQT TMGDDMAEST LDFDRVQDAS LTSSILSGAS
2060 2070 2080 2090 2100
LTDSTSSATL SIPDVKITQH FSTEEFEDEY VTDYTREIQE IIAHESLILT
2110 2120 2130 2140 2150
YSEPSESATS VPPSDTPSLT SSISSVCTTD SSSPVTTLDS LTTVYTEPAD
2160 2170 2180 2190 2200
VITKFKDSEE ISSTYFPGSV IDYPEDIGVS LDRTITPESR TNADQIMISF
2210 2220 2230 2240 2250
PGIAPSITES VATKPERPQA DTISTDLPIS EKELIKGKKE TGDGIILEVL
2260 2270 2280 2290 2300
DAYKDKREES EAELTKISLP ETGLAPTPSS QTKEQPGSPH SVSGEILGQE
2310 2320 2330 2340 2350
KPTYRSPSGG LPVSTHPSKS HPFFRSSSLD ISAQPPPPPP PPPPPPPPPP
2360 2370 2380 2390 2400
PPPPPPLPPA TSPKPPTYPK RKLAAAAPVA PTAIVTAHAD AIPTVEATAA
2410 2420 2430 2440 2450
RRSNGLPATK ICAAAPPPVP PKPSSIPTGL VFTHRPEASK PPIAPKPAVP
2460 2470 2480 2490 2500
EIPVTTQKTT DTCPKPTGLP LTSNMSLNLV TSADYKLPSP TSPLSPHSNK
2510 2520 2530 2540 2550
SSPRYSKSLM ETYVVITLPS EPGTPTDSSA AQAITSWPLG SPPKDLVSLE
2560 2570 2580 2590 2600
TVFSVVPPMT STEIPSASQP TLYTSGALGT FSVTPAVTAS LFQTVPTSLT
2610 2620 2630 2640 2650
QFLPAEASKP EVSAVSSAVP SVAPRSVSIP IPPEPLALDR HQYKENGKLP
2660 2670 2680 2690 2700
LIGDAIDLRT IPKSEVKVTE KCMDLSASAM DVKRQTTANE VYRRQISAVQ
2710 2720 2730 2740 2750
PSIINLSAAS SLGTPVTMDS KTVAVVTCTD TTIYTTGTES QVGIEHAVTS
2760 2770 2780 2790 2800
PLQLTTSKHT ELQYRKPSSQ AFPMIRDEAP INLSLGPSTQ AVTLAVTKPV
2810 2820 2830 2840 2850
TVPPVGVTNG WTDSTISQGI TDGEVVDLST SKSHRTVVTM DESTSNVVTK
2860 2870 2880 2890 2900
IIEDEEKPVD LTAGRRAVCC DMVYKLPFGR SCTAQQPATT LPEDRFGYRD
2910 2920 2930 2940 2950
DHYQYDRSGP YGYRGIGGMK PSMSDTNLAE AGHFFYKSKN AFDYSGGTEA
2960 2970 2980 2990 3000
AVDLTSGRVS TGEVMDYSSK TTGPYPETRQ VISGVGISTP QYSTARMTPP
3010 3020 3030 3040 3050
PGPQYGVGSV LRSSNGVVYS SVATPIPSTF AITTQPGSIF STTVRDLSGI
3060 3070 3080 3090 3100
HTTDAITSLS ALHQSQPMPR SYFITTGASE TDISVTSIDI NASLQTITME
3110 3120 3130 3140 3150
TLPAETMDSV PTLTTASEVF SEVVGEESTL LIVPDEDKQQ QQLDLERELL
3160 3170 3180 3190 3200
ELEKIKQQRF AEELEWERQE IQRFREQEKI MVQKKLEELQ SMKQHLLYQQ
3210 3220 3230 3240 3250
EEERQAQFMM RQETLAQQQL QLEQIQQLQQ QLHQQLEEQK LRQIYQYNYE
3260 3270 3280 3290 3300
PSGTASPQTT TEQAILEGQY VATEGSQFWA TEDATTTAST VVAIEIPQSQ
3310 3320 3330 3340 3350
GWYTVQSDGV TQYIAPPGIL STVSEIPLTD VVVKEEKQPK KRSSGAKVRG
3360 3370 3380 3390 3400
QYDEMGESMA DDPRNLKKIV DSGVQTDDEE TADRTYASRR RRTKKSVDTS
3410 3420 3430 3440 3450
VQTDDEDQDE WDMPSRSRRK ARTGKYGDST AEGDKTKPPS KVSSVAVQTV
3460 3470 3480 3490 3500
AEISVQTEPL GTIRTPSIRA RVDAKVEIIK HISAPEKTYK GGSLGCQTET
3510 3520 3530 3540 3550
DPDTQSPPYM GATSPPKDKK RPTPLEIGYS SSHLRADPTV QLAPSPPKSP
3560 3570 3580 3590 3600
KVLYSPISPL SPGHALEPAF VPYEKPLPDD ISPQKVLHPD MAKVPPASPK
3610 3620 3630 3640 3650
TAKMMQRSMS DPKPLSPTAD ESSRAPFQYS EGFTAKGSQT TSGTQKKVKR
3660 3670 3680 3690 3700
TLPNPPPEEA STGTQSTYST MGTASRRRMC RTNTMARAKI LQDIDRELDL
3710 3720 3730 3740 3750
VERESAKLRK KQAELDEEEK EIDAKLRYLE MGINRRKEAL LKEREKRERA
3760 3770 3780 3790 3800
YLQGVAEDRD YMSDSEVSST RPSRVESQHG IERPRTAPQT EFSQFIPPQT
3810 3820 3830 3840 3850
QTEAQLVPPT SPYTQYQYSS PALPTQAPTP YTQQSHFQQQ TLYHQQVSPY
3860 3870 3880 3890 3900
QTQPTFQAVA TMSFTPQAQP TPTPQPSYQL PSQMMVIQQK PRQTTLYLEP
3910 3920 3930 3940 3950
KITSTYEVIR NQPLMIAPVS TDNTYAVSHL GSKYNSLDLR IGLEERSSMA
3960 3970 3980 3990 4000
SSPISSISAD SFYADIDHHT SRNYVLIDDI GDITKGTAAL SSAFSLHEKD
4010 4020 4030 4040 4050
LSKTDRLLRT TETRRSQEVT DFLAPLQTSS RLHSYVKAEE DSMEDPYELK
4060 4070 4080 4090 4100
LLKHQIKQEF RRGTESLDHL AGLSHYYHAD TSYRHFPKSE KYSISRLTLE
4110 4120 4130 4140 4150
KQAAKQLPAA ILYQKQSKHK KALIDPKMSK FSPIQESRDL EPDYPTYLSS
4160 4170 4180 4190 4200
STSSIGGISS RARLLQDDIT FGLRKNITDQ QKFMGSSLGS GLGTLGNTIR
4210 4220 4230 4240 4250
SALQDEADKP YSSGSRSRPS SRPSSVYGLD LSIKRDSSSS SLRLKAQEAE
4260 4270 4280 4290 4300
ALDVSFGHSS SSARTKPTSL PISQSRGRIP IVAQNSEEES PLSPVGQPMG
4310 4320 4330 4340 4350
MARAAAGPLP PISADTRDQF GSSHSLPEVQ QHMREESRTR GYDRDIAFIM
4360 4370 4380 4390 4400
DDFQHAMSDS EAYHLRREET DWFDKPRESR LENGHGLDRK LPERLVHSRP
4410 4420 4430 4440 4450
LSQHQEQILQ MNGKTMHYIF PHARIKITRD SKDHTVSGNG LGIRIVGGKE
4460 4470 4480 4490 4500
IPGHSGEIGA YIAKILPGGS AEHSGKLIEG MQVLEWNGIP LTSKTYEEVQ
4510 4520 4530 4540 4550
SIINQQSGEA EICVRLDLNM LSDSENPQHL ELHEPPKVVD KAKSPGVDPK
4560 4570 4580 4590 4600
QLAAELQKVS LQQSPLVMSS VVEKGAHAHS GPTSAGSSSV PSPGQPGSPS
4610 4620 4630 4640 4650
VSKKKHGGSK PTDVSKTASH PITGEIQLQI NYDLGNLIIH ILQARNLVPR
4660 4670 4680 4690 4700
DNNGYSDPFV KVYLLPGRGQ VMVVQNASVE YKRRTKYVQK SLNPEWNQTV
4710 4720 4730 4740 4750
IYKSISMEQL MKKTLEVTVW DYDRFSSNDF LGEVLIDLSS TSHLDNTPRW
4760 4770 4780 4790 4800
YPLKEQTESI EHGKSHSSQN SQQSPKPSVI KSRSHGIFPD PSKDMQVPTI
4810 4820 4830 4840 4850
EKSHSSPGSS KSSSEGHLRS HGPSRSQSKT SVAQTHLEDA GAAIAAAEAA
4860 4870 4880 4890 4900
VQQLRIQPTK PTNHRPAETS VSTGSSGSSV GSGYSVDSEG SSCVAGEPNL
4910 4920 4930 4940 4950
LPIPRIGKMG QNGQDPVKQP GMGAADTEAK TQVMGEIKLA LKKEMKTDGE
4960 4970 4980 4990 5000
QLIVEILQCR NITYKFKSPD HLPDLYVKIY VINIATQKKV IKKKTRVCRH
5010 5020 5030 5040 5050
DREPSFNETF RFSLSPAGHS LQILLFSNGG KFMKKTLIGE ACIWLDKVDL
5060
RKRIVNWHKL LMSPTQTH
Length:5,068
Mass (Da):550,834
Last modified:January 9, 2013 - v4
Checksum:iDBF54D47501AC79A
GO
Isoform 2 (identifier: Q9QYX7-2) [UniParc]FASTAAdd to Basket

Also known as: S

The sequence of this isoform differs from the canonical sequence as follows:
     4859-4863: TKPTN → SKRRK
     4864-5068: Missing.

Show »
Length:4,863
Mass (Da):528,257
Checksum:i6F9A9B68DCBA59D2
GO

Sequence cautioni

The sequence BAC53723.1 differs from that shown. Reason: Unlikely isoform. Several sequence problems.
The sequence BAC53724.1 differs from that shown. Reason: Unlikely isoform. Several sequence problems.
The sequence CAB60731.2 differs from that shown. Reason: Probable cloning artifact.
The sequence CAB60732.2 differs from that shown. Reason: Probable cloning artifact.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti156 – 1561D → E in CAB60731. (PubMed:10508862)Curated
Sequence conflicti156 – 1561D → E in CAB60732. (PubMed:10508862)Curated
Sequence conflicti366 – 3661A → S in CAB60731. (PubMed:10508862)Curated
Sequence conflicti366 – 3661A → S in CAB60732. (PubMed:10508862)Curated
Sequence conflicti438 – 4381H → Q in CAB60731. (PubMed:10508862)Curated
Sequence conflicti438 – 4381H → Q in CAB60732. (PubMed:10508862)Curated
Sequence conflicti438 – 4381H → Q in BAC53723. (PubMed:12401793)Curated
Sequence conflicti438 – 4381H → Q in BAC53724. (PubMed:12401793)Curated
Sequence conflicti478 – 4781H → Q in CAB60731. (PubMed:10508862)Curated
Sequence conflicti478 – 4781H → Q in CAB60732. (PubMed:10508862)Curated
Sequence conflicti478 – 4781H → Q in BAC53723. (PubMed:12401793)Curated
Sequence conflicti478 – 4781H → Q in BAC53724. (PubMed:12401793)Curated
Sequence conflicti923 – 9231P → Q in CAB60731. (PubMed:10508862)Curated
Sequence conflicti923 – 9231P → Q in CAB60732. (PubMed:10508862)Curated
Sequence conflicti923 – 9231P → Q in BAC53723. (PubMed:12401793)Curated
Sequence conflicti923 – 9231P → Q in BAC53724. (PubMed:12401793)Curated
Sequence conflicti951 – 9511V → A in CAB60731. (PubMed:10508862)Curated
Sequence conflicti951 – 9511V → A in CAB60732. (PubMed:10508862)Curated
Sequence conflicti965 – 9651P → H in CAB60731. (PubMed:10508862)Curated
Sequence conflicti965 – 9651P → H in CAB60732. (PubMed:10508862)Curated
Sequence conflicti1920 – 19201Q → P in CAB60731. (PubMed:10508862)Curated
Sequence conflicti1920 – 19201Q → P in CAB60732. (PubMed:10508862)Curated
Sequence conflicti1931 – 19311Q → R in CAB60731. (PubMed:10508862)Curated
Sequence conflicti1931 – 19311Q → R in CAB60732. (PubMed:10508862)Curated
Sequence conflicti2297 – 22971L → S in CAB60731. (PubMed:10508862)Curated
Sequence conflicti2297 – 22971L → S in CAB60732. (PubMed:10508862)Curated
Sequence conflicti2335 – 234612Missing in BAC53723. (PubMed:12401793)CuratedAdd
BLAST
Sequence conflicti2335 – 234612Missing in BAC53724. (PubMed:12401793)CuratedAdd
BLAST
Sequence conflicti2855 – 28551E → D in CAB60731. (PubMed:10508862)Curated
Sequence conflicti2855 – 28551E → D in CAB60732. (PubMed:10508862)Curated
Sequence conflicti4042 – 40421S → P in CAB60731. (PubMed:10508862)Curated
Sequence conflicti4042 – 40421S → P in CAB60732. (PubMed:10508862)Curated
Sequence conflicti4670 – 46789Missing in BAC53724. (PubMed:12401793)Curated
Sequence conflicti5062 – 50621M → V in CAB60731. (PubMed:10508862)Curated
Sequence conflicti5062 – 50621M → V in CAB60732. (PubMed:10508862)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei4859 – 48635TKPTN → SKRRK in isoform 2. 2 PublicationsVSP_003928
Alternative sequencei4864 – 5068205Missing in isoform 2. 2 PublicationsVSP_003929Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y19185 mRNA. Translation: CAB60731.2. Sequence problems.
Y19186 mRNA. Translation: CAB60732.2. Sequence problems.
AB083477 mRNA. Translation: BAC53723.1. Sequence problems.
AB083478 mRNA. Translation: BAC53724.1. Sequence problems.
AC125043 Genomic DNA. No translation available.
AC125533 Genomic DNA. No translation available.
AC144480 Genomic DNA. No translation available.
AC144625 Genomic DNA. No translation available.
AF181269 mRNA. Translation: AAD55786.2.
CCDSiCCDS51415.1. [Q9QYX7-1]
CCDS59667.1. [Q9QYX7-2]
RefSeqiNP_001104266.1. NM_001110796.2. [Q9QYX7-2]
NP_036125.4. NM_011995.4. [Q9QYX7-1]
UniGeneiMm.146275.

Genome annotation databases

EnsembliENSMUST00000030691; ENSMUSP00000030691; ENSMUSG00000061601. [Q9QYX7-1]
ENSMUST00000182407; ENSMUSP00000138419; ENSMUSG00000061601. [Q9QYX7-2]
GeneIDi26875.
KEGGimmu:26875.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y19185 mRNA. Translation: CAB60731.2 . Sequence problems.
Y19186 mRNA. Translation: CAB60732.2 . Sequence problems.
AB083477 mRNA. Translation: BAC53723.1 . Sequence problems.
AB083478 mRNA. Translation: BAC53724.1 . Sequence problems.
AC125043 Genomic DNA. No translation available.
AC125533 Genomic DNA. No translation available.
AC144480 Genomic DNA. No translation available.
AC144625 Genomic DNA. No translation available.
AF181269 mRNA. Translation: AAD55786.2 .
CCDSi CCDS51415.1. [Q9QYX7-1 ]
CCDS59667.1. [Q9QYX7-2 ]
RefSeqi NP_001104266.1. NM_001110796.2. [Q9QYX7-2 ]
NP_036125.4. NM_011995.4. [Q9QYX7-1 ]
UniGenei Mm.146275.

3D structure databases

ProteinModelPortali Q9QYX7.
SMRi Q9QYX7. Positions 4412-4520, 4618-4759.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 205033. 3 interactions.
IntActi Q9QYX7. 2 interactions.
MINTi MINT-4106700.
STRINGi 10090.ENSMUSP00000030691.

PTM databases

PhosphoSitei Q9QYX7.

Proteomic databases

MaxQBi Q9QYX7.
PaxDbi Q9QYX7.
PRIDEi Q9QYX7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000030691 ; ENSMUSP00000030691 ; ENSMUSG00000061601 . [Q9QYX7-1 ]
ENSMUST00000182407 ; ENSMUSP00000138419 ; ENSMUSG00000061601 . [Q9QYX7-2 ]
GeneIDi 26875.
KEGGi mmu:26875.

Organism-specific databases

CTDi 27445.
MGIi MGI:1349390. Pclo.

Phylogenomic databases

eggNOGi NOG12793.
GeneTreei ENSGT00620000087961.
HOGENOMi HOG000168263.
HOVERGENi HBG031058.
InParanoidi Q9QYX7.
KOi K16882.
OMAi IDYPEEV.
OrthoDBi EOG73805D.

Miscellaneous databases

ChiTaRSi PCLO. mouse.
NextBioi 304679.
PROi Q9QYX7.
SOURCEi Search...

Gene expression databases

CleanExi MM_PCLO.
Genevestigatori Q9QYX7.

Family and domain databases

Gene3Di 2.30.42.10. 1 hit.
2.60.40.150. 2 hits.
3.30.40.10. 2 hits.
InterProi IPR000008. C2_dom.
IPR001478. PDZ.
IPR011011. Znf_FYVE_PHD.
IPR008899. Znf_piccolo.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
Pfami PF00168. C2. 2 hits.
PF00595. PDZ. 1 hit.
PF05715. zf-piccolo. 2 hits.
[Graphical view ]
SMARTi SM00239. C2. 2 hits.
SM00228. PDZ. 1 hit.
[Graphical view ]
SUPFAMi SSF49562. SSF49562. 2 hits.
SSF50156. SSF50156. 1 hit.
SSF57903. SSF57903. 2 hits.
PROSITEi PS50004. C2. 2 hits.
PS50106. PDZ. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Aczonin, a 550-kd putative scaffolding protein of presynaptic active zones, shares homology regions with rim and bassoon and binds profilin."
    Wang X., Kibschull M., Laue M.M., Lichte B., Petrasch-Parwez E., Kilimann M.W.
    J. Cell Biol. 147:151-162(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, SUBCELLULAR LOCATION, ALTERNATIVE SPLICING, TISSUE SPECIFICITY, INTERACTION WITH PROFILIN.
    Tissue: Brain.
  2. Kilimann M.W.
    Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  3. "Piccolo, a Ca2+ sensor in pancreatic beta-cells. Involvement of cAMP-GEFII.Rim2.Piccolo complex in cAMP-dependent exocytosis."
    Fujimoto K., Shibasaki T., Yokoi N., Kashima Y., Matsumoto M., Sasaki T., Tajima N., Iwanaga T., Seino S.
    J. Biol. Chem. 277:50497-50502(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY, INTERACTION WITH RIMS2.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  5. "Mus musculus brain-derived reactive mRNA."
    Huang W., Jin W., Huang C., Chen B., Zhang J., Ju G.
    Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4532-4712.
    Tissue: Brain.
  6. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
    Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1766; SER-3358 AND THR-3376, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.
  7. "O-linked N-acetylglucosamine proteomics of postsynaptic density preparations using lectin weak affinity chromatography and mass spectrometry."
    Vosseller K., Trinidad J.C., Chalkley R.J., Specht C.G., Thalhammer A., Lynn A.J., Snedecor J.O., Guan S., Medzihradszky K.F., Maltby D.A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:923-934(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT THR-2686 AND SER-2960.
    Tissue: Brain.
  8. "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
    Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
    Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain cortex.
  9. "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
    Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.
    J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.

Entry informationi

Entry nameiPCLO_MOUSE
AccessioniPrimary (citable) accession number: Q9QYX7
Secondary accession number(s): E9QK94
, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: January 9, 2013
Last modified: October 29, 2014
This is version 120 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3