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Q9QYX7

- PCLO_MOUSE

UniProt

Q9QYX7 - PCLO_MOUSE

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Protein
Protein piccolo
Gene
Pclo, Acz
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May act as a scaffolding protein involved in the organization of synaptic active zones and in synaptic vesicle trafficking.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri532 – 55625C4-type Reviewed prediction
Add
BLAST
Zinc fingeri997 – 102024C4-type Reviewed prediction
Add
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: UniProtKB
  2. calcium-dependent phospholipid binding Source: UniProtKB
  3. profilin binding Source: UniProtKB
  4. protein binding Source: MGI
Complete GO annotation...

GO - Biological processi

  1. cAMP-mediated signaling Source: MGI
  2. cytoskeleton organization Source: MGI
  3. insulin secretion Source: MGI
  4. regulation of exocytosis Source: MGI
  5. synaptic vesicle targeting Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Calcium, Calcium/phospholipid-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein piccolo
Alternative name(s):
Aczonin
Brain-derived HLMN protein
Multidomain presynaptic cytomatrix protein
Gene namesi
Name:Pclo
Synonyms:Acz
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:1349390. Pclo.

Subcellular locationi

Cell junctionsynapse
Note: Concentrated at the presynaptic side of synaptic junctions.1 Publication

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. synapse Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 50685068Protein piccolo
PRO_0000058251Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1766 – 17661Phosphoserine1 Publication
Glycosylationi2686 – 26861O-linked (GlcNAc)1 Publication
Glycosylationi2960 – 29601O-linked (GlcNAc)1 Publication
Modified residuei3358 – 33581Phosphoserine1 Publication
Modified residuei3376 – 33761Phosphothreonine1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9QYX7.
PaxDbiQ9QYX7.
PRIDEiQ9QYX7.

PTM databases

PhosphoSiteiQ9QYX7.

Expressioni

Tissue specificityi

Highly expressed in brain. Moderately expressed in pituitary gland and pancreatic islets. Low levels found in stomach.2 Publications

Gene expression databases

CleanExiMM_PCLO.
GenevestigatoriQ9QYX7.

Interactioni

Subunit structurei

Interacts with RABAC1/PRA1, RIMS2 and profilin.2 Publications

Protein-protein interaction databases

BioGridi205033. 3 interactions.
IntActiQ9QYX7. 2 interactions.
MINTiMINT-4106700.
STRINGi10090.ENSMUSP00000030691.

Structurei

3D structure databases

ProteinModelPortaliQ9QYX7.
SMRiQ9QYX7. Positions 4412-4520, 4618-4759.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4424 – 451895PDZ
Add
BLAST
Domaini4637 – 473599C2 1
Add
BLAST
Domaini4952 – 504291C2 2
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni401 – 50010010 X 10 AA tandem approximate repeats of P-A-K-P-Q-P-Q-Q-P-X
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi2335 – 235925Poly-Pro
Add
BLAST

Domaini

C2 domain 1 is involved in binding calcium and phospholipids. Calcium binds with low affinity but with high specificity and induces a large conformational change.By similarity

Sequence similaritiesi

Contains 2 C2 domains.
Contains 1 PDZ (DHR) domain.

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG12793.
GeneTreeiENSGT00620000087961.
HOGENOMiHOG000168263.
HOVERGENiHBG031058.
InParanoidiQ9QYX7.
KOiK16882.
OMAiIDYPEEV.
OrthoDBiEOG73805D.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
2.60.40.150. 2 hits.
3.30.40.10. 2 hits.
InterProiIPR000008. C2_dom.
IPR001478. PDZ.
IPR011011. Znf_FYVE_PHD.
IPR008899. Znf_piccolo.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00168. C2. 2 hits.
PF00595. PDZ. 1 hit.
PF05715. zf-piccolo. 2 hits.
[Graphical view]
SMARTiSM00239. C2. 2 hits.
SM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 2 hits.
SSF50156. SSF50156. 1 hit.
SSF57903. SSF57903. 2 hits.
PROSITEiPS50004. C2. 2 hits.
PS50106. PDZ. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9QYX7-1) [UniParc]FASTAAdd to Basket

Also known as: L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGNEASLEGE GLPEGLAAAA GGAGGSGSAL HPGIPAGMEA DLSQLSEEER     50
RQIAAVMSRA QGLPKGSVPA AAAESPSMHR KQELDSSQAP QQPGKPPDPG 100
RPPQHGLSKS RTTDTFRSEQ KLPGRSPSTI SLKESKSRTD FKEEYKSSMM 150
PGFFSDVNPL SAVSSVVNKF NPFDLISDSE AVQEETTKKQ KVAQKDQGKS 200
EGITKPSLQQ PSPKLIPKQQ GPGKEVIPQD IPSKSVSSQQ AEKTKPQAPG 250
TAKPSQQSPA QTPAQQAKPV AQQPGPAKAT VQQPGPAKSP AQPAGTGKSP 300
AQPPVTAKPP AQQAGLEKTS LQQPGPKSLA QTPGQGKVPP GPAKSPAQQP 350
GTAKLPAQQP GPQTAAKVPG PTKTPAQLSG PGKTPAQQPG PTKPSPQQPI 400
PAKPQPQQPV ATKPQPQQPA PAKPQPQHPT PAKPQPQHPT PAKPQPQQPT 450
PAKPQPQQPT PAKPQPQQPT PAKPQPQHPT PAKPQPQQPG LGKPSAQQPS 500
KSISQTVTGR PLQAPPTSAA QAPAQGLSKT ICPLCNTTEL LLHTPEKANF 550
NTCTECQSTV CSLCGFNPNP HLTEIKEWLC LNCQMQRALG GELAAIPSSP 600
QPTPKAASVQ PATASKSPVP SQQASPKKEL PSKQDSPKAP ESKKPPPLVK 650
QPTLHGPTPA TAPQPPVAEA LPKPAPPKKP SAALPEQAKA PVADVEPKQP 700
KTTETLTDSP SSAAATSKPA ILSSQVQAQA QVTTAPPLKT DSAKTSQSFP 750
PTGDTITPLD SKAMPRPASD SKIVSHPGPT SESKDPVQKK EEPKKAQTKV 800
TPKPDTKPVP KGSPTPSGTR PTTGQATPQS QQPPKPPEQS RRFSLNLGGI 850
ADAPKSQPTT PQETVTGKLF GFGASIFSQA SNLISTAGQQ APHPQTGPAA 900
PSKQAPPPSQ TLAAQGPPKS TGPHPSAPAK TTAVKKETKG PAAENLEAKP 950
VQAPTVKKAE KDKKPPPGKV SKPPPTEPEK AVLAQKPDKT TKPKPACPLC 1000
RTELNVGSQD PPNFNTCTEC KNQVCNLCGF NPTPHLTEIQ EWLCLNCQTQ 1050
RAISGQLGDM DKMPPASSGP KASPVPAPAE PPPQKTPTAA HAKGKKKETE 1100
VKAETEKQIP EKETPSIEKT PPAVATDQKL EESEVTKSLV SVLPEKKPSE 1150
EEKALPADKK EKKPPAAEAP PLEEKKPIPD DQKLPPDAKP SASEGEEKRD 1200
LLKAHVQIPE EGPIGKVASL ACEGEQQPDT RPEDLPGATP QTLPKDRQKE 1250
SRDVTQPQAE GTAKEGRGEP SKDRTEKEED KSDTSSSQQP KSPQGLSDTG 1300
YSSDGISGSL GEIPSLIPSD EKDLLKGLKK DSFSQESSPS SPSDLAKLES 1350
TVLSILEAQA STLVGEKAEK KTQPQKVSPE QPQDQQKTQT PSETRDISIS 1400
EEEIKESQEK KVTSKKDSAQ GFPSRKEHKE NPELVDDLSP RRASYDSVED 1450
SSESENSPVA RRKRRTSIGS SSSEEYKQED SQGSGEDEDF IRKQIIEMSA 1500
DEDASGSEDE EFIRSQLKEI GGVTESQKRE ETKGKGKSPA GKHRRLTRKS 1550
STSFDDDAGR RHSWHDEDDE TFDESPELKF RETKSQESEE LVVAGGGGLR 1600
RFKTIELNST VTDKYSAESS QKKTTLYFDE EPELEMESLT DSPEDRSRGE 1650
GSSSLHASSF TPGTSPTSVS SLDEDSDSSP SHKKGESKQQ RKARHRSHGP 1700
LLPTIEDSSE EEELREEEEL LKEQEKQREL EQQQRKSSSK KSKKDKDELR 1750
AQRRRERPKT PPSNLSPIED ASPTEELRQA AEMEELHRSS CSEYSPSIES 1800
DPEGFEISPE KIIEVQKVYK LPTAVSLYSP TDEQSVMQKE GAQKALKSAE 1850
EMYEEMMHKP HKYKAFPAAN ERDEVFEKEP LYGGMLIEDY IYESLVEDTY 1900
NGSVDGSLLT RQDEQNGFMQ QRGREQKIRL QEQIYDDPMQ KITDLQKEFY 1950
ELESLHSIVP QEDIVSSSYI IPESHEIVDL GSMVTSTSEE KKLLDADAAY 2000
EELMKRQQMQ VTDGSSLIQT TMGDDMAEST LDFDRVQDAS LTSSILSGAS 2050
LTDSTSSATL SIPDVKITQH FSTEEFEDEY VTDYTREIQE IIAHESLILT 2100
YSEPSESATS VPPSDTPSLT SSISSVCTTD SSSPVTTLDS LTTVYTEPAD 2150
VITKFKDSEE ISSTYFPGSV IDYPEDIGVS LDRTITPESR TNADQIMISF 2200
PGIAPSITES VATKPERPQA DTISTDLPIS EKELIKGKKE TGDGIILEVL 2250
DAYKDKREES EAELTKISLP ETGLAPTPSS QTKEQPGSPH SVSGEILGQE 2300
KPTYRSPSGG LPVSTHPSKS HPFFRSSSLD ISAQPPPPPP PPPPPPPPPP 2350
PPPPPPLPPA TSPKPPTYPK RKLAAAAPVA PTAIVTAHAD AIPTVEATAA 2400
RRSNGLPATK ICAAAPPPVP PKPSSIPTGL VFTHRPEASK PPIAPKPAVP 2450
EIPVTTQKTT DTCPKPTGLP LTSNMSLNLV TSADYKLPSP TSPLSPHSNK 2500
SSPRYSKSLM ETYVVITLPS EPGTPTDSSA AQAITSWPLG SPPKDLVSLE 2550
TVFSVVPPMT STEIPSASQP TLYTSGALGT FSVTPAVTAS LFQTVPTSLT 2600
QFLPAEASKP EVSAVSSAVP SVAPRSVSIP IPPEPLALDR HQYKENGKLP 2650
LIGDAIDLRT IPKSEVKVTE KCMDLSASAM DVKRQTTANE VYRRQISAVQ 2700
PSIINLSAAS SLGTPVTMDS KTVAVVTCTD TTIYTTGTES QVGIEHAVTS 2750
PLQLTTSKHT ELQYRKPSSQ AFPMIRDEAP INLSLGPSTQ AVTLAVTKPV 2800
TVPPVGVTNG WTDSTISQGI TDGEVVDLST SKSHRTVVTM DESTSNVVTK 2850
IIEDEEKPVD LTAGRRAVCC DMVYKLPFGR SCTAQQPATT LPEDRFGYRD 2900
DHYQYDRSGP YGYRGIGGMK PSMSDTNLAE AGHFFYKSKN AFDYSGGTEA 2950
AVDLTSGRVS TGEVMDYSSK TTGPYPETRQ VISGVGISTP QYSTARMTPP 3000
PGPQYGVGSV LRSSNGVVYS SVATPIPSTF AITTQPGSIF STTVRDLSGI 3050
HTTDAITSLS ALHQSQPMPR SYFITTGASE TDISVTSIDI NASLQTITME 3100
TLPAETMDSV PTLTTASEVF SEVVGEESTL LIVPDEDKQQ QQLDLERELL 3150
ELEKIKQQRF AEELEWERQE IQRFREQEKI MVQKKLEELQ SMKQHLLYQQ 3200
EEERQAQFMM RQETLAQQQL QLEQIQQLQQ QLHQQLEEQK LRQIYQYNYE 3250
PSGTASPQTT TEQAILEGQY VATEGSQFWA TEDATTTAST VVAIEIPQSQ 3300
GWYTVQSDGV TQYIAPPGIL STVSEIPLTD VVVKEEKQPK KRSSGAKVRG 3350
QYDEMGESMA DDPRNLKKIV DSGVQTDDEE TADRTYASRR RRTKKSVDTS 3400
VQTDDEDQDE WDMPSRSRRK ARTGKYGDST AEGDKTKPPS KVSSVAVQTV 3450
AEISVQTEPL GTIRTPSIRA RVDAKVEIIK HISAPEKTYK GGSLGCQTET 3500
DPDTQSPPYM GATSPPKDKK RPTPLEIGYS SSHLRADPTV QLAPSPPKSP 3550
KVLYSPISPL SPGHALEPAF VPYEKPLPDD ISPQKVLHPD MAKVPPASPK 3600
TAKMMQRSMS DPKPLSPTAD ESSRAPFQYS EGFTAKGSQT TSGTQKKVKR 3650
TLPNPPPEEA STGTQSTYST MGTASRRRMC RTNTMARAKI LQDIDRELDL 3700
VERESAKLRK KQAELDEEEK EIDAKLRYLE MGINRRKEAL LKEREKRERA 3750
YLQGVAEDRD YMSDSEVSST RPSRVESQHG IERPRTAPQT EFSQFIPPQT 3800
QTEAQLVPPT SPYTQYQYSS PALPTQAPTP YTQQSHFQQQ TLYHQQVSPY 3850
QTQPTFQAVA TMSFTPQAQP TPTPQPSYQL PSQMMVIQQK PRQTTLYLEP 3900
KITSTYEVIR NQPLMIAPVS TDNTYAVSHL GSKYNSLDLR IGLEERSSMA 3950
SSPISSISAD SFYADIDHHT SRNYVLIDDI GDITKGTAAL SSAFSLHEKD 4000
LSKTDRLLRT TETRRSQEVT DFLAPLQTSS RLHSYVKAEE DSMEDPYELK 4050
LLKHQIKQEF RRGTESLDHL AGLSHYYHAD TSYRHFPKSE KYSISRLTLE 4100
KQAAKQLPAA ILYQKQSKHK KALIDPKMSK FSPIQESRDL EPDYPTYLSS 4150
STSSIGGISS RARLLQDDIT FGLRKNITDQ QKFMGSSLGS GLGTLGNTIR 4200
SALQDEADKP YSSGSRSRPS SRPSSVYGLD LSIKRDSSSS SLRLKAQEAE 4250
ALDVSFGHSS SSARTKPTSL PISQSRGRIP IVAQNSEEES PLSPVGQPMG 4300
MARAAAGPLP PISADTRDQF GSSHSLPEVQ QHMREESRTR GYDRDIAFIM 4350
DDFQHAMSDS EAYHLRREET DWFDKPRESR LENGHGLDRK LPERLVHSRP 4400
LSQHQEQILQ MNGKTMHYIF PHARIKITRD SKDHTVSGNG LGIRIVGGKE 4450
IPGHSGEIGA YIAKILPGGS AEHSGKLIEG MQVLEWNGIP LTSKTYEEVQ 4500
SIINQQSGEA EICVRLDLNM LSDSENPQHL ELHEPPKVVD KAKSPGVDPK 4550
QLAAELQKVS LQQSPLVMSS VVEKGAHAHS GPTSAGSSSV PSPGQPGSPS 4600
VSKKKHGGSK PTDVSKTASH PITGEIQLQI NYDLGNLIIH ILQARNLVPR 4650
DNNGYSDPFV KVYLLPGRGQ VMVVQNASVE YKRRTKYVQK SLNPEWNQTV 4700
IYKSISMEQL MKKTLEVTVW DYDRFSSNDF LGEVLIDLSS TSHLDNTPRW 4750
YPLKEQTESI EHGKSHSSQN SQQSPKPSVI KSRSHGIFPD PSKDMQVPTI 4800
EKSHSSPGSS KSSSEGHLRS HGPSRSQSKT SVAQTHLEDA GAAIAAAEAA 4850
VQQLRIQPTK PTNHRPAETS VSTGSSGSSV GSGYSVDSEG SSCVAGEPNL 4900
LPIPRIGKMG QNGQDPVKQP GMGAADTEAK TQVMGEIKLA LKKEMKTDGE 4950
QLIVEILQCR NITYKFKSPD HLPDLYVKIY VINIATQKKV IKKKTRVCRH 5000
DREPSFNETF RFSLSPAGHS LQILLFSNGG KFMKKTLIGE ACIWLDKVDL 5050
RKRIVNWHKL LMSPTQTH 5068
Length:5,068
Mass (Da):550,834
Last modified:January 9, 2013 - v4
Checksum:iDBF54D47501AC79A
GO
Isoform 2 (identifier: Q9QYX7-2) [UniParc]FASTAAdd to Basket

Also known as: S

The sequence of this isoform differs from the canonical sequence as follows:
     4859-4863: TKPTN → SKRRK
     4864-5068: Missing.

Show »
Length:4,863
Mass (Da):528,257
Checksum:i6F9A9B68DCBA59D2
GO

Sequence cautioni

The sequence BAC53723.1 differs from that shown. Reason: Unlikely isoform. Several sequence problems.
The sequence BAC53724.1 differs from that shown. Reason: Unlikely isoform. Several sequence problems.
The sequence CAB60731.2 differs from that shown. Reason: Probable cloning artifact.
The sequence CAB60732.2 differs from that shown. Reason: Probable cloning artifact.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei4859 – 48635TKPTN → SKRRK in isoform 2.
VSP_003928
Alternative sequencei4864 – 5068205Missing in isoform 2.
VSP_003929Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti156 – 1561D → E in CAB60731. 1 Publication
Sequence conflicti156 – 1561D → E in CAB60732. 1 Publication
Sequence conflicti366 – 3661A → S in CAB60731. 1 Publication
Sequence conflicti366 – 3661A → S in CAB60732. 1 Publication
Sequence conflicti438 – 4381H → Q in CAB60731. 1 Publication
Sequence conflicti438 – 4381H → Q in CAB60732. 1 Publication
Sequence conflicti438 – 4381H → Q in BAC53723. 1 Publication
Sequence conflicti438 – 4381H → Q in BAC53724. 1 Publication
Sequence conflicti478 – 4781H → Q in CAB60731. 1 Publication
Sequence conflicti478 – 4781H → Q in CAB60732. 1 Publication
Sequence conflicti478 – 4781H → Q in BAC53723. 1 Publication
Sequence conflicti478 – 4781H → Q in BAC53724. 1 Publication
Sequence conflicti923 – 9231P → Q in CAB60731. 1 Publication
Sequence conflicti923 – 9231P → Q in CAB60732. 1 Publication
Sequence conflicti923 – 9231P → Q in BAC53723. 1 Publication
Sequence conflicti923 – 9231P → Q in BAC53724. 1 Publication
Sequence conflicti951 – 9511V → A in CAB60731. 1 Publication
Sequence conflicti951 – 9511V → A in CAB60732. 1 Publication
Sequence conflicti965 – 9651P → H in CAB60731. 1 Publication
Sequence conflicti965 – 9651P → H in CAB60732. 1 Publication
Sequence conflicti1920 – 19201Q → P in CAB60731. 1 Publication
Sequence conflicti1920 – 19201Q → P in CAB60732. 1 Publication
Sequence conflicti1931 – 19311Q → R in CAB60731. 1 Publication
Sequence conflicti1931 – 19311Q → R in CAB60732. 1 Publication
Sequence conflicti2297 – 22971L → S in CAB60731. 1 Publication
Sequence conflicti2297 – 22971L → S in CAB60732. 1 Publication
Sequence conflicti2335 – 234612Missing in BAC53723. 1 Publication
Add
BLAST
Sequence conflicti2335 – 234612Missing in BAC53724. 1 Publication
Add
BLAST
Sequence conflicti2855 – 28551E → D in CAB60731. 1 Publication
Sequence conflicti2855 – 28551E → D in CAB60732. 1 Publication
Sequence conflicti4042 – 40421S → P in CAB60731. 1 Publication
Sequence conflicti4042 – 40421S → P in CAB60732. 1 Publication
Sequence conflicti4670 – 46789Missing in BAC53724. 1 Publication
Sequence conflicti5062 – 50621M → V in CAB60731. 1 Publication
Sequence conflicti5062 – 50621M → V in CAB60732. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y19185 mRNA. Translation: CAB60731.2. Sequence problems.
Y19186 mRNA. Translation: CAB60732.2. Sequence problems.
AB083477 mRNA. Translation: BAC53723.1. Sequence problems.
AB083478 mRNA. Translation: BAC53724.1. Sequence problems.
AC125043 Genomic DNA. No translation available.
AC125533 Genomic DNA. No translation available.
AC144480 Genomic DNA. No translation available.
AC144625 Genomic DNA. No translation available.
AF181269 mRNA. Translation: AAD55786.2.
CCDSiCCDS51415.1. [Q9QYX7-1]
CCDS59667.1. [Q9QYX7-2]
RefSeqiNP_001104266.1. NM_001110796.2. [Q9QYX7-2]
NP_036125.4. NM_011995.4. [Q9QYX7-1]
UniGeneiMm.146275.

Genome annotation databases

EnsembliENSMUST00000030691; ENSMUSP00000030691; ENSMUSG00000061601. [Q9QYX7-1]
ENSMUST00000182407; ENSMUSP00000138419; ENSMUSG00000061601. [Q9QYX7-2]
GeneIDi26875.
KEGGimmu:26875.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y19185 mRNA. Translation: CAB60731.2 . Sequence problems.
Y19186 mRNA. Translation: CAB60732.2 . Sequence problems.
AB083477 mRNA. Translation: BAC53723.1 . Sequence problems.
AB083478 mRNA. Translation: BAC53724.1 . Sequence problems.
AC125043 Genomic DNA. No translation available.
AC125533 Genomic DNA. No translation available.
AC144480 Genomic DNA. No translation available.
AC144625 Genomic DNA. No translation available.
AF181269 mRNA. Translation: AAD55786.2 .
CCDSi CCDS51415.1. [Q9QYX7-1 ]
CCDS59667.1. [Q9QYX7-2 ]
RefSeqi NP_001104266.1. NM_001110796.2. [Q9QYX7-2 ]
NP_036125.4. NM_011995.4. [Q9QYX7-1 ]
UniGenei Mm.146275.

3D structure databases

ProteinModelPortali Q9QYX7.
SMRi Q9QYX7. Positions 4412-4520, 4618-4759.
ModBasei Search...

Protein-protein interaction databases

BioGridi 205033. 3 interactions.
IntActi Q9QYX7. 2 interactions.
MINTi MINT-4106700.
STRINGi 10090.ENSMUSP00000030691.

PTM databases

PhosphoSitei Q9QYX7.

Proteomic databases

MaxQBi Q9QYX7.
PaxDbi Q9QYX7.
PRIDEi Q9QYX7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000030691 ; ENSMUSP00000030691 ; ENSMUSG00000061601 . [Q9QYX7-1 ]
ENSMUST00000182407 ; ENSMUSP00000138419 ; ENSMUSG00000061601 . [Q9QYX7-2 ]
GeneIDi 26875.
KEGGi mmu:26875.

Organism-specific databases

CTDi 27445.
MGIi MGI:1349390. Pclo.

Phylogenomic databases

eggNOGi NOG12793.
GeneTreei ENSGT00620000087961.
HOGENOMi HOG000168263.
HOVERGENi HBG031058.
InParanoidi Q9QYX7.
KOi K16882.
OMAi IDYPEEV.
OrthoDBi EOG73805D.

Miscellaneous databases

ChiTaRSi PCLO. mouse.
NextBioi 304679.
PROi Q9QYX7.
SOURCEi Search...

Gene expression databases

CleanExi MM_PCLO.
Genevestigatori Q9QYX7.

Family and domain databases

Gene3Di 2.30.42.10. 1 hit.
2.60.40.150. 2 hits.
3.30.40.10. 2 hits.
InterProi IPR000008. C2_dom.
IPR001478. PDZ.
IPR011011. Znf_FYVE_PHD.
IPR008899. Znf_piccolo.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
Pfami PF00168. C2. 2 hits.
PF00595. PDZ. 1 hit.
PF05715. zf-piccolo. 2 hits.
[Graphical view ]
SMARTi SM00239. C2. 2 hits.
SM00228. PDZ. 1 hit.
[Graphical view ]
SUPFAMi SSF49562. SSF49562. 2 hits.
SSF50156. SSF50156. 1 hit.
SSF57903. SSF57903. 2 hits.
PROSITEi PS50004. C2. 2 hits.
PS50106. PDZ. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Aczonin, a 550-kd putative scaffolding protein of presynaptic active zones, shares homology regions with rim and bassoon and binds profilin."
    Wang X., Kibschull M., Laue M.M., Lichte B., Petrasch-Parwez E., Kilimann M.W.
    J. Cell Biol. 147:151-162(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, SUBCELLULAR LOCATION, ALTERNATIVE SPLICING, TISSUE SPECIFICITY, INTERACTION WITH PROFILIN.
    Tissue: Brain.
  2. Kilimann M.W.
    Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  3. "Piccolo, a Ca2+ sensor in pancreatic beta-cells. Involvement of cAMP-GEFII.Rim2.Piccolo complex in cAMP-dependent exocytosis."
    Fujimoto K., Shibasaki T., Yokoi N., Kashima Y., Matsumoto M., Sasaki T., Tajima N., Iwanaga T., Seino S.
    J. Biol. Chem. 277:50497-50502(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY, INTERACTION WITH RIMS2.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  5. "Mus musculus brain-derived reactive mRNA."
    Huang W., Jin W., Huang C., Chen B., Zhang J., Ju G.
    Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4532-4712.
    Tissue: Brain.
  6. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
    Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1766; SER-3358 AND THR-3376, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.
  7. "O-linked N-acetylglucosamine proteomics of postsynaptic density preparations using lectin weak affinity chromatography and mass spectrometry."
    Vosseller K., Trinidad J.C., Chalkley R.J., Specht C.G., Thalhammer A., Lynn A.J., Snedecor J.O., Guan S., Medzihradszky K.F., Maltby D.A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:923-934(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT THR-2686 AND SER-2960.
    Tissue: Brain.
  8. "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
    Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
    Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain cortex.
  9. "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
    Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.
    J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.

Entry informationi

Entry nameiPCLO_MOUSE
AccessioniPrimary (citable) accession number: Q9QYX7
Secondary accession number(s): E9QK94
, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: January 9, 2013
Last modified: July 9, 2014
This is version 118 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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