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Q9QYX7

- PCLO_MOUSE

UniProt

Q9QYX7 - PCLO_MOUSE

Protein

Protein piccolo

Gene

Pclo

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 4 (09 Jan 2013)
      Previous versions | rss
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    Functioni

    May act as a scaffolding protein involved in the organization of synaptic active zones and in synaptic vesicle trafficking.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri532 – 55625C4-typeSequence AnalysisAdd
    BLAST
    Zinc fingeri997 – 102024C4-typeSequence AnalysisAdd
    BLAST

    GO - Molecular functioni

    1. calcium-dependent phospholipid binding Source: UniProtKB
    2. calcium ion binding Source: UniProtKB
    3. profilin binding Source: UniProtKB
    4. protein binding Source: MGI

    GO - Biological processi

    1. cAMP-mediated signaling Source: MGI
    2. cytoskeleton organization Source: MGI
    3. insulin secretion Source: MGI
    4. regulation of exocytosis Source: MGI
    5. synaptic vesicle targeting Source: UniProtKB

    Keywords - Ligandi

    Calcium, Calcium/phospholipid-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein piccolo
    Alternative name(s):
    Aczonin
    Brain-derived HLMN protein
    Multidomain presynaptic cytomatrix protein
    Gene namesi
    Name:Pclo
    Synonyms:Acz
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:1349390. Pclo.

    Subcellular locationi

    Cell junctionsynapse 1 Publication
    Note: Concentrated at the presynaptic side of synaptic junctions.

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. synapse Source: UniProtKB

    Keywords - Cellular componenti

    Cell junction, Synapse

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 50685068Protein piccoloPRO_0000058251Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1766 – 17661Phosphoserine1 Publication
    Glycosylationi2686 – 26861O-linked (GlcNAc)1 Publication
    Glycosylationi2960 – 29601O-linked (GlcNAc)1 Publication
    Modified residuei3358 – 33581Phosphoserine1 Publication
    Modified residuei3376 – 33761Phosphothreonine1 Publication

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiQ9QYX7.
    PaxDbiQ9QYX7.
    PRIDEiQ9QYX7.

    PTM databases

    PhosphoSiteiQ9QYX7.

    Expressioni

    Tissue specificityi

    Highly expressed in brain. Moderately expressed in pituitary gland and pancreatic islets. Low levels found in stomach.2 Publications

    Gene expression databases

    CleanExiMM_PCLO.
    GenevestigatoriQ9QYX7.

    Interactioni

    Subunit structurei

    Interacts with RABAC1/PRA1, RIMS2 and profilin.2 Publications

    Protein-protein interaction databases

    BioGridi205033. 3 interactions.
    IntActiQ9QYX7. 2 interactions.
    MINTiMINT-4106700.
    STRINGi10090.ENSMUSP00000030691.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9QYX7.
    SMRiQ9QYX7. Positions 4412-4520, 4618-4759.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4424 – 451895PDZPROSITE-ProRule annotationAdd
    BLAST
    Domaini4637 – 473599C2 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini4952 – 504291C2 2PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni401 – 50010010 X 10 AA tandem approximate repeats of P-A-K-P-Q-P-Q-Q-P-XAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi2335 – 235925Poly-ProAdd
    BLAST

    Domaini

    C2 domain 1 is involved in binding calcium and phospholipids. Calcium binds with low affinity but with high specificity and induces a large conformational change.By similarity

    Sequence similaritiesi

    Contains 2 C2 domains.PROSITE-ProRule annotation
    Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri532 – 55625C4-typeSequence AnalysisAdd
    BLAST
    Zinc fingeri997 – 102024C4-typeSequence AnalysisAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG12793.
    GeneTreeiENSGT00620000087961.
    HOGENOMiHOG000168263.
    HOVERGENiHBG031058.
    InParanoidiQ9QYX7.
    KOiK16882.
    OMAiIDYPEEV.
    OrthoDBiEOG73805D.

    Family and domain databases

    Gene3Di2.30.42.10. 1 hit.
    2.60.40.150. 2 hits.
    3.30.40.10. 2 hits.
    InterProiIPR000008. C2_dom.
    IPR001478. PDZ.
    IPR011011. Znf_FYVE_PHD.
    IPR008899. Znf_piccolo.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view]
    PfamiPF00168. C2. 2 hits.
    PF00595. PDZ. 1 hit.
    PF05715. zf-piccolo. 2 hits.
    [Graphical view]
    SMARTiSM00239. C2. 2 hits.
    SM00228. PDZ. 1 hit.
    [Graphical view]
    SUPFAMiSSF49562. SSF49562. 2 hits.
    SSF50156. SSF50156. 1 hit.
    SSF57903. SSF57903. 2 hits.
    PROSITEiPS50004. C2. 2 hits.
    PS50106. PDZ. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9QYX7-1) [UniParc]FASTAAdd to Basket

    Also known as: L

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGNEASLEGE GLPEGLAAAA GGAGGSGSAL HPGIPAGMEA DLSQLSEEER     50
    RQIAAVMSRA QGLPKGSVPA AAAESPSMHR KQELDSSQAP QQPGKPPDPG 100
    RPPQHGLSKS RTTDTFRSEQ KLPGRSPSTI SLKESKSRTD FKEEYKSSMM 150
    PGFFSDVNPL SAVSSVVNKF NPFDLISDSE AVQEETTKKQ KVAQKDQGKS 200
    EGITKPSLQQ PSPKLIPKQQ GPGKEVIPQD IPSKSVSSQQ AEKTKPQAPG 250
    TAKPSQQSPA QTPAQQAKPV AQQPGPAKAT VQQPGPAKSP AQPAGTGKSP 300
    AQPPVTAKPP AQQAGLEKTS LQQPGPKSLA QTPGQGKVPP GPAKSPAQQP 350
    GTAKLPAQQP GPQTAAKVPG PTKTPAQLSG PGKTPAQQPG PTKPSPQQPI 400
    PAKPQPQQPV ATKPQPQQPA PAKPQPQHPT PAKPQPQHPT PAKPQPQQPT 450
    PAKPQPQQPT PAKPQPQQPT PAKPQPQHPT PAKPQPQQPG LGKPSAQQPS 500
    KSISQTVTGR PLQAPPTSAA QAPAQGLSKT ICPLCNTTEL LLHTPEKANF 550
    NTCTECQSTV CSLCGFNPNP HLTEIKEWLC LNCQMQRALG GELAAIPSSP 600
    QPTPKAASVQ PATASKSPVP SQQASPKKEL PSKQDSPKAP ESKKPPPLVK 650
    QPTLHGPTPA TAPQPPVAEA LPKPAPPKKP SAALPEQAKA PVADVEPKQP 700
    KTTETLTDSP SSAAATSKPA ILSSQVQAQA QVTTAPPLKT DSAKTSQSFP 750
    PTGDTITPLD SKAMPRPASD SKIVSHPGPT SESKDPVQKK EEPKKAQTKV 800
    TPKPDTKPVP KGSPTPSGTR PTTGQATPQS QQPPKPPEQS RRFSLNLGGI 850
    ADAPKSQPTT PQETVTGKLF GFGASIFSQA SNLISTAGQQ APHPQTGPAA 900
    PSKQAPPPSQ TLAAQGPPKS TGPHPSAPAK TTAVKKETKG PAAENLEAKP 950
    VQAPTVKKAE KDKKPPPGKV SKPPPTEPEK AVLAQKPDKT TKPKPACPLC 1000
    RTELNVGSQD PPNFNTCTEC KNQVCNLCGF NPTPHLTEIQ EWLCLNCQTQ 1050
    RAISGQLGDM DKMPPASSGP KASPVPAPAE PPPQKTPTAA HAKGKKKETE 1100
    VKAETEKQIP EKETPSIEKT PPAVATDQKL EESEVTKSLV SVLPEKKPSE 1150
    EEKALPADKK EKKPPAAEAP PLEEKKPIPD DQKLPPDAKP SASEGEEKRD 1200
    LLKAHVQIPE EGPIGKVASL ACEGEQQPDT RPEDLPGATP QTLPKDRQKE 1250
    SRDVTQPQAE GTAKEGRGEP SKDRTEKEED KSDTSSSQQP KSPQGLSDTG 1300
    YSSDGISGSL GEIPSLIPSD EKDLLKGLKK DSFSQESSPS SPSDLAKLES 1350
    TVLSILEAQA STLVGEKAEK KTQPQKVSPE QPQDQQKTQT PSETRDISIS 1400
    EEEIKESQEK KVTSKKDSAQ GFPSRKEHKE NPELVDDLSP RRASYDSVED 1450
    SSESENSPVA RRKRRTSIGS SSSEEYKQED SQGSGEDEDF IRKQIIEMSA 1500
    DEDASGSEDE EFIRSQLKEI GGVTESQKRE ETKGKGKSPA GKHRRLTRKS 1550
    STSFDDDAGR RHSWHDEDDE TFDESPELKF RETKSQESEE LVVAGGGGLR 1600
    RFKTIELNST VTDKYSAESS QKKTTLYFDE EPELEMESLT DSPEDRSRGE 1650
    GSSSLHASSF TPGTSPTSVS SLDEDSDSSP SHKKGESKQQ RKARHRSHGP 1700
    LLPTIEDSSE EEELREEEEL LKEQEKQREL EQQQRKSSSK KSKKDKDELR 1750
    AQRRRERPKT PPSNLSPIED ASPTEELRQA AEMEELHRSS CSEYSPSIES 1800
    DPEGFEISPE KIIEVQKVYK LPTAVSLYSP TDEQSVMQKE GAQKALKSAE 1850
    EMYEEMMHKP HKYKAFPAAN ERDEVFEKEP LYGGMLIEDY IYESLVEDTY 1900
    NGSVDGSLLT RQDEQNGFMQ QRGREQKIRL QEQIYDDPMQ KITDLQKEFY 1950
    ELESLHSIVP QEDIVSSSYI IPESHEIVDL GSMVTSTSEE KKLLDADAAY 2000
    EELMKRQQMQ VTDGSSLIQT TMGDDMAEST LDFDRVQDAS LTSSILSGAS 2050
    LTDSTSSATL SIPDVKITQH FSTEEFEDEY VTDYTREIQE IIAHESLILT 2100
    YSEPSESATS VPPSDTPSLT SSISSVCTTD SSSPVTTLDS LTTVYTEPAD 2150
    VITKFKDSEE ISSTYFPGSV IDYPEDIGVS LDRTITPESR TNADQIMISF 2200
    PGIAPSITES VATKPERPQA DTISTDLPIS EKELIKGKKE TGDGIILEVL 2250
    DAYKDKREES EAELTKISLP ETGLAPTPSS QTKEQPGSPH SVSGEILGQE 2300
    KPTYRSPSGG LPVSTHPSKS HPFFRSSSLD ISAQPPPPPP PPPPPPPPPP 2350
    PPPPPPLPPA TSPKPPTYPK RKLAAAAPVA PTAIVTAHAD AIPTVEATAA 2400
    RRSNGLPATK ICAAAPPPVP PKPSSIPTGL VFTHRPEASK PPIAPKPAVP 2450
    EIPVTTQKTT DTCPKPTGLP LTSNMSLNLV TSADYKLPSP TSPLSPHSNK 2500
    SSPRYSKSLM ETYVVITLPS EPGTPTDSSA AQAITSWPLG SPPKDLVSLE 2550
    TVFSVVPPMT STEIPSASQP TLYTSGALGT FSVTPAVTAS LFQTVPTSLT 2600
    QFLPAEASKP EVSAVSSAVP SVAPRSVSIP IPPEPLALDR HQYKENGKLP 2650
    LIGDAIDLRT IPKSEVKVTE KCMDLSASAM DVKRQTTANE VYRRQISAVQ 2700
    PSIINLSAAS SLGTPVTMDS KTVAVVTCTD TTIYTTGTES QVGIEHAVTS 2750
    PLQLTTSKHT ELQYRKPSSQ AFPMIRDEAP INLSLGPSTQ AVTLAVTKPV 2800
    TVPPVGVTNG WTDSTISQGI TDGEVVDLST SKSHRTVVTM DESTSNVVTK 2850
    IIEDEEKPVD LTAGRRAVCC DMVYKLPFGR SCTAQQPATT LPEDRFGYRD 2900
    DHYQYDRSGP YGYRGIGGMK PSMSDTNLAE AGHFFYKSKN AFDYSGGTEA 2950
    AVDLTSGRVS TGEVMDYSSK TTGPYPETRQ VISGVGISTP QYSTARMTPP 3000
    PGPQYGVGSV LRSSNGVVYS SVATPIPSTF AITTQPGSIF STTVRDLSGI 3050
    HTTDAITSLS ALHQSQPMPR SYFITTGASE TDISVTSIDI NASLQTITME 3100
    TLPAETMDSV PTLTTASEVF SEVVGEESTL LIVPDEDKQQ QQLDLERELL 3150
    ELEKIKQQRF AEELEWERQE IQRFREQEKI MVQKKLEELQ SMKQHLLYQQ 3200
    EEERQAQFMM RQETLAQQQL QLEQIQQLQQ QLHQQLEEQK LRQIYQYNYE 3250
    PSGTASPQTT TEQAILEGQY VATEGSQFWA TEDATTTAST VVAIEIPQSQ 3300
    GWYTVQSDGV TQYIAPPGIL STVSEIPLTD VVVKEEKQPK KRSSGAKVRG 3350
    QYDEMGESMA DDPRNLKKIV DSGVQTDDEE TADRTYASRR RRTKKSVDTS 3400
    VQTDDEDQDE WDMPSRSRRK ARTGKYGDST AEGDKTKPPS KVSSVAVQTV 3450
    AEISVQTEPL GTIRTPSIRA RVDAKVEIIK HISAPEKTYK GGSLGCQTET 3500
    DPDTQSPPYM GATSPPKDKK RPTPLEIGYS SSHLRADPTV QLAPSPPKSP 3550
    KVLYSPISPL SPGHALEPAF VPYEKPLPDD ISPQKVLHPD MAKVPPASPK 3600
    TAKMMQRSMS DPKPLSPTAD ESSRAPFQYS EGFTAKGSQT TSGTQKKVKR 3650
    TLPNPPPEEA STGTQSTYST MGTASRRRMC RTNTMARAKI LQDIDRELDL 3700
    VERESAKLRK KQAELDEEEK EIDAKLRYLE MGINRRKEAL LKEREKRERA 3750
    YLQGVAEDRD YMSDSEVSST RPSRVESQHG IERPRTAPQT EFSQFIPPQT 3800
    QTEAQLVPPT SPYTQYQYSS PALPTQAPTP YTQQSHFQQQ TLYHQQVSPY 3850
    QTQPTFQAVA TMSFTPQAQP TPTPQPSYQL PSQMMVIQQK PRQTTLYLEP 3900
    KITSTYEVIR NQPLMIAPVS TDNTYAVSHL GSKYNSLDLR IGLEERSSMA 3950
    SSPISSISAD SFYADIDHHT SRNYVLIDDI GDITKGTAAL SSAFSLHEKD 4000
    LSKTDRLLRT TETRRSQEVT DFLAPLQTSS RLHSYVKAEE DSMEDPYELK 4050
    LLKHQIKQEF RRGTESLDHL AGLSHYYHAD TSYRHFPKSE KYSISRLTLE 4100
    KQAAKQLPAA ILYQKQSKHK KALIDPKMSK FSPIQESRDL EPDYPTYLSS 4150
    STSSIGGISS RARLLQDDIT FGLRKNITDQ QKFMGSSLGS GLGTLGNTIR 4200
    SALQDEADKP YSSGSRSRPS SRPSSVYGLD LSIKRDSSSS SLRLKAQEAE 4250
    ALDVSFGHSS SSARTKPTSL PISQSRGRIP IVAQNSEEES PLSPVGQPMG 4300
    MARAAAGPLP PISADTRDQF GSSHSLPEVQ QHMREESRTR GYDRDIAFIM 4350
    DDFQHAMSDS EAYHLRREET DWFDKPRESR LENGHGLDRK LPERLVHSRP 4400
    LSQHQEQILQ MNGKTMHYIF PHARIKITRD SKDHTVSGNG LGIRIVGGKE 4450
    IPGHSGEIGA YIAKILPGGS AEHSGKLIEG MQVLEWNGIP LTSKTYEEVQ 4500
    SIINQQSGEA EICVRLDLNM LSDSENPQHL ELHEPPKVVD KAKSPGVDPK 4550
    QLAAELQKVS LQQSPLVMSS VVEKGAHAHS GPTSAGSSSV PSPGQPGSPS 4600
    VSKKKHGGSK PTDVSKTASH PITGEIQLQI NYDLGNLIIH ILQARNLVPR 4650
    DNNGYSDPFV KVYLLPGRGQ VMVVQNASVE YKRRTKYVQK SLNPEWNQTV 4700
    IYKSISMEQL MKKTLEVTVW DYDRFSSNDF LGEVLIDLSS TSHLDNTPRW 4750
    YPLKEQTESI EHGKSHSSQN SQQSPKPSVI KSRSHGIFPD PSKDMQVPTI 4800
    EKSHSSPGSS KSSSEGHLRS HGPSRSQSKT SVAQTHLEDA GAAIAAAEAA 4850
    VQQLRIQPTK PTNHRPAETS VSTGSSGSSV GSGYSVDSEG SSCVAGEPNL 4900
    LPIPRIGKMG QNGQDPVKQP GMGAADTEAK TQVMGEIKLA LKKEMKTDGE 4950
    QLIVEILQCR NITYKFKSPD HLPDLYVKIY VINIATQKKV IKKKTRVCRH 5000
    DREPSFNETF RFSLSPAGHS LQILLFSNGG KFMKKTLIGE ACIWLDKVDL 5050
    RKRIVNWHKL LMSPTQTH 5068
    Length:5,068
    Mass (Da):550,834
    Last modified:January 9, 2013 - v4
    Checksum:iDBF54D47501AC79A
    GO
    Isoform 2 (identifier: Q9QYX7-2) [UniParc]FASTAAdd to Basket

    Also known as: S

    The sequence of this isoform differs from the canonical sequence as follows:
         4859-4863: TKPTN → SKRRK
         4864-5068: Missing.

    Show »
    Length:4,863
    Mass (Da):528,257
    Checksum:i6F9A9B68DCBA59D2
    GO

    Sequence cautioni

    The sequence BAC53723.1 differs from that shown. Reason: Unlikely isoform. Several sequence problems.
    The sequence BAC53724.1 differs from that shown. Reason: Unlikely isoform. Several sequence problems.
    The sequence CAB60731.2 differs from that shown. Reason: Probable cloning artifact.
    The sequence CAB60732.2 differs from that shown. Reason: Probable cloning artifact.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti156 – 1561D → E in CAB60731. (PubMed:10508862)Curated
    Sequence conflicti156 – 1561D → E in CAB60732. (PubMed:10508862)Curated
    Sequence conflicti366 – 3661A → S in CAB60731. (PubMed:10508862)Curated
    Sequence conflicti366 – 3661A → S in CAB60732. (PubMed:10508862)Curated
    Sequence conflicti438 – 4381H → Q in CAB60731. (PubMed:10508862)Curated
    Sequence conflicti438 – 4381H → Q in CAB60732. (PubMed:10508862)Curated
    Sequence conflicti438 – 4381H → Q in BAC53723. (PubMed:12401793)Curated
    Sequence conflicti438 – 4381H → Q in BAC53724. (PubMed:12401793)Curated
    Sequence conflicti478 – 4781H → Q in CAB60731. (PubMed:10508862)Curated
    Sequence conflicti478 – 4781H → Q in CAB60732. (PubMed:10508862)Curated
    Sequence conflicti478 – 4781H → Q in BAC53723. (PubMed:12401793)Curated
    Sequence conflicti478 – 4781H → Q in BAC53724. (PubMed:12401793)Curated
    Sequence conflicti923 – 9231P → Q in CAB60731. (PubMed:10508862)Curated
    Sequence conflicti923 – 9231P → Q in CAB60732. (PubMed:10508862)Curated
    Sequence conflicti923 – 9231P → Q in BAC53723. (PubMed:12401793)Curated
    Sequence conflicti923 – 9231P → Q in BAC53724. (PubMed:12401793)Curated
    Sequence conflicti951 – 9511V → A in CAB60731. (PubMed:10508862)Curated
    Sequence conflicti951 – 9511V → A in CAB60732. (PubMed:10508862)Curated
    Sequence conflicti965 – 9651P → H in CAB60731. (PubMed:10508862)Curated
    Sequence conflicti965 – 9651P → H in CAB60732. (PubMed:10508862)Curated
    Sequence conflicti1920 – 19201Q → P in CAB60731. (PubMed:10508862)Curated
    Sequence conflicti1920 – 19201Q → P in CAB60732. (PubMed:10508862)Curated
    Sequence conflicti1931 – 19311Q → R in CAB60731. (PubMed:10508862)Curated
    Sequence conflicti1931 – 19311Q → R in CAB60732. (PubMed:10508862)Curated
    Sequence conflicti2297 – 22971L → S in CAB60731. (PubMed:10508862)Curated
    Sequence conflicti2297 – 22971L → S in CAB60732. (PubMed:10508862)Curated
    Sequence conflicti2335 – 234612Missing in BAC53723. (PubMed:12401793)CuratedAdd
    BLAST
    Sequence conflicti2335 – 234612Missing in BAC53724. (PubMed:12401793)CuratedAdd
    BLAST
    Sequence conflicti2855 – 28551E → D in CAB60731. (PubMed:10508862)Curated
    Sequence conflicti2855 – 28551E → D in CAB60732. (PubMed:10508862)Curated
    Sequence conflicti4042 – 40421S → P in CAB60731. (PubMed:10508862)Curated
    Sequence conflicti4042 – 40421S → P in CAB60732. (PubMed:10508862)Curated
    Sequence conflicti4670 – 46789Missing in BAC53724. (PubMed:12401793)Curated
    Sequence conflicti5062 – 50621M → V in CAB60731. (PubMed:10508862)Curated
    Sequence conflicti5062 – 50621M → V in CAB60732. (PubMed:10508862)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei4859 – 48635TKPTN → SKRRK in isoform 2. 2 PublicationsVSP_003928
    Alternative sequencei4864 – 5068205Missing in isoform 2. 2 PublicationsVSP_003929Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y19185 mRNA. Translation: CAB60731.2. Sequence problems.
    Y19186 mRNA. Translation: CAB60732.2. Sequence problems.
    AB083477 mRNA. Translation: BAC53723.1. Sequence problems.
    AB083478 mRNA. Translation: BAC53724.1. Sequence problems.
    AC125043 Genomic DNA. No translation available.
    AC125533 Genomic DNA. No translation available.
    AC144480 Genomic DNA. No translation available.
    AC144625 Genomic DNA. No translation available.
    AF181269 mRNA. Translation: AAD55786.2.
    CCDSiCCDS51415.1. [Q9QYX7-1]
    CCDS59667.1. [Q9QYX7-2]
    RefSeqiNP_001104266.1. NM_001110796.2. [Q9QYX7-2]
    NP_036125.4. NM_011995.4. [Q9QYX7-1]
    UniGeneiMm.146275.

    Genome annotation databases

    EnsembliENSMUST00000030691; ENSMUSP00000030691; ENSMUSG00000061601. [Q9QYX7-1]
    ENSMUST00000182407; ENSMUSP00000138419; ENSMUSG00000061601. [Q9QYX7-2]
    GeneIDi26875.
    KEGGimmu:26875.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y19185 mRNA. Translation: CAB60731.2 . Sequence problems.
    Y19186 mRNA. Translation: CAB60732.2 . Sequence problems.
    AB083477 mRNA. Translation: BAC53723.1 . Sequence problems.
    AB083478 mRNA. Translation: BAC53724.1 . Sequence problems.
    AC125043 Genomic DNA. No translation available.
    AC125533 Genomic DNA. No translation available.
    AC144480 Genomic DNA. No translation available.
    AC144625 Genomic DNA. No translation available.
    AF181269 mRNA. Translation: AAD55786.2 .
    CCDSi CCDS51415.1. [Q9QYX7-1 ]
    CCDS59667.1. [Q9QYX7-2 ]
    RefSeqi NP_001104266.1. NM_001110796.2. [Q9QYX7-2 ]
    NP_036125.4. NM_011995.4. [Q9QYX7-1 ]
    UniGenei Mm.146275.

    3D structure databases

    ProteinModelPortali Q9QYX7.
    SMRi Q9QYX7. Positions 4412-4520, 4618-4759.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 205033. 3 interactions.
    IntActi Q9QYX7. 2 interactions.
    MINTi MINT-4106700.
    STRINGi 10090.ENSMUSP00000030691.

    PTM databases

    PhosphoSitei Q9QYX7.

    Proteomic databases

    MaxQBi Q9QYX7.
    PaxDbi Q9QYX7.
    PRIDEi Q9QYX7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000030691 ; ENSMUSP00000030691 ; ENSMUSG00000061601 . [Q9QYX7-1 ]
    ENSMUST00000182407 ; ENSMUSP00000138419 ; ENSMUSG00000061601 . [Q9QYX7-2 ]
    GeneIDi 26875.
    KEGGi mmu:26875.

    Organism-specific databases

    CTDi 27445.
    MGIi MGI:1349390. Pclo.

    Phylogenomic databases

    eggNOGi NOG12793.
    GeneTreei ENSGT00620000087961.
    HOGENOMi HOG000168263.
    HOVERGENi HBG031058.
    InParanoidi Q9QYX7.
    KOi K16882.
    OMAi IDYPEEV.
    OrthoDBi EOG73805D.

    Miscellaneous databases

    ChiTaRSi PCLO. mouse.
    NextBioi 304679.
    PROi Q9QYX7.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_PCLO.
    Genevestigatori Q9QYX7.

    Family and domain databases

    Gene3Di 2.30.42.10. 1 hit.
    2.60.40.150. 2 hits.
    3.30.40.10. 2 hits.
    InterProi IPR000008. C2_dom.
    IPR001478. PDZ.
    IPR011011. Znf_FYVE_PHD.
    IPR008899. Znf_piccolo.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view ]
    Pfami PF00168. C2. 2 hits.
    PF00595. PDZ. 1 hit.
    PF05715. zf-piccolo. 2 hits.
    [Graphical view ]
    SMARTi SM00239. C2. 2 hits.
    SM00228. PDZ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49562. SSF49562. 2 hits.
    SSF50156. SSF50156. 1 hit.
    SSF57903. SSF57903. 2 hits.
    PROSITEi PS50004. C2. 2 hits.
    PS50106. PDZ. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Aczonin, a 550-kd putative scaffolding protein of presynaptic active zones, shares homology regions with rim and bassoon and binds profilin."
      Wang X., Kibschull M., Laue M.M., Lichte B., Petrasch-Parwez E., Kilimann M.W.
      J. Cell Biol. 147:151-162(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, SUBCELLULAR LOCATION, ALTERNATIVE SPLICING, TISSUE SPECIFICITY, INTERACTION WITH PROFILIN.
      Tissue: Brain.
    2. Kilimann M.W.
      Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    3. "Piccolo, a Ca2+ sensor in pancreatic beta-cells. Involvement of cAMP-GEFII.Rim2.Piccolo complex in cAMP-dependent exocytosis."
      Fujimoto K., Shibasaki T., Yokoi N., Kashima Y., Matsumoto M., Sasaki T., Tajima N., Iwanaga T., Seino S.
      J. Biol. Chem. 277:50497-50502(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY, INTERACTION WITH RIMS2.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    5. "Mus musculus brain-derived reactive mRNA."
      Huang W., Jin W., Huang C., Chen B., Zhang J., Ju G.
      Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4532-4712.
      Tissue: Brain.
    6. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
      Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
      Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1766; SER-3358 AND THR-3376, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Brain.
    7. "O-linked N-acetylglucosamine proteomics of postsynaptic density preparations using lectin weak affinity chromatography and mass spectrometry."
      Vosseller K., Trinidad J.C., Chalkley R.J., Specht C.G., Thalhammer A., Lynn A.J., Snedecor J.O., Guan S., Medzihradszky K.F., Maltby D.A., Schoepfer R., Burlingame A.L.
      Mol. Cell. Proteomics 5:923-934(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT THR-2686 AND SER-2960.
      Tissue: Brain.
    8. "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
      Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
      Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Brain cortex.
    9. "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
      Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.
      J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Brain.

    Entry informationi

    Entry nameiPCLO_MOUSE
    AccessioniPrimary (citable) accession number: Q9QYX7
    Secondary accession number(s): E9QK94
    , Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 19, 2002
    Last sequence update: January 9, 2013
    Last modified: October 1, 2014
    This is version 119 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3