Q9QYX7 (PCLO_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein piccolo

Alternative name(s):
Aczonin
Brain-derived HLMN protein
Multidomain presynaptic cytomatrix protein

Gene names

Name:	Pclo
Synonyms:	Acz

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	5068 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May act as a scaffolding protein involved in the organization of synaptic active zones and in synaptic vesicle trafficking. Ref.1
Subunit structure	Interacts with RABAC1/PRA1, RIMS2 and profilin. Ref.1 Ref.3
Subcellular location	Cell junction › synapse. Note: Concentrated at the presynaptic side of synaptic junctions. Ref.1
Tissue specificity	Highly expressed in brain. Moderately expressed in pituitary gland and pancreatic islets. Low levels found in stomach. Ref.1 Ref.3
Domain	C2 domain 1 is involved in binding calcium and phospholipids. Calcium binds with low affinity but with high specificity and induces a large conformational change. UniProtKB Q9JKS6
Sequence similarities	Contains 2 C2 domains. Contains 1 PDZ (DHR) domain.
Sequence caution	The sequence BAC53723.1 differs from that shown. Reason: Unlikely isoform. Several sequence problems. The sequence BAC53724.1 differs from that shown. Reason: Unlikely isoform. Several sequence problems. The sequence CAB60731.2 differs from that shown. Reason: Probable cloning artifact. The sequence CAB60732.2 differs from that shown. Reason: Probable cloning artifact.

Ontologies

Keywords
Cellular component	Cell junction Synapse
Coding sequence diversity	Alternative splicing
Domain	Repeat Zinc-finger
Ligand	Calcium Calcium/phospholipid-binding Metal-binding Zinc
PTM	Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cAMP-mediated signaling Inferred from direct assay Ref.3. Source: MGI cytoskeleton organization Inferred from direct assay Ref.1. Source: MGI insulin secretion Inferred from direct assay Ref.3. Source: MGI regulation of exocytosis Inferred from direct assay Ref.3. Source: MGI synaptic vesicle targeting Non-traceable author statement Ref.1. Source: UniProtKB
Cellular_component	cell junction Inferred from electronic annotation. Source: UniProtKB-KW synapse Inferred from direct assay Ref.1. Source: UniProtKB
Molecular_function	calcium ion binding Inferred from sequence or structural similarity. Source: UniProtKB calcium-dependent phospholipid binding Inferred from sequence or structural similarity. Source: UniProtKB profilin binding Inferred from direct assay Ref.1. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9QYX7-1)

Also known as: L;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9QYX7-2)

Also known as: S;

The sequence of this isoform differs from the canonical sequence as follows:
     4859-4863: TKPTN → SKRRK
     4864-5068: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 5068	5068	Protein piccolo		PRO_0000058251
Regions
	Domain	4424 – 4518	95	PDZ
	Domain	4637 – 4735	99	C2 1
	Domain	4952 – 5042	91	C2 2
	Zinc finger	532 – 556	25	C4-type Potential
	Zinc finger	997 – 1020	24	C4-type Potential
	Region	401 – 500	100	10 X 10 AA tandem approximate repeats of P-A-K-P-Q-P-Q-Q-P-X
	Compositional bias	2335 – 2359	25	Poly-Pro
Amino acid modifications
	Modified residue	625	1	Phosphoserine Ref.10
	Modified residue	748	1	Phosphoserine Ref.10
	Modified residue	860	1	Phosphothreonine Ref.10
	Modified residue	1120	1	Phosphothreonine Ref.10
	Modified residue	1340	1	Phosphoserine Ref.10
	Modified residue	1341	1	Phosphoserine Ref.10
	Modified residue	1400	1	Phosphoserine Ref.10
	Modified residue	1439	1	Phosphoserine Ref.6 Ref.7 Ref.10
	Modified residue	1444	1	Phosphoserine Ref.10
	Modified residue	1457	1	Phosphoserine Ref.10
	Modified residue	1575	1	Phosphoserine Ref.6
	Modified residue	1585	1	Phosphoserine Ref.10
	Modified residue	1760	1	Phosphothreonine Ref.6
	Modified residue	1763	1	Phosphoserine Ref.10
	Modified residue	1766	1	Phosphoserine Ref.6 Ref.7 Ref.10
	Modified residue	1772	1	Phosphoserine Ref.6 Ref.7 Ref.10
	Modified residue	1808	1	Phosphoserine Ref.10
	Modified residue	1828	1	Phosphotyrosine Ref.10
	Modified residue	1829	1	Phosphoserine Ref.6 Ref.7
	Modified residue	2998	1	Phosphothreonine Ref.7 Ref.10
	Modified residue	3358	1	Phosphoserine Ref.7
	Modified residue	3376	1	Phosphothreonine Ref.7
	Modified residue	3513	1	Phosphothreonine Ref.10
	Modified residue	3545	1	Phosphoserine Ref.10
	Modified residue	3610	1	Phosphoserine Ref.6 Ref.7 Ref.10
	Modified residue	3616	1	Phosphoserine Ref.6 Ref.7
	Modified residue	3761	1	Phosphotyrosine Ref.9
	Modified residue	3763	1	Phosphoserine Ref.7 Ref.9
	Modified residue	3894	1	Phosphothreonine Ref.6
	Modified residue	3895	1	Phosphothreonine Ref.6
	Modified residue	3936	1	Phosphoserine Ref.10
	Modified residue	3952	1	Phosphoserine Ref.7
	Modified residue	4286	1	Phosphoserine Ref.6
	Modified residue	4290	1	Phosphoserine Ref.6
	Modified residue	4293	1	Phosphoserine Ref.6
	Modified residue	4325	1	Phosphoserine Ref.6
	Glycosylation	2686	1	O-linked (GlcNAc) Ref.8
	Glycosylation	2960	1	O-linked (GlcNAc) Ref.8
Natural variations
	Alternative sequence	4859 – 4863	5	TKPTN → SKRRK in isoform 2.		VSP_003928
	Alternative sequence	4864 – 5068	205	Missing in isoform 2.		VSP_003929
Experimental info
	Sequence conflict	156	1	D → E in CAB60731. Ref.1
	Sequence conflict	156	1	D → E in CAB60732. Ref.1
	Sequence conflict	366	1	A → S in CAB60731. Ref.1
	Sequence conflict	366	1	A → S in CAB60732. Ref.1
	Sequence conflict	438	1	H → Q in CAB60731. Ref.1
	Sequence conflict	438	1	H → Q in CAB60732. Ref.1
	Sequence conflict	438	1	H → Q in BAC53723. Ref.3
	Sequence conflict	438	1	H → Q in BAC53724. Ref.3
	Sequence conflict	478	1	H → Q in CAB60731. Ref.1
	Sequence conflict	478	1	H → Q in CAB60732. Ref.1
	Sequence conflict	478	1	H → Q in BAC53723. Ref.3
	Sequence conflict	478	1	H → Q in BAC53724. Ref.3
	Sequence conflict	923	1	P → Q in CAB60731. Ref.1
	Sequence conflict	923	1	P → Q in CAB60732. Ref.1
	Sequence conflict	923	1	P → Q in BAC53723. Ref.3
	Sequence conflict	923	1	P → Q in BAC53724. Ref.3
	Sequence conflict	951	1	V → A in CAB60731. Ref.1
	Sequence conflict	951	1	V → A in CAB60732. Ref.1
	Sequence conflict	965	1	P → H in CAB60731. Ref.1
	Sequence conflict	965	1	P → H in CAB60732. Ref.1
	Sequence conflict	1920	1	Q → P in CAB60731. Ref.1
	Sequence conflict	1920	1	Q → P in CAB60732. Ref.1
	Sequence conflict	1931	1	Q → R in CAB60731. Ref.1
	Sequence conflict	1931	1	Q → R in CAB60732. Ref.1
	Sequence conflict	2297	1	L → S in CAB60731. Ref.1
	Sequence conflict	2297	1	L → S in CAB60732. Ref.1
	Sequence conflict	2335 – 2346	12	Missing in BAC53723. Ref.3
	Sequence conflict	2335 – 2346	12	Missing in BAC53724. Ref.3
	Sequence conflict	2855	1	E → D in CAB60731. Ref.1
	Sequence conflict	2855	1	E → D in CAB60732. Ref.1
	Sequence conflict	4042	1	S → P in CAB60731. Ref.1
	Sequence conflict	4042	1	S → P in CAB60732. Ref.1
	Sequence conflict	4670 – 4678	9	Missing in BAC53724. Ref.3
	Sequence conflict	5062	1	M → V in CAB60731. Ref.1
	Sequence conflict	5062	1	M → V in CAB60732. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (L) [UniParc]. Last modified January 9, 2013. Version 4. Checksum: DBF54D47501AC79A	FASTA	5,068	550,834
	10 20 30 40 50 60 MGNEASLEGE GLPEGLAAAA GGAGGSGSAL HPGIPAGMEA DLSQLSEEER RQIAAVMSRA 70 80 90 100 110 120 QGLPKGSVPA AAAESPSMHR KQELDSSQAP QQPGKPPDPG RPPQHGLSKS RTTDTFRSEQ 130 140 150 160 170 180 KLPGRSPSTI SLKESKSRTD FKEEYKSSMM PGFFSDVNPL SAVSSVVNKF NPFDLISDSE 190 200 210 220 230 240 AVQEETTKKQ KVAQKDQGKS EGITKPSLQQ PSPKLIPKQQ GPGKEVIPQD IPSKSVSSQQ 250 260 270 280 290 300 AEKTKPQAPG TAKPSQQSPA QTPAQQAKPV AQQPGPAKAT VQQPGPAKSP AQPAGTGKSP 310 320 330 340 350 360 AQPPVTAKPP AQQAGLEKTS LQQPGPKSLA QTPGQGKVPP GPAKSPAQQP GTAKLPAQQP 370 380 390 400 410 420 GPQTAAKVPG PTKTPAQLSG PGKTPAQQPG PTKPSPQQPI PAKPQPQQPV ATKPQPQQPA 430 440 450 460 470 480 PAKPQPQHPT PAKPQPQHPT PAKPQPQQPT PAKPQPQQPT PAKPQPQQPT PAKPQPQHPT 490 500 510 520 530 540 PAKPQPQQPG LGKPSAQQPS KSISQTVTGR PLQAPPTSAA QAPAQGLSKT ICPLCNTTEL 550 560 570 580 590 600 LLHTPEKANF NTCTECQSTV CSLCGFNPNP HLTEIKEWLC LNCQMQRALG GELAAIPSSP 610 620 630 640 650 660 QPTPKAASVQ PATASKSPVP SQQASPKKEL PSKQDSPKAP ESKKPPPLVK QPTLHGPTPA 670 680 690 700 710 720 TAPQPPVAEA LPKPAPPKKP SAALPEQAKA PVADVEPKQP KTTETLTDSP SSAAATSKPA 730 740 750 760 770 780 ILSSQVQAQA QVTTAPPLKT DSAKTSQSFP PTGDTITPLD SKAMPRPASD SKIVSHPGPT 790 800 810 820 830 840 SESKDPVQKK EEPKKAQTKV TPKPDTKPVP KGSPTPSGTR PTTGQATPQS QQPPKPPEQS 850 860 870 880 890 900 RRFSLNLGGI ADAPKSQPTT PQETVTGKLF GFGASIFSQA SNLISTAGQQ APHPQTGPAA 910 920 930 940 950 960 PSKQAPPPSQ TLAAQGPPKS TGPHPSAPAK TTAVKKETKG PAAENLEAKP VQAPTVKKAE 970 980 990 1000 1010 1020 KDKKPPPGKV SKPPPTEPEK AVLAQKPDKT TKPKPACPLC RTELNVGSQD PPNFNTCTEC 1030 1040 1050 1060 1070 1080 KNQVCNLCGF NPTPHLTEIQ EWLCLNCQTQ RAISGQLGDM DKMPPASSGP KASPVPAPAE 1090 1100 1110 1120 1130 1140 PPPQKTPTAA HAKGKKKETE VKAETEKQIP EKETPSIEKT PPAVATDQKL EESEVTKSLV 1150 1160 1170 1180 1190 1200 SVLPEKKPSE EEKALPADKK EKKPPAAEAP PLEEKKPIPD DQKLPPDAKP SASEGEEKRD 1210 1220 1230 1240 1250 1260 LLKAHVQIPE EGPIGKVASL ACEGEQQPDT RPEDLPGATP QTLPKDRQKE SRDVTQPQAE 1270 1280 1290 1300 1310 1320 GTAKEGRGEP SKDRTEKEED KSDTSSSQQP KSPQGLSDTG YSSDGISGSL GEIPSLIPSD 1330 1340 1350 1360 1370 1380 EKDLLKGLKK DSFSQESSPS SPSDLAKLES TVLSILEAQA STLVGEKAEK KTQPQKVSPE 1390 1400 1410 1420 1430 1440 QPQDQQKTQT PSETRDISIS EEEIKESQEK KVTSKKDSAQ GFPSRKEHKE NPELVDDLSP 1450 1460 1470 1480 1490 1500 RRASYDSVED SSESENSPVA RRKRRTSIGS SSSEEYKQED SQGSGEDEDF IRKQIIEMSA 1510 1520 1530 1540 1550 1560 DEDASGSEDE EFIRSQLKEI GGVTESQKRE ETKGKGKSPA GKHRRLTRKS STSFDDDAGR 1570 1580 1590 1600 1610 1620 RHSWHDEDDE TFDESPELKF RETKSQESEE LVVAGGGGLR RFKTIELNST VTDKYSAESS 1630 1640 1650 1660 1670 1680 QKKTTLYFDE EPELEMESLT DSPEDRSRGE GSSSLHASSF TPGTSPTSVS SLDEDSDSSP 1690 1700 1710 1720 1730 1740 SHKKGESKQQ RKARHRSHGP LLPTIEDSSE EEELREEEEL LKEQEKQREL EQQQRKSSSK 1750 1760 1770 1780 1790 1800 KSKKDKDELR AQRRRERPKT PPSNLSPIED ASPTEELRQA AEMEELHRSS CSEYSPSIES 1810 1820 1830 1840 1850 1860 DPEGFEISPE KIIEVQKVYK LPTAVSLYSP TDEQSVMQKE GAQKALKSAE EMYEEMMHKP 1870 1880 1890 1900 1910 1920 HKYKAFPAAN ERDEVFEKEP LYGGMLIEDY IYESLVEDTY NGSVDGSLLT RQDEQNGFMQ 1930 1940 1950 1960 1970 1980 QRGREQKIRL QEQIYDDPMQ KITDLQKEFY ELESLHSIVP QEDIVSSSYI IPESHEIVDL 1990 2000 2010 2020 2030 2040 GSMVTSTSEE KKLLDADAAY EELMKRQQMQ VTDGSSLIQT TMGDDMAEST LDFDRVQDAS 2050 2060 2070 2080 2090 2100 LTSSILSGAS LTDSTSSATL SIPDVKITQH FSTEEFEDEY VTDYTREIQE IIAHESLILT 2110 2120 2130 2140 2150 2160 YSEPSESATS VPPSDTPSLT SSISSVCTTD SSSPVTTLDS LTTVYTEPAD VITKFKDSEE 2170 2180 2190 2200 2210 2220 ISSTYFPGSV IDYPEDIGVS LDRTITPESR TNADQIMISF PGIAPSITES VATKPERPQA 2230 2240 2250 2260 2270 2280 DTISTDLPIS EKELIKGKKE TGDGIILEVL DAYKDKREES EAELTKISLP ETGLAPTPSS 2290 2300 2310 2320 2330 2340 QTKEQPGSPH SVSGEILGQE KPTYRSPSGG LPVSTHPSKS HPFFRSSSLD ISAQPPPPPP 2350 2360 2370 2380 2390 2400 PPPPPPPPPP PPPPPPLPPA TSPKPPTYPK RKLAAAAPVA PTAIVTAHAD AIPTVEATAA 2410 2420 2430 2440 2450 2460 RRSNGLPATK ICAAAPPPVP PKPSSIPTGL VFTHRPEASK PPIAPKPAVP EIPVTTQKTT 2470 2480 2490 2500 2510 2520 DTCPKPTGLP LTSNMSLNLV TSADYKLPSP TSPLSPHSNK SSPRYSKSLM ETYVVITLPS 2530 2540 2550 2560 2570 2580 EPGTPTDSSA AQAITSWPLG SPPKDLVSLE TVFSVVPPMT STEIPSASQP TLYTSGALGT 2590 2600 2610 2620 2630 2640 FSVTPAVTAS LFQTVPTSLT QFLPAEASKP EVSAVSSAVP SVAPRSVSIP IPPEPLALDR 2650 2660 2670 2680 2690 2700 HQYKENGKLP LIGDAIDLRT IPKSEVKVTE KCMDLSASAM DVKRQTTANE VYRRQISAVQ 2710 2720 2730 2740 2750 2760 PSIINLSAAS SLGTPVTMDS KTVAVVTCTD TTIYTTGTES QVGIEHAVTS PLQLTTSKHT 2770 2780 2790 2800 2810 2820 ELQYRKPSSQ AFPMIRDEAP INLSLGPSTQ AVTLAVTKPV TVPPVGVTNG WTDSTISQGI 2830 2840 2850 2860 2870 2880 TDGEVVDLST SKSHRTVVTM DESTSNVVTK IIEDEEKPVD LTAGRRAVCC DMVYKLPFGR 2890 2900 2910 2920 2930 2940 SCTAQQPATT LPEDRFGYRD DHYQYDRSGP YGYRGIGGMK PSMSDTNLAE AGHFFYKSKN 2950 2960 2970 2980 2990 3000 AFDYSGGTEA AVDLTSGRVS TGEVMDYSSK TTGPYPETRQ VISGVGISTP QYSTARMTPP 3010 3020 3030 3040 3050 3060 PGPQYGVGSV LRSSNGVVYS SVATPIPSTF AITTQPGSIF STTVRDLSGI HTTDAITSLS 3070 3080 3090 3100 3110 3120 ALHQSQPMPR SYFITTGASE TDISVTSIDI NASLQTITME TLPAETMDSV PTLTTASEVF 3130 3140 3150 3160 3170 3180 SEVVGEESTL LIVPDEDKQQ QQLDLERELL ELEKIKQQRF AEELEWERQE IQRFREQEKI 3190 3200 3210 3220 3230 3240 MVQKKLEELQ SMKQHLLYQQ EEERQAQFMM RQETLAQQQL QLEQIQQLQQ QLHQQLEEQK 3250 3260 3270 3280 3290 3300 LRQIYQYNYE PSGTASPQTT TEQAILEGQY VATEGSQFWA TEDATTTAST VVAIEIPQSQ 3310 3320 3330 3340 3350 3360 GWYTVQSDGV TQYIAPPGIL STVSEIPLTD VVVKEEKQPK KRSSGAKVRG QYDEMGESMA 3370 3380 3390 3400 3410 3420 DDPRNLKKIV DSGVQTDDEE TADRTYASRR RRTKKSVDTS VQTDDEDQDE WDMPSRSRRK 3430 3440 3450 3460 3470 3480 ARTGKYGDST AEGDKTKPPS KVSSVAVQTV AEISVQTEPL GTIRTPSIRA RVDAKVEIIK 3490 3500 3510 3520 3530 3540 HISAPEKTYK GGSLGCQTET DPDTQSPPYM GATSPPKDKK RPTPLEIGYS SSHLRADPTV 3550 3560 3570 3580 3590 3600 QLAPSPPKSP KVLYSPISPL SPGHALEPAF VPYEKPLPDD ISPQKVLHPD MAKVPPASPK 3610 3620 3630 3640 3650 3660 TAKMMQRSMS DPKPLSPTAD ESSRAPFQYS EGFTAKGSQT TSGTQKKVKR TLPNPPPEEA 3670 3680 3690 3700 3710 3720 STGTQSTYST MGTASRRRMC RTNTMARAKI LQDIDRELDL VERESAKLRK KQAELDEEEK 3730 3740 3750 3760 3770 3780 EIDAKLRYLE MGINRRKEAL LKEREKRERA YLQGVAEDRD YMSDSEVSST RPSRVESQHG 3790 3800 3810 3820 3830 3840 IERPRTAPQT EFSQFIPPQT QTEAQLVPPT SPYTQYQYSS PALPTQAPTP YTQQSHFQQQ 3850 3860 3870 3880 3890 3900 TLYHQQVSPY QTQPTFQAVA TMSFTPQAQP TPTPQPSYQL PSQMMVIQQK PRQTTLYLEP 3910 3920 3930 3940 3950 3960 KITSTYEVIR NQPLMIAPVS TDNTYAVSHL GSKYNSLDLR IGLEERSSMA SSPISSISAD 3970 3980 3990 4000 4010 4020 SFYADIDHHT SRNYVLIDDI GDITKGTAAL SSAFSLHEKD LSKTDRLLRT TETRRSQEVT 4030 4040 4050 4060 4070 4080 DFLAPLQTSS RLHSYVKAEE DSMEDPYELK LLKHQIKQEF RRGTESLDHL AGLSHYYHAD 4090 4100 4110 4120 4130 4140 TSYRHFPKSE KYSISRLTLE KQAAKQLPAA ILYQKQSKHK KALIDPKMSK FSPIQESRDL 4150 4160 4170 4180 4190 4200 EPDYPTYLSS STSSIGGISS RARLLQDDIT FGLRKNITDQ QKFMGSSLGS GLGTLGNTIR 4210 4220 4230 4240 4250 4260 SALQDEADKP YSSGSRSRPS SRPSSVYGLD LSIKRDSSSS SLRLKAQEAE ALDVSFGHSS 4270 4280 4290 4300 4310 4320 SSARTKPTSL PISQSRGRIP IVAQNSEEES PLSPVGQPMG MARAAAGPLP PISADTRDQF 4330 4340 4350 4360 4370 4380 GSSHSLPEVQ QHMREESRTR GYDRDIAFIM DDFQHAMSDS EAYHLRREET DWFDKPRESR 4390 4400 4410 4420 4430 4440 LENGHGLDRK LPERLVHSRP LSQHQEQILQ MNGKTMHYIF PHARIKITRD SKDHTVSGNG 4450 4460 4470 4480 4490 4500 LGIRIVGGKE IPGHSGEIGA YIAKILPGGS AEHSGKLIEG MQVLEWNGIP LTSKTYEEVQ 4510 4520 4530 4540 4550 4560 SIINQQSGEA EICVRLDLNM LSDSENPQHL ELHEPPKVVD KAKSPGVDPK QLAAELQKVS 4570 4580 4590 4600 4610 4620 LQQSPLVMSS VVEKGAHAHS GPTSAGSSSV PSPGQPGSPS VSKKKHGGSK PTDVSKTASH 4630 4640 4650 4660 4670 4680 PITGEIQLQI NYDLGNLIIH ILQARNLVPR DNNGYSDPFV KVYLLPGRGQ VMVVQNASVE 4690 4700 4710 4720 4730 4740 YKRRTKYVQK SLNPEWNQTV IYKSISMEQL MKKTLEVTVW DYDRFSSNDF LGEVLIDLSS 4750 4760 4770 4780 4790 4800 TSHLDNTPRW YPLKEQTESI EHGKSHSSQN SQQSPKPSVI KSRSHGIFPD PSKDMQVPTI 4810 4820 4830 4840 4850 4860 EKSHSSPGSS KSSSEGHLRS HGPSRSQSKT SVAQTHLEDA GAAIAAAEAA VQQLRIQPTK 4870 4880 4890 4900 4910 4920 PTNHRPAETS VSTGSSGSSV GSGYSVDSEG SSCVAGEPNL LPIPRIGKMG QNGQDPVKQP 4930 4940 4950 4960 4970 4980 GMGAADTEAK TQVMGEIKLA LKKEMKTDGE QLIVEILQCR NITYKFKSPD HLPDLYVKIY 4990 5000 5010 5020 5030 5040 VINIATQKKV IKKKTRVCRH DREPSFNETF RFSLSPAGHS LQILLFSNGG KFMKKTLIGE 5050 5060 ACIWLDKVDL RKRIVNWHKL LMSPTQTH
	Isoform 2 (S) [UniParc]. Checksum: 6F9A9B68DCBA59D2	FASTA	4,863	528,257
	10 20 30 40 50 60 MGNEASLEGE GLPEGLAAAA GGAGGSGSAL HPGIPAGMEA DLSQLSEEER RQIAAVMSRA 70 80 90 100 110 120 QGLPKGSVPA AAAESPSMHR KQELDSSQAP QQPGKPPDPG RPPQHGLSKS RTTDTFRSEQ 130 140 150 160 170 180 KLPGRSPSTI SLKESKSRTD FKEEYKSSMM PGFFSDVNPL SAVSSVVNKF NPFDLISDSE 190 200 210 220 230 240 AVQEETTKKQ KVAQKDQGKS EGITKPSLQQ PSPKLIPKQQ GPGKEVIPQD IPSKSVSSQQ 250 260 270 280 290 300 AEKTKPQAPG TAKPSQQSPA QTPAQQAKPV AQQPGPAKAT VQQPGPAKSP AQPAGTGKSP 310 320 330 340 350 360 AQPPVTAKPP AQQAGLEKTS LQQPGPKSLA QTPGQGKVPP GPAKSPAQQP GTAKLPAQQP 370 380 390 400 410 420 GPQTAAKVPG PTKTPAQLSG PGKTPAQQPG PTKPSPQQPI PAKPQPQQPV ATKPQPQQPA 430 440 450 460 470 480 PAKPQPQHPT PAKPQPQHPT PAKPQPQQPT PAKPQPQQPT PAKPQPQQPT PAKPQPQHPT 490 500 510 520 530 540 PAKPQPQQPG LGKPSAQQPS KSISQTVTGR PLQAPPTSAA QAPAQGLSKT ICPLCNTTEL 550 560 570 580 590 600 LLHTPEKANF NTCTECQSTV CSLCGFNPNP HLTEIKEWLC LNCQMQRALG GELAAIPSSP 610 620 630 640 650 660 QPTPKAASVQ PATASKSPVP SQQASPKKEL PSKQDSPKAP ESKKPPPLVK QPTLHGPTPA 670 680 690 700 710 720 TAPQPPVAEA LPKPAPPKKP SAALPEQAKA PVADVEPKQP KTTETLTDSP SSAAATSKPA 730 740 750 760 770 780 ILSSQVQAQA QVTTAPPLKT DSAKTSQSFP PTGDTITPLD SKAMPRPASD SKIVSHPGPT 790 800 810 820 830 840 SESKDPVQKK EEPKKAQTKV TPKPDTKPVP KGSPTPSGTR PTTGQATPQS QQPPKPPEQS 850 860 870 880 890 900 RRFSLNLGGI ADAPKSQPTT PQETVTGKLF GFGASIFSQA SNLISTAGQQ APHPQTGPAA 910 920 930 940 950 960 PSKQAPPPSQ TLAAQGPPKS TGPHPSAPAK TTAVKKETKG PAAENLEAKP VQAPTVKKAE 970 980 990 1000 1010 1020 KDKKPPPGKV SKPPPTEPEK AVLAQKPDKT TKPKPACPLC RTELNVGSQD PPNFNTCTEC 1030 1040 1050 1060 1070 1080 KNQVCNLCGF NPTPHLTEIQ EWLCLNCQTQ RAISGQLGDM DKMPPASSGP KASPVPAPAE 1090 1100 1110 1120 1130 1140 PPPQKTPTAA HAKGKKKETE VKAETEKQIP EKETPSIEKT PPAVATDQKL EESEVTKSLV 1150 1160 1170 1180 1190 1200 SVLPEKKPSE EEKALPADKK EKKPPAAEAP PLEEKKPIPD DQKLPPDAKP SASEGEEKRD 1210 1220 1230 1240 1250 1260 LLKAHVQIPE EGPIGKVASL ACEGEQQPDT RPEDLPGATP QTLPKDRQKE SRDVTQPQAE 1270 1280 1290 1300 1310 1320 GTAKEGRGEP SKDRTEKEED KSDTSSSQQP KSPQGLSDTG YSSDGISGSL GEIPSLIPSD 1330 1340 1350 1360 1370 1380 EKDLLKGLKK DSFSQESSPS SPSDLAKLES TVLSILEAQA STLVGEKAEK KTQPQKVSPE 1390 1400 1410 1420 1430 1440 QPQDQQKTQT PSETRDISIS EEEIKESQEK KVTSKKDSAQ GFPSRKEHKE NPELVDDLSP 1450 1460 1470 1480 1490 1500 RRASYDSVED SSESENSPVA RRKRRTSIGS SSSEEYKQED SQGSGEDEDF IRKQIIEMSA 1510 1520 1530 1540 1550 1560 DEDASGSEDE EFIRSQLKEI GGVTESQKRE ETKGKGKSPA GKHRRLTRKS STSFDDDAGR 1570 1580 1590 1600 1610 1620 RHSWHDEDDE TFDESPELKF RETKSQESEE LVVAGGGGLR RFKTIELNST VTDKYSAESS 1630 1640 1650 1660 1670 1680 QKKTTLYFDE EPELEMESLT DSPEDRSRGE GSSSLHASSF TPGTSPTSVS SLDEDSDSSP 1690 1700 1710 1720 1730 1740 SHKKGESKQQ RKARHRSHGP LLPTIEDSSE EEELREEEEL LKEQEKQREL EQQQRKSSSK 1750 1760 1770 1780 1790 1800 KSKKDKDELR AQRRRERPKT PPSNLSPIED ASPTEELRQA AEMEELHRSS CSEYSPSIES 1810 1820 1830 1840 1850 1860 DPEGFEISPE KIIEVQKVYK LPTAVSLYSP TDEQSVMQKE GAQKALKSAE EMYEEMMHKP 1870 1880 1890 1900 1910 1920 HKYKAFPAAN ERDEVFEKEP LYGGMLIEDY IYESLVEDTY NGSVDGSLLT RQDEQNGFMQ 1930 1940 1950 1960 1970 1980 QRGREQKIRL QEQIYDDPMQ KITDLQKEFY ELESLHSIVP QEDIVSSSYI IPESHEIVDL 1990 2000 2010 2020 2030 2040 GSMVTSTSEE KKLLDADAAY EELMKRQQMQ VTDGSSLIQT TMGDDMAEST LDFDRVQDAS 2050 2060 2070 2080 2090 2100 LTSSILSGAS LTDSTSSATL SIPDVKITQH FSTEEFEDEY VTDYTREIQE IIAHESLILT 2110 2120 2130 2140 2150 2160 YSEPSESATS VPPSDTPSLT SSISSVCTTD SSSPVTTLDS LTTVYTEPAD VITKFKDSEE 2170 2180 2190 2200 2210 2220 ISSTYFPGSV IDYPEDIGVS LDRTITPESR TNADQIMISF PGIAPSITES VATKPERPQA 2230 2240 2250 2260 2270 2280 DTISTDLPIS EKELIKGKKE TGDGIILEVL DAYKDKREES EAELTKISLP ETGLAPTPSS 2290 2300 2310 2320 2330 2340 QTKEQPGSPH SVSGEILGQE KPTYRSPSGG LPVSTHPSKS HPFFRSSSLD ISAQPPPPPP 2350 2360 2370 2380 2390 2400 PPPPPPPPPP PPPPPPLPPA TSPKPPTYPK RKLAAAAPVA PTAIVTAHAD AIPTVEATAA 2410 2420 2430 2440 2450 2460 RRSNGLPATK ICAAAPPPVP PKPSSIPTGL VFTHRPEASK PPIAPKPAVP EIPVTTQKTT 2470 2480 2490 2500 2510 2520 DTCPKPTGLP LTSNMSLNLV TSADYKLPSP TSPLSPHSNK SSPRYSKSLM ETYVVITLPS 2530 2540 2550 2560 2570 2580 EPGTPTDSSA AQAITSWPLG SPPKDLVSLE TVFSVVPPMT STEIPSASQP TLYTSGALGT 2590 2600 2610 2620 2630 2640 FSVTPAVTAS LFQTVPTSLT QFLPAEASKP EVSAVSSAVP SVAPRSVSIP IPPEPLALDR 2650 2660 2670 2680 2690 2700 HQYKENGKLP LIGDAIDLRT IPKSEVKVTE KCMDLSASAM DVKRQTTANE VYRRQISAVQ 2710 2720 2730 2740 2750 2760 PSIINLSAAS SLGTPVTMDS KTVAVVTCTD TTIYTTGTES QVGIEHAVTS PLQLTTSKHT 2770 2780 2790 2800 2810 2820 ELQYRKPSSQ AFPMIRDEAP INLSLGPSTQ AVTLAVTKPV TVPPVGVTNG WTDSTISQGI 2830 2840 2850 2860 2870 2880 TDGEVVDLST SKSHRTVVTM DESTSNVVTK IIEDEEKPVD LTAGRRAVCC DMVYKLPFGR 2890 2900 2910 2920 2930 2940 SCTAQQPATT LPEDRFGYRD DHYQYDRSGP YGYRGIGGMK PSMSDTNLAE AGHFFYKSKN 2950 2960 2970 2980 2990 3000 AFDYSGGTEA AVDLTSGRVS TGEVMDYSSK TTGPYPETRQ VISGVGISTP QYSTARMTPP 3010 3020 3030 3040 3050 3060 PGPQYGVGSV LRSSNGVVYS SVATPIPSTF AITTQPGSIF STTVRDLSGI HTTDAITSLS 3070 3080 3090 3100 3110 3120 ALHQSQPMPR SYFITTGASE TDISVTSIDI NASLQTITME TLPAETMDSV PTLTTASEVF 3130 3140 3150 3160 3170 3180 SEVVGEESTL LIVPDEDKQQ QQLDLERELL ELEKIKQQRF AEELEWERQE IQRFREQEKI 3190 3200 3210 3220 3230 3240 MVQKKLEELQ SMKQHLLYQQ EEERQAQFMM RQETLAQQQL QLEQIQQLQQ QLHQQLEEQK 3250 3260 3270 3280 3290 3300 LRQIYQYNYE PSGTASPQTT TEQAILEGQY VATEGSQFWA TEDATTTAST VVAIEIPQSQ 3310 3320 3330 3340 3350 3360 GWYTVQSDGV TQYIAPPGIL STVSEIPLTD VVVKEEKQPK KRSSGAKVRG QYDEMGESMA 3370 3380 3390 3400 3410 3420 DDPRNLKKIV DSGVQTDDEE TADRTYASRR RRTKKSVDTS VQTDDEDQDE WDMPSRSRRK 3430 3440 3450 3460 3470 3480 ARTGKYGDST AEGDKTKPPS KVSSVAVQTV AEISVQTEPL GTIRTPSIRA RVDAKVEIIK 3490 3500 3510 3520 3530 3540 HISAPEKTYK GGSLGCQTET DPDTQSPPYM GATSPPKDKK RPTPLEIGYS SSHLRADPTV 3550 3560 3570 3580 3590 3600 QLAPSPPKSP KVLYSPISPL SPGHALEPAF VPYEKPLPDD ISPQKVLHPD MAKVPPASPK 3610 3620 3630 3640 3650 3660 TAKMMQRSMS DPKPLSPTAD ESSRAPFQYS EGFTAKGSQT TSGTQKKVKR TLPNPPPEEA 3670 3680 3690 3700 3710 3720 STGTQSTYST MGTASRRRMC RTNTMARAKI LQDIDRELDL VERESAKLRK KQAELDEEEK 3730 3740 3750 3760 3770 3780 EIDAKLRYLE MGINRRKEAL LKEREKRERA YLQGVAEDRD YMSDSEVSST RPSRVESQHG 3790 3800 3810 3820 3830 3840 IERPRTAPQT EFSQFIPPQT QTEAQLVPPT SPYTQYQYSS PALPTQAPTP YTQQSHFQQQ 3850 3860 3870 3880 3890 3900 TLYHQQVSPY QTQPTFQAVA TMSFTPQAQP TPTPQPSYQL PSQMMVIQQK PRQTTLYLEP 3910 3920 3930 3940 3950 3960 KITSTYEVIR NQPLMIAPVS TDNTYAVSHL GSKYNSLDLR IGLEERSSMA SSPISSISAD 3970 3980 3990 4000 4010 4020 SFYADIDHHT SRNYVLIDDI GDITKGTAAL SSAFSLHEKD LSKTDRLLRT TETRRSQEVT 4030 4040 4050 4060 4070 4080 DFLAPLQTSS RLHSYVKAEE DSMEDPYELK LLKHQIKQEF RRGTESLDHL AGLSHYYHAD 4090 4100 4110 4120 4130 4140 TSYRHFPKSE KYSISRLTLE KQAAKQLPAA ILYQKQSKHK KALIDPKMSK FSPIQESRDL 4150 4160 4170 4180 4190 4200 EPDYPTYLSS STSSIGGISS RARLLQDDIT FGLRKNITDQ QKFMGSSLGS GLGTLGNTIR 4210 4220 4230 4240 4250 4260 SALQDEADKP YSSGSRSRPS SRPSSVYGLD LSIKRDSSSS SLRLKAQEAE ALDVSFGHSS 4270 4280 4290 4300 4310 4320 SSARTKPTSL PISQSRGRIP IVAQNSEEES PLSPVGQPMG MARAAAGPLP PISADTRDQF 4330 4340 4350 4360 4370 4380 GSSHSLPEVQ QHMREESRTR GYDRDIAFIM DDFQHAMSDS EAYHLRREET DWFDKPRESR 4390 4400 4410 4420 4430 4440 LENGHGLDRK LPERLVHSRP LSQHQEQILQ MNGKTMHYIF PHARIKITRD SKDHTVSGNG 4450 4460 4470 4480 4490 4500 LGIRIVGGKE IPGHSGEIGA YIAKILPGGS AEHSGKLIEG MQVLEWNGIP LTSKTYEEVQ 4510 4520 4530 4540 4550 4560 SIINQQSGEA EICVRLDLNM LSDSENPQHL ELHEPPKVVD KAKSPGVDPK QLAAELQKVS 4570 4580 4590 4600 4610 4620 LQQSPLVMSS VVEKGAHAHS GPTSAGSSSV PSPGQPGSPS VSKKKHGGSK PTDVSKTASH 4630 4640 4650 4660 4670 4680 PITGEIQLQI NYDLGNLIIH ILQARNLVPR DNNGYSDPFV KVYLLPGRGQ VMVVQNASVE 4690 4700 4710 4720 4730 4740 YKRRTKYVQK SLNPEWNQTV IYKSISMEQL MKKTLEVTVW DYDRFSSNDF LGEVLIDLSS 4750 4760 4770 4780 4790 4800 TSHLDNTPRW YPLKEQTESI EHGKSHSSQN SQQSPKPSVI KSRSHGIFPD PSKDMQVPTI 4810 4820 4830 4840 4850 4860 EKSHSSPGSS KSSSEGHLRS HGPSRSQSKT SVAQTHLEDA GAAIAAAEAA VQQLRIQPSK RRK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Aczonin, a 550-kd putative scaffolding protein of presynaptic active zones, shares homology regions with rim and bassoon and binds profilin." Wang X., Kibschull M., Laue M.M., Lichte B., Petrasch-Parwez E., Kilimann M.W. J. Cell Biol. 147:151-162(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, SUBCELLULAR LOCATION, ALTERNATIVE SPLICING, TISSUE SPECIFICITY, INTERACTION WITH PROFILIN. Tissue: Brain.
[2]	Kilimann M.W. Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.
[3]	"Piccolo, a Ca2+ sensor in pancreatic beta-cells. Involvement of cAMP-GEFII.Rim2.Piccolo complex in cAMP-dependent exocytosis." Fujimoto K., Shibasaki T., Yokoi N., Kashima Y., Matsumoto M., Sasaki T., Tajima N., Iwanaga T., Seino S. J. Biol. Chem. 277:50497-50502(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY, INTERACTION WITH RIMS2.
[4]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[5]	"Mus musculus brain-derived reactive mRNA." Huang W., Jin W., Huang C., Chen B., Zhang J., Ju G. Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4532-4712. Tissue: Brain.
[6]	"Proteomic analysis of in vivo phosphorylated synaptic proteins." Collins M.O., Yu L., Coba M.P., Husi H., Campuzano I., Blackstock W.P., Choudhary J.S., Grant S.G. J. Biol. Chem. 280:5972-5982(2005) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1439; SER-1575; THR-1760; SER-1766; SER-1772; SER-1829; SER-3610; SER-3616; THR-3894; THR-3895; SER-4286; SER-4290; SER-4293 AND SER-4325, MASS SPECTROMETRY. Tissue: Forebrain.
[7]	"Comprehensive identification of phosphorylation sites in postsynaptic density preparations." Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L. Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1439; SER-1766; SER-1772; SER-1829; THR-2998; SER-3358; THR-3376; SER-3610; SER-3616; SER-3763 AND SER-3952, MASS SPECTROMETRY. Tissue: Brain.
[8]	"O-linked N-acetylglucosamine proteomics of postsynaptic density preparations using lectin weak affinity chromatography and mass spectrometry." Vosseller K., Trinidad J.C., Chalkley R.J., Specht C.G., Thalhammer A., Lynn A.J., Snedecor J.O., Guan S., Medzihradszky K.F., Maltby D.A., Schoepfer R., Burlingame A.L. Mol. Cell. Proteomics 5:923-934(2006) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT THR-2686 AND SER-2960, MASS SPECTROMETRY. Tissue: Brain.
[9]	"Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain." Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P. J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-3761 AND SER-3763, MASS SPECTROMETRY. Tissue: Brain.
[10]	"Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations." Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M. Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-625; SER-748; THR-860; THR-1120; SER-1340; SER-1341; SER-1400; SER-1439; SER-1444; SER-1457; SER-1585; SER-1763; SER-1766; SER-1772; SER-1808; TYR-1828; THR-2998; THR-3513; SER-3545; SER-3610 AND SER-3936, MASS SPECTROMETRY. Tissue: Brain cortex.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y19185 mRNA. Translation: CAB60731.2. Sequence problems. Y19186 mRNA. Translation: CAB60732.2. Sequence problems. AB083477 mRNA. Translation: BAC53723.1. Sequence problems. AB083478 mRNA. Translation: BAC53724.1. Sequence problems. AC125043 Genomic DNA. No translation available. AC125533 Genomic DNA. No translation available. AC144480 Genomic DNA. No translation available. AC144625 Genomic DNA. No translation available. AF181269 mRNA. Translation: AAD55786.2.
IPI	IPI00225140. IPI00468100. IPI00752192. IPI00754054.
RefSeq	NP_001104266.1. NM_001110796.1. NP_036125.4. NM_011995.4.
UniGene	Mm.146275.
3D structure databases
ProteinModelPortal	Q9QYX7.
SMR	Q9QYX7. Positions 4412-4520, 4618-4759.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9QYX7. 1 interaction.
STRING	10090.ENSMUSP00000030691.
PTM databases
PhosphoSite	Q9QYX7.
Proteomic databases
PaxDb	Q9QYX7.
PRIDE	Q9QYX7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000030691; ENSMUSP00000030691; ENSMUSG00000061601.
GeneID	26875.
KEGG	mmu:26875.
UCSC	uc008wmi.2. mouse.
Organism-specific databases
CTD	27445.
MGI	MGI:1349390. Pclo.
Phylogenomic databases
eggNOG	NOG12793.
GeneTree	ENSGT00620000087961.
HOGENOM	HOG000168263.
HOVERGEN	HBG031058.
InParanoid	Q9QYX7.
OMA	YSVDSEG.
Gene expression databases
CleanEx	MM_PCLO.
Genevestigator	Q9QYX7.
GermOnline	ENSMUSG00000061601. Mus musculus.
Family and domain databases
Gene3D	3.30.40.10. 2 hits.
InterPro	IPR000008. C2_Ca-dep. IPR008973. C2_Ca/lipid-bd_dom_CaLB. IPR018029. C2_membr_targeting. IPR001478. PDZ. IPR011011. Znf_FYVE_PHD. IPR008899. Znf_piccolo. IPR013083. Znf_RING/FYVE/PHD. [Graphical view]
Pfam	PF00168. C2. 2 hits. PF00595. PDZ. 1 hit. PF05715. zf-piccolo. 2 hits. [Graphical view]
SMART	SM00239. C2. 2 hits. SM00228. PDZ. 1 hit. [Graphical view]
SUPFAM	SSF49562. C2_CaLB. 2 hits. SSF57903. FYVE_PHD_ZnF. 2 hits. SSF50156. PDZ. 1 hit.
PROSITE	PS50004. C2. 2 hits. PS50106. PDZ. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	PCLO. mouse.
NextBio	304679.
SOURCE	Search...

Entry information

Entry name

PCLO_MOUSE

Accession

Primary (citable) accession number: Q9QYX7
Secondary accession number(s): E9QK94 , Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 19, 2002
Last sequence update:	January 9, 2013
Last modified:	May 1, 2013
This is version 106 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program