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Q9QYX7 (PCLO_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein piccolo
Alternative name(s):
Aczonin
Brain-derived HLMN protein
Multidomain presynaptic cytomatrix protein
Gene names
Name:Pclo
Synonyms:Acz
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length5068 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May act as a scaffolding protein involved in the organization of synaptic active zones and in synaptic vesicle trafficking. Ref.1

Subunit structure

Interacts with RABAC1/PRA1, RIMS2 and profilin. Ref.1 Ref.3

Subcellular location

Cell junctionsynapse. Note: Concentrated at the presynaptic side of synaptic junctions. Ref.1

Tissue specificity

Highly expressed in brain. Moderately expressed in pituitary gland and pancreatic islets. Low levels found in stomach. Ref.1 Ref.3

Domain

C2 domain 1 is involved in binding calcium and phospholipids. Calcium binds with low affinity but with high specificity and induces a large conformational change. UniProtKB Q9JKS6

Sequence similarities

Contains 2 C2 domains.

Contains 1 PDZ (DHR) domain.

Sequence caution

The sequence BAC53723.1 differs from that shown. Reason: Unlikely isoform. Several sequence problems.

The sequence BAC53724.1 differs from that shown. Reason: Unlikely isoform. Several sequence problems.

The sequence CAB60731.2 differs from that shown. Reason: Probable cloning artifact.

The sequence CAB60732.2 differs from that shown. Reason: Probable cloning artifact.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9QYX7-1)

Also known as: L;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9QYX7-2)

Also known as: S;

The sequence of this isoform differs from the canonical sequence as follows:
     4859-4863: TKPTN → SKRRK
     4864-5068: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 50685068Protein piccolo
PRO_0000058251

Regions

Domain4424 – 451895PDZ
Domain4637 – 473599C2 1
Domain4952 – 504291C2 2
Zinc finger532 – 55625C4-type Potential
Zinc finger997 – 102024C4-type Potential
Region401 – 50010010 X 10 AA tandem approximate repeats of P-A-K-P-Q-P-Q-Q-P-X
Compositional bias2335 – 235925Poly-Pro

Amino acid modifications

Modified residue17661Phosphoserine Ref.6
Modified residue33581Phosphoserine Ref.6
Modified residue33761Phosphothreonine Ref.6
Glycosylation26861O-linked (GlcNAc) Ref.7
Glycosylation29601O-linked (GlcNAc) Ref.7

Natural variations

Alternative sequence4859 – 48635TKPTN → SKRRK in isoform 2.
VSP_003928
Alternative sequence4864 – 5068205Missing in isoform 2.
VSP_003929

Experimental info

Sequence conflict1561D → E in CAB60731. Ref.1
Sequence conflict1561D → E in CAB60732. Ref.1
Sequence conflict3661A → S in CAB60731. Ref.1
Sequence conflict3661A → S in CAB60732. Ref.1
Sequence conflict4381H → Q in CAB60731. Ref.1
Sequence conflict4381H → Q in CAB60732. Ref.1
Sequence conflict4381H → Q in BAC53723. Ref.3
Sequence conflict4381H → Q in BAC53724. Ref.3
Sequence conflict4781H → Q in CAB60731. Ref.1
Sequence conflict4781H → Q in CAB60732. Ref.1
Sequence conflict4781H → Q in BAC53723. Ref.3
Sequence conflict4781H → Q in BAC53724. Ref.3
Sequence conflict9231P → Q in CAB60731. Ref.1
Sequence conflict9231P → Q in CAB60732. Ref.1
Sequence conflict9231P → Q in BAC53723. Ref.3
Sequence conflict9231P → Q in BAC53724. Ref.3
Sequence conflict9511V → A in CAB60731. Ref.1
Sequence conflict9511V → A in CAB60732. Ref.1
Sequence conflict9651P → H in CAB60731. Ref.1
Sequence conflict9651P → H in CAB60732. Ref.1
Sequence conflict19201Q → P in CAB60731. Ref.1
Sequence conflict19201Q → P in CAB60732. Ref.1
Sequence conflict19311Q → R in CAB60731. Ref.1
Sequence conflict19311Q → R in CAB60732. Ref.1
Sequence conflict22971L → S in CAB60731. Ref.1
Sequence conflict22971L → S in CAB60732. Ref.1
Sequence conflict2335 – 234612Missing in BAC53723. Ref.3
Sequence conflict2335 – 234612Missing in BAC53724. Ref.3
Sequence conflict28551E → D in CAB60731. Ref.1
Sequence conflict28551E → D in CAB60732. Ref.1
Sequence conflict40421S → P in CAB60731. Ref.1
Sequence conflict40421S → P in CAB60732. Ref.1
Sequence conflict4670 – 46789Missing in BAC53724. Ref.3
Sequence conflict50621M → V in CAB60731. Ref.1
Sequence conflict50621M → V in CAB60732. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (L) [UniParc].

Last modified January 9, 2013. Version 4.
Checksum: DBF54D47501AC79A

FASTA5,068550,834
        10         20         30         40         50         60 
MGNEASLEGE GLPEGLAAAA GGAGGSGSAL HPGIPAGMEA DLSQLSEEER RQIAAVMSRA 

        70         80         90        100        110        120 
QGLPKGSVPA AAAESPSMHR KQELDSSQAP QQPGKPPDPG RPPQHGLSKS RTTDTFRSEQ 

       130        140        150        160        170        180 
KLPGRSPSTI SLKESKSRTD FKEEYKSSMM PGFFSDVNPL SAVSSVVNKF NPFDLISDSE 

       190        200        210        220        230        240 
AVQEETTKKQ KVAQKDQGKS EGITKPSLQQ PSPKLIPKQQ GPGKEVIPQD IPSKSVSSQQ 

       250        260        270        280        290        300 
AEKTKPQAPG TAKPSQQSPA QTPAQQAKPV AQQPGPAKAT VQQPGPAKSP AQPAGTGKSP 

       310        320        330        340        350        360 
AQPPVTAKPP AQQAGLEKTS LQQPGPKSLA QTPGQGKVPP GPAKSPAQQP GTAKLPAQQP 

       370        380        390        400        410        420 
GPQTAAKVPG PTKTPAQLSG PGKTPAQQPG PTKPSPQQPI PAKPQPQQPV ATKPQPQQPA 

       430        440        450        460        470        480 
PAKPQPQHPT PAKPQPQHPT PAKPQPQQPT PAKPQPQQPT PAKPQPQQPT PAKPQPQHPT 

       490        500        510        520        530        540 
PAKPQPQQPG LGKPSAQQPS KSISQTVTGR PLQAPPTSAA QAPAQGLSKT ICPLCNTTEL 

       550        560        570        580        590        600 
LLHTPEKANF NTCTECQSTV CSLCGFNPNP HLTEIKEWLC LNCQMQRALG GELAAIPSSP 

       610        620        630        640        650        660 
QPTPKAASVQ PATASKSPVP SQQASPKKEL PSKQDSPKAP ESKKPPPLVK QPTLHGPTPA 

       670        680        690        700        710        720 
TAPQPPVAEA LPKPAPPKKP SAALPEQAKA PVADVEPKQP KTTETLTDSP SSAAATSKPA 

       730        740        750        760        770        780 
ILSSQVQAQA QVTTAPPLKT DSAKTSQSFP PTGDTITPLD SKAMPRPASD SKIVSHPGPT 

       790        800        810        820        830        840 
SESKDPVQKK EEPKKAQTKV TPKPDTKPVP KGSPTPSGTR PTTGQATPQS QQPPKPPEQS 

       850        860        870        880        890        900 
RRFSLNLGGI ADAPKSQPTT PQETVTGKLF GFGASIFSQA SNLISTAGQQ APHPQTGPAA 

       910        920        930        940        950        960 
PSKQAPPPSQ TLAAQGPPKS TGPHPSAPAK TTAVKKETKG PAAENLEAKP VQAPTVKKAE 

       970        980        990       1000       1010       1020 
KDKKPPPGKV SKPPPTEPEK AVLAQKPDKT TKPKPACPLC RTELNVGSQD PPNFNTCTEC 

      1030       1040       1050       1060       1070       1080 
KNQVCNLCGF NPTPHLTEIQ EWLCLNCQTQ RAISGQLGDM DKMPPASSGP KASPVPAPAE 

      1090       1100       1110       1120       1130       1140 
PPPQKTPTAA HAKGKKKETE VKAETEKQIP EKETPSIEKT PPAVATDQKL EESEVTKSLV 

      1150       1160       1170       1180       1190       1200 
SVLPEKKPSE EEKALPADKK EKKPPAAEAP PLEEKKPIPD DQKLPPDAKP SASEGEEKRD 

      1210       1220       1230       1240       1250       1260 
LLKAHVQIPE EGPIGKVASL ACEGEQQPDT RPEDLPGATP QTLPKDRQKE SRDVTQPQAE 

      1270       1280       1290       1300       1310       1320 
GTAKEGRGEP SKDRTEKEED KSDTSSSQQP KSPQGLSDTG YSSDGISGSL GEIPSLIPSD 

      1330       1340       1350       1360       1370       1380 
EKDLLKGLKK DSFSQESSPS SPSDLAKLES TVLSILEAQA STLVGEKAEK KTQPQKVSPE 

      1390       1400       1410       1420       1430       1440 
QPQDQQKTQT PSETRDISIS EEEIKESQEK KVTSKKDSAQ GFPSRKEHKE NPELVDDLSP 

      1450       1460       1470       1480       1490       1500 
RRASYDSVED SSESENSPVA RRKRRTSIGS SSSEEYKQED SQGSGEDEDF IRKQIIEMSA 

      1510       1520       1530       1540       1550       1560 
DEDASGSEDE EFIRSQLKEI GGVTESQKRE ETKGKGKSPA GKHRRLTRKS STSFDDDAGR 

      1570       1580       1590       1600       1610       1620 
RHSWHDEDDE TFDESPELKF RETKSQESEE LVVAGGGGLR RFKTIELNST VTDKYSAESS 

      1630       1640       1650       1660       1670       1680 
QKKTTLYFDE EPELEMESLT DSPEDRSRGE GSSSLHASSF TPGTSPTSVS SLDEDSDSSP 

      1690       1700       1710       1720       1730       1740 
SHKKGESKQQ RKARHRSHGP LLPTIEDSSE EEELREEEEL LKEQEKQREL EQQQRKSSSK 

      1750       1760       1770       1780       1790       1800 
KSKKDKDELR AQRRRERPKT PPSNLSPIED ASPTEELRQA AEMEELHRSS CSEYSPSIES 

      1810       1820       1830       1840       1850       1860 
DPEGFEISPE KIIEVQKVYK LPTAVSLYSP TDEQSVMQKE GAQKALKSAE EMYEEMMHKP 

      1870       1880       1890       1900       1910       1920 
HKYKAFPAAN ERDEVFEKEP LYGGMLIEDY IYESLVEDTY NGSVDGSLLT RQDEQNGFMQ 

      1930       1940       1950       1960       1970       1980 
QRGREQKIRL QEQIYDDPMQ KITDLQKEFY ELESLHSIVP QEDIVSSSYI IPESHEIVDL 

      1990       2000       2010       2020       2030       2040 
GSMVTSTSEE KKLLDADAAY EELMKRQQMQ VTDGSSLIQT TMGDDMAEST LDFDRVQDAS 

      2050       2060       2070       2080       2090       2100 
LTSSILSGAS LTDSTSSATL SIPDVKITQH FSTEEFEDEY VTDYTREIQE IIAHESLILT 

      2110       2120       2130       2140       2150       2160 
YSEPSESATS VPPSDTPSLT SSISSVCTTD SSSPVTTLDS LTTVYTEPAD VITKFKDSEE 

      2170       2180       2190       2200       2210       2220 
ISSTYFPGSV IDYPEDIGVS LDRTITPESR TNADQIMISF PGIAPSITES VATKPERPQA 

      2230       2240       2250       2260       2270       2280 
DTISTDLPIS EKELIKGKKE TGDGIILEVL DAYKDKREES EAELTKISLP ETGLAPTPSS 

      2290       2300       2310       2320       2330       2340 
QTKEQPGSPH SVSGEILGQE KPTYRSPSGG LPVSTHPSKS HPFFRSSSLD ISAQPPPPPP 

      2350       2360       2370       2380       2390       2400 
PPPPPPPPPP PPPPPPLPPA TSPKPPTYPK RKLAAAAPVA PTAIVTAHAD AIPTVEATAA 

      2410       2420       2430       2440       2450       2460 
RRSNGLPATK ICAAAPPPVP PKPSSIPTGL VFTHRPEASK PPIAPKPAVP EIPVTTQKTT 

      2470       2480       2490       2500       2510       2520 
DTCPKPTGLP LTSNMSLNLV TSADYKLPSP TSPLSPHSNK SSPRYSKSLM ETYVVITLPS 

      2530       2540       2550       2560       2570       2580 
EPGTPTDSSA AQAITSWPLG SPPKDLVSLE TVFSVVPPMT STEIPSASQP TLYTSGALGT 

      2590       2600       2610       2620       2630       2640 
FSVTPAVTAS LFQTVPTSLT QFLPAEASKP EVSAVSSAVP SVAPRSVSIP IPPEPLALDR 

      2650       2660       2670       2680       2690       2700 
HQYKENGKLP LIGDAIDLRT IPKSEVKVTE KCMDLSASAM DVKRQTTANE VYRRQISAVQ 

      2710       2720       2730       2740       2750       2760 
PSIINLSAAS SLGTPVTMDS KTVAVVTCTD TTIYTTGTES QVGIEHAVTS PLQLTTSKHT 

      2770       2780       2790       2800       2810       2820 
ELQYRKPSSQ AFPMIRDEAP INLSLGPSTQ AVTLAVTKPV TVPPVGVTNG WTDSTISQGI 

      2830       2840       2850       2860       2870       2880 
TDGEVVDLST SKSHRTVVTM DESTSNVVTK IIEDEEKPVD LTAGRRAVCC DMVYKLPFGR 

      2890       2900       2910       2920       2930       2940 
SCTAQQPATT LPEDRFGYRD DHYQYDRSGP YGYRGIGGMK PSMSDTNLAE AGHFFYKSKN 

      2950       2960       2970       2980       2990       3000 
AFDYSGGTEA AVDLTSGRVS TGEVMDYSSK TTGPYPETRQ VISGVGISTP QYSTARMTPP 

      3010       3020       3030       3040       3050       3060 
PGPQYGVGSV LRSSNGVVYS SVATPIPSTF AITTQPGSIF STTVRDLSGI HTTDAITSLS 

      3070       3080       3090       3100       3110       3120 
ALHQSQPMPR SYFITTGASE TDISVTSIDI NASLQTITME TLPAETMDSV PTLTTASEVF 

      3130       3140       3150       3160       3170       3180 
SEVVGEESTL LIVPDEDKQQ QQLDLERELL ELEKIKQQRF AEELEWERQE IQRFREQEKI 

      3190       3200       3210       3220       3230       3240 
MVQKKLEELQ SMKQHLLYQQ EEERQAQFMM RQETLAQQQL QLEQIQQLQQ QLHQQLEEQK 

      3250       3260       3270       3280       3290       3300 
LRQIYQYNYE PSGTASPQTT TEQAILEGQY VATEGSQFWA TEDATTTAST VVAIEIPQSQ 

      3310       3320       3330       3340       3350       3360 
GWYTVQSDGV TQYIAPPGIL STVSEIPLTD VVVKEEKQPK KRSSGAKVRG QYDEMGESMA 

      3370       3380       3390       3400       3410       3420 
DDPRNLKKIV DSGVQTDDEE TADRTYASRR RRTKKSVDTS VQTDDEDQDE WDMPSRSRRK 

      3430       3440       3450       3460       3470       3480 
ARTGKYGDST AEGDKTKPPS KVSSVAVQTV AEISVQTEPL GTIRTPSIRA RVDAKVEIIK 

      3490       3500       3510       3520       3530       3540 
HISAPEKTYK GGSLGCQTET DPDTQSPPYM GATSPPKDKK RPTPLEIGYS SSHLRADPTV 

      3550       3560       3570       3580       3590       3600 
QLAPSPPKSP KVLYSPISPL SPGHALEPAF VPYEKPLPDD ISPQKVLHPD MAKVPPASPK 

      3610       3620       3630       3640       3650       3660 
TAKMMQRSMS DPKPLSPTAD ESSRAPFQYS EGFTAKGSQT TSGTQKKVKR TLPNPPPEEA 

      3670       3680       3690       3700       3710       3720 
STGTQSTYST MGTASRRRMC RTNTMARAKI LQDIDRELDL VERESAKLRK KQAELDEEEK 

      3730       3740       3750       3760       3770       3780 
EIDAKLRYLE MGINRRKEAL LKEREKRERA YLQGVAEDRD YMSDSEVSST RPSRVESQHG 

      3790       3800       3810       3820       3830       3840 
IERPRTAPQT EFSQFIPPQT QTEAQLVPPT SPYTQYQYSS PALPTQAPTP YTQQSHFQQQ 

      3850       3860       3870       3880       3890       3900 
TLYHQQVSPY QTQPTFQAVA TMSFTPQAQP TPTPQPSYQL PSQMMVIQQK PRQTTLYLEP 

      3910       3920       3930       3940       3950       3960 
KITSTYEVIR NQPLMIAPVS TDNTYAVSHL GSKYNSLDLR IGLEERSSMA SSPISSISAD 

      3970       3980       3990       4000       4010       4020 
SFYADIDHHT SRNYVLIDDI GDITKGTAAL SSAFSLHEKD LSKTDRLLRT TETRRSQEVT 

      4030       4040       4050       4060       4070       4080 
DFLAPLQTSS RLHSYVKAEE DSMEDPYELK LLKHQIKQEF RRGTESLDHL AGLSHYYHAD 

      4090       4100       4110       4120       4130       4140 
TSYRHFPKSE KYSISRLTLE KQAAKQLPAA ILYQKQSKHK KALIDPKMSK FSPIQESRDL 

      4150       4160       4170       4180       4190       4200 
EPDYPTYLSS STSSIGGISS RARLLQDDIT FGLRKNITDQ QKFMGSSLGS GLGTLGNTIR 

      4210       4220       4230       4240       4250       4260 
SALQDEADKP YSSGSRSRPS SRPSSVYGLD LSIKRDSSSS SLRLKAQEAE ALDVSFGHSS 

      4270       4280       4290       4300       4310       4320 
SSARTKPTSL PISQSRGRIP IVAQNSEEES PLSPVGQPMG MARAAAGPLP PISADTRDQF 

      4330       4340       4350       4360       4370       4380 
GSSHSLPEVQ QHMREESRTR GYDRDIAFIM DDFQHAMSDS EAYHLRREET DWFDKPRESR 

      4390       4400       4410       4420       4430       4440 
LENGHGLDRK LPERLVHSRP LSQHQEQILQ MNGKTMHYIF PHARIKITRD SKDHTVSGNG 

      4450       4460       4470       4480       4490       4500 
LGIRIVGGKE IPGHSGEIGA YIAKILPGGS AEHSGKLIEG MQVLEWNGIP LTSKTYEEVQ 

      4510       4520       4530       4540       4550       4560 
SIINQQSGEA EICVRLDLNM LSDSENPQHL ELHEPPKVVD KAKSPGVDPK QLAAELQKVS 

      4570       4580       4590       4600       4610       4620 
LQQSPLVMSS VVEKGAHAHS GPTSAGSSSV PSPGQPGSPS VSKKKHGGSK PTDVSKTASH 

      4630       4640       4650       4660       4670       4680 
PITGEIQLQI NYDLGNLIIH ILQARNLVPR DNNGYSDPFV KVYLLPGRGQ VMVVQNASVE 

      4690       4700       4710       4720       4730       4740 
YKRRTKYVQK SLNPEWNQTV IYKSISMEQL MKKTLEVTVW DYDRFSSNDF LGEVLIDLSS 

      4750       4760       4770       4780       4790       4800 
TSHLDNTPRW YPLKEQTESI EHGKSHSSQN SQQSPKPSVI KSRSHGIFPD PSKDMQVPTI 

      4810       4820       4830       4840       4850       4860 
EKSHSSPGSS KSSSEGHLRS HGPSRSQSKT SVAQTHLEDA GAAIAAAEAA VQQLRIQPTK 

      4870       4880       4890       4900       4910       4920 
PTNHRPAETS VSTGSSGSSV GSGYSVDSEG SSCVAGEPNL LPIPRIGKMG QNGQDPVKQP 

      4930       4940       4950       4960       4970       4980 
GMGAADTEAK TQVMGEIKLA LKKEMKTDGE QLIVEILQCR NITYKFKSPD HLPDLYVKIY 

      4990       5000       5010       5020       5030       5040 
VINIATQKKV IKKKTRVCRH DREPSFNETF RFSLSPAGHS LQILLFSNGG KFMKKTLIGE 

      5050       5060 
ACIWLDKVDL RKRIVNWHKL LMSPTQTH 

« Hide

Isoform 2 (S) [UniParc].

Checksum: 6F9A9B68DCBA59D2
Show »

FASTA4,863528,257

References

« Hide 'large scale' references
[1]"Aczonin, a 550-kd putative scaffolding protein of presynaptic active zones, shares homology regions with rim and bassoon and binds profilin."
Wang X., Kibschull M., Laue M.M., Lichte B., Petrasch-Parwez E., Kilimann M.W.
J. Cell Biol. 147:151-162(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, SUBCELLULAR LOCATION, ALTERNATIVE SPLICING, TISSUE SPECIFICITY, INTERACTION WITH PROFILIN.
Tissue: Brain.
[2]Kilimann M.W.
Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION.
[3]"Piccolo, a Ca2+ sensor in pancreatic beta-cells. Involvement of cAMP-GEFII.Rim2.Piccolo complex in cAMP-dependent exocytosis."
Fujimoto K., Shibasaki T., Yokoi N., Kashima Y., Matsumoto M., Sasaki T., Tajima N., Iwanaga T., Seino S.
J. Biol. Chem. 277:50497-50502(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY, INTERACTION WITH RIMS2.
[4]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[5]"Mus musculus brain-derived reactive mRNA."
Huang W., Jin W., Huang C., Chen B., Zhang J., Ju G.
Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4532-4712.
Tissue: Brain.
[6]"Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1766; SER-3358 AND THR-3376, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Brain.
[7]"O-linked N-acetylglucosamine proteomics of postsynaptic density preparations using lectin weak affinity chromatography and mass spectrometry."
Vosseller K., Trinidad J.C., Chalkley R.J., Specht C.G., Thalhammer A., Lynn A.J., Snedecor J.O., Guan S., Medzihradszky K.F., Maltby D.A., Schoepfer R., Burlingame A.L.
Mol. Cell. Proteomics 5:923-934(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT THR-2686 AND SER-2960.
Tissue: Brain.
[8]"Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Brain cortex.
[9]"Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.
J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y19185 mRNA. Translation: CAB60731.2. Sequence problems.
Y19186 mRNA. Translation: CAB60732.2. Sequence problems.
AB083477 mRNA. Translation: BAC53723.1. Sequence problems.
AB083478 mRNA. Translation: BAC53724.1. Sequence problems.
AC125043 Genomic DNA. No translation available.
AC125533 Genomic DNA. No translation available.
AC144480 Genomic DNA. No translation available.
AC144625 Genomic DNA. No translation available.
AF181269 mRNA. Translation: AAD55786.2.
RefSeqNP_001104266.1. NM_001110796.2.
NP_036125.4. NM_011995.4.
UniGeneMm.146275.

3D structure databases

ProteinModelPortalQ9QYX7.
SMRQ9QYX7. Positions 4412-4520, 4618-4759.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid205033. 3 interactions.
IntActQ9QYX7. 2 interactions.
MINTMINT-4106700.
STRING10090.ENSMUSP00000030691.

PTM databases

PhosphoSiteQ9QYX7.

Proteomic databases

PaxDbQ9QYX7.
PRIDEQ9QYX7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000030691; ENSMUSP00000030691; ENSMUSG00000061601. [Q9QYX7-1]
ENSMUST00000182407; ENSMUSP00000138419; ENSMUSG00000061601. [Q9QYX7-2]
GeneID26875.
KEGGmmu:26875.

Organism-specific databases

CTD27445.
MGIMGI:1349390. Pclo.

Phylogenomic databases

eggNOGNOG12793.
GeneTreeENSGT00620000087961.
HOGENOMHOG000168263.
HOVERGENHBG031058.
InParanoidQ9QYX7.
KOK16882.
OMAPAAILYQ.
OrthoDBEOG73805D.

Gene expression databases

CleanExMM_PCLO.
GenevestigatorQ9QYX7.

Family and domain databases

Gene3D2.30.42.10. 1 hit.
2.60.40.150. 2 hits.
3.30.40.10. 2 hits.
InterProIPR000008. C2_dom.
IPR001478. PDZ.
IPR011011. Znf_FYVE_PHD.
IPR008899. Znf_piccolo.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamPF00168. C2. 2 hits.
PF00595. PDZ. 1 hit.
PF05715. zf-piccolo. 2 hits.
[Graphical view]
SMARTSM00239. C2. 2 hits.
SM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMSSF49562. SSF49562. 2 hits.
SSF50156. SSF50156. 1 hit.
SSF57903. SSF57903. 2 hits.
PROSITEPS50004. C2. 2 hits.
PS50106. PDZ. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSPCLO. mouse.
NextBio304679.
PROQ9QYX7.
SOURCESearch...

Entry information

Entry namePCLO_MOUSE
AccessionPrimary (citable) accession number: Q9QYX7
Secondary accession number(s): E9QK94 expand/collapse secondary AC list , Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0
Entry history
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: January 9, 2013
Last modified: April 16, 2014
This is version 115 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot