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Protein

Epithelial membrane protein 3

Gene

Emp3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probably involved in cell proliferation and cell-cell interactions.

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Epithelial membrane protein 3
Short name:
EMP-3
Gene namesi
Name:Emp3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi621094. Emp3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei4 – 2421HelicalSequence analysisAdd
BLAST
Transmembranei66 – 8621HelicalSequence analysisAdd
BLAST
Transmembranei100 – 12021HelicalSequence analysisAdd
BLAST
Transmembranei139 – 15921HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 163163Epithelial membrane protein 3PRO_0000164662Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi46 – 461N-linked (GlcNAc...)Sequence analysis
Glycosylationi56 – 561N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9QYW5.

Expressioni

Gene expression databases

GenevisibleiQ9QYW5. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028656.

Family & Domainsi

Sequence similaritiesi

Belongs to the PMP-22/EMP/MP20 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IY40. Eukaryota.
ENOG4111MF9. LUCA.
GeneTreeiENSGT00510000046328.
HOGENOMiHOG000059542.
HOVERGENiHBG001690.
InParanoidiQ9QYW5.
OMAiSDLWYNC.
OrthoDBiEOG7FBRKJ.
PhylomeDBiQ9QYW5.
TreeFamiTF330414.

Family and domain databases

InterProiIPR003934. EMP_3.
IPR004031. PMP22/EMP/MP20/Claudin.
IPR004032. PMP22_EMP_MP20.
[Graphical view]
PANTHERiPTHR10671:SF8. PTHR10671:SF8. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01453. EPMEMFAMILY.
PR01456. EPMEMPROT3.
PROSITEiPS01221. PMP22_1. 1 hit.
PS01222. PMP22_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9QYW5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLLLLVVSA LHILILVLLF VATLDKSWWT LPEKESLNLW YDCTWNTTAK
60 70 80 90 100
TWACSNVSEN GWLKAVQALM VLSLILCCLS FILFMIQLYT MRRGGLFYAT
110 120 130 140 150
GLCQLCTSAA VFSGALIYAI HAKEILAKHP SGGSFGYCFA LAWVAFPLAL
160
VSGIIYIHLR KRE
Length:163
Mass (Da):18,198
Last modified:May 1, 2000 - v1
Checksum:i8B395380D0C92558
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y10889 mRNA. Translation: CAB61834.1.
BC088131 mRNA. Translation: AAH88131.1.
RefSeqiNP_110474.1. NM_030847.1.
XP_006229220.1. XM_006229158.2.
XP_008757640.1. XM_008759418.1.
UniGeneiRn.6782.

Genome annotation databases

EnsembliENSRNOT00000028656; ENSRNOP00000028656; ENSRNOG00000021104.
GeneIDi81505.
KEGGirno:81505.
UCSCiRGD:621094. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y10889 mRNA. Translation: CAB61834.1.
BC088131 mRNA. Translation: AAH88131.1.
RefSeqiNP_110474.1. NM_030847.1.
XP_006229220.1. XM_006229158.2.
XP_008757640.1. XM_008759418.1.
UniGeneiRn.6782.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028656.

Proteomic databases

PaxDbiQ9QYW5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000028656; ENSRNOP00000028656; ENSRNOG00000021104.
GeneIDi81505.
KEGGirno:81505.
UCSCiRGD:621094. rat.

Organism-specific databases

CTDi2014.
RGDi621094. Emp3.

Phylogenomic databases

eggNOGiENOG410IY40. Eukaryota.
ENOG4111MF9. LUCA.
GeneTreeiENSGT00510000046328.
HOGENOMiHOG000059542.
HOVERGENiHBG001690.
InParanoidiQ9QYW5.
OMAiSDLWYNC.
OrthoDBiEOG7FBRKJ.
PhylomeDBiQ9QYW5.
TreeFamiTF330414.

Miscellaneous databases

NextBioi614963.
PROiQ9QYW5.

Gene expression databases

GenevisibleiQ9QYW5. RN.

Family and domain databases

InterProiIPR003934. EMP_3.
IPR004031. PMP22/EMP/MP20/Claudin.
IPR004032. PMP22_EMP_MP20.
[Graphical view]
PANTHERiPTHR10671:SF8. PTHR10671:SF8. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01453. EPMEMFAMILY.
PR01456. EPMEMPROT3.
PROSITEiPS01221. PMP22_1. 1 hit.
PS01222. PMP22_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genetic dissection of dome formation in a mammary cell line: identification of two genes with opposing action."
    Zucchi I., Montagna C., Susani L., Montesano R., Affer M., Zanotti S., Redolfi E., Vezzoni P., Dulbecco R.
    Proc. Natl. Acad. Sci. U.S.A. 96:13766-13770(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Spleen.

Entry informationi

Entry nameiEMP3_RAT
AccessioniPrimary (citable) accession number: Q9QYW5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: May 1, 2000
Last modified: March 16, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.