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Q9QYW3 (PHOCN_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
MOB-like protein phocein
Alternative name(s):
Class II mMOB1
Mob1 homolog 3
Short name=Mob3
Mps one binder kinase activator-like 3
Phocein
Preimplantation protein 3
Gene names
Name:Mob4
Synonyms:Mob3, Mobkl1, Phocn, Prei3
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length225 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May play a role in membrane trafficking, specifically in membrane budding reactions. Ref.3

Subunit structure

Binds STRN, STRN3 and STRN4. Part of a ternary complex containing MOB4/PHOCN, STRN and/or STRN3 and PPA2. Interacts with DNM1 and EPS15. Interacts with nucleoside diphosphate kinase. Interacts with CTTNBP2. Interacts with CTTNBP2NL By similarity. Ref.1 Ref.3 Ref.4

Subcellular location

Cytoplasm. Membrane; Peripheral membrane protein. Golgi apparatusGolgi stack membrane; Peripheral membrane protein. Note: Detected in cell bodies and dendrites of neurons, but not in axons. Ref.1 Ref.3

Tissue specificity

Highly expressed in adrenal gland, spinal cord, brain and cerebellum. Detected at lower levels in heart and skeletal muscle, and at very low levels in spleen, liver and intestine. Ref.1

Post-translational modification

Phosphorylated on serine residues By similarity.

Sequence similarities

Belongs to the MOB1/phocein family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 225225MOB-like protein phocein
PRO_0000193578

Sites

Metal binding921Zinc By similarity
Metal binding971Zinc By similarity
Metal binding1691Zinc By similarity
Metal binding1741Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9QYW3 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: D0EF1219711458BA

FASTA22526,032
        10         20         30         40         50         60 
MVMAEGTAVL RRNRPGTKAQ DFYNWPDESF DEMDSTLAVQ QYIQQNIRAD CSNIDKILEP 

        70         80         90        100        110        120 
PEGQDEGVWK YEHLRQFCLE LNGLAVKLQS ECHPDTCTQM TATEQWIFLC AAHKTPKECP 

       130        140        150        160        170        180 
AIDYTRHTLD GAACLLNSNK YFPSRVSIKE SSVAKLGSVC RRIYRIFSHA YFHHRQIFDE 

       190        200        210        220 
YENETFLCHR FTKFVMKYNL MSKDNLIVPI LEEEVQNSVS GESEA 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning and characterization of phocein, a protein found from the Golgi complex to dendritic spines."
Baillat G., Moqrich A., Castets F., Baude A., Bailly Y., Benmerah A., Monneron A.
Mol. Biol. Cell 12:663-673(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH STRN; STRN3 AND STRN4, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
Strain: Wistar.
Tissue: Brain.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Heart.
[3]"Interactions of phocein with nucleoside-diphosphate kinase, Eps15, and Dynamin I."
Baillat G., Gaillard S., Castets F., Monneron A.
J. Biol. Chem. 277:18961-18966(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH DNM1 AND EPS15, SUBUNIT, SUBCELLULAR LOCATION.
[4]"CTTNBP2, but not CTTNBP2NL, regulates dendritic spinogenesis and synaptic distribution of the striatin-PP2A complex."
Chen Y.K., Chen C.Y., Hu H.T., Hsueh Y.P.
Mol. Biol. Cell 23:4383-4392(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH CTTNBP2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ132008 mRNA. Translation: CAB57295.1.
BC085708 mRNA. Translation: AAH85708.1.
RefSeqNP_598212.1. NM_133528.1.
UniGeneRn.12262.

3D structure databases

ProteinModelPortalQ9QYW3.
SMRQ9QYW3. Positions 61-196.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid251067. 3 interactions.
MINTMINT-233176.
STRING10116.ENSRNOP00000020536.

PTM databases

PhosphoSiteQ9QYW3.

Proteomic databases

PaxDbQ9QYW3.
PRIDEQ9QYW3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000020536; ENSRNOP00000020536; ENSRNOG00000014980.
GeneID171050.
KEGGrno:171050.
UCSCRGD:620183. rat.

Organism-specific databases

CTD25843.
RGD620183. Mob4.

Phylogenomic databases

eggNOGNOG297181.
GeneTreeENSGT00390000012143.
HOGENOMHOG000253925.
HOVERGENHBG052490.
InParanoidQ9QYW3.
OMADEPFEEM.
OrthoDBEOG7VDXQ5.
PhylomeDBQ9QYW3.
TreeFamTF314078.

Gene expression databases

GenevestigatorQ9QYW3.

Family and domain databases

Gene3D1.20.140.30. 1 hit.
InterProIPR005301. Mob1_phocein.
[Graphical view]
PANTHERPTHR22599. PTHR22599. 1 hit.
PfamPF03637. Mob1_phocein. 1 hit.
[Graphical view]
SUPFAMSSF101152. SSF101152. 1 hit.
ProtoNetSearch...

Other

NextBio621589.
PROQ9QYW3.

Entry information

Entry namePHOCN_RAT
AccessionPrimary (citable) accession number: Q9QYW3
Entry history
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: May 1, 2000
Last modified: June 11, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families