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Q9QYW3

- PHOCN_RAT

UniProt

Q9QYW3 - PHOCN_RAT

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Protein

MOB-like protein phocein

Gene
Mob4, Mob3, Mobkl1, Phocn, Prei3
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May play a role in membrane trafficking, specifically in membrane budding reactions.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi92 – 921Zinc By similarity
Metal bindingi97 – 971Zinc By similarity
Metal bindingi169 – 1691Zinc By similarity
Metal bindingi174 – 1741Zinc By similarity

GO - Molecular functioni

  1. kinase binding Source: RGD
  2. metal ion binding Source: UniProtKB-KW
  3. protein binding Source: UniProtKB

GO - Biological processi

  1. membrane budding Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
MOB-like protein phocein
Alternative name(s):
Class II mMOB1
Mob1 homolog 3
Short name:
Mob3
Mps one binder kinase activator-like 3
Phocein
Preimplantation protein 3
Gene namesi
Name:Mob4
Synonyms:Mob3, Mobkl1, Phocn, Prei3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 9

Organism-specific databases

RGDi620183. Mob4.

Subcellular locationi

Cytoplasm. Membrane; Peripheral membrane protein. Golgi apparatusGolgi stack membrane; Peripheral membrane protein
Note: Detected in cell bodies and dendrites of neurons, but not in axons.2 Publications

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. cytosol Source: RGD
  3. dendritic spine Source: RGD
  4. Golgi apparatus Source: UniProtKB
  5. Golgi cisterna membrane Source: UniProtKB-SubCell
  6. membrane Source: RGD
  7. neuronal cell body Source: RGD
  8. perinuclear region of cytoplasm Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 225225MOB-like protein phoceinPRO_0000193578Add
BLAST

Post-translational modificationi

Phosphorylated on serine residues By similarity.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9QYW3.
PRIDEiQ9QYW3.

PTM databases

PhosphoSiteiQ9QYW3.

Expressioni

Tissue specificityi

Highly expressed in adrenal gland, spinal cord, brain and cerebellum. Detected at lower levels in heart and skeletal muscle, and at very low levels in spleen, liver and intestine.1 Publication

Gene expression databases

GenevestigatoriQ9QYW3.

Interactioni

Subunit structurei

Binds STRN, STRN3 and STRN4. Part of a ternary complex containing MOB4/PHOCN, STRN and/or STRN3 and PPA2. Interacts with DNM1 and EPS15. Interacts with nucleoside diphosphate kinase. Interacts with CTTNBP2. Interacts with CTTNBP2NL By similarity.3 Publications

Protein-protein interaction databases

BioGridi251067. 3 interactions.
MINTiMINT-233176.
STRINGi10116.ENSRNOP00000020536.

Structurei

3D structure databases

ProteinModelPortaliQ9QYW3.
SMRiQ9QYW3. Positions 61-196.

Family & Domainsi

Sequence similaritiesi

Belongs to the MOB1/phocein family.

Phylogenomic databases

eggNOGiNOG297181.
GeneTreeiENSGT00390000012143.
HOGENOMiHOG000253925.
HOVERGENiHBG052490.
InParanoidiQ9QYW3.
OMAiDEPFEEM.
OrthoDBiEOG7VDXQ5.
PhylomeDBiQ9QYW3.
TreeFamiTF314078.

Family and domain databases

Gene3Di1.20.140.30. 1 hit.
InterProiIPR005301. Mob1_phocein.
[Graphical view]
PANTHERiPTHR22599. PTHR22599. 1 hit.
PfamiPF03637. Mob1_phocein. 1 hit.
[Graphical view]
SUPFAMiSSF101152. SSF101152. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9QYW3-1 [UniParc]FASTAAdd to Basket

« Hide

MVMAEGTAVL RRNRPGTKAQ DFYNWPDESF DEMDSTLAVQ QYIQQNIRAD    50
CSNIDKILEP PEGQDEGVWK YEHLRQFCLE LNGLAVKLQS ECHPDTCTQM 100
TATEQWIFLC AAHKTPKECP AIDYTRHTLD GAACLLNSNK YFPSRVSIKE 150
SSVAKLGSVC RRIYRIFSHA YFHHRQIFDE YENETFLCHR FTKFVMKYNL 200
MSKDNLIVPI LEEEVQNSVS GESEA 225
Length:225
Mass (Da):26,032
Last modified:May 1, 2000 - v1
Checksum:iD0EF1219711458BA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ132008 mRNA. Translation: CAB57295.1.
BC085708 mRNA. Translation: AAH85708.1.
RefSeqiNP_598212.1. NM_133528.1.
UniGeneiRn.12262.

Genome annotation databases

EnsembliENSRNOT00000020536; ENSRNOP00000020536; ENSRNOG00000014980.
GeneIDi171050.
KEGGirno:171050.
UCSCiRGD:620183. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ132008 mRNA. Translation: CAB57295.1 .
BC085708 mRNA. Translation: AAH85708.1 .
RefSeqi NP_598212.1. NM_133528.1.
UniGenei Rn.12262.

3D structure databases

ProteinModelPortali Q9QYW3.
SMRi Q9QYW3. Positions 61-196.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 251067. 3 interactions.
MINTi MINT-233176.
STRINGi 10116.ENSRNOP00000020536.

PTM databases

PhosphoSitei Q9QYW3.

Proteomic databases

PaxDbi Q9QYW3.
PRIDEi Q9QYW3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000020536 ; ENSRNOP00000020536 ; ENSRNOG00000014980 .
GeneIDi 171050.
KEGGi rno:171050.
UCSCi RGD:620183. rat.

Organism-specific databases

CTDi 25843.
RGDi 620183. Mob4.

Phylogenomic databases

eggNOGi NOG297181.
GeneTreei ENSGT00390000012143.
HOGENOMi HOG000253925.
HOVERGENi HBG052490.
InParanoidi Q9QYW3.
OMAi DEPFEEM.
OrthoDBi EOG7VDXQ5.
PhylomeDBi Q9QYW3.
TreeFami TF314078.

Miscellaneous databases

NextBioi 621589.
PROi Q9QYW3.

Gene expression databases

Genevestigatori Q9QYW3.

Family and domain databases

Gene3Di 1.20.140.30. 1 hit.
InterProi IPR005301. Mob1_phocein.
[Graphical view ]
PANTHERi PTHR22599. PTHR22599. 1 hit.
Pfami PF03637. Mob1_phocein. 1 hit.
[Graphical view ]
SUPFAMi SSF101152. SSF101152. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of phocein, a protein found from the Golgi complex to dendritic spines."
    Baillat G., Moqrich A., Castets F., Baude A., Bailly Y., Benmerah A., Monneron A.
    Mol. Biol. Cell 12:663-673(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH STRN; STRN3 AND STRN4, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
    Strain: Wistar.
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.
  3. "Interactions of phocein with nucleoside-diphosphate kinase, Eps15, and Dynamin I."
    Baillat G., Gaillard S., Castets F., Monneron A.
    J. Biol. Chem. 277:18961-18966(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH DNM1 AND EPS15, SUBUNIT, SUBCELLULAR LOCATION.
  4. "CTTNBP2, but not CTTNBP2NL, regulates dendritic spinogenesis and synaptic distribution of the striatin-PP2A complex."
    Chen Y.K., Chen C.Y., Hu H.T., Hsueh Y.P.
    Mol. Biol. Cell 23:4383-4392(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CTTNBP2.

Entry informationi

Entry nameiPHOCN_RAT
AccessioniPrimary (citable) accession number: Q9QYW3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: May 1, 2000
Last modified: June 11, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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