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Q9QYW3

- PHOCN_RAT

UniProt

Q9QYW3 - PHOCN_RAT

Protein

MOB-like protein phocein

Gene

Mob4

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    May play a role in membrane trafficking, specifically in membrane budding reactions.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi92 – 921ZincBy similarity
    Metal bindingi97 – 971ZincBy similarity
    Metal bindingi169 – 1691ZincBy similarity
    Metal bindingi174 – 1741ZincBy similarity

    GO - Molecular functioni

    1. kinase binding Source: RGD
    2. metal ion binding Source: UniProtKB-KW
    3. protein binding Source: UniProtKB

    GO - Biological processi

    1. membrane budding Source: UniProtKB

    Keywords - Biological processi

    Transport

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    MOB-like protein phocein
    Alternative name(s):
    Class II mMOB1
    Mob1 homolog 3
    Short name:
    Mob3
    Mps one binder kinase activator-like 3
    Phocein
    Preimplantation protein 3
    Gene namesi
    Name:Mob4
    Synonyms:Mob3, Mobkl1, Phocn, Prei3
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 9

    Organism-specific databases

    RGDi620183. Mob4.

    Subcellular locationi

    Cytoplasm. Membrane; Peripheral membrane protein. Golgi apparatusGolgi stack membrane; Peripheral membrane protein
    Note: Detected in cell bodies and dendrites of neurons, but not in axons.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. cytosol Source: RGD
    3. dendritic spine Source: RGD
    4. Golgi apparatus Source: UniProtKB
    5. Golgi cisterna membrane Source: UniProtKB-SubCell
    6. membrane Source: RGD
    7. neuronal cell body Source: RGD
    8. perinuclear region of cytoplasm Source: RGD

    Keywords - Cellular componenti

    Cytoplasm, Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 225225MOB-like protein phoceinPRO_0000193578Add
    BLAST

    Post-translational modificationi

    Phosphorylated on serine residues.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ9QYW3.
    PRIDEiQ9QYW3.

    PTM databases

    PhosphoSiteiQ9QYW3.

    Expressioni

    Tissue specificityi

    Highly expressed in adrenal gland, spinal cord, brain and cerebellum. Detected at lower levels in heart and skeletal muscle, and at very low levels in spleen, liver and intestine.1 Publication

    Gene expression databases

    GenevestigatoriQ9QYW3.

    Interactioni

    Subunit structurei

    Binds STRN, STRN3 and STRN4. Part of a ternary complex containing MOB4/PHOCN, STRN and/or STRN3 and PPA2. Interacts with DNM1 and EPS15. Interacts with nucleoside diphosphate kinase. Interacts with CTTNBP2. Interacts with CTTNBP2NL By similarity.By similarity

    Protein-protein interaction databases

    BioGridi251067. 3 interactions.
    MINTiMINT-233176.
    STRINGi10116.ENSRNOP00000020536.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9QYW3.
    SMRiQ9QYW3. Positions 61-196.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the MOB1/phocein family.Curated

    Phylogenomic databases

    eggNOGiNOG297181.
    GeneTreeiENSGT00390000012143.
    HOGENOMiHOG000253925.
    HOVERGENiHBG052490.
    InParanoidiQ9QYW3.
    OMAiDEPFEEM.
    OrthoDBiEOG7VDXQ5.
    PhylomeDBiQ9QYW3.
    TreeFamiTF314078.

    Family and domain databases

    Gene3Di1.20.140.30. 1 hit.
    InterProiIPR005301. Mob1_phocein.
    [Graphical view]
    PANTHERiPTHR22599. PTHR22599. 1 hit.
    PfamiPF03637. Mob1_phocein. 1 hit.
    [Graphical view]
    SUPFAMiSSF101152. SSF101152. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9QYW3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVMAEGTAVL RRNRPGTKAQ DFYNWPDESF DEMDSTLAVQ QYIQQNIRAD    50
    CSNIDKILEP PEGQDEGVWK YEHLRQFCLE LNGLAVKLQS ECHPDTCTQM 100
    TATEQWIFLC AAHKTPKECP AIDYTRHTLD GAACLLNSNK YFPSRVSIKE 150
    SSVAKLGSVC RRIYRIFSHA YFHHRQIFDE YENETFLCHR FTKFVMKYNL 200
    MSKDNLIVPI LEEEVQNSVS GESEA 225
    Length:225
    Mass (Da):26,032
    Last modified:May 1, 2000 - v1
    Checksum:iD0EF1219711458BA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ132008 mRNA. Translation: CAB57295.1.
    BC085708 mRNA. Translation: AAH85708.1.
    RefSeqiNP_598212.1. NM_133528.1.
    UniGeneiRn.12262.

    Genome annotation databases

    EnsembliENSRNOT00000020536; ENSRNOP00000020536; ENSRNOG00000014980.
    GeneIDi171050.
    KEGGirno:171050.
    UCSCiRGD:620183. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ132008 mRNA. Translation: CAB57295.1 .
    BC085708 mRNA. Translation: AAH85708.1 .
    RefSeqi NP_598212.1. NM_133528.1.
    UniGenei Rn.12262.

    3D structure databases

    ProteinModelPortali Q9QYW3.
    SMRi Q9QYW3. Positions 61-196.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 251067. 3 interactions.
    MINTi MINT-233176.
    STRINGi 10116.ENSRNOP00000020536.

    PTM databases

    PhosphoSitei Q9QYW3.

    Proteomic databases

    PaxDbi Q9QYW3.
    PRIDEi Q9QYW3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000020536 ; ENSRNOP00000020536 ; ENSRNOG00000014980 .
    GeneIDi 171050.
    KEGGi rno:171050.
    UCSCi RGD:620183. rat.

    Organism-specific databases

    CTDi 25843.
    RGDi 620183. Mob4.

    Phylogenomic databases

    eggNOGi NOG297181.
    GeneTreei ENSGT00390000012143.
    HOGENOMi HOG000253925.
    HOVERGENi HBG052490.
    InParanoidi Q9QYW3.
    OMAi DEPFEEM.
    OrthoDBi EOG7VDXQ5.
    PhylomeDBi Q9QYW3.
    TreeFami TF314078.

    Miscellaneous databases

    NextBioi 621589.
    PROi Q9QYW3.

    Gene expression databases

    Genevestigatori Q9QYW3.

    Family and domain databases

    Gene3Di 1.20.140.30. 1 hit.
    InterProi IPR005301. Mob1_phocein.
    [Graphical view ]
    PANTHERi PTHR22599. PTHR22599. 1 hit.
    Pfami PF03637. Mob1_phocein. 1 hit.
    [Graphical view ]
    SUPFAMi SSF101152. SSF101152. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of phocein, a protein found from the Golgi complex to dendritic spines."
      Baillat G., Moqrich A., Castets F., Baude A., Bailly Y., Benmerah A., Monneron A.
      Mol. Biol. Cell 12:663-673(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH STRN; STRN3 AND STRN4, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
      Strain: Wistar.
      Tissue: Brain.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Heart.
    3. "Interactions of phocein with nucleoside-diphosphate kinase, Eps15, and Dynamin I."
      Baillat G., Gaillard S., Castets F., Monneron A.
      J. Biol. Chem. 277:18961-18966(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH DNM1 AND EPS15, SUBUNIT, SUBCELLULAR LOCATION.
    4. "CTTNBP2, but not CTTNBP2NL, regulates dendritic spinogenesis and synaptic distribution of the striatin-PP2A complex."
      Chen Y.K., Chen C.Y., Hu H.T., Hsueh Y.P.
      Mol. Biol. Cell 23:4383-4392(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CTTNBP2.

    Entry informationi

    Entry nameiPHOCN_RAT
    AccessioniPrimary (citable) accession number: Q9QYW3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 21, 2004
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3