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Protein

MOB-like protein phocein

Gene

Mob4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in membrane trafficking, specifically in membrane budding reactions.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi92 – 921ZincBy similarity
Metal bindingi97 – 971ZincBy similarity
Metal bindingi169 – 1691ZincBy similarity
Metal bindingi174 – 1741ZincBy similarity

GO - Molecular functioni

  • kinase binding Source: RGD
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • membrane budding Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
MOB-like protein phocein
Alternative name(s):
Class II mMOB1
Mob1 homolog 3
Short name:
Mob3
Mps one binder kinase activator-like 3
Phocein
Preimplantation protein 3
Gene namesi
Name:Mob4
Synonyms:Mob3, Mobkl1, Phocn, Prei3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi620183. Mob4.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • cytosol Source: RGD
  • dendritic spine Source: RGD
  • Golgi apparatus Source: UniProtKB
  • Golgi cisterna membrane Source: UniProtKB-SubCell
  • membrane Source: RGD
  • neuronal cell body Source: RGD
  • perinuclear region of cytoplasm Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 225225MOB-like protein phoceinPRO_0000193578Add
BLAST

Post-translational modificationi

Phosphorylated on serine residues.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9QYW3.
PRIDEiQ9QYW3.

PTM databases

PhosphoSiteiQ9QYW3.

Expressioni

Tissue specificityi

Highly expressed in adrenal gland, spinal cord, brain and cerebellum. Detected at lower levels in heart and skeletal muscle, and at very low levels in spleen, liver and intestine.1 Publication

Gene expression databases

GenevisibleiQ9QYW3. RN.

Interactioni

Subunit structurei

Binds STRN, STRN3 and STRN4. Part of a ternary complex containing MOB4/PHOCN, STRN and/or STRN3 and PPA2. Interacts with DNM1 and EPS15. Interacts with nucleoside diphosphate kinase. Interacts with CTTNBP2. Interacts with CTTNBP2NL (By similarity).By similarity

Protein-protein interaction databases

BioGridi251067. 3 interactions.
MINTiMINT-233176.
STRINGi10116.ENSRNOP00000020536.

Structurei

3D structure databases

ProteinModelPortaliQ9QYW3.
SMRiQ9QYW3. Positions 61-196.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MOB1/phocein family.Curated

Phylogenomic databases

eggNOGiNOG297181.
GeneTreeiENSGT00390000012143.
HOGENOMiHOG000253925.
HOVERGENiHBG052490.
InParanoidiQ9QYW3.
OMAiDEPFEEM.
OrthoDBiEOG7VDXQ5.
PhylomeDBiQ9QYW3.
TreeFamiTF314078.

Family and domain databases

Gene3Di1.20.140.30. 1 hit.
InterProiIPR005301. MOB_kinase_act_fam.
[Graphical view]
PANTHERiPTHR22599. PTHR22599. 1 hit.
PfamiPF03637. Mob1_phocein. 1 hit.
[Graphical view]
SUPFAMiSSF101152. SSF101152. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9QYW3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVMAEGTAVL RRNRPGTKAQ DFYNWPDESF DEMDSTLAVQ QYIQQNIRAD
60 70 80 90 100
CSNIDKILEP PEGQDEGVWK YEHLRQFCLE LNGLAVKLQS ECHPDTCTQM
110 120 130 140 150
TATEQWIFLC AAHKTPKECP AIDYTRHTLD GAACLLNSNK YFPSRVSIKE
160 170 180 190 200
SSVAKLGSVC RRIYRIFSHA YFHHRQIFDE YENETFLCHR FTKFVMKYNL
210 220
MSKDNLIVPI LEEEVQNSVS GESEA
Length:225
Mass (Da):26,032
Last modified:May 1, 2000 - v1
Checksum:iD0EF1219711458BA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ132008 mRNA. Translation: CAB57295.1.
BC085708 mRNA. Translation: AAH85708.1.
RefSeqiNP_598212.1. NM_133528.1.
UniGeneiRn.12262.

Genome annotation databases

EnsembliENSRNOT00000020536; ENSRNOP00000020536; ENSRNOG00000014980.
GeneIDi171050.
KEGGirno:171050.
UCSCiRGD:620183. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ132008 mRNA. Translation: CAB57295.1.
BC085708 mRNA. Translation: AAH85708.1.
RefSeqiNP_598212.1. NM_133528.1.
UniGeneiRn.12262.

3D structure databases

ProteinModelPortaliQ9QYW3.
SMRiQ9QYW3. Positions 61-196.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi251067. 3 interactions.
MINTiMINT-233176.
STRINGi10116.ENSRNOP00000020536.

PTM databases

PhosphoSiteiQ9QYW3.

Proteomic databases

PaxDbiQ9QYW3.
PRIDEiQ9QYW3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000020536; ENSRNOP00000020536; ENSRNOG00000014980.
GeneIDi171050.
KEGGirno:171050.
UCSCiRGD:620183. rat.

Organism-specific databases

CTDi25843.
RGDi620183. Mob4.

Phylogenomic databases

eggNOGiNOG297181.
GeneTreeiENSGT00390000012143.
HOGENOMiHOG000253925.
HOVERGENiHBG052490.
InParanoidiQ9QYW3.
OMAiDEPFEEM.
OrthoDBiEOG7VDXQ5.
PhylomeDBiQ9QYW3.
TreeFamiTF314078.

Miscellaneous databases

NextBioi621589.
PROiQ9QYW3.

Gene expression databases

GenevisibleiQ9QYW3. RN.

Family and domain databases

Gene3Di1.20.140.30. 1 hit.
InterProiIPR005301. MOB_kinase_act_fam.
[Graphical view]
PANTHERiPTHR22599. PTHR22599. 1 hit.
PfamiPF03637. Mob1_phocein. 1 hit.
[Graphical view]
SUPFAMiSSF101152. SSF101152. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of phocein, a protein found from the Golgi complex to dendritic spines."
    Baillat G., Moqrich A., Castets F., Baude A., Bailly Y., Benmerah A., Monneron A.
    Mol. Biol. Cell 12:663-673(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH STRN; STRN3 AND STRN4, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
    Strain: Wistar.
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.
  3. "Interactions of phocein with nucleoside-diphosphate kinase, Eps15, and Dynamin I."
    Baillat G., Gaillard S., Castets F., Monneron A.
    J. Biol. Chem. 277:18961-18966(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH DNM1 AND EPS15, SUBUNIT, SUBCELLULAR LOCATION.
  4. "CTTNBP2, but not CTTNBP2NL, regulates dendritic spinogenesis and synaptic distribution of the striatin-PP2A complex."
    Chen Y.K., Chen C.Y., Hu H.T., Hsueh Y.P.
    Mol. Biol. Cell 23:4383-4392(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CTTNBP2.

Entry informationi

Entry nameiPHOCN_RAT
AccessioniPrimary (citable) accession number: Q9QYW3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: May 1, 2000
Last modified: June 24, 2015
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.