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Protein

Protein AATF

Gene

Aatf

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. May negatively regulate the pro-apoptotic activity of DAPK3/ZIPK. Can act cooperatively with TSG101 to stimulate AR mediated transcription activation (By similarity). May negatively regulate the pro-apoptotic activity of DAPK3/ZIPK. Can act cooperatively with TSG101 to stimulate AR mediated transcription activation.By similarity1 Publication

GO - Molecular functioni

  • leucine zipper domain binding Source: RGD
  • poly(A) RNA binding Source: Ensembl
  • protein domain specific binding Source: RGD
  • tau protein binding Source: RGD
  • transcription factor activity, sequence-specific DNA binding Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Protein AATF
Alternative name(s):
Apoptosis-antagonizing transcription factor
Gene namesi
Name:Aatf
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi620685. Aatf.

Subcellular locationi

  • Nucleus 1 Publication

GO - Cellular componenti

  • centrosome Source: Ensembl
  • cytoplasm Source: RGD
  • focal adhesion Source: Ensembl
  • Golgi apparatus Source: RGD
  • nucleolus Source: GO_Central
  • nucleus Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 523522Protein AATFPRO_0000056618Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei62 – 621PhosphoserineBy similarity
Modified residuei167 – 1671PhosphoserineBy similarity
Modified residuei237 – 2371PhosphoserineBy similarity
Modified residuei280 – 2801PhosphoserineCombined sources
Modified residuei284 – 2841PhosphoserineCombined sources
Modified residuei285 – 2851PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ9QYW0.
PRIDEiQ9QYW0.

PTM databases

iPTMnetiQ9QYW0.
PhosphoSiteiQ9QYW0.

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiENSRNOG00000002778.
GenevisibleiQ9QYW0. RN.

Interactioni

Subunit structurei

Binds PAWR, POLR2J, RB1/RB, RBL1/P107, RBL2/P130 and SP1 (By similarity). Binds DAPK3/ZIPK and TSG101. May also bind MAPT.By similarity

GO - Molecular functioni

  • leucine zipper domain binding Source: RGD
  • protein domain specific binding Source: RGD
  • tau protein binding Source: RGD

Protein-protein interaction databases

BioGridi250358. 1 interaction.
MINTiMINT-1037353.
STRINGi10116.ENSRNOP00000000258.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni237 – 27943Binds POLR2JBy similarityAdd
BLAST
Regioni280 – 33556Binds RB1By similarityAdd
BLAST
Regioni336 – 435100Binds RB1 and SP1By similarityAdd
BLAST
Regioni447 – 52377Binds to TSG101Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi96 – 16873Glu-richAdd
BLAST

Sequence similaritiesi

Belongs to the AATF family.Curated

Phylogenomic databases

eggNOGiKOG2773. Eukaryota.
ENOG410XWGK. LUCA.
GeneTreeiENSGT00390000000288.
HOGENOMiHOG000007555.
HOVERGENiHBG080805.
InParanoidiQ9QYW0.
KOiK14782.
OMAiSHCANTA.
OrthoDBiEOG091G0F1H.
PhylomeDBiQ9QYW0.
TreeFamiTF324341.

Family and domain databases

InterProiIPR025160. AATF.
IPR012617. AATF_C.
[Graphical view]
PfamiPF13339. AATF-Che1. 1 hit.
PF08164. TRAUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QYW0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAELQPLALQ LEQLLNPRPR EADPEADPEE ATRARVIDRF DEGEEEEDDL
60 70 80 90 100
PVSSIRKLAP VSLLDTDKRY SGKTTSRKAW KEDHWDQTLP SSSDNEIPDE
110 120 130 140 150
GGSEAGDSEG LEELSEDVEE DLEDNEIPDE GGSEDGDSEG LEEEISEDVE
160 170 180 190 200
EDLEGEDEED REEDRNSEDD GVVMAFSGVK VSEEVEKGRA VKNQIALWDQ
210 220 230 240 250
LLEGRIKLQK ALLTTNQLPQ PDVFPVFKDK GGPEFASALK NSHKALKALL
260 270 280 290 300
RSLVDLQEEL LFQYPDTRYL VKGTKPNAES EEISSEDDEL VGEKKKQRKA
310 320 330 340 350
PPKRKLEMED YPSFMAKRSA DFTVYRNRTL QKWHDKTKLA SGKLGKGFGA
360 370 380 390 400
FERSILTQID HILMDKERLL RRTQTKRSAY RVLGKPEPVP EPVAETLPGE
410 420 430 440 450
PESLPQVPAN AHLKDLDEEI FDDDDFYHQL LRELIERKTS SLDPNDQVAM
460 470 480 490 500
GRQWLAIQKL RSKIRKKVDR KASKGRKLRF HVLSKLLSFM APIDHTAMND
510 520
EARTELYRSL FGQLNRLDAD HGQ
Length:523
Mass (Da):59,497
Last modified:May 1, 2000 - v1
Checksum:iB66C0FA591FB5FB4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ238717 mRNA. Translation: CAB59426.1.
BC078769 mRNA. Translation: AAH78769.1.
RefSeqiNP_446172.1. NM_053720.1.
UniGeneiRn.15500.

Genome annotation databases

EnsembliENSRNOT00000000258; ENSRNOP00000000258; ENSRNOG00000002778.
GeneIDi114512.
KEGGirno:114512.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ238717 mRNA. Translation: CAB59426.1.
BC078769 mRNA. Translation: AAH78769.1.
RefSeqiNP_446172.1. NM_053720.1.
UniGeneiRn.15500.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi250358. 1 interaction.
MINTiMINT-1037353.
STRINGi10116.ENSRNOP00000000258.

PTM databases

iPTMnetiQ9QYW0.
PhosphoSiteiQ9QYW0.

Proteomic databases

PaxDbiQ9QYW0.
PRIDEiQ9QYW0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000000258; ENSRNOP00000000258; ENSRNOG00000002778.
GeneIDi114512.
KEGGirno:114512.

Organism-specific databases

CTDi26574.
RGDi620685. Aatf.

Phylogenomic databases

eggNOGiKOG2773. Eukaryota.
ENOG410XWGK. LUCA.
GeneTreeiENSGT00390000000288.
HOGENOMiHOG000007555.
HOVERGENiHBG080805.
InParanoidiQ9QYW0.
KOiK14782.
OMAiSHCANTA.
OrthoDBiEOG091G0F1H.
PhylomeDBiQ9QYW0.
TreeFamiTF324341.

Miscellaneous databases

PROiQ9QYW0.

Gene expression databases

BgeeiENSRNOG00000002778.
GenevisibleiQ9QYW0. RN.

Family and domain databases

InterProiIPR025160. AATF.
IPR012617. AATF_C.
[Graphical view]
PfamiPF13339. AATF-Che1. 1 hit.
PF08164. TRAUB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAATF_RAT
AccessioniPrimary (citable) accession number: Q9QYW0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: May 1, 2000
Last modified: September 7, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.